Details of the Target

General Information of Target

Target ID LDTP10166
Target Name Integrator complex subunit 12 (INTS12)
Gene Name INTS12
Gene ID 57117
Synonyms
PHF22; Integrator complex subunit 12; Int12; PHD finger protein 22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLR
PLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQD
KVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPW
EEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGGVSPAEAQRAWWVLEPPGARDVE
AQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSRVRTFLS
Target Bioclass
Other
Family
Integrator subunit 12 family
Subcellular location
Nucleus
Function
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
Uniprot ID
Q96CB8
Ensemble ID
ENST00000340139.10
HGNC ID
HGNC:25067

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C379(1.02)  LDD2117  [2]
AHL-Pu-1
 Probe Info  		C379(2.06)  LDD0171  [3]
DBIA
 Probe Info  		C379(0.98)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C190(0.00); C379(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C379(1.02)  LDD2117  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C379(2.06)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C379(0.93)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C379(0.87)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C379(1.33)  LDD0543  [4]
 LDCM0230  AC113 HCT 116 C379(1.07)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C379(1.33)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C379(1.88)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C379(1.75)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C379(1.35)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C379(1.23)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C379(1.51)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C379(0.71)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C379(1.63)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C379(1.12)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C379(1.34)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C379(1.25)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C379(1.17)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C379(1.35)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C379(1.85)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C379(1.72)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C379(1.37)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C379(0.81)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C379(1.20)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C379(0.91)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C379(0.83)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C379(1.01)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C379(1.04)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C379(0.99)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C379(1.00)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C379(0.82)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C379(0.81)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C379(0.98)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C379(0.65)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C379(0.98)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C379(0.87)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C379(0.73)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C379(1.25)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C379(1.89)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C379(1.45)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C379(1.60)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C379(1.87)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C379(1.92)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C379(1.93)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C379(1.07)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C379(1.15)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C379(1.63)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C379(1.65)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C379(3.30)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C379(1.89)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C379(2.17)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C379(1.64)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C379(1.25)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C379(0.95)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C379(1.13)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C379(0.90)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C379(0.96)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C379(0.96)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C379(1.05)  LDD1520  [10]
 LDCM0283  AC23 HEK-293T C379(1.00)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C379(1.03)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C379(1.01)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C379(1.04)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C379(1.00)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C379(0.99)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C379(1.02)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C379(0.97)  LDD1529  [10]
 LDCM0292  AC31 HEK-293T C379(0.95)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C379(1.03)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C379(0.93)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C379(1.05)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C379(0.90)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C379(0.90)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C379(0.92)  LDD1537  [10]
 LDCM0300  AC39 HEK-293T C379(0.95)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C379(0.98)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C379(0.95)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C379(0.90)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C379(1.09)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C379(0.93)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C379(0.95)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C379(1.00)  LDD1546  [10]
 LDCM0309  AC47 HEK-293T C379(0.98)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C379(0.88)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C379(0.94)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C379(0.92)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C379(1.12)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C379(0.90)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C379(0.94)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C379(0.96)  LDD1555  [10]
 LDCM0318  AC55 HEK-293T C379(0.99)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C379(0.93)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C379(0.93)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C379(1.05)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C379(0.89)  LDD1561  [10]
 LDCM0323  AC6 HCT 116 C379(0.76)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C379(0.96)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C379(0.99)  LDD1564  [10]
 LDCM0327  AC63 HEK-293T C379(0.97)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C379(0.94)  LDD1567  [10]
 LDCM0332  AC68 HCT 116 C379(0.94)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C379(1.07)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C379(0.70)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C379(1.20)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C379(0.96)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C379(1.45)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C379(1.29)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C379(1.25)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C379(1.70)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C379(1.57)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C379(1.26)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C379(1.15)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C379(0.99)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C379(0.81)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C379(1.62)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C379(1.36)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C379(1.55)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C379(1.28)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C379(1.31)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C379(2.03)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C379(0.87)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C379(0.76)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C379(1.51)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C379(0.80)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C379(0.54)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C379(2.49)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C379(2.11)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C379(1.48)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C379(0.82)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C379(1.63)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C379(1.27)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C379(1.17)  LDD0681  [4]
 LDCM0248  AKOS034007472 HCT 116 C379(0.92)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C379(0.97)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C379(1.40)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C379(0.98)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C190(20.00)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C379(1.15)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C379(1.36)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C379(0.88)  LDD1573  [10]
 LDCM0370  CL101 HCT 116 C379(1.09)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C379(0.76)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C379(0.83)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C379(0.75)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C379(0.98)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C379(0.97)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C379(0.92)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C379(0.96)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C379(0.97)  LDD1582  [10]
 LDCM0379  CL11 HCT 116 C379(1.15)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C379(0.96)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C379(1.06)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C379(1.01)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C379(0.98)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C379(0.96)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C379(0.94)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C379(0.91)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C379(0.97)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C379(0.94)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C379(0.88)  LDD1593  [10]
 LDCM0390  CL12 HCT 116 C379(1.23)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C379(0.88)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C379(0.94)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C379(0.98)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C379(0.82)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C379(0.90)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C379(0.95)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C379(0.96)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C379(0.97)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C379(0.96)  LDD1603  [10]
 LDCM0400  CL13 HCT 116 C379(1.26)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C379(1.36)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C379(1.19)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C379(1.16)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C379(0.88)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C379(0.62)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C379(0.73)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C379(1.15)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C379(0.83)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C379(0.85)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C379(0.63)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C379(1.04)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C379(0.93)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C379(0.84)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C379(1.77)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C379(0.81)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C379(0.81)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C379(1.12)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C379(1.52)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C379(1.05)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C379(0.95)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C379(1.04)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C379(0.82)  LDD1626  [10]
 LDCM0424  CL35 HEK-293T C379(1.10)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C379(1.01)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C379(0.96)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C379(0.95)  LDD1632  [10]
 LDCM0429  CL4 HCT 116 C379(0.98)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C379(0.97)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C379(0.92)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C379(1.03)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C379(0.99)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C379(1.02)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C379(0.94)  LDD1639  [10]
 LDCM0437  CL47 HEK-293T C379(1.07)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C379(1.02)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C379(0.89)  LDD1643  [10]
 LDCM0440  CL5 HCT 116 C379(0.94)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C379(0.95)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C379(0.88)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C379(0.87)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C379(1.02)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C379(0.88)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C379(0.99)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C379(0.91)  LDD1651  [10]
 LDCM0450  CL59 HEK-293T C379(1.01)  LDD1653  [10]
 LDCM0451  CL6 HCT 116 C379(1.10)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C379(0.87)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C379(0.94)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C379(0.97)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C379(1.05)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C379(0.89)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C379(0.96)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C379(0.99)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C379(0.93)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C379(0.95)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C379(0.93)  LDD1664  [10]
 LDCM0462  CL7 HCT 116 C379(1.05)  LDD0779  [4]
 LDCM0464  CL71 HEK-293T C379(1.04)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C379(0.99)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C379(0.96)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C379(0.94)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C379(0.87)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C379(0.90)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C379(1.02)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C379(0.93)  LDD1675  [10]
 LDCM0473  CL8 HCT 116 C379(1.24)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C379(0.91)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C379(0.96)  LDD1678  [10]
 LDCM0477  CL83 HEK-293T C379(1.02)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C379(0.91)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C379(0.95)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C379(0.88)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C379(0.93)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C379(0.89)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C379(0.90)  LDD1686  [10]
 LDCM0484  CL9 HCT 116 C379(1.24)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C379(0.89)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C379(0.85)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C379(0.87)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C379(0.89)  LDD1691  [10]
 LDCM0490  CL95 HEK-293T C379(0.93)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C379(0.90)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C379(0.94)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C379(1.00)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C379(1.01)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C379(0.98)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C190(1.16)  LDD1702  [2]
 LDCM0625  F8 Ramos C379(1.24)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C379(0.85)  LDD2189  [11]
 LDCM0574  Fragment12 Ramos C379(0.57)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C379(1.07)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C379(0.77)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C379(0.49)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C379(1.16)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C379(0.65)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C379(0.94)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C379(1.04)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C379(1.01)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C379(0.59)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C379(1.05)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C379(0.90)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C379(0.80)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C379(0.91)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C379(0.98)  LDD1631  [10]
 LDCM0610  Fragment52 Ramos C379(1.20)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C379(0.90)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C379(1.00)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C379(0.61)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C379(1.00); C190(0.93)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C379(1.03); C190(1.00)  LDD1497  [10]
 LDCM0024  KB05 SKMEL24 C209(1.06)  LDD3323  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C379(1.06)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C379(0.99)  LDD2136  [2]
 LDCM0021  THZ1 HCT 116 C379(1.80); C179(1.27); C182(1.27)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) TFII-I family Q9UHL9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
HUWE1-associated protein modifying stress responses 1 (HAPSTR1) HAPSTR1 family Q14CZ0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840