Details of the Target

General Information of Target

Target ID LDTP08391
Target Name Histone-lysine N-methyltransferase KMT5C (KMT5C)
Gene Name KMT5C
Gene ID 84787
Synonyms
SUV420H2; Histone-lysine N-methyltransferase KMT5C; Lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C; Suppressor of variegation 4-20 homolog 2; Su(var)4-20 homolog 2; Suv4-20h2; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; EC 2.1.1.362; [histone H4]-lysine20 N-methyltransferase KMT5B; EC 2.1.1.361
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRD
LEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSMETNG
AKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDFSIMYSTRKRSAQLWLGPAAF
INHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEG
AFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGSRQGLLGPRACVHPSPLRRDPFCAA
CQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRKRRRPRPRRAPVLSTHHAARVSLHRWG
GCGPHCRLRGEALVALGQPPHARWAPQQDWHWARRYGLPYVVRVDLRRLAPAPPATPAPA
GTPGPILIPKQALAFAPFSPPKRLRLVVSHGSIDLDVGGEEL
Target Type
Preclinical
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
TTD ID
T68490
Uniprot ID
Q86Y97
DrugMap ID
TT7H3YM
Ensemble ID
ENST00000255613.8
HGNC ID
HGNC:28405
ChEMBL ID
CHEMBL2321644

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL23 SNV: p.E224D .
HCT15 SNV: p.T19N .
HDQP1 SNV: p.E136G .
KELLY SNV: p.R408L DBIA    Probe Info 
KYSE30 SNV: p.E117K .
MCC26 SNV: p.D184E .
MEWO SNV: p.H92Q .
MFE319 SNV: p.P324S .
NCIH1793 SNV: p.R333L .
SUPT1 SNV: p.V374L DBIA    Probe Info 
TOV21G SNV: p.Q327K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C309(1.46)  LDD1701  [1]
DBIA
 Probe Info  		C298(1.09); C301(1.09)  LDD0078  [2]
IA-alkyne
 Probe Info  		C111(0.00); C286(0.00); C200(0.00)  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C229(0.94); C234(0.94); C298(1.04); C301(1.04)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C229(1.37); C231(1.37); C234(1.37)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C229(0.99); C231(1.36); C234(1.03)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C229(1.07); C231(1.28); C234(1.12)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C229(0.92); C231(1.15); C234(0.92)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C229(1.18); C231(1.22); C234(1.42)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C229(0.96); C231(1.25); C234(1.01)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C229(1.09); C231(1.26); C234(1.16)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C229(1.20); C231(1.29); C234(1.19)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C229(0.83); C231(0.94); C234(0.99)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C229(0.94); C231(1.18); C234(0.96)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C229(0.85); C231(1.04); C234(1.02)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C229(1.08); C231(1.08); C234(1.08)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C229(1.00); C231(1.36); C234(1.23)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C229(1.16); C231(1.41); C234(1.22)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C229(1.18); C231(1.69); C234(1.49)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C229(1.00); C231(0.98); C234(1.00)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C229(1.20); C231(1.45); C234(1.19)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C229(1.23); C231(1.81); C234(1.41)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C229(1.29); C231(1.56); C234(1.22)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C229(1.29); C231(1.48); C234(1.19)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C229(1.38); C231(1.58); C234(1.36)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C229(1.11); C231(1.07); C234(1.03)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C229(0.94); C231(0.94); C234(0.94)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C229(0.80); C231(0.74); C234(0.78)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C229(1.24); C231(1.28); C234(1.16)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C229(1.63); C231(1.54); C234(1.51)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C229(1.10); C231(1.26); C234(1.12)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C229(1.15); C231(1.35); C234(1.05)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C229(1.27); C231(1.52); C234(1.28)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C229(1.14); C231(1.20); C234(1.16)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C229(1.27); C231(1.43); C234(1.28)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C229(1.32); C234(1.31); C298(1.01); C301(1.01)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C229(1.41); C234(1.25); C298(0.99); C301(0.99)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C229(1.27); C234(1.18); C298(0.80); C301(0.80)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C229(0.97); C234(1.43); C298(0.90); C301(0.90)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C229(1.53); C234(1.42); C298(0.91); C301(0.91)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C229(0.86); C234(0.96); C298(0.88); C301(0.88)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C229(1.25); C234(1.32); C298(0.90); C301(0.90)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C229(0.80); C234(1.01); C298(1.01); C301(1.01)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C229(1.35); C234(1.18); C298(1.02); C301(1.02)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C229(1.45); C234(1.23); C298(0.92); C301(0.92)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C229(1.24); C234(1.10); C298(0.69); C301(0.69)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C229(1.28); C234(1.18); C298(0.90); C301(0.90)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C229(0.72); C231(0.72); C234(0.72)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C229(1.68); C234(1.32); C298(1.09); C301(1.09)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C229(1.49); C234(1.14); C298(0.97); C301(0.97)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C229(1.48); C234(1.17); C298(0.94); C301(0.94)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C229(1.08); C231(1.08); C234(1.08)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C229(1.34); C231(1.34); C234(1.34)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C229(1.58); C231(1.58); C234(1.58)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C229(1.56); C231(1.56); C234(1.56)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C229(1.71); C231(1.71); C234(1.71)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C229(1.94); C231(1.94); C234(1.94)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C229(1.88); C231(1.88); C234(1.88)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C229(0.89); C231(0.89); C234(0.89)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C229(1.32); C231(1.32); C234(1.32)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C229(1.19); C231(1.19); C234(1.19)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C229(1.26); C231(1.26); C234(1.26)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C229(1.93); C231(1.93); C234(1.93)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C229(1.79); C231(1.79); C234(1.79)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C229(1.41); C231(1.41); C234(1.41)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C229(1.27); C231(1.27); C234(1.27)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C229(1.64); C231(1.64); C234(1.64)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C229(1.15); C231(1.15); C234(1.15)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C229(1.21); C231(1.21); C234(1.21)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C229(0.97); C231(0.97); C234(0.97)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C229(1.15); C234(1.15); C298(1.06); C301(1.06)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C229(1.06); C231(1.06); C234(1.06)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C229(1.18); C231(1.18); C234(1.18)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C229(1.20); C231(1.20); C234(1.20)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C229(0.87); C231(0.87); C234(0.87)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C229(0.76); C231(0.76); C234(0.76)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C229(0.84); C234(0.84); C231(0.92)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C229(1.11); C234(1.11); C231(1.37)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C231(0.89); C229(1.31); C234(1.31)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C229(0.94); C234(0.94); C231(0.94)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C229(0.98); C234(0.98); C231(1.04)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C229(0.77); C234(0.77); C298(1.02); C301(1.02)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C229(1.50); C234(1.50); C231(1.73)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C229(1.12); C234(1.12); C231(1.25)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C231(1.21); C229(1.26); C234(1.26)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C229(1.45); C234(1.45); C231(1.52)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C229(1.25); C234(1.25); C231(1.34)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C229(0.59); C234(0.59)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C229(1.07); C234(1.07)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C229(1.17); C234(1.17)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C229(0.91); C234(0.91)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C229(0.95); C234(0.95)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C229(0.94); C234(0.94); C298(0.96); C301(0.96)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C229(0.95); C234(0.95)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C229(1.11); C234(1.11)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C229(1.04); C234(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C229(0.99); C234(0.99)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C229(1.15); C234(1.15)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C229(1.23); C234(1.23)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C229(1.36); C234(1.36); C231(1.42)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C229(1.49); C234(1.49); C231(1.82)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C229(1.60); C234(1.60); C231(1.80)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C229(1.80); C234(1.80); C231(1.98)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C229(0.88); C234(0.88); C298(0.89); C301(0.89)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C231(1.13); C229(1.36); C234(1.36)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C229(1.47); C234(1.47); C231(1.98)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C229(1.36); C234(1.36); C231(1.47)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C229(1.60); C234(1.60); C231(2.02)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C231(1.32); C229(1.35); C234(1.35)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C229(1.98); C234(1.98); C231(2.34)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C231(2.15); C229(2.17); C234(2.17)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C231(1.34); C229(1.35); C234(1.35)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C229(1.54); C234(1.54); C231(1.68)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C229(1.04); C234(1.04); C231(1.27)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C229(1.16); C231(1.16); C234(1.16)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C229(1.36); C234(1.36); C231(1.45)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C229(1.53); C234(1.53); C231(1.82)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C229(1.41); C234(1.41); C231(1.44)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C229(1.08); C234(1.08); C231(1.11)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C231(1.35); C229(1.43); C234(1.43)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C229(1.32); C234(1.32); C231(1.56)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C229(1.07); C234(1.07); C231(1.23)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C229(1.21); C234(1.21); C231(1.38)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C231(0.86); C234(1.32); C229(1.37)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C231(0.88); C234(1.34); C229(1.39)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C229(0.99); C231(0.99); C234(0.99)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C231(1.18); C229(1.83); C234(1.83)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C231(0.98); C234(1.00); C229(1.02)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C229(1.09); C231(1.10); C234(1.12)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C231(1.01); C234(1.80); C229(1.84)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C231(0.95); C234(1.44); C229(1.44)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C231(1.00); C229(1.56); C234(1.57)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C231(0.99); C229(1.37); C234(1.40)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C231(0.94); C234(1.65); C229(1.67)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C231(0.97); C234(1.22); C229(1.27)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C231(0.99); C229(1.10); C234(1.14)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C229(1.02); C231(1.02); C234(1.02)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C231(1.10); C229(1.14); C234(1.18)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C231(0.89); C229(0.97); C234(0.97)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C231(1.09); C229(1.59); C234(1.59)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C229(1.15); C231(1.15); C234(1.15)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C229(0.88); C231(0.88); C234(0.88)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C229(0.74); C231(0.74); C234(0.74)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C229(0.75); C231(0.75); C234(0.75)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C229(0.89); C231(0.89); C234(0.89)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C229(1.01); C231(1.01); C234(1.01)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C229(0.95); C231(0.95); C234(0.95)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C229(1.06); C231(1.06); C234(1.06)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C229(1.19); C231(1.19); C234(1.19)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C229(1.03); C231(1.03); C234(1.03)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C229(0.68); C231(0.68); C234(0.68)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C229(0.59); C231(0.59); C234(0.59)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C229(0.96); C231(0.96); C234(0.96)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C229(1.05); C231(1.05); C234(1.05)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C229(0.87); C231(0.87); C234(0.87)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C229(1.28); C234(1.34); C231(1.49)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C229(0.83); C234(0.91); C231(1.14)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C229(1.41); C231(1.41); C234(1.41)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C229(1.13); C231(1.13); C234(1.13)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C229(1.30); C231(1.30); C234(1.30)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C298(1.09); C301(1.09)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C111(20.00)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C229(0.95); C231(0.95); C234(0.95); C298(1.37)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C229(0.79); C231(0.79); C234(0.79); C298(1.13)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C229(0.91); C234(0.91); C298(0.99); C301(0.99)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C229(1.17); C231(1.17); C234(1.17)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C229(1.02); C231(1.02); C234(1.02)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C229(1.15); C231(1.15); C234(1.15)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C229(1.46); C231(1.46); C234(1.46)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C229(0.84); C231(0.84); C234(0.84)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C229(0.97); C231(0.97); C234(0.97)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C229(1.45); C231(1.45); C234(1.45)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C229(1.26); C231(1.26); C234(1.26)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C229(1.06); C231(1.06); C234(1.06)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C229(0.85); C231(0.85); C234(0.85); C298(0.85)  LDD0977  [2]
 LDCM0380  CL110 HCT 116 C229(1.13); C231(1.13); C234(1.13)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C229(1.23); C231(1.23); C234(1.23)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C229(0.90); C234(0.90); C231(1.05)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C229(1.13); C234(1.13); C231(1.40)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C229(1.57); C234(1.57); C231(2.19)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C229(1.35); C234(1.35); C231(1.55)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C229(1.30); C234(1.30); C231(1.52)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C229(1.25); C234(1.25)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C229(1.03); C234(1.03)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C229(0.79); C234(0.79)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C229(1.09); C231(1.09); C234(1.09); C298(1.09)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C229(0.78); C234(0.78)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C229(1.90); C234(1.90); C231(2.59)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C231(1.23); C229(1.32); C234(1.32)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C229(1.31); C234(1.31); C231(1.49)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C229(1.45); C234(1.45); C231(1.68)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C229(1.31); C234(1.31); C231(1.69)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C229(0.87); C234(0.87); C231(1.08)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C229(1.13); C234(1.13); C231(1.35)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C229(1.45); C234(1.45); C231(1.64)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C229(0.91); C231(0.91); C234(0.91); C298(1.06)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C229(1.04); C231(1.04); C234(1.04); C298(1.21)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C229(0.77); C231(0.77); C234(0.77); C298(1.21)  LDD1000  [2]
 LDCM0403  CL16 HCT 116 C229(0.79); C231(0.79); C234(0.79)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C229(1.47); C231(1.47); C234(1.47)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C229(1.26); C231(1.26); C234(1.26)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C229(1.16); C231(1.16); C234(1.16)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C229(0.91); C231(0.91); C234(0.91); C298(1.14)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C229(1.24); C231(1.24); C234(1.24)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C229(1.65); C231(1.65); C234(1.65)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C229(2.18); C231(2.18); C234(2.18)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C229(1.20); C231(1.20); C234(1.20)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C229(1.11); C231(1.11); C234(1.11)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C229(1.52); C231(1.52); C234(1.52)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C229(0.98); C231(0.98); C234(0.98)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C229(1.75); C231(1.75); C234(1.75)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C229(1.28); C231(1.28); C234(1.28)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C229(1.27); C231(1.27); C234(1.27)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C229(0.81); C231(0.81); C234(0.81); C298(0.98)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C229(1.03); C231(1.03); C234(1.03)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C229(1.08); C231(1.08); C234(1.08); C298(1.08)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C229(1.40); C231(1.40); C234(1.40); C298(1.06)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C229(1.01); C231(1.01); C234(1.01); C298(1.32)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C229(1.06); C231(1.06); C234(1.06); C298(1.29)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C229(1.07); C231(1.07); C234(1.07); C298(0.98)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C229(1.13); C231(1.13); C234(1.13); C298(1.15)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C229(1.07); C231(1.07); C234(1.07); C298(1.02)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C229(0.89); C231(0.89); C234(0.89); C298(1.07)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C229(1.17); C231(1.17); C234(1.17); C298(1.20)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C229(1.20); C231(1.20); C234(1.20); C298(1.20)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C229(1.05); C231(1.05); C234(1.05); C298(1.15)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C229(1.16); C231(1.16); C234(1.16); C298(1.03)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C229(1.28); C231(1.28); C234(1.28); C298(1.09)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C229(1.04); C231(1.04); C234(1.04); C298(1.12)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C229(1.03); C231(1.03); C234(1.03); C298(1.02)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C229(1.06); C231(1.17); C234(1.17); C298(1.02)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C229(1.37); C231(1.07); C234(1.07); C298(1.10)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C229(1.10); C231(0.93); C234(0.93); C298(0.93)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C229(1.16); C231(1.24); C234(1.24); C298(1.00)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C229(1.14); C231(1.14); C234(1.14); C298(1.01)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C229(0.90); C231(0.83); C234(0.83); C298(1.09)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C229(1.26); C231(1.05); C234(1.05); C298(0.87)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C229(1.17); C231(0.98); C234(0.98); C298(0.99)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C229(0.96); C231(0.83); C234(0.83); C298(1.02)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C229(1.15); C231(0.95); C234(0.95); C298(1.04)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C229(0.98); C231(0.96); C234(0.96); C298(0.97)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C229(1.21); C231(1.00); C234(1.00); C298(0.89)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C229(1.31); C231(1.10); C234(1.10); C298(0.88)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C229(1.57); C231(1.37); C234(1.37); C298(0.92)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C229(1.34); C231(1.16); C234(1.16); C298(0.88)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C229(0.80); C231(0.80); C234(0.80); C298(1.08)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C229(1.25); C231(1.20); C234(1.20); C298(0.96)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C298(1.20); C301(1.20)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C298(1.13); C301(1.13)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C298(1.02); C301(1.02)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C298(1.03); C301(1.03)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C298(1.40); C301(1.40)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C298(1.14); C301(1.14)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C298(1.31); C301(1.31)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C298(1.17); C301(1.17)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C298(1.35); C301(1.35)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C229(0.95); C231(0.95); C234(0.95); C298(0.88)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C298(1.19); C301(1.19)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C298(1.11); C301(1.11)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C298(1.25); C301(1.25)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C298(1.21); C301(1.21)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C298(0.95); C301(0.95)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C229(1.18); C231(1.18); C234(1.18); C298(0.94)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C229(0.99); C231(0.99); C234(0.99); C298(1.03)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C229(0.94); C231(0.94); C234(0.94); C298(0.95)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C229(0.98); C231(0.98); C234(0.98); C298(0.83)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C229(1.53); C231(1.46); C234(1.49); C298(0.48)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C229(1.30); C231(1.30); C234(1.30); C298(1.04)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C229(1.07); C231(1.07); C234(1.07); C298(0.82)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C229(1.25); C231(1.25); C234(1.25); C298(0.94)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C229(0.80); C231(0.80); C234(0.80); C298(0.89)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C229(1.10); C231(1.10); C234(1.10); C298(0.97)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C229(1.01); C231(1.01); C234(1.01); C298(1.07)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C229(1.10); C231(1.10); C234(1.10); C298(0.88)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C229(1.10); C231(1.10); C234(1.10); C298(1.04)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C229(1.04); C231(1.04); C234(1.04); C298(1.01)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C229(0.88); C231(0.88); C234(0.88); C298(0.89)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C229(1.22); C231(1.26); C234(1.55); C298(0.82)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C229(1.29); C231(1.29); C234(1.29); C298(0.88)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C229(0.92); C234(0.92); C298(0.94); C301(0.94)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C229(0.74); C234(0.74); C298(0.96); C301(0.96)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C229(1.16); C234(1.16); C298(1.11); C301(1.11)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C229(0.92); C234(0.92); C298(1.18); C301(1.18)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C229(1.15); C234(1.15); C298(1.35); C301(1.35)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C229(0.61); C234(0.61); C298(1.28); C301(1.28)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C229(0.95); C234(0.95); C298(1.49); C301(1.49)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C229(0.90); C234(0.90); C298(1.16); C301(1.16)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C229(0.96); C234(0.96); C298(1.02); C301(1.02)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C111(1.13); C141(1.00); C234(0.93)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C309(1.78)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C298(1.16); C301(1.16)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C229(1.17); C231(1.17); C234(1.17); C298(0.98)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C111(1.25)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C111(1.81)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C111(1.53)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C229(1.35); C231(1.35); C234(1.35)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromobox protein homolog 3 (CBX3) . Q13185

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
A-196 Small molecular drug D0P2EH

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402