Details of the Target

General Information of Target

Target ID LDTP09796
Target Name Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)
Gene Name BAP1
Gene ID 8314
Synonyms
KIAA0272; Ubiquitin carboxyl-terminal hydrolase BAP1; EC 3.4.19.12; BRCA1-associated protein 1; Cerebral protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ
TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCISSA
TGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPA
TALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEV
QGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIP
ASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIA
VEYSDSEDDSEFDEVDWLE
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase C12 family, BAP1 subfamily
Subcellular location
Cytoplasm
Function
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.
TTD ID
T92628
Uniprot ID
Q92560
DrugMap ID
TT47RXJ
Ensemble ID
ENST00000460680.6
HGNC ID
HGNC:950
ChEMBL ID
CHEMBL1293314

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C638(2.79); C649(2.79)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
AOyne
 Probe Info  		13.90  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C638(0.79)  LDD0812  [2]
 LDCM0215  AC10 PaTu 8988t C638(1.17); C649(1.17); C39(1.01)  LDD1094  [2]
 LDCM0216  AC100 HEK-293T C638(0.93); C649(0.93)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C638(0.85); C649(0.85)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C638(0.92); C649(0.92)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C638(0.88); C649(0.88)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C638(0.97); C649(0.97)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C638(0.82); C649(0.82)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C638(0.88); C649(0.88)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C638(0.85); C649(0.85)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C638(0.85); C649(0.85)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C638(0.97); C649(0.97)  LDD0823  [2]
 LDCM0226  AC11 PaTu 8988t C638(1.09); C649(1.09); C39(1.04)  LDD1105  [2]
 LDCM0227  AC110 HEK-293T C638(0.78); C649(0.78)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C638(0.83); C649(0.83)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C638(0.85); C649(0.85)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C638(1.09); C649(1.09)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C638(0.89); C649(0.89)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C638(0.91); C649(0.91)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C638(1.15); C649(1.15)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C638(1.04); C649(1.04)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C638(0.91); C649(0.91)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C638(1.18); C649(1.18)  LDD0834  [2]
 LDCM0237  AC12 PaTu 8988t C638(1.27); C649(1.27); C39(1.05)  LDD1116  [2]
 LDCM0238  AC120 HEK-293T C638(1.04); C649(1.04)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C638(1.01); C649(1.01)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C638(1.05); C649(1.05)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C638(1.25); C649(1.25)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C638(1.02); C649(1.02)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C638(0.97); C649(0.97)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C638(1.10); C649(1.10)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C638(1.11); C649(1.11)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C638(1.19); C649(1.19)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C638(0.98); C649(0.98)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C638(0.95); C649(0.95)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C638(0.86); C649(0.86)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C638(0.90); C649(0.90)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C638(0.90); C649(0.90)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C638(0.96); C649(0.96)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C638(1.05); C649(1.05)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C638(0.97); C649(0.97)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C638(0.96); C649(0.96)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C638(1.43); C649(1.43)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C638(1.18); C649(1.18)  LDD0856  [2]
 LDCM0259  AC14 PaTu 8988t C638(1.05); C649(1.05); C39(1.02)  LDD1138  [2]
 LDCM0260  AC140 HEK-293T C638(0.95); C649(0.95)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C638(0.99); C649(0.99)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C638(1.08); C649(1.08)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C638(0.90); C649(0.90)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C638(0.86); C649(0.86)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C638(0.96); C649(0.96)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C638(0.98); C649(0.98)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C638(0.95); C649(0.95)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C638(0.94); C649(0.94)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C638(0.96); C649(0.96)  LDD0586  [2]
 LDCM0270  AC15 PaTu 8988t C638(1.12); C649(1.12); C39(1.01)  LDD1149  [2]
 LDCM0271  AC150 HCT 116 C638(0.88); C649(0.88)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C638(1.08); C649(1.08)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C638(1.06); C649(1.06)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C638(0.91); C649(0.91)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C638(1.10); C649(1.10)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C638(0.92); C649(0.92)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C638(0.95); C649(0.95)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C638(1.05); C649(1.05)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C638(0.99); C649(0.99)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C638(0.88); C649(0.88)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C638(1.06); C649(1.06)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C638(0.94)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C638(1.17); C649(1.17)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C638(1.35); C649(1.35)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C638(1.05); C649(1.05)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C638(0.91); C649(0.91)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C638(1.09); C649(1.09)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C649(0.82)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C649(0.86)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C649(0.87)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C649(1.08)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C649(0.91)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C638(1.08)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C649(0.95)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C649(0.85)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C649(0.94)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C649(1.12)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C649(0.94)  LDD0893  [2]
 LDCM0296  AC35 PaTu 8988t C638(1.15); C649(1.15); C39(0.88)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C638(1.40); C649(1.40); C39(0.86)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C638(1.06); C649(1.06); C39(0.80)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C638(1.25); C649(1.25); C39(0.88)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C638(1.36); C649(1.36); C39(0.75)  LDD1179  [2]
 LDCM0301  AC4 HEK-293T C638(0.98)  LDD0899  [2]
 LDCM0302  AC40 PaTu 8988t C638(1.64); C649(1.64); C39(0.78)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C638(1.05); C649(1.05); C39(0.77)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C638(1.32); C649(1.32); C39(0.73)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C638(1.31); C649(1.31); C39(0.79)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C638(1.24); C649(1.24); C39(0.79)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C638(1.22); C649(1.22); C39(0.77)  LDD1186  [2]
 LDCM0308  AC46 HCT 116 C638(0.99); C649(0.99)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C638(1.12); C649(1.12)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C638(1.04); C649(1.04)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C638(1.12); C649(1.12)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C638(0.92)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C638(1.14); C649(1.14)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C638(1.13); C649(1.13)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C638(0.90); C649(0.90)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C638(1.42); C649(1.42)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C638(0.86); C649(0.86)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C638(1.05); C649(1.05)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C638(0.89); C649(0.89)  LDD0636  [2]
 LDCM0320  AC57 PaTu 8988t C39(1.07)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C39(1.01)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C39(1.04)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C638(0.89); C649(0.89); C39(1.02)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C39(1.00)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C39(0.99)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C39(0.95)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C39(1.02)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C39(1.09)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C39(0.97)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C39(0.96)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C39(1.06)  LDD1210  [2]
 LDCM0332  AC68 HEK-293T C649(1.05)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C649(1.05)  LDD0931  [2]
 LDCM0334  AC7 PaTu 8988t C638(1.13); C649(1.13); C39(1.03)  LDD1213  [2]
 LDCM0335  AC70 HEK-293T C649(1.06)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C649(1.24)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C649(1.23)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C649(1.15)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C649(1.18)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C649(1.17)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C649(1.14)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C649(1.16)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C649(1.17)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C649(1.13)  LDD0942  [2]
 LDCM0345  AC8 PaTu 8988t C638(1.08); C649(1.08); C39(0.91)  LDD1224  [2]
 LDCM0346  AC80 HEK-293T C649(0.98)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C649(1.28)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C649(1.42)  LDD0946  [2]
 LDCM0365  AC98 HEK-293T C638(0.90); C649(0.90)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C638(0.96); C649(0.96)  LDD0964  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C638(1.29); C649(1.29); C39(0.95)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C638(1.12); C649(1.12); C39(1.13)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C638(1.13); C649(1.13); C39(1.02)  LDD1154  [2]
 LDCM0156  Aniline NCI-H1299 13.41  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C638(1.20); C649(1.20)  LDD2171  [2]
 LDCM0367  CL1 PaTu 8988t C638(0.94); C649(0.94); C39(0.84)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C638(1.13); C649(1.13); C39(0.86)  LDD1247  [2]
 LDCM0369  CL100 HEK-293T C638(0.95)  LDD0967  [2]
 LDCM0370  CL101 PaTu 8988t C638(0.97); C649(0.97); C39(1.04)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C638(1.06); C649(1.06); C39(0.95)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C638(1.38); C649(1.38); C39(1.03)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C638(0.96); C649(0.96); C39(0.95)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C638(0.95); C649(0.95)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C638(0.93); C649(0.93)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C638(0.92); C649(0.92)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C638(1.35); C649(1.35)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C638(0.84); C649(0.84)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C638(0.92); C649(0.92); C39(0.74)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C638(1.09); C649(1.09)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C638(0.89); C649(0.89)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C649(0.81)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C649(0.91)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C649(0.92)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C649(0.89)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C649(0.98)  LDD0984  [2]
 LDCM0387  CL117 PaTu 8988t C638(1.14); C649(1.14); C39(0.76)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C638(1.28); C649(1.28); C39(0.72)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C638(1.16); C649(1.16); C39(0.73)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C638(0.95); C649(0.95); C39(0.86)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C638(1.43); C649(1.43); C39(0.83)  LDD1270  [2]
 LDCM0392  CL121 HCT 116 C638(1.18); C649(1.18)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C638(1.01); C649(1.01)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C638(0.82); C649(0.82)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C638(0.89); C649(0.89)  LDD0712  [2]
 LDCM0396  CL125 PaTu 8988t C39(0.93)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C39(0.96)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C39(0.96)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C39(1.03)  LDD1278  [2]
 LDCM0400  CL13 PaTu 8988t C638(1.51); C649(1.51); C39(1.10)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C638(1.79); C649(1.79); C39(0.93)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C638(1.04); C649(1.04); C39(1.00)  LDD1281  [2]
 LDCM0403  CL16 HEK-293T C638(1.09); C649(1.09)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C638(1.02); C649(1.02)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C638(1.11); C649(1.11)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C638(1.00); C649(1.00)  LDD1004  [2]
 LDCM0407  CL2 PaTu 8988t C638(1.02); C649(1.02); C39(0.85)  LDD1286  [2]
 LDCM0408  CL20 HEK-293T C638(1.22); C649(1.22)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C638(1.36); C649(1.36)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C638(1.26); C649(1.26)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C638(1.27); C649(1.27)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C638(0.86); C649(0.86)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C638(1.27); C649(1.27)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C638(1.22); C649(1.22)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C638(1.15); C649(1.15)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C638(1.22); C649(1.22)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C638(1.21); C649(1.21)  LDD1015  [2]
 LDCM0418  CL3 PaTu 8988t C638(1.05); C649(1.05); C39(0.72)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C638(1.17); C649(1.17)  LDD1017  [2]
 LDCM0420  CL31 PaTu 8988t C39(0.99)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C39(1.07)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C39(0.92)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C39(1.04)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C39(1.12)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C39(0.99)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C39(1.16)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C39(1.05)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C638(1.09); C649(1.09); C39(0.76)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C39(1.04)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C39(0.99)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C39(1.19)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C39(1.31)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C39(1.11)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C39(0.99)  LDD1314  [2]
 LDCM0436  CL46 HCT 116 C638(1.21); C649(1.21)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C638(1.62); C649(1.62)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C638(1.21); C649(1.21)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C638(1.35); C649(1.35)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C638(1.30); C649(1.30); C39(0.91)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C638(1.24); C649(1.24)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C638(1.61); C649(1.61)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C638(1.27); C649(1.27)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C638(1.53); C649(1.53)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C638(1.24); C649(1.24)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C638(1.20); C649(1.20)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C638(1.43); C649(1.43)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C638(1.50); C649(1.50)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C638(1.13); C649(1.13)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C638(1.34); C649(1.34)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C638(1.12); C649(1.12); C39(0.85)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C638(1.40); C649(1.40)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C638(1.12)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C638(1.28)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C638(1.11)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C638(0.99)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C638(0.96)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C638(1.25)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C638(1.12)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C638(1.66)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C638(1.37)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C638(1.12); C649(1.12); C39(0.93)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C638(1.23)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C638(1.50)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C638(1.40)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C638(1.43)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C638(1.75)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C638(1.05); C649(1.05)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C638(1.29); C649(1.29)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C638(1.12); C649(1.12)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C638(1.06); C649(1.06)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C638(1.13); C649(1.13); C39(1.29)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C638(1.04); C649(1.04)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C638(1.00); C649(1.00)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C638(0.90); C649(0.90)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C638(0.92); C649(0.92)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C638(1.14); C649(1.14)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C638(1.01); C649(1.01)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C638(1.19); C649(1.19)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C638(1.18); C649(1.18)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C638(1.00); C649(1.00)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C638(0.88); C649(0.88)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C638(1.35); C649(1.35); C39(0.88)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C638(0.96); C649(0.96)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C638(0.72)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C638(0.71)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C638(0.97)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C638(0.91)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C638(0.88)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C638(0.87)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C638(0.92)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C638(0.82)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C638(0.85)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C39(0.82)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C638(1.50)  LDD1066  [2]
 LDCM0427  Fragment51 PaTu 8988t C39(1.07)  LDD1306  [2]
 LDCM0022  KB02 HCT 116 C638(2.79); C649(2.79)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C638(2.43); C649(2.43)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C638(3.53); C649(3.53)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C638(1.20); C649(1.20)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) InsP3 receptor family Q14573
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polycomb group protein ASXL1 (ASXL1) Asx family Q8IXJ9
Host cell factor 1 (HCFC1) . P51610

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402