Details of the Target

General Information of Target

Target ID LDTP10457
Target Name Vam6/Vps39-like protein (VPS39)
Gene Name VPS39
Gene ID 23339
Synonyms
KIAA0770; TLP; VAM6; Vam6/Vps39-like protein; TRAP1-like protein; hVam6p
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSP
WLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFK
ALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVA
RIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVN
SQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAG
LVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEEL
SEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQ
RRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS
KETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKP
YVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIV
NDSLHDACAQLLSAIQKAQEEPQWVPATWISSDTESQ
Target Bioclass
Other
Family
VAM6/VPS39 family
Subcellular location
Cytoplasm
Function
Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes. Required for fusion of endosomes and autophagosomes with lysosomes.
Uniprot ID
Q96JC1
Ensemble ID
ENST00000318006.10
HGNC ID
HGNC:20593

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K71(7.42)  LDD0277  [2]
DBIA
 Probe Info  		C681(6.38)  LDD0209  [3]
IA-alkyne
 Probe Info  		C681(0.00); C239(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		C844(0.00); C235(0.00); C753(0.00); C681(0.00)  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C621(1.02); C627(1.02)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C621(1.17); C627(1.17); C844(0.84)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C173(1.03); C358(1.10); C621(0.80); C844(1.16)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C173(1.03); C358(1.50); C621(0.86); C844(1.03)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C173(0.89); C358(0.96); C621(0.95); C844(1.06)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C173(1.01); C358(1.00); C621(1.05); C844(1.16)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C173(0.86); C358(1.08); C621(0.86); C844(1.34)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C173(1.16); C358(0.97); C621(0.94); C844(0.88)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C173(1.13); C358(1.26); C621(1.53); C844(0.73)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C173(1.00); C358(0.88); C621(0.93); C844(1.17)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C173(1.17); C358(1.00); C621(0.93); C844(1.01)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C173(0.99); C358(1.67); C621(0.99); C844(0.82)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C621(1.23); C627(1.23); C844(0.81)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C173(1.04); C358(0.79); C621(0.97); C844(1.68)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C173(0.93); C358(0.88); C621(1.11); C844(2.14)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C173(0.88); C358(0.91); C621(1.06); C844(1.56)  LDD0827  [8]
 LDCM0230  AC113 HEK-293T C358(0.96); C621(0.95); C627(0.95); C844(0.92)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C358(0.91); C621(0.99); C627(0.99); C844(1.30)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C358(1.06); C621(0.91); C627(0.91); C844(1.28)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C358(0.98); C621(0.98); C627(0.98); C844(0.83)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C358(1.18); C621(1.00); C627(1.00); C844(1.05)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C358(1.22); C621(0.91); C627(0.91); C844(1.11)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C358(1.15); C621(0.84); C627(0.84); C844(1.42)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C621(1.18); C627(1.18); C844(0.92)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C358(0.95); C621(1.89); C627(1.89); C844(0.92)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C358(1.18); C621(0.82); C627(0.82); C844(1.31)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C358(1.22); C621(0.84); C627(0.84); C844(1.53)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C358(1.03); C621(0.87); C627(0.87); C844(1.84)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C358(0.99); C621(0.84); C627(0.84); C844(1.34)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C358(0.99); C621(0.81); C627(0.81); C844(1.45)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C358(1.02); C621(0.85); C627(0.85); C844(2.21)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C358(0.80); C621(0.91); C627(0.91); C844(2.18)  LDD0843  [8]
 LDCM0246  AC128 HCT 116 C621(1.22); C627(1.22)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C621(1.03); C627(1.03)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C621(1.14); C627(1.14)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C621(1.10); C627(1.10)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C621(0.96); C627(0.96)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C621(1.14); C627(1.14)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C621(1.20); C627(1.20)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C621(1.03); C627(1.03)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C621(0.99); C627(0.99)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C621(0.96); C627(0.96)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C621(0.94); C627(0.94)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C621(0.98); C627(0.98)  LDD0575  [8]
 LDCM0259  AC14 HEK-293T C621(1.24); C627(1.24); C844(0.92)  LDD0857  [8]
 LDCM0260  AC140 HCT 116 C621(0.93); C627(0.93)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C621(1.04); C627(1.04)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C621(0.96); C627(0.96)  LDD0579  [8]
 LDCM0263  AC143 HEK-293T C173(0.94); C358(0.69); C621(1.21); C844(1.26)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C173(1.06); C358(0.74); C621(1.02); C844(1.84)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C173(0.85); C358(0.55); C621(1.21); C844(1.41)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C173(1.10); C358(0.66); C621(1.05); C844(1.87)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C173(1.03); C358(0.58); C621(1.29); C844(1.65)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C173(1.08); C358(0.44); C621(1.50); C844(1.13)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C173(1.07); C358(0.59); C621(1.15); C844(0.96)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C621(1.22); C627(1.22); C844(1.07)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C173(1.07); C358(0.93); C621(1.09); C844(1.54)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C173(0.97); C358(1.41); C621(0.99); C844(1.17)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C173(0.87); C358(0.64); C621(0.97); C844(1.49)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C173(1.02); C358(0.89); C621(1.06); C844(1.41)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C173(0.98); C358(0.56); C621(0.95); C844(1.14)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C173(1.03); C358(0.56); C621(1.02); C844(1.15)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C173(1.33); C358(0.68); C621(1.53); C844(2.05)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C173(1.11); C358(0.52); C621(1.12); C844(2.03)  LDD2165  [8]
 LDCM0276  AC17 HCT 116 C627(0.81); C621(0.84)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C627(0.92); C621(0.93)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C621(0.96); C627(0.98)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C621(1.00); C627(1.00)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C621(0.93); C627(0.93)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C627(0.85); C621(0.87)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C627(0.89); C621(0.90)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C621(0.80); C627(0.81)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C627(0.93); C621(1.04)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C621(0.78); C627(0.78)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C621(0.71); C627(0.71)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C621(0.79); C627(0.79)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C621(0.74); C627(0.74)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C621(0.86); C627(0.86)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C621(1.02); C627(1.02)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C621(0.89); C627(0.89)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C621(0.74); C627(0.74)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C621(0.80); C627(0.80)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C621(0.78); C627(0.78)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C621(0.88); C627(0.88)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C621(0.99); C627(0.99)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C621(0.96); C627(0.96)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C621(1.05); C627(1.05)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C621(1.10); C627(1.10)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C621(1.00); C627(1.00)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C621(1.02); C627(1.02)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C621(1.06); C627(1.06)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C621(0.94); C627(0.94)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C621(1.02); C627(1.02)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C621(0.95); C627(0.95)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C621(1.19); C627(1.19)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C621(1.00); C627(1.00)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C621(1.02); C627(1.02)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C621(0.90); C627(0.90)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C621(0.90); C627(0.90)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C621(1.14); C627(1.14)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C621(1.10); C627(1.10)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C621(1.00); C627(1.00)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C621(0.97); C627(0.97)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C621(0.90); C627(0.90)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C621(0.99); C627(0.99)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C621(0.99); C627(0.99)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C621(1.04); C627(1.04)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C621(1.27); C627(1.27)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C621(1.06); C627(1.06)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C621(1.11); C627(1.11)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C621(0.90); C627(0.90)  LDD0639  [8]
 LDCM0323  AC6 HEK-293T C621(1.11); C627(1.11); C844(0.80)  LDD0921  [8]
 LDCM0324  AC60 HCT 116 C621(0.92); C627(0.92)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C621(1.04); C627(1.04)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C621(0.92); C627(0.92)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C621(0.80); C627(0.80)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C621(0.92); C627(0.92)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C621(0.94); C627(0.94)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C621(1.14); C627(1.14)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C621(0.91); C627(0.91)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C621(1.38); C627(1.38)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C621(1.42); C627(1.42)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C621(1.23); C627(1.23); C844(0.87)  LDD0932  [8]
 LDCM0335  AC70 HCT 116 C621(1.07); C627(1.07)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C621(1.37); C627(1.37)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C621(1.03); C627(1.03)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C621(0.98); C627(0.98)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C621(1.18); C627(1.18)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C621(1.05); C627(1.05)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C621(1.13); C627(1.13)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C621(1.26); C627(1.26)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C621(1.13); C627(1.13)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C621(1.11); C627(1.11)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C621(1.24); C627(1.24); C844(1.08)  LDD0943  [8]
 LDCM0346  AC80 HCT 116 C621(1.03); C627(1.03)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C621(1.25); C627(1.25)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C621(1.04); C627(1.04)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C621(1.05); C627(1.05)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C621(1.19); C627(1.19)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C621(0.97); C627(0.97)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C621(1.05); C627(1.05)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C621(0.99); C627(0.99)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C621(0.94); C627(0.94)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C621(1.17); C627(1.17)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C621(1.22); C627(1.22)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C621(1.08); C627(1.08)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C621(1.08); C627(1.08)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C621(1.02); C627(1.02)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C621(1.07); C627(1.07)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C621(0.94); C627(0.94)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C621(1.02); C627(1.02)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C621(0.97); C627(0.97)  LDD0681  [8]
 LDCM0365  AC98 HEK-293T C173(0.91); C358(1.74); C621(1.01); C844(1.03)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C173(1.05); C358(0.91); C621(1.03); C844(0.97)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C621(1.00); C627(1.00); C844(0.79)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C621(1.25); C627(1.25); C844(1.16)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C621(1.23); C627(1.23); C844(0.99)  LDD0873  [8]
 LDCM0632  CL-Sc Hep-G2 C358(3.01)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C621(0.99); C627(0.99)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C621(1.11); C627(1.11)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C621(0.96); C627(0.96)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C621(1.15); C627(1.15); C844(1.25)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C621(1.08); C627(1.08); C844(1.29)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C621(1.18); C627(1.18); C844(1.09)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C621(1.18); C627(1.18); C844(0.99)  LDD0971  [8]
 LDCM0374  CL105 HCT 116 C621(0.83); C627(0.84)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C621(0.76); C627(0.83)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C621(0.83); C627(0.90)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C621(0.91); C627(1.05)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C627(0.90); C621(0.95)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C621(1.24); C627(1.24)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C621(0.87); C627(0.88)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C627(0.75); C621(0.83)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C621(0.84); C627(0.84)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C621(0.77); C627(0.77)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C621(0.80); C627(0.80)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C621(0.75); C627(0.75)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C621(0.76); C627(0.76)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C621(1.15); C627(1.15)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C621(0.94); C627(0.94)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C621(0.95); C627(0.95)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C621(1.08); C627(1.08)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C621(0.92); C627(0.92)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C621(1.22); C627(1.22)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C621(0.96); C627(0.96)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C621(0.99); C627(0.99)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C621(1.00); C627(1.00)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C621(0.91); C627(0.91)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C621(0.90); C627(0.90)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C621(0.89); C627(0.89)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C621(1.01); C627(1.01)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C621(1.09); C627(1.09)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C621(1.06); C627(1.06)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C621(0.90); C627(0.90)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C844(0.96)  LDD1001  [8]
 LDCM0404  CL17 HCT 116 C621(0.92)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C621(1.03)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C621(0.90)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C621(1.02); C627(1.02)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C621(1.08)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C621(1.04)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C621(1.12)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C621(0.88)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C621(1.19)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C621(0.82)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C621(0.78)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C621(1.05)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C621(1.24)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C621(1.38)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C621(1.03); C627(1.03)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C621(1.09)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C621(1.00)  LDD0737  [8]
 LDCM0421  CL32 HEK-293T C358(0.88); C621(0.65); C844(1.16)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C358(0.62); C621(0.64); C844(1.43)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C358(0.97); C621(0.83); C844(1.38)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C358(0.73); C621(0.80); C844(1.40)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C358(1.09); C621(0.84); C844(1.09)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C358(1.07); C621(0.72); C844(1.14)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C358(0.82); C621(0.72); C844(2.44)  LDD1026  [8]
 LDCM0429  CL4 HCT 116 C621(0.93); C627(0.93)  LDD0746  [8]
 LDCM0430  CL40 HEK-293T C358(1.21); C621(0.95); C844(1.54)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C358(1.56); C621(0.71); C844(1.96)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C358(0.68); C621(0.97); C844(1.95)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C358(0.98); C621(0.89); C844(1.95)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C358(1.54); C621(0.80); C844(1.37)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C358(1.42); C621(0.76); C844(1.56)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C358(1.16); C844(1.14)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C358(1.05); C844(0.98)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C358(1.03); C844(1.00)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C358(1.12); C844(1.03)  LDD1037  [8]
 LDCM0440  CL5 HCT 116 C621(1.06); C627(1.06)  LDD0757  [8]
 LDCM0441  CL50 HEK-293T C358(1.01); C844(1.36)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C358(0.97); C844(1.18)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C358(0.91); C844(0.81)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C358(0.86); C844(0.83)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C358(1.02); C844(1.08)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C358(1.13); C844(1.09)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C358(0.86); C844(0.99)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C358(1.06); C844(0.95)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C358(1.43); C844(0.94)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C358(1.16); C844(1.29)  LDD1048  [8]
 LDCM0451  CL6 HCT 116 C621(1.01); C627(1.01)  LDD0768  [8]
 LDCM0452  CL60 HEK-293T C358(1.31); C844(1.25)  LDD1050  [8]
 LDCM0453  CL61 HCT 116 C621(0.92); C627(0.92)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C621(0.92); C627(0.92)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C621(0.81); C627(0.81)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C621(0.81); C627(0.81)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C621(0.96); C627(0.96)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C621(0.92); C627(0.92)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C621(1.13); C627(1.13)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C621(0.96); C627(0.96)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C621(1.05); C627(1.05)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C621(0.99); C627(0.99)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C621(0.97); C627(0.97)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C621(0.80); C627(0.80)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C621(0.84); C627(0.84)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C621(1.32); C627(1.32)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C621(1.30); C627(1.30)  LDD0784  [8]
 LDCM0469  CL76 HEK-293T C358(1.06); C627(1.27); C844(0.92)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C358(0.60); C627(0.81); C844(1.14)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C358(0.58); C627(0.53); C844(0.89)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C358(0.68); C627(1.13); C844(1.07)  LDD1070  [8]
 LDCM0473  CL8 HCT 116 C621(1.23); C627(1.23)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C358(0.60); C627(0.79); C844(0.96)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C358(0.59); C627(0.76); C844(0.98)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C358(1.23); C627(1.55); C844(0.99)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C358(1.06); C627(2.02); C844(0.97)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C358(0.56); C627(0.73); C844(0.91)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C358(0.77); C627(0.86); C844(0.98)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C358(0.53); C627(0.70); C844(1.20)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C358(0.56); C627(0.77); C844(1.25)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C358(1.27); C627(1.43); C844(1.09)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C358(1.01); C627(0.79); C844(1.10)  LDD1081  [8]
 LDCM0484  CL9 HCT 116 C621(0.96); C627(0.96)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C358(0.56); C627(1.41); C844(1.10)  LDD1083  [8]
 LDCM0486  CL91 HCT 116 C621(0.90); C627(0.90)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C621(0.97); C627(0.97)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C621(0.96); C627(0.96)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C621(0.88); C627(0.88)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C621(0.88); C627(0.88)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C621(0.91); C627(0.91)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C621(1.07); C627(1.07)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C621(0.95); C627(0.95)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C621(1.05); C627(1.05)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C723(0.96); C844(1.13); C753(0.97); C467(1.02)  LDD1698  [9]
 LDCM0625  F8 Ramos C681(1.09)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C681(1.19)  LDD2189  [10]
 LDCM0574  Fragment12 Ramos C681(0.66)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C681(0.89)  LDD2192  [10]
 LDCM0579  Fragment20 Ramos C681(1.84)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C681(0.77)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C681(1.54)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C681(0.81)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C681(0.23)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C681(0.84)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C681(0.68)  LDD2200  [10]
 LDCM0468  Fragment33 HCT 116 C621(1.04); C627(1.04)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C681(2.45)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C681(1.20)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C358(1.15); C621(0.86); C844(1.17)  LDD1025  [8]
 LDCM0610  Fragment52 Ramos C681(0.69)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C681(3.11)  LDD2205  [10]
 LDCM0571  Fragment9 Ramos C681(1.19)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C844(0.97); C753(1.01); C681(0.70); C239(1.05)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C681(6.38)  LDD0209  [3]
 LDCM0024  KB05 HMCB C467(1.62); C681(2.68); C235(1.75)  LDD3312  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-7a (RAB7A) Rab family P51149
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-17 (STX17) Syntaxin family P56962
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 11 homolog (VPS11) VPS11 family Q9H270
Vacuolar protein sorting-associated protein 18 homolog (VPS18) VPS18 family Q9P253
Pleckstrin homology domain-containing family M member 1 (PLEKHM1) . Q9Y4G2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840