Details of the Target

General Information of Target

Target ID LDTP08066
Target Name Low-density lipoprotein receptor-related protein 10 (LRP10)
Gene Name LRP10
Gene ID 26020
Synonyms
Low-density lipoprotein receptor-related protein 10; LRP-10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWL
ILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAG
ARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP
GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALD
LGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNA
TYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH
FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG
QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPL
SRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG
GPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAR
EGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRG
RLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAEDEPLLT
Target Bioclass
Other
Family
LDLR family
Subcellular location
Membrane
Function Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver.
Uniprot ID
Q7Z4F1
Ensemble ID
ENST00000359591.9
HGNC ID
HGNC:14553

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.D312G; p.P314H .
EFO27 Deletion: p.P676LfsTer28 .
IPC298 SNV: p.P617L .
JURKAT Deletion: p.P32QfsTer5 .
KURAMOCHI SNV: p.S53T .
MEWO SNV: p.P188L
Substitution: p.T571I		 .
MOLT4 SNV: p.L60I .
OVK18 SNV: p.G597C .
REH Insertion: p.P180LfsTer50 .
RKO SNV: p.G639W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K75(10.00)  LDD0277  [1]
BTD
 Probe Info  		C80(1.16)  LDD2137  [2]
IPM
 Probe Info  		C80(1.25)  LDD1701  [2]
DBIA
 Probe Info  		C80(0.91)  LDD0531  [3]
IA-alkyne
 Probe Info  		C381(0.00); C399(0.00); C331(0.00); C308(0.00)  LDD0162  [4]
NAIA_5
 Probe Info  		C331(0.00); C28(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C80(0.91)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C80(1.02)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C80(1.05)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C80(1.03)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C80(1.07)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C80(0.93)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C80(1.03)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C80(0.98)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C80(0.98)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C80(1.04)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C80(0.85)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C80(0.74)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C80(0.91)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C80(0.73)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C80(0.92)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C80(1.10)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C80(0.78)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C80(1.06)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C80(2.07)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C80(0.78)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C80(0.67)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C80(0.95)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C80(0.99)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C80(0.85)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C80(1.24)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C80(1.01)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C80(0.92)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C80(1.04)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C80(1.08)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C80(0.96)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C80(0.59)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C80(0.29)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C80(1.50)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C80(0.88)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C80(1.20)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C80(0.79)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C80(0.99)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C80(1.28)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C80(1.02)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C80(1.20)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C80(1.16)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C80(1.02)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C80(1.21)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C80(1.39)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C80(1.09)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C80(1.10)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C80(1.10)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C80(1.14)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C80(0.99)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C80(1.33)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C80(1.25)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C80(1.24)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C80(1.39)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C80(2.10)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C80(1.44)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C80(0.92)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C80(1.17)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C80(1.01)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C80(1.52)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C80(1.78)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C80(1.22)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C80(1.41)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C80(1.03)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C80(0.99)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C80(0.90)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C80(0.77)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C80(0.99)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C80(0.85)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C80(1.01)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C80(0.91)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C80(0.96)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C80(0.86)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C80(0.88)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C80(1.11)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C80(1.17)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C80(1.18)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C80(1.23)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C80(1.14)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C80(1.04)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C80(1.21)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C80(1.41)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C80(1.31)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C80(1.21)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C80(1.25)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C80(0.82)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C80(0.81)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C80(1.06)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C80(0.99)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C80(1.04)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C80(1.00)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C80(1.12)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C80(1.05)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C80(1.17)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C80(1.04)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C80(1.19)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C80(1.38)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C80(1.06)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C80(1.10)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C80(0.98)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C80(1.16)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C80(1.10)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C80(1.27)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C80(1.52)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C80(1.96)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C80(1.36)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C80(1.19)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C80(1.07)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C80(1.11)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C80(1.31)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C80(1.05)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C80(1.50)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C80(0.95)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C80(1.47)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C80(1.30)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C80(1.41)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C80(1.32)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C80(1.55)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C80(1.65)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C80(1.67)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C80(1.86)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C80(1.37)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C80(1.29)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C80(0.93)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C80(1.59)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C80(1.70)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C80(1.21)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C80(1.78)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C80(0.86)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C80(1.05)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C80(1.37)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C80(1.64)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C80(1.26)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C80(1.05)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C80(0.88)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C80(1.22)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C80(1.17)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C80(1.52)  LDD0946  [3]
 LDCM0365  AC98 HCT 116 C80(1.30)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C80(0.77)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C80(1.30)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C80(1.00)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C80(0.96)  LDD0873  [3]
 LDCM0367  CL1 PaTu 8988t C80(1.09)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C80(1.42)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C80(0.83)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C80(1.02)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C80(1.06)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C80(1.10)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C80(0.95)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C80(0.89)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C80(1.01)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C80(1.31)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C80(1.14)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C80(0.98)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C80(1.13)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C80(1.12)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C80(0.87)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C80(1.05)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C80(1.16)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C80(1.02)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C80(1.40)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C80(1.42)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C80(1.09)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C80(1.11)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C80(1.08)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C80(1.76)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C80(1.08)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C80(1.45)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C80(1.07)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C80(1.26)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C80(1.22)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C80(0.96)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C80(0.92)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C80(0.97)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C80(1.32)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C80(1.64)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C80(0.80)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C80(1.21)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C80(1.04)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C80(0.94)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C80(1.16)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C80(1.34)  LDD0723  [3]
 LDCM0407  CL2 PaTu 8988t C80(1.05)  LDD1286  [3]
 LDCM0408  CL20 HCT 116 C80(1.19)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C80(1.56)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C80(1.85)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C80(1.45)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C80(1.50)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C80(1.40)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C80(1.15)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C80(1.44)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C80(1.40)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C80(1.30)  LDD0734  [3]
 LDCM0418  CL3 PaTu 8988t C80(1.12)  LDD1297  [3]
 LDCM0419  CL30 HCT 116 C80(1.09)  LDD0736  [3]
 LDCM0422  CL33 HEK-293T C80(1.08); C399(1.12)  LDD1626  [6]
 LDCM0428  CL39 HEK-293T C80(1.01)  LDD1632  [6]
 LDCM0429  CL4 PaTu 8988t C80(1.11)  LDD1308  [3]
 LDCM0430  CL40 HEK-293T C80(0.99)  LDD1634  [6]
 LDCM0435  CL45 HEK-293T C80(1.06); C399(1.13)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C80(1.13)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C80(1.18)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C80(1.11)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C80(1.17)  LDD1037  [3]
 LDCM0440  CL5 PaTu 8988t C80(1.26)  LDD1319  [3]
 LDCM0441  CL50 HEK-293T C80(1.17)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C80(1.02)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C80(1.07)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C80(1.13)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C80(1.31)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C80(1.21)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C80(0.91)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C80(0.93)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C80(1.25)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C80(1.02)  LDD1048  [3]
 LDCM0451  CL6 PaTu 8988t C80(1.22)  LDD1330  [3]
 LDCM0452  CL60 HEK-293T C80(1.54)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C80(1.29)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C80(1.16)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C80(1.62)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C80(1.25)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C80(1.04)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C80(1.34)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C80(0.85)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C80(1.02)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C80(1.47)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C80(1.34)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C80(1.14)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C80(1.06)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C80(1.46)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C80(0.82)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C80(1.08)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C80(0.88)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C80(0.79)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C80(0.75)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C80(0.94)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C80(1.12)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C80(0.99)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C80(0.93)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C80(0.92)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C80(0.91)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C80(0.88)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C80(0.84)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C80(0.82)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C80(0.78)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C80(0.79)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C80(0.77)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C80(1.38)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C80(0.74)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C80(0.87)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C80(0.91)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C80(0.96)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C80(1.16)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C80(0.96)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C80(0.98)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C80(0.94)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C80(0.89)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C80(0.77)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C80(1.01)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C80(1.16)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C331(1.03)  LDD1631  [6]
 LDCM0023  KB03 MDA-MB-231 C80(1.25)  LDD1701  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C80(1.16)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6) Glycosyltransferase 29 family Q969X2
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Urea transporter 2 (SLC14A2) Urea transporter family Q15849
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein notochord (NOTO) . A8MTQ0
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Programmed cell death 1 ligand 2 (PDCD1LG2) BTN/MOG family Q9BQ51
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein mS40 (MRPS18B) Bacterial ribosomal protein bS18 family Q9Y676
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Gap junction beta-5 protein (GJB5) Connexin family O95377
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Fertilization-influencing membrane protein (FIMP) . Q96LL3
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) . Q53GL0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402