Details of the Target

General Information of Target

Target ID LDTP09093
Target Name NFATC2-interacting protein (NFATC2IP)
Gene Name NFATC2IP
Gene ID 84901
Synonyms
NIP45; NFATC2-interacting protein; 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEPVGKRGRWSGGSGAGRGGRGGWGGRGRRPRAQRSPSRGTLDVVSVDLVTDSDEEILE
VATARGAADEVEVEPPEPPGPVASRDNSNSDSEGEDRRPAGPPREPVRRRRRLVLDPGEA
PLVPVYSGKVKSSLRLIPDDLSLLKLYPPGDEEEAELADSSGLYHEGSPSPGSPWKTKLR
TKDKEEKKKTEFLDLDNSPLSPPSPRTKSRTHTRALKKLSEVNKRLQDLRSCLSPKPPQG
QEQQGQEDEVVLVEGPTLPETPRLFPLKIRCRADLVRLPLRMSEPLQSVVDHMATHLGVS
PSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQT
LEVSLSRDSPLKTLMSHYEEAMGLSGRKLSFFFDGTKLSGRELPADLGMESGDLIEVWG
Target Bioclass
Other
Subcellular location
Nucleus
Function
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
Uniprot ID
Q8NCF5
Ensemble ID
ENST00000320805.9
HGNC ID
HGNC:25906

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.P205L .
HCT15 SNV: p.G167S; p.P205Q .
MOLT4 SNV: p.G245D .
PANC0403 Insertion: p.E191RfsTer31 .
RPMI7951 SNV: p.L297F .
SKMEL5 SNV: p.E310K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K218(0.85); K268(10.00)  LDD0277  [2]
BTD
 Probe Info  		C232(0.63)  LDD2125  [3]
AHL-Pu-1
 Probe Info  		C232(2.53)  LDD0170  [4]
DBIA
 Probe Info  		C232(1.43)  LDD0532  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C232(2.53)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C232(2.10)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C232(1.02)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C232(1.43)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C232(1.00)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C232(0.97)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C232(0.97)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C232(1.12)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C232(0.92)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C232(0.85)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C232(0.88)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C232(0.64)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C232(1.35)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C232(1.22)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C232(1.32)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C232(1.37)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C232(1.02)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C232(0.66)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C232(1.14)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C232(1.40)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C232(0.94)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C232(1.09)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C232(0.98)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C232(1.58)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C232(1.72)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C232(2.73)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C232(2.34)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C232(1.45)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C232(1.08)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C232(1.54)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C232(1.52)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C232(2.54)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C232(1.20)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C232(1.42)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C232(0.91)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C232(0.90)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C232(0.91)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C232(1.37)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C232(0.93)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C232(0.96)  LDD1518  [9]
 LDCM0280  AC20 HCT 116 C232(0.94)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C232(0.88)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C232(0.81)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C232(0.85)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C232(0.81)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C232(1.08)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C232(1.20)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C232(1.22)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C232(1.27)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C232(1.22)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C232(0.98)  LDD1529  [9]
 LDCM0291  AC30 HCT 116 C232(1.26)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C232(1.30)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C232(1.82)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C232(1.49)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C232(1.63)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C232(0.99)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C232(0.96)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C232(0.98)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C232(1.13)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C232(1.14); C332(1.02)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C232(0.86)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C232(1.03)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C232(1.07)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C232(1.12)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C232(1.00)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C232(1.06)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C232(0.96)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C232(1.06)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C232(1.12); C332(0.90)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C232(1.02)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C232(0.97)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C232(0.87)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C232(0.98)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C232(0.95)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C232(0.95)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C232(1.03)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C232(1.08)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C232(0.97); C332(0.89)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C232(0.92)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C232(0.99)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C232(0.91)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C232(0.95)  LDD1561  [9]
 LDCM0323  AC6 HCT 116 C232(1.39)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C232(0.99)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C232(1.00)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C232(1.07)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C232(1.10); C332(0.93)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C232(0.95)  LDD1567  [9]
 LDCM0334  AC7 HCT 116 C232(1.19)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C232(1.21)  LDD0662  [5]
 LDCM0349  AC83 PaTu 8988t C232(1.03)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C232(0.73)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C232(0.91)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C232(1.60)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C232(1.14)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C232(1.03)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C232(1.15)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C232(1.27)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C232(0.98)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C232(1.16)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C232(0.85)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C232(1.13)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C232(1.13)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C232(1.27)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C232(1.00)  LDD1243  [5]
 LDCM0365  AC98 HCT 116 C232(1.34)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C232(0.78)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C232(1.13)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C232(1.25)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C232(1.96)  LDD0592  [5]
 LDCM0630  CCW28-3 231MFP C232(1.31)  LDD2214  [10]
 LDCM0367  CL1 HEK-293T C232(1.18)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C232(1.00)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C232(0.99)  LDD1573  [9]
 LDCM0370  CL101 HCT 116 C232(1.54)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C232(1.18)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C232(1.16)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C232(1.33)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C232(1.11)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C232(1.55)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C232(1.31)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C232(1.60)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C232(1.00)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C232(1.08); C332(1.00)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C232(1.25)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C232(1.40)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C232(0.98)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C232(1.39)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C232(1.24)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C232(1.20)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C232(1.14)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C232(1.07)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C232(0.99)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C232(1.04)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C232(1.10)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C232(1.04)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C232(1.00)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C232(0.97)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C232(0.86)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C232(0.91)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C232(1.08)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C232(0.93)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C232(1.03)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C232(0.95)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C232(1.25)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C232(1.13)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C232(0.86)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C232(1.08)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C232(1.01)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C232(1.00)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C232(1.08)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C232(0.98)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C232(0.98)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C232(1.01)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C232(1.15)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C232(1.01); C332(1.01)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C232(1.11)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C232(1.08)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C232(0.98)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C232(1.04)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C232(0.87)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C232(1.00)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C232(1.09)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C232(0.98)  LDD1623  [9]
 LDCM0420  CL31 PaTu 8988t C232(1.17)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C232(1.01)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C232(1.02)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C232(1.22)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C232(1.02)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C232(1.64)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C232(0.99)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C232(1.64)  LDD1307  [5]
 LDCM0429  CL4 HEK-293T C232(0.98)  LDD1633  [9]
 LDCM0430  CL40 PaTu 8988t C232(0.95)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C232(1.39)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C232(1.20)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C232(1.59)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C232(1.81)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C232(1.38)  LDD1314  [5]
 LDCM0436  CL46 HCT 116 C232(0.74)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C232(0.81)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C232(0.55)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C232(0.75)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C232(1.04)  LDD1644  [9]
 LDCM0441  CL50 HCT 116 C232(0.71)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C232(0.71)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C232(0.81)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C232(0.71)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C232(0.64)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C232(0.69)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C232(0.81)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C232(0.71)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C232(0.74)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C232(0.76)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C232(1.01)  LDD1654  [9]
 LDCM0452  CL60 HCT 116 C232(0.78)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C232(1.09)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C232(1.15)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C232(1.02)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C232(0.84)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C232(1.02)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C232(1.06)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C232(0.96)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C232(0.89)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C232(1.05)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C232(1.05)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C232(1.04)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C232(1.17); C332(1.08)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C232(1.04)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C232(1.09)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C232(0.93)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C232(0.89)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C232(0.86)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C232(1.03)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C232(0.93)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C232(0.86)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C232(0.93)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C232(1.06)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C232(1.06)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C232(0.93); C332(0.96)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C232(1.03)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C232(1.09)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C232(1.06)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C232(0.87)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C232(1.07)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C232(1.10)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C232(1.01)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C232(0.93)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C232(1.04)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C232(0.98)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C232(1.03)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C232(1.01)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C232(0.99); C332(0.76)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C232(1.03)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C232(1.03)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C232(1.07)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C232(0.92)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C232(1.11)  LDD1698  [9]
 LDCM0625  F8 Ramos C232(1.47)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C232(1.59)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C232(0.24)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C232(0.75)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C232(0.90)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C232(0.87)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C232(0.71)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C232(0.98)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C232(1.25)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C232(1.07)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C232(0.86)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C232(0.82)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C232(0.77)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C232(1.36)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C232(0.99)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C232(0.87)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C232(0.95)  LDD2184  [11]
 LDCM0427  Fragment51 PaTu 8988t C232(1.38)  LDD1306  [5]
 LDCM0610  Fragment52 Ramos C232(0.69)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C232(0.79)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C232(1.68)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C232(0.89)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C232(1.07)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C232(1.08)  LDD1497  [9]
 LDCM0024  KB05 MKN-1 C232(3.62)  LDD3331  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C232(0.63)  LDD2125  [3]
 LDCM0131  RA190 MM1.R C232(1.46)  LDD0304  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein axonemal light chain 4 (DNAL4) Dynein light chain family O96015
Small nuclear ribonucleoprotein G (SNRPG) SnRNP Sm proteins family P62308
Synaptic plasticity regulator PANTS (C22orf39) UPF0545 family Q6P5X5
Coiled-coil domain-containing protein 157 (CCDC157) . Q569K6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.