Details of the Target

General Information of Target

Target ID LDTP08260
Target Name Probable E3 ubiquitin-protein ligase DTX2 (DTX2)
Gene Name DTX2
Gene ID 113878
Synonyms
KIAA1528; RNF58; Probable E3 ubiquitin-protein ligase DTX2; EC 2.3.2.27; Protein deltex-2; Deltex2; hDTX2; RING finger protein 58; RING-type E3 ubiquitin transferase DTX2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLA
HSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGS
WTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPY
PVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGT
HQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSG
AVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTS
PPASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVPPDEDCIICMEKLS
TASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKT
GTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLP
DNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPN
YLQNVLAELAAQGVTEDCLEQQ
Target Bioclass
Enzyme
Family
Deltex family
Subcellular location
Cytoplasm
Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Uniprot ID
Q86UW9
Ensemble ID
ENST00000324432.9
HGNC ID
HGNC:15973

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C537(1.12)  LDD0547  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
NAIA_4
 Probe Info  		C351(0.00); 0.00  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
HHS-482
 Probe Info  		Y75(0.97)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C537(1.12)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C537(1.32)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C537(1.16)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C537(1.39)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C537(1.21)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C537(1.58)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C537(1.21)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C537(1.46)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C537(1.00)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C537(1.36)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C537(1.00)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C537(1.17)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C537(1.55)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C537(1.65)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C537(1.45)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C537(0.81)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C537(1.08)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C537(1.16)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C537(0.95)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C537(1.08)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C537(0.94)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C537(0.87)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C537(1.01)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C537(0.97)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C537(0.86)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C537(0.81)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C537(0.91)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C537(0.94)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C537(0.89)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C537(0.96)  LDD0579  [1]
 LDCM0285  AC25 HCT 116 C537(1.06)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C537(0.70)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C537(0.71)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C537(0.69)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C537(0.53)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C537(0.53)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C537(0.70)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C537(0.57)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C537(0.98)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C537(1.00)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C537(1.06)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C537(0.98)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C537(1.04)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C537(0.81)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C537(0.87)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C537(0.89)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C537(0.90)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C537(0.84)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C537(0.73)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C537(1.17)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C537(1.25)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C469(1.01); C472(1.01)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C469(0.83); C472(0.83)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C469(0.79); C472(0.79)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C469(0.57); C472(0.57)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C469(0.62); C472(0.62)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C469(1.17); C472(1.17)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C469(0.86); C472(0.86)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C469(0.70); C472(0.70)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C469(0.72); C472(0.72)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C469(0.62); C472(0.62)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C469(0.49); C472(0.49)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C537(0.81); C469(0.87); C472(0.87)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C537(0.69); C469(0.90); C472(0.90)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C537(0.77); C469(0.99); C472(0.99)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C537(0.83); C469(0.95); C472(0.95)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C469(0.93); C472(0.93); C537(1.13)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C537(0.81); C469(0.95); C472(0.95)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C537(0.90); C469(1.14); C472(1.14)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C537(0.87); C469(1.07); C472(1.07)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C469(0.85); C472(0.85); C537(1.37)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C537(0.78); C469(1.06); C472(1.06)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C537(0.87); C469(0.91); C472(0.91)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C537(0.52); C469(1.00); C472(1.00)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C537(0.57); C469(0.95); C472(0.95)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C537(0.35); C469(0.84); C472(0.84)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C537(0.91); C469(1.12); C472(1.12)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C537(0.51); C469(0.87); C472(0.87)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C537(0.50); C469(0.87); C472(0.87)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C537(0.65); C469(1.14); C472(1.14)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C537(0.75); C469(1.09); C472(1.09)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C537(0.49); C469(1.09); C472(1.09)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C537(0.44); C469(0.92); C472(0.92)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C537(0.61); C469(1.16); C472(1.16)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C537(0.70); C469(0.94); C472(0.94)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C537(0.64); C469(1.37); C472(1.37)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C469(0.97); C472(0.97); C537(1.13)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C537(0.46); C469(1.18); C472(1.18)  LDD0665  [1]
 LDCM0382  CL112 HCT 116 C537(0.90)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C537(0.67)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C537(0.58)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C537(0.91)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C537(0.89)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C537(0.81)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C537(0.85)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C537(0.82)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C537(0.81)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C469(1.73); C472(1.73)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C469(0.68); C472(0.68)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C469(0.68); C472(0.68)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C469(0.64); C472(0.64)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C537(0.90); C469(0.91); C472(0.91)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C537(0.69); C469(0.89); C472(0.89)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C469(0.94); C472(0.94); C537(1.16)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C469(0.86); C472(0.86); C537(1.16)  LDD0716  [1]
 LDCM0420  CL31 HCT 116 C537(0.84)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C537(0.87)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C537(0.74)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C537(0.69)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C537(0.88)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C537(0.55)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C537(0.93)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C537(0.96)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C537(0.52)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C537(0.94)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C537(0.76)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C537(0.84)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C537(0.73)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C537(0.56)  LDD0752  [1]
 LDCM0453  CL61 HCT 116 C469(1.12); C472(1.12)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C469(1.15); C472(1.15)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C469(0.88); C472(0.88)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C469(1.28); C472(1.28)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C469(1.27); C472(1.27)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C469(0.98); C472(0.98)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C469(1.23); C472(1.23)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C469(1.47); C472(1.47)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C469(0.82); C472(0.82)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C469(1.11); C472(1.11)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C469(0.86); C472(0.86)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C469(1.13); C472(1.13)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C469(1.12); C472(1.12)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C469(1.00); C472(1.00)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C469(1.17); C472(1.17)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C469(1.70); C472(1.70)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C469(1.50); C472(1.50)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C469(1.58); C472(1.58)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C469(1.98); C472(1.98)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C469(1.58); C472(1.58)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C469(1.64); C472(1.64)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C469(0.99); C472(0.99)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C469(0.99); C472(0.99)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C469(1.09); C472(1.09)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C469(1.35); C472(1.35)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C469(1.23); C472(1.23)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C469(1.18); C472(1.18)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C469(1.28); C472(1.28)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C469(1.09); C472(1.09)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C469(1.27); C472(1.27)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C537(0.65)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C618(1.10)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C618(1.09)  LDD1497  [6]
 LDCM0024  KB05 HMCB C537(1.45)  LDD3312  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4) AlkB family Q9NXW9
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) ANT/ATPSC lysine N-methyltransferase family Q9BQD7
Cytochrome c oxidase assembly factor 6 homolog (COA6) Cytochrome c oxidase subunit 6B family Q5JTJ3
Poly(A) RNA polymerase GLD2 (TENT2) DNA polymerase type-B-like family Q6PIY7
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Histidine decarboxylase (HDC) Group II decarboxylase family P19113
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Proteasome subunit beta type-4 (PSMB4) Peptidase T1B family P28070
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Ubiquitin-conjugating enzyme family P61077
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
Bcl-2-like protein 11 (BCL2L11) Bcl-2 family O43521
Neuron-specific calcium-binding protein hippocalcin (HPCA) Recoverin family P84074
Major vault protein (MVP) . Q14764
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Homeobox protein Hox-B2 (HOXB2) Antp homeobox family P14652
H2.0-like homeobox protein (HLX) H2.0 homeobox family Q14774
Heat shock transcription factor, Y-linked (HSFY1; HSFY2) HSF family Q96LI6
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) . Q9HBZ2
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Paired box protein Pax-5 (PAX5) . Q02548
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) . Q5JUK2
T-box transcription factor TBX15 (TBX15) . Q96SF7
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fc receptor-like protein 4 (FCRL4) . Q96PJ5
Matrix remodeling-associated protein 8 (MXRA8) . Q9BRK3
Other
Click To Hide/Show 56 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) ECSIT family Q9BQ95
Zinc finger protein 503 (ZNF503) Elbow/Noc family Q96F45
Protein FAM168A (FAM168A) FAM168 family Q92567
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Protein Mis18-beta (OIP5) Mis18 family O43482
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Hippocalcin-like protein 1 (HPCAL1) Recoverin family P37235
Hippocalcin-like protein 4 (HPCAL4) Recoverin family Q9UM19
Neurocalcin-delta (NCALD) Recoverin family P61601
Neuronal calcium sensor 1 (NCS1) Recoverin family P62166
Visinin-like protein 1 (VSNL1) Recoverin family P62760
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Protein transport protein Sec23B (SEC23B) SEC23/SEC24 family Q15437
Sperm-associated antigen 8 (SPAG8) SPAG8 family Q99932
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Tektin-5 (TEKT5) Tektin family Q96M29
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Synaptic plasticity regulator PANTS (C22orf39) UPF0545 family Q6P5X5
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) . Q6AI39
Ciliary microtubule inner protein 1 (CIMIP1) . Q9H1P6
DAZ-associated protein 2 (DAZAP2) . Q15038
Extracellular matrix protein 1 (ECM1) . Q16610
Four and a half LIM domains protein 2 (FHL2) . Q14192
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
LRP2-binding protein (LRP2BP) . Q9P2M1
NHL-repeat-containing protein 4 (NHLRC4) . P0CG21
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Proline-rich protein 32 (PRR32) . B1ATL7
Proline-rich protein 34 (PRR34) . Q9NV39
Puratrophin-1 (PLEKHG4) . Q58EX7
Putative protein MSS51 homolog, mitochondrial (MSS51) . Q4VC12
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Splicing regulator RBM11 (RBM11) . P57052
Transmembrane protein 42 (TMEM42) . Q69YG0
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840