Details of the Target

General Information of Target

Target ID LDTP09731
Target Name Intraflagellar transport protein 81 homolog (IFT81)
Gene Name IFT81
Gene ID 28981
Synonyms
CDV1; Intraflagellar transport protein 81 homolog; Carnitine deficiency-associated protein expressed in ventricle 1; CDV-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ
TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR
FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL
QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS
EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE
LKAEFGLLQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVDEMKG
RTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQECDEKKSQYDSCAAGLE
SNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATDEMKAYISSDQQEKRKAI
REQYTKNTAEQENLGKKLREKQKVIRESHGPNMKQAKMWRDLEQLMECKKQCFLKQQSQT
SIGQVIQEGGEDRLIL
Target Bioclass
Transporter and channel
Family
IFT81 family
Subcellular location
Cell projection, cilium
Function
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.
Uniprot ID
Q8WYA0
Ensemble ID
ENST00000242591.10
HGNC ID
HGNC:14313

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.E267K .
Ishikawa (Heraklio) 02 ER Deletion: p.K453RfsTer13 .
JURLMK1 SNV: p.E269V .
KMRC20 Deletion: p.V624LfsTer10 .
MCC26 SNV: p.E575Q .
OVKATE SNV: p.I175T .
SKN SNV: p.G630R .
SNGM SNV: p.S129I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K414(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y221(13.02)  LDD3495  [2]
DBIA
 Probe Info  		C535(1.36)  LDD0080  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		C557(0.00); C535(0.00)  LDD0165  [5]
AOyne
 Probe Info  		10.30  LDD0443  [6]
HHS-475
 Probe Info  		Y158(1.53)  LDD2238  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C535(0.98)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C535(1.29)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C535(1.07)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C535(1.24)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C535(1.22)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C535(1.24)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C535(1.36)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C535(1.68)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C535(1.35)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C535(1.39)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C535(1.24)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C535(1.21)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C535(1.06)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C535(1.41)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C535(1.58)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C535(1.40)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C535(0.78)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C535(0.78)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C535(0.88)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C535(0.72)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C535(0.85)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C535(0.85)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C535(0.82)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C535(0.89)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C535(0.92)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C535(0.93)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C535(0.89)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C535(0.87)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C535(0.83)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C535(0.90)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C535(0.81)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C535(0.73)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C535(1.26)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C535(0.95)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C535(1.17)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C535(1.00)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C535(1.21)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C535(1.06)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C535(0.99)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C535(1.15)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C535(1.16)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C535(1.16)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C535(1.05)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C535(1.06)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C535(0.98)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C535(0.95)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C535(1.21)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C535(1.15)  LDD0579  [3]
 LDCM0270  AC15 HEK-293T C535(1.20)  LDD0868  [3]
 LDCM0276  AC17 HCT 116 C535(0.66)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C535(1.25)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C535(0.68)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C535(0.98)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C535(0.72)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C535(0.91)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C535(1.28)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C535(1.69)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C535(0.83)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C535(0.65)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C535(0.51)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C535(0.55)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C535(0.44)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C535(0.50)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C535(0.86)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C535(0.49)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C535(0.51)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C535(0.46)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C535(0.53)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C535(0.54)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C535(1.38); C648(1.10)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C535(0.83)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C535(0.98); C648(1.26)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C648(0.91)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C648(1.09)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C535(0.98)  LDD0899  [3]
 LDCM0304  AC42 HEK-293T C535(0.67); C648(0.98)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C535(1.07); C648(1.02)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C535(1.32)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C535(1.09); C648(1.14)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C535(0.88)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C535(1.02)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C535(0.89)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C535(0.91)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C535(1.38)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C535(0.92)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C535(0.84)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C535(0.84)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C535(0.91)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C535(0.86)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C535(0.90)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C535(0.88)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C535(0.83)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C535(0.68)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C535(0.79)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C535(0.93)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C535(0.75)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C535(0.78)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C535(0.78)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C535(0.86)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C535(0.84)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C535(0.80)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C535(0.75)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C535(0.80)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C535(1.07)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C535(1.29)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C535(1.10)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C535(1.22)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C535(1.19)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C535(1.09)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C535(1.41)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C535(1.44)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C535(1.54)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C535(1.11)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C535(1.14)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C535(1.35)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C535(1.15)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C535(0.95)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C535(1.16)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C535(1.51)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C535(1.73)  LDD0665  [3]
 LDCM0365  AC98 HEK-293T C535(1.19)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C535(1.32)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C535(0.96)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C535(1.24)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C535(1.09)  LDD0873  [3]
 LDCM0367  CL1 HEK-293T C535(1.13)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C535(1.03)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C535(1.24)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C535(1.10)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C535(1.17)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C535(0.95)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C535(1.12)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C535(0.48)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C535(0.69)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C535(0.53)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C535(0.58)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C535(0.49)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C535(0.97)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C535(0.56)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C535(0.50)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C535(0.55)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C535(0.53)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C535(0.41)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C535(0.37)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C535(0.43)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C535(0.99)  LDD1591  [8]
 LDCM0389  CL119 HEK-293T C648(1.11)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C535(0.70)  LDD0988  [3]
 LDCM0392  CL121 HEK-293T C535(1.00)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C535(0.92)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C535(1.02)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C535(0.86)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C535(0.84)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C535(0.81)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C535(0.76)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C535(0.82)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C535(0.77)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C535(1.10)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C535(1.05)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C535(1.19)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C535(1.06)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C535(1.26)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C535(1.35)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C535(0.92)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C535(1.06)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C535(1.40)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C535(1.53)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C535(1.30)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C535(0.89)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C535(0.91)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C535(1.05)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C535(0.96)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C535(1.39)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C535(1.18)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C535(0.84)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C535(1.69)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C535(0.79)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C535(1.07)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C535(0.94)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C535(0.90)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C535(0.88)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C535(0.88)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C535(0.91)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C535(0.86)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C535(0.70)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C535(0.72)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C535(0.84)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C535(1.20)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C535(0.94)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C535(0.85)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C535(0.90)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C535(1.27)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C535(1.21)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C535(0.91)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C535(1.25)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C535(0.71)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C535(1.62)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C535(1.27)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C535(1.22)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C535(1.15)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C535(1.36)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C535(1.34)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C535(1.15)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C535(1.30)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C535(1.02)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C535(1.22)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C535(0.80)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C535(1.35)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C535(1.09)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C535(1.17)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C535(1.29)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C535(1.34)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C535(0.95)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C535(1.20)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C535(1.09)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C535(1.29)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C535(1.17)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C535(0.84)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C535(1.06)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C535(1.38)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C535(2.49)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C535(1.06)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C535(1.31)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C535(0.75)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C535(0.84)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C535(0.57)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C535(0.56)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C535(0.53)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C535(0.47)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C535(0.52)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C535(0.76)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C535(0.88)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C535(0.63)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C535(0.61)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C535(0.43)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C535(0.59)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C535(0.64)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C535(0.52)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C535(0.54)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C535(0.89)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C535(1.25)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C535(1.46)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C535(0.89)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C535(1.24)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C535(1.47)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C535(1.01)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C535(1.16)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C535(1.36)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C535(1.23)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C648(1.14)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C535(1.66)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C535(1.22)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C535(1.36)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C535(1.47)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C535(1.25)  LDD0082  [3]

References

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Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402