Details of the Target

General Information of Target

Target ID LDTP09507
Target Name Rho guanine nucleotide exchange factor 40 (ARHGEF40)
Gene Name ARHGEF40
Gene ID 55701
Synonyms
SOLO; Rho guanine nucleotide exchange factor 40; Protein SOLO
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA
KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA
LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE
LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG
EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ
DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG
GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP
SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL
CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG
GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL
PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW
ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ
KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ
EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE
ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE
AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA
SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG
PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK
RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH
FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL
PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR
GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK
TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE
LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG
ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI
LGLSRQSHARALSDPTTPL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May act as a guanine nucleotide exchange factor (GEF).
Uniprot ID
Q8TER5
Ensemble ID
ENST00000298694.9
HGNC ID
HGNC:25516

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.R1076GfsTer18 .
CAL51 Deletion: p.R1076GfsTer18 DBIA    Probe Info 
HCT15 SNV: p.L731V .
HEC1B SNV: p.R130W .
JURKAT Deletion: p.P337QfsTer14 .
LNCaP clone FGC SNV: p.A142V .
LOXIMVI SNV: p.G72A DBIA    Probe Info 
MCC13 SNV: p.H573Y DBIA    Probe Info 
MFE319 SNV: p.V777M; p.K1191R DBIA    Probe Info 
MOLT4 Deletion: p.A737PfsTer3 .
NCIH1975 SNV: p.A140V DBIA    Probe Info 
REH Deletion: p.A737PfsTer3 .
RKO Deletion: p.A737PfsTer3
SNV: .		 DBIA    Probe Info 
RL952 Deletion: p.R1076GfsTer18 DBIA    Probe Info 
SUDHL6 SNV: p.Q544L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C462(2.64)  LDD0170  [1]
DBIA
 Probe Info  		C1282(2.32)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_4
 Probe Info  		C462(0.00); C636(0.00); C1442(0.00)  LDD2226  [4]
IPM
 Probe Info  		C183(0.00); C1158(0.00)  LDD0005  [5]
TFBX
 Probe Info  		C1233(0.00); C1148(0.00); C945(0.00); C1158(0.00)  LDD0148  [6]
W1
 Probe Info  		C183(0.00); C1233(0.00)  LDD0236  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C462(2.64)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C481(6.49); C462(2.47); C1442(5.06)  LDD0171  [1]
 LDCM0214  AC1 PaTu 8988t C1148(0.56); C123(0.86); C1282(0.91); C1233(0.97)  LDD1093  [2]
 LDCM0215  AC10 HCT 116 C123(0.93)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C1148(1.04); C1233(1.04)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C1148(1.08); C1233(1.08)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C1148(1.08); C1233(1.08)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C1148(1.06); C1233(1.06)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C1148(1.06); C1233(1.06)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C1148(0.90); C1233(0.90)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C1148(0.96); C1233(0.96)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C1148(0.99); C1233(0.99)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C1148(0.89); C1233(0.89)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C1148(0.99); C1233(0.99)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C123(0.90)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C1148(1.16); C1233(1.16)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C1148(1.56); C1233(1.56)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C1148(1.24); C1233(1.24)  LDD0827  [2]
 LDCM0230  AC113 PaTu 8988t C1148(0.81); C1233(1.03); C183(1.03)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C1148(0.89); C1233(1.22); C183(1.06)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C1148(1.13); C1233(0.91); C183(0.99)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C1148(1.02); C1233(1.44); C183(0.97)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C1148(0.89); C1233(1.14); C183(1.12)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C1148(0.97); C1233(1.00); C183(0.99)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C1148(0.93); C1233(1.19); C183(1.12)  LDD1115  [2]
 LDCM0237  AC12 HCT 116 C123(0.75)  LDD0554  [2]
 LDCM0238  AC120 PaTu 8988t C1148(0.86); C1233(1.00); C183(0.92)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C1148(1.11); C1233(1.46); C183(1.03)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C1148(0.82); C1233(1.12); C183(1.02)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C1148(0.86); C1233(1.29); C183(0.95)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C1148(1.16); C1233(1.65); C183(1.05)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C1148(0.89); C1233(1.06); C183(1.00)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C1148(0.88); C1233(1.36); C183(0.95)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C1148(1.07); C1233(1.48); C183(1.06)  LDD1124  [2]
 LDCM0246  AC128 HEK-293T C1148(0.86)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C1148(0.92)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C1148(0.89)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C1148(0.80)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C1148(1.02)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C1148(0.92)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C1148(1.01)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C1148(0.95)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C1148(0.88)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C1148(0.89)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C1148(0.89)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C1148(0.92)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C123(0.86)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C1148(1.03)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C1148(0.78)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C1148(0.90)  LDD0860  [2]
 LDCM0263  AC143 PaTu 8988t C1148(0.99); C1282(1.16); C183(1.35)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C1148(0.96); C1282(1.38); C183(1.17)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C1148(0.96); C1282(1.18); C183(1.16)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C1148(0.69); C1282(1.40); C183(1.21)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C1148(0.88); C1282(1.18); C183(1.13)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C1148(1.07); C1282(1.57); C183(1.42)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C1148(1.21); C1282(1.80); C183(1.53)  LDD1148  [2]
 LDCM0270  AC15 HCT 116 C123(0.92)  LDD0587  [2]
 LDCM0271  AC150 PaTu 8988t C1148(0.85); C1282(1.58); C183(1.37)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C1148(1.08); C1282(1.99); C183(1.82)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C1148(1.08); C1282(1.75); C183(1.46)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C1148(1.02); C1282(1.68); C183(1.52)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C1148(0.87); C1282(2.01); C183(1.65)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C1148(1.09); C1282(1.83); C183(1.37)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C1148(1.14); C1282(1.62); C183(1.53)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C1148(0.88); C1282(1.77); C183(1.31)  LDD2169  [2]
 LDCM0276  AC17 HEK-293T C1148(1.40); C1233(1.40)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C1148(1.27); C1233(1.27)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C1148(1.01); C1233(1.01)  LDD0876  [2]
 LDCM0279  AC2 PaTu 8988t C1148(0.53); C123(0.86); C1282(0.80); C1233(0.97)  LDD1158  [2]
 LDCM0280  AC20 HEK-293T C1148(1.21); C1233(1.21)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C1148(1.24); C1233(1.24)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C1148(1.25); C1233(1.25)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C1148(1.34); C1233(1.34)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C1148(1.06); C1233(1.06)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C123(0.88); C183(0.97)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C183(1.09); C123(1.50)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C123(1.12); C183(1.15)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C183(1.04); C123(1.22)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C183(1.08); C123(1.28)  LDD0606  [2]
 LDCM0290  AC3 PaTu 8988t C1148(0.59); C123(0.96); C1282(0.83); C1233(0.85)  LDD1169  [2]
 LDCM0291  AC30 HCT 116 C183(1.04); C123(1.26)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C183(1.06); C123(1.72)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C183(1.33); C123(1.83)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C183(1.22); C123(1.63)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C123(1.13); C183(1.33)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C123(0.97)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C123(0.76)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C123(0.57)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C123(1.11)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C123(0.83)  LDD0617  [2]
 LDCM0301  AC4 PaTu 8988t C1148(0.44); C123(0.92); C1282(0.76); C1233(0.97)  LDD1180  [2]
 LDCM0302  AC40 HCT 116 C123(0.90)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C123(0.99)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C123(0.85)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C123(1.28)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C123(0.81)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C123(1.16)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C123(1.37)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C123(1.31)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C123(1.23)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C123(1.71)  LDD0628  [2]
 LDCM0312  AC5 PaTu 8988t C1148(0.55); C123(0.83); C1282(0.82); C1233(1.24)  LDD1191  [2]
 LDCM0313  AC50 HCT 116 C123(1.75)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C123(0.98)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C123(1.36)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C123(1.46)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C123(1.37)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C123(1.64)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C123(1.97)  LDD0636  [2]
 LDCM0320  AC57 PaTu 8988t C183(1.08)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C183(1.13)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C183(1.05)  LDD1201  [2]
 LDCM0323  AC6 HCT 116 C123(0.97)  LDD0640  [2]
 LDCM0324  AC60 PaTu 8988t C183(0.99)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C183(1.11)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C183(1.21)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C183(1.09)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C183(1.10)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C183(0.96)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C183(1.03)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C183(1.09)  LDD1210  [2]
 LDCM0332  AC68 HEK-293T C1148(1.08); C1233(1.08)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C1148(1.17); C1233(1.17)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C123(0.84)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C1148(1.05); C1233(1.05)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C1148(1.07); C1233(1.07)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C1148(1.06); C1233(1.06)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C1148(1.20); C1233(1.20)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C1148(1.18); C1233(1.18)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C1148(0.96); C1233(0.96)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C1148(0.97); C1233(0.97)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C1148(1.02); C1233(1.02)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C1148(1.06); C1233(1.06)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C1148(1.19); C1233(1.19)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C123(0.83)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C1148(1.20); C1233(1.20)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C1148(1.08); C1233(1.08)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C1148(1.27); C1233(1.27)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C1148(0.87); C1233(0.87)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C1148(0.78); C1233(0.78)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C1148(0.79); C1233(0.79)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C1148(0.82); C1233(0.82)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C1148(0.88); C1233(0.88)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C1148(0.88); C1233(0.88)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C1148(0.83); C1233(0.83)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C1148(1.03); C1233(1.03)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C1148(0.76); C1233(0.76)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C1148(0.69); C1233(0.69)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C1148(0.83); C1233(0.83)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C1148(0.95); C1233(0.95)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C1148(0.84); C1233(0.84)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C1148(1.03); C1233(1.03)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C1148(1.41); C1233(1.41)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C1148(1.08); C1233(1.08)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C1148(1.01); C1233(1.01)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C123(1.20)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C123(0.86)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C123(1.09)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C183(0.88); C123(0.99)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C183(1.09); C123(1.47)  LDD0685  [2]
 LDCM0369  CL100 PaTu 8988t C1148(0.47); C123(0.62); C1282(0.58); C1233(0.61)  LDD1248  [2]
 LDCM0370  CL101 HCT 116 C123(0.93)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C123(1.37)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C123(1.01)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C123(1.01)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C1148(1.29); C1233(1.29)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C1148(1.24); C1233(1.24)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C1148(1.27); C1233(1.27)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C1148(1.30); C1233(1.30)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C1148(1.16); C1233(1.16)  LDD0976  [2]
 LDCM0379  CL11 HCT 116 C123(1.34); C183(1.36)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C1148(1.30); C1233(1.30)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C1148(1.17); C1233(1.17)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C183(0.98); C123(1.90)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C183(1.12); C123(1.26)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C183(0.90); C123(1.41)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C183(1.06); C123(1.36)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C183(1.02); C123(1.64)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C123(1.58)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C123(1.00)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C123(0.75)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C183(1.50); C123(1.75)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C123(1.02)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C123(1.20)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C123(1.59)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C123(1.36)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C123(1.76)  LDD0712  [2]
 LDCM0396  CL125 PaTu 8988t C183(1.12)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C183(1.10)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C183(0.98)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C183(0.96)  LDD1278  [2]
 LDCM0400  CL13 HCT 116 C123(1.11); C183(1.39)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C183(1.07); C123(1.70)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C123(1.21); C183(1.22)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C183(0.99)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C183(0.91)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C183(1.12)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C183(1.13)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C183(0.94); C123(0.98)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C183(1.14)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C183(1.15)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C183(1.53)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C183(1.16)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C183(1.18)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C183(1.24)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C183(1.00)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C183(1.09)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C183(1.08)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C183(1.17)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C123(0.99); C183(1.08)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C183(1.03)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C1148(1.35); C1233(1.35)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C1148(0.92); C1233(0.92)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C1148(1.72); C1233(1.72)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C1148(1.07); C1233(1.07)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C1148(1.07); C1233(1.07)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C1148(0.98); C1233(0.98)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C1148(0.98); C1233(0.98)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C1148(1.44); C1233(1.44)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C123(1.15); C183(1.00)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C1148(0.88); C1233(0.88)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C1148(1.16); C1233(1.16)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C1148(1.20); C1233(1.20)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C1148(1.15); C1233(1.15)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C1148(0.96); C1233(0.96)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C1148(1.12); C1233(1.12)  LDD1033  [2]
 LDCM0436  CL46 PaTu 8988t C123(1.12); C1282(1.13); C1233(0.99); C183(1.10)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C123(0.94); C1282(1.03); C1233(1.15); C183(1.09)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C123(1.02); C1282(1.10); C1233(1.20); C183(1.16)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C123(1.11); C1282(1.08); C1233(1.09); C183(1.10)  LDD1318  [2]
 LDCM0440  CL5 HCT 116 C123(1.05); C183(1.09)  LDD0757  [2]
 LDCM0441  CL50 PaTu 8988t C123(1.20); C1282(1.29); C1233(1.33); C183(1.15)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C123(1.05); C1282(1.13); C1233(1.04); C183(1.11)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C123(0.99); C1282(1.18); C1233(1.04); C183(1.17)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C123(0.93); C1282(1.29); C1233(1.43); C183(1.18)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C123(1.02); C1282(0.98); C1233(1.07); C183(1.18)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C123(1.07); C1282(1.23); C1233(1.27); C183(1.15)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C123(0.23); C1282(1.15); C1233(0.59); C183(0.77)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C123(1.63); C1282(1.09); C1233(2.46); C183(1.70)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C123(1.02); C1282(1.10); C1233(1.45); C183(1.28)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C123(1.60); C1282(1.07); C1233(2.26); C183(1.56)  LDD1329  [2]
 LDCM0451  CL6 HCT 116 C123(0.91); C183(1.23)  LDD0768  [2]
 LDCM0452  CL60 PaTu 8988t C123(1.42); C1282(1.12); C1233(1.96); C183(1.39)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C183(1.28)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C183(1.19)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C183(1.52)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C183(1.60)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C183(1.22)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C183(2.00)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C183(1.67)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C183(1.35)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C183(1.29)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C123(1.03); C183(1.44)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C183(1.45)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C183(1.68)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C183(1.20)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C183(1.50)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C183(1.46)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C1148(1.29); C1233(1.29)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C1148(1.83); C1233(1.83)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C1148(2.40); C1233(2.40)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C1148(1.43); C1233(1.43)  LDD1070  [2]
 LDCM0473  CL8 HCT 116 C123(1.25); C183(1.42)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C1148(1.35); C1233(1.35)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C1148(1.20); C1233(1.20)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C1148(0.94); C1233(0.94)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C1148(1.01); C1233(1.01)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C1148(1.71); C1233(1.71)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C1148(1.53); C1233(1.53)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C1148(1.45); C1233(1.45)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C1148(1.31); C1233(1.31)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C1148(1.15); C1233(1.15)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C1148(1.25); C1233(1.25)  LDD1081  [2]
 LDCM0484  CL9 HCT 116 C123(1.44); C183(1.25)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C1148(1.59); C1233(1.59)  LDD1083  [2]
 LDCM0486  CL91 PaTu 8988t C1148(0.41); C123(0.71); C1282(0.66); C1233(0.71)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C1148(0.44); C123(0.77); C1282(0.67); C1233(0.80)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C1148(0.48); C123(0.89); C1282(0.73); C1233(0.66)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C1148(0.44); C123(0.75); C1282(0.80); C1233(0.78)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C1148(0.36); C123(0.69); C1282(1.30); C1233(1.01)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C1148(0.44); C123(0.81); C1282(0.70); C1233(0.82)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C1148(0.42); C123(0.97); C1282(0.77); C1233(0.90)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C1148(0.49); C123(1.03); C1282(0.90); C1233(0.92)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C1148(0.41); C123(1.05); C1282(0.68); C1233(0.95)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C428(1.02); C1158(1.17); C1096(0.83); C1148(1.05)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C428(1.06); C1148(0.77)  LDD1702  [9]
 LDCM0468  Fragment33 HCT 116 C183(1.45)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C1148(0.99); C1233(0.99)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C1282(2.32)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C1282(1.88)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C1282(2.75)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
G-protein-signaling modulator 2 (GPSM2) GPSM family P81274

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761