Details of the Target

General Information of Target

Target ID LDTP09459
Target Name Volume-regulated anion channel subunit LRRC8C (LRRC8C)
Gene Name LRRC8C
Gene ID 84230
Synonyms
AD158; FAD158; Volume-regulated anion channel subunit LRRC8C; Factor for adipocyte differentiation 158; Leucine-rich repeat-containing protein 8C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ
PAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERAL
HWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSG
EDSEEKDNRKNNMNRSNTIQSGPEDSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKA
LFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDM
TGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGI
DDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQT
NAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVK
IHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRD
LKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCD
LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT
SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES
LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA
GLVVEDALFETLPSDVREQMKTE
Target Bioclass
Transporter and channel
Family
LRRC8 family
Subcellular location
Cell membrane
Function
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Uniprot ID
Q8TDW0
Ensemble ID
ENST00000370454.9
HGNC ID
HGNC:25075

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C682(3.80)  LDD3335  [1]
BTD
 Probe Info  		C571(1.11)  LDD2089  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
PF-06672131
 Probe Info  		N.A.  LDD0152  [4]
HHS-465
 Probe Info  		N.A.  LDD2240  [5]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		22.78  LDD1816  [6]
C293
 Probe Info  		16.22  LDD1963  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C571(1.03)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C571(0.96); C682(0.95)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C571(0.91); C115(0.96)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C571(1.15); C682(1.07); C115(1.28)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C571(1.05)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C571(0.95); C682(1.01); C115(0.83)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C571(1.10); C115(1.05)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C571(0.96); C682(0.98)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C571(1.03); C115(0.99)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C571(0.96); C682(0.88); C115(1.42)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C571(1.04); C115(1.03)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C571(1.25)  LDD1519  [7]
 LDCM0282  AC22 HEK-293T C571(1.00); C682(1.04); C115(0.68)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C571(1.15); C115(0.98)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C115(1.18)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C571(0.97); C682(1.02)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C571(0.97); C115(1.09)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C571(1.04); C682(0.97); C115(1.20)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C571(0.85)  LDD1527  [7]
 LDCM0290  AC3 HEK-293T C571(1.05); C682(1.06); C115(1.17)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C571(1.33); C682(1.02); C115(0.93)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C571(1.25); C115(1.13)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C115(1.09)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C571(0.97); C682(1.22)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C571(1.14); C115(1.07)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C571(1.07); C682(1.11); C115(1.12)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C571(1.11)  LDD1536  [7]
 LDCM0299  AC38 HEK-293T C571(0.97); C682(1.10); C115(0.99)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C571(1.36); C115(1.02)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C571(1.13)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C115(1.17)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C571(1.03); C682(1.07)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C571(1.11); C115(1.02)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C571(1.07); C682(1.07); C115(0.95)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C571(1.18)  LDD1545  [7]
 LDCM0308  AC46 HEK-293T C571(1.60); C682(1.08); C115(0.74)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C571(1.13); C115(1.15)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C115(0.95)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C571(1.03); C682(1.16)  LDD1550  [7]
 LDCM0313  AC50 HEK-293T C571(0.97); C115(1.09)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C571(1.19); C682(1.11); C115(1.12)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C571(1.27)  LDD1554  [7]
 LDCM0317  AC54 HEK-293T C571(1.05); C682(1.05); C115(1.05)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C571(1.18); C115(1.08)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C115(1.12)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C571(1.01); C682(1.02)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C571(0.86); C115(1.01)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C571(1.08); C682(1.10); C115(1.02)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C571(0.97); C682(0.86); C115(0.76)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C571(1.35)  LDD1563  [7]
 LDCM0326  AC62 HEK-293T C571(1.47); C682(1.12); C115(1.04)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C571(1.04); C115(1.22)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C115(0.97)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C571(1.05); C115(1.04)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C115(1.05)  LDD1569  [7]
 LDCM0356  AKOS034007680 HEK-293T C571(1.01); C682(1.11)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C115(1.07)  LDD1514  [7]
 LDCM0498  BS-3668 MDA-MB-231 C571(0.62)  LDD2091  [2]
 LDCM0367  CL1 HEK-293T C571(1.00); C682(0.91)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C571(1.55); C682(1.15); C115(1.28)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C682(0.87); C115(1.10)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C571(1.04); C682(1.04)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C682(0.90)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C682(1.09); C115(0.99)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C571(0.97); C682(0.97)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C682(0.88)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C682(1.07); C115(0.98)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C571(1.03); C682(0.99)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C571(1.22); C115(1.23)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C682(0.86)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C682(0.97); C115(1.01)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C571(1.06); C682(1.08)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C682(0.91)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C682(1.14); C115(1.07)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C571(1.04); C682(1.15)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C682(0.91)  LDD1592  [7]
 LDCM0390  CL12 HEK-293T C115(1.40)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C682(1.15); C115(1.00)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C571(0.95); C682(1.09)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C682(0.94)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C682(1.05); C115(1.24)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C571(1.10); C682(1.06)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C682(1.02)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C682(1.18); C115(1.14)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C571(0.97); C682(0.98)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C682(1.12)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C682(1.16); C115(1.05)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C571(0.91); C682(1.20)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C571(0.91); C115(1.02)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C571(1.10); C682(1.18); C115(1.14)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C682(0.99)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C571(1.26)  LDD1612  [7]
 LDCM0410  CL22 HEK-293T C571(1.31); C682(1.15); C115(1.07)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C571(1.08); C115(1.05)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C115(0.89)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C571(0.93); C682(0.86)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C682(0.99)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C682(0.97); C115(1.03)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C571(1.01); C682(1.10)  LDD1621  [7]
 LDCM0419  CL30 HEK-293T C571(1.01); C115(1.11)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C571(0.92); C682(1.01); C115(1.02)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C571(1.29)  LDD1625  [7]
 LDCM0423  CL34 HEK-293T C571(1.01); C682(1.13); C115(0.98)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C571(1.20); C115(1.26)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C115(1.18)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C571(1.01); C682(1.00)  LDD1630  [7]
 LDCM0429  CL4 HEK-293T C682(1.02); C115(1.05)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C682(1.13); C115(1.01)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C571(1.00); C682(1.09)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C571(0.89); C115(0.99)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C571(1.09); C682(1.17); C115(1.10)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C571(1.27)  LDD1638  [7]
 LDCM0436  CL46 HEK-293T C571(1.82); C682(1.11); C115(0.82)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C571(0.92); C115(1.19)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C115(1.17)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C571(0.85); C682(1.04)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C571(1.01); C682(1.11)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C682(0.91)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C682(1.10); C115(0.98)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C571(0.83); C682(1.09)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C571(0.90); C115(1.23)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C571(0.90); C682(1.14); C115(1.20)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C571(1.34)  LDD1650  [7]
 LDCM0449  CL58 HEK-293T C571(1.58); C682(1.12); C115(0.78)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C571(1.08); C115(1.10)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C571(0.94); C115(1.31)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C115(1.23)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C571(1.06); C682(1.01)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C682(1.00)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C682(1.20); C115(1.10)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C571(0.98); C682(1.21)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C571(1.25); C115(1.13)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C571(1.07); C682(1.24); C115(0.97)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C571(2.46)  LDD1663  [7]
 LDCM0462  CL7 HEK-293T C571(1.04); C682(1.09); C115(1.27)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C571(1.14); C682(1.11); C115(0.95)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C571(1.63); C115(1.01)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C115(1.20)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C571(1.08); C682(0.99)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C682(1.10)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C682(1.06); C115(1.04)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C571(1.04); C682(1.04)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C571(1.27); C115(0.97)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C571(1.11); C682(1.09); C115(1.08)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C571(1.06)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C571(0.94)  LDD1677  [7]
 LDCM0476  CL82 HEK-293T C571(1.15); C682(1.01); C115(0.80)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C571(1.14); C115(1.34)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C115(0.94)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C571(1.06); C682(1.01)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C682(1.00)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C682(1.13); C115(1.06)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C571(1.04); C682(1.02)  LDD1686  [7]
 LDCM0485  CL90 HEK-293T C571(0.93); C115(1.48)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C571(1.14); C682(1.20); C115(1.08)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C571(1.08)  LDD1690  [7]
 LDCM0489  CL94 HEK-293T C571(1.23); C682(1.19); C115(1.03)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C571(0.99); C115(1.42)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C115(1.33)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C571(0.99); C682(1.00)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C682(0.84)  LDD1696  [7]
 LDCM0427  Fragment51 HEK-293T C682(0.98)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C571(0.96); C115(1.01)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C571(1.02); C115(1.00)  LDD1497  [7]
 LDCM0024  KB05 MONO-MAC-6 C682(3.80)  LDD3335  [1]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C571(1.11)  LDD2089  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C682(1.19)  LDD2123  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C682(0.75)  LDD2127  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C682(1.79)  LDD2135  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Volume-regulated anion channel subunit LRRC8A (LRRC8A) LRRC8 family Q8IWT6

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402