Details of the Target

General Information of Target

Target ID LDTP08028
Target Name KAT8 regulatory NSL complex subunit 1 (KANSL1)
Gene Name KANSL1
Gene ID 284058
Synonyms
CENP-36; KIAA1267; MSL1V1; NSL1; KAT8 regulatory NSL complex subunit 1; MLL1/MLL complex subunit KANSL1; MSL1 homolog 1; hMSL1v1; NSL complex protein NSL1; Non-specific lethal 1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPS
LDFRNNPTKEDLGKLQPLVASYLCSDVTSVPSKESLKLQGVFSKQTVLKSHPLLSQSYEL
RAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQP
ALQGSSRLSPGTDSSSNLGGVKLEGKKSPLSSILFSALDSDTRITALLRRQADIESRARR
LQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTR
ADPEQRHVPLRRRSEWKWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLI
VLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGAPIIGHISESLSTKSCG
ALRPVNGVINTLQPVLADHIPGDSSDAEEQLHKKQRLNLVSSSSDGTCVAARTRPVLSCK
KRRLVRPNSIVPLSKKVHRNSTIRPGCDVNPSCALCGSGSINTMPPEIHYEAPLLERLSQ
LDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPPKKLSLKHRAPMPGSLPDSAR
KDRHKLVSSFLTTAKLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAERLLNPPPPVHD
PNHSKMRLRDHSSERSEVLKHHTDMSSSSYLAATHHPPHSPLVRQLSTSSDSPAPASSSS
QVTASTSQQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDLQSLKG
SPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLG
SANPSTPQPASPDVSSSHSLSEYSHGQSPRSPISPELHSAPLTPVARDTPRHLASEDTRC
STPELGLDEQSVQPWERRTFPLAHSPQAECEDQLDAQERAARCTRRTSGSKTGRETEAAP
TSPPIVPLKSRHLVAAATAQRPTHR
Target Bioclass
Other
Subcellular location
Nucleus
Function As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Uniprot ID
Q7Z3B3
Ensemble ID
ENST00000262419.10
HGNC ID
HGNC:24565

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C208(1.32)  LDD1702  [1]
DBIA
 Probe Info  		C208(0.82)  LDD0533  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		C1020(0.00); C53(0.00); C224(0.00)  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info  		C1050(0.00); C1020(0.00)  LDD0018  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C208(1.02); C599(1.10)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C208(1.06); C599(1.05)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C208(0.82)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C208(1.01)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C208(0.97)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C208(1.42)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C208(1.07)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C208(1.12)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C208(1.10)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C208(1.26)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C208(0.82)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C208(0.92)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C208(1.01); C599(1.10)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C208(1.00)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C208(1.01)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C208(1.09)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C208(1.14)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C208(1.65)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C208(1.23)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C208(1.64)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C208(1.15)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C208(1.25)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C208(1.19)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C599(1.06)  LDD1510  [8]
 LDCM0238  AC120 HCT 116 C208(1.48)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C208(1.01)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C208(1.31)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C208(1.01)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C208(1.23)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C208(1.41)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C208(1.82)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C208(1.42)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C208(1.33)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C208(0.70)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C208(1.01)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C208(0.82)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C208(0.77)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C208(1.08)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C208(1.00)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C208(0.78)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C208(0.96)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C208(0.81)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C208(0.69)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C208(1.04)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C208(1.09); C599(1.06)  LDD1512  [8]
 LDCM0260  AC140 HCT 116 C208(0.95)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C208(0.80)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C208(0.79)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C208(1.22)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C208(1.62)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C208(1.03)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C208(1.51)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C208(1.37)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C208(2.29)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C208(1.56)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C208(1.04); C599(0.99)  LDD1513  [8]
 LDCM0271  AC150 HCT 116 C208(1.17)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C208(1.15)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C208(1.65)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C208(2.49)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C208(1.47)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C208(2.05)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C208(1.18)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C208(1.24)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C208(1.08); C599(0.99)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C208(1.04); C599(0.99)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C208(1.34); C599(1.47)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C208(0.96); C599(1.02)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C599(1.02)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C208(1.06); C599(1.02)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C208(1.05); C599(0.95)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C208(1.04); C599(0.98)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C208(0.92)  LDD1523  [8]
 LDCM0285  AC25 HCT 116 C208(0.96)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C208(1.12)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C208(0.99)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C208(0.94)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C208(1.05)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C208(1.08); C599(1.03)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C208(0.88)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C208(1.10)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C208(1.03)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C208(1.08)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C208(0.93)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C208(1.02); C599(1.02)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C599(1.06)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C208(1.02); C599(1.02)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C208(0.98); C599(1.07)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C208(1.08); C599(0.96)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C599(1.09)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C208(0.96)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C208(1.13); C599(1.07)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C208(1.20); C599(1.06)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C208(0.99); C599(1.07)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C599(1.10)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C208(1.00); C599(1.05)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C208(1.02); C599(1.04)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C208(0.97); C599(0.98)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C208(0.96)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C208(1.16); C599(1.01)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C208(1.07); C599(1.11)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C208(1.13); C599(1.05)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C208(1.03); C599(1.04)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C599(1.02)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C208(1.00); C599(0.98)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C208(1.06); C599(1.02)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C208(0.90); C599(1.02)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C208(1.05)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C208(1.15); C599(1.07)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C208(1.07); C599(1.07)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C208(1.00); C599(1.08)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C208(1.14); C599(1.07)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C599(1.06)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C208(1.01); C599(1.04)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C208(1.06); C599(1.08)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C208(0.93); C599(0.99)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C208(0.99)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C208(0.94); C599(0.97)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C208(0.91)  LDD1569  [8]
 LDCM0349  AC83 HCT 116 C208(1.76)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C208(1.86)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C208(1.10)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C208(1.33)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C208(1.54)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C208(1.45)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C208(1.41)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C208(0.75)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C208(1.93)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C208(1.64)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C208(1.36)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C208(1.39)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C208(1.52)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C208(1.52)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C208(1.59)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C208(2.10)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C208(0.97)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C208(1.10); C599(1.05)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C208(1.15); C599(1.09)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C208(1.07)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C208(0.95); C599(0.88); C1050(0.94)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C208(0.97); C599(1.05)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C208(1.00); C599(1.08); C588(1.12)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C208(1.04); C599(1.05); C1050(0.97)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C208(0.96); C599(1.04); C1050(0.80); C588(1.22)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C208(1.15); C599(1.04)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C208(1.03); C599(1.02); C588(1.03)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C208(1.06); C599(0.97); C1050(0.93)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C208(1.03); C599(0.97); C1050(1.36); C588(1.38)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C208(1.09); C599(0.92)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C208(1.00); C599(1.00); C588(1.24)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C208(1.00); C599(0.94); C1050(0.97)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C208(0.92); C599(0.99)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C208(0.92); C599(0.96); C1050(0.82); C588(1.12)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C208(1.05); C599(0.96)  LDD1585  [8]
 LDCM0382  CL112 HCT 116 C208(0.83)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C208(0.86)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C208(1.09)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C208(0.98)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C208(1.24)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C208(1.02); C599(1.03); C1050(1.04)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C208(0.99); C599(1.03); C1050(1.22); C588(1.12)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C208(1.18); C599(0.93)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C208(0.98)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C208(1.11); C599(1.12); C588(1.12)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C208(1.01); C599(1.04); C1050(0.93)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C208(0.98); C599(1.09); C1050(1.08); C588(1.08)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C208(0.99); C599(0.93)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C208(0.99); C599(0.97); C588(0.82)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C208(0.92); C599(1.00); C1050(0.99)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C208(0.92); C599(1.02); C1050(0.83); C588(1.08)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C208(1.11); C599(0.99)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C208(1.05); C599(0.99); C588(0.94)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C208(1.04); C599(1.11); C1050(0.95)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C208(1.03); C599(1.11); C1050(1.08); C588(1.02)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C208(1.06); C599(0.96)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C208(1.04); C599(1.02); C588(0.93)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C208(1.00); C599(1.11)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C208(0.97); C599(1.11)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C208(1.02); C599(1.09)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C208(0.95); C599(1.03); C1050(0.78); C588(1.16)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C599(1.06)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C208(1.01); C599(1.03)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C208(1.01); C599(1.01)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C208(0.94); C599(1.04)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C208(0.99)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C208(0.86); C599(1.02); C1050(0.79)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C208(0.99); C599(0.99); C1050(0.68); C588(1.02)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C208(1.05); C599(1.01)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C208(0.98); C599(1.11); C588(0.96)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C208(1.13); C599(1.02)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C208(1.05); C599(0.94)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C208(0.97); C599(1.00)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C208(1.00); C599(1.09)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C599(1.03)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C208(0.98); C599(1.02)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C208(1.04); C599(1.02)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C208(1.03); C599(1.00)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C208(1.10)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C208(0.96); C599(1.02); C1050(0.82)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C208(1.04); C599(1.00)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C208(0.92); C599(1.02); C588(1.29)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C208(0.93); C599(1.07); C588(0.80)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C208(1.08); C599(0.99)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C208(0.97); C599(1.05)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C208(1.06); C599(1.04)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C599(1.03)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C208(1.04); C599(1.08)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C208(1.09); C599(1.01)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C208(1.06); C599(1.01)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C208(1.11)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C208(0.95); C599(1.04); C1050(1.01)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C208(1.11); C599(0.92)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C208(0.96); C599(1.03); C1050(0.82); C588(1.13)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C208(1.07); C599(1.11); C588(1.28)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C208(1.03); C599(1.07)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C208(1.02); C599(0.99)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C208(1.04); C599(1.05)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C599(1.12)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C208(1.04); C599(1.21)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C208(1.01); C599(1.11)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C208(0.95); C599(1.01)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C208(1.00); C599(1.06)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C208(1.01)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C208(0.88); C599(1.01); C1050(0.92)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C208(1.02); C599(0.98); C1050(1.07); C588(1.16)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C208(1.11); C599(1.02)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C208(0.90); C599(1.08); C588(1.00)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C208(1.10); C599(1.06)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C208(1.06); C599(1.01)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C208(1.04); C599(1.06)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C599(1.05)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C208(0.98); C599(1.08)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C208(0.97); C599(0.97)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C208(1.05); C599(1.04)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C208(1.01); C599(1.00)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C208(1.02)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C208(0.90); C599(1.03); C1050(1.04)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C208(0.99); C599(1.02); C1050(0.59); C588(1.14)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C208(1.04); C599(1.12); C588(0.81)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C208(1.01); C599(1.10)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C208(1.06); C599(0.99)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C208(0.96); C599(1.06)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C599(0.97)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C599(1.01)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C208(1.06); C599(1.03)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C208(0.96); C599(1.05)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C208(0.97); C599(1.04)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C208(1.05)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C208(0.97); C599(1.03); C1050(0.99)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C208(0.95); C599(1.04); C1050(1.11); C588(1.27)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C208(1.03); C599(1.07)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C208(0.92); C599(1.08); C588(0.81)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C208(0.96); C599(1.02)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C208(0.96); C599(1.04)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C208(1.04); C599(1.17)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C208(1.02); C599(1.01)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C599(1.08)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C208(1.04); C599(1.09)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C208(1.09); C599(1.06)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C208(0.93); C599(0.99)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C208(1.00)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C208(0.99); C599(0.96); C1050(0.90)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C208(1.00); C599(1.03); C1050(0.91); C588(1.26)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C208(1.00); C599(1.08)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C208(1.12); C599(1.02)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C208(1.32)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C208(1.05); C599(1.01)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C208(1.02); C599(0.95); C1050(0.70); C588(1.26)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C208(0.96); C588(0.98)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C208(0.92); C588(0.98)  LDD1497  [8]
 LDCM0024  KB05 IGR39 C208(1.53)  LDD3315  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Coiled-coil domain-containing protein 85B (CCDC85B) CCDC85 family Q15834
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Dysbindin (DTNBP1) Dysbindin family Q96EV8
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein Hook homolog 2 (HOOK2) Hook family Q96ED9
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
NUT family member 1 (NUTM1) NUT family Q86Y26
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Melanoma-associated antigen 12 (MAGEA12) . P43365
Sperm-associated antigen 5 (SPAG5) . Q96R06

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840