Details of the Target

General Information of Target

Target ID LDTP07859
Target Name Rho GTPase-activating protein SYDE1 (SYDE1)
Gene Name SYDE1
Gene ID 85360
Synonyms
Rho GTPase-activating protein SYDE1; Synapse defective protein 1 homolog 1; Protein syd-1 homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSS
PEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDP
RPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRL
SLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPA
GPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEAR
ARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGC
QAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKC
VGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLR
ELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVS
SFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW
PDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGR
DFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALI
LDLERELSKQINVCL
Target Bioclass
Other
Function
GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1.
Uniprot ID
Q6ZW31
Ensemble ID
ENST00000342784.7
HGNC ID
HGNC:25824

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.R165H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K493(10.00)  LDD0277  [1]
IA-alkyne
 Probe Info  		C658(2.25)  LDD2157  [2]
AHL-Pu-1
 Probe Info  		C658(2.19)  LDD0170  [3]
DBIA
 Probe Info  		C360(1.20)  LDD0602  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		C665(0.00); C360(0.00)  LDD0147  [6]
TFBX
 Probe Info  		C346(0.00); C665(0.00); C520(0.00)  LDD0148  [6]
AOyne
 Probe Info  		12.90  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C658(2.19)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C658(2.55); C459(2.49)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C665(0.98)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C665(1.23)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C665(1.07)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C665(0.97)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C665(0.90)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C665(0.98)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C665(1.03)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C665(0.86)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C665(0.89)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C665(0.98)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C665(0.95)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C665(0.86)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C665(1.05)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C665(1.06)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C665(1.23)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C665(1.20)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C665(1.09)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C665(1.06)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C665(1.18)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C665(0.98)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C665(1.17)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C665(1.13)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C665(1.20)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C665(1.10)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C665(1.27)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C665(1.13)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C665(1.44)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C665(1.31)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C665(1.25)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C665(1.31)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C665(1.65)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C665(1.55)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C665(0.93)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C665(0.77)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C665(0.70)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C665(0.69)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C665(1.03)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C665(0.90)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C665(0.87)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C665(1.06)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C665(1.11)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C665(0.90)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C665(0.95)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C665(0.99)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C665(1.21)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C665(0.82)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C665(0.85)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C665(1.01)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C665(1.21)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C665(1.15)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C665(1.14)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C665(1.21)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C665(1.22)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C665(1.21)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C665(1.09)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C665(1.30)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C665(1.21)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C665(1.11)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C665(1.22)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C665(1.22)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C665(1.07)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C665(0.99)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C665(1.16)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C665(1.36)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C665(1.19)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C665(1.05)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C665(1.10)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C665(1.07)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C665(1.20)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C665(1.12)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C665(1.27)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C665(1.59)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C665(1.00)  LDD0882  [4]
 LDCM0285  AC25 HCT 116 C360(1.20)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C360(1.24)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C360(1.37)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C360(1.41)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C360(1.13)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C665(1.01)  LDD0888  [4]
 LDCM0291  AC30 HCT 116 C360(1.54)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C360(1.08)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C360(1.42)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C360(1.66)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C360(1.87)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C360(0.98)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C360(0.73)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C360(0.90)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C360(0.86)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C360(1.41)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C665(1.00)  LDD0899  [4]
 LDCM0302  AC40 HCT 116 C360(1.15)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C360(1.43)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C360(1.56)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C360(0.77)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C360(1.35)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C360(0.99)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C665(1.13)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C665(1.20)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C665(1.25)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C665(1.16)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C665(1.00)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C665(1.25)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C665(1.50)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C665(1.35)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C665(1.08)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C665(1.38)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C665(1.28)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C665(1.21)  LDD0917  [4]
 LDCM0320  AC57 HCT 116 C360(2.45)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C360(1.93)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C360(1.92)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C665(0.97)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C360(1.86)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C360(2.34)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C360(2.59)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C360(2.12)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C360(2.37)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C360(2.33)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C360(3.02)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C360(3.27)  LDD0648  [4]
 LDCM0332  AC68 HEK-293T C665(0.94)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C665(1.02)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C665(1.08)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C665(1.09)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C665(1.01)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C665(1.13)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C665(1.06)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C665(0.97)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C665(0.93)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C665(1.16)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C665(1.07)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C665(1.09)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C665(0.97)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C665(1.10)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C665(1.05)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C665(1.01)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C665(1.15)  LDD0946  [4]
 LDCM0349  AC83 HCT 116 C360(2.49)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C360(1.96)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C360(1.06)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C360(1.32)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C360(1.42)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C360(1.14)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C360(1.55)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C360(0.99)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C360(2.07)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C360(1.81)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C360(1.04)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C360(1.07)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C360(0.81)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C360(1.55)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C360(1.67)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C665(0.91)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C665(0.83)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C665(1.03)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C665(1.18)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C665(1.07)  LDD0873  [4]
 LDCM0367  CL1 HEK-293T C665(0.94)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C665(1.47)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C665(1.12)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C665(1.12)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C665(1.16)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C665(1.19)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C665(1.05)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C665(1.05)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C665(1.16)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C665(1.00)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C665(1.17)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C665(1.02)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C665(1.35)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C665(1.08)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C665(0.96)  LDD0979  [4]
 LDCM0382  CL112 HCT 116 C360(1.06)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C360(1.63)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C360(1.18)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C360(1.10)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C360(1.24)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C360(1.48)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C360(0.90)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C360(0.84)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C665(0.86)  LDD0988  [4]
 LDCM0391  CL120 HCT 116 C360(1.02)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C665(1.21)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C665(1.18)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C665(1.16)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C665(1.11)  LDD0993  [4]
 LDCM0396  CL125 HCT 116 C360(1.14)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C360(1.33)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C360(1.59)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C360(1.76)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C665(0.87)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C665(0.94)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C665(1.04)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C665(0.84)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C665(0.99)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C665(0.98)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C665(1.00)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C665(0.95)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C665(0.90)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C665(1.12)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C665(1.31)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C665(1.31)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C665(1.06)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C665(1.05)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C665(1.07)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C665(1.02)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C665(0.96)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C665(1.01)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C665(0.76)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C665(1.49)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C665(0.86)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C665(1.01)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C665(1.16)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C665(0.75)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C665(1.03)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C665(1.11)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C665(1.01)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C665(1.55)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C665(1.01)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C665(1.26)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C665(1.30)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C665(1.39)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C665(1.48)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C665(1.11)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C665(1.32)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C665(0.93)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C665(0.81)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C665(0.93)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C665(1.03)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C665(1.12)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C665(1.04)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C665(1.02)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C665(0.71)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C665(0.79)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C665(0.95)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C665(0.94)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C665(0.89)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C665(0.90)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C665(0.79)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C665(0.91)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C665(1.09)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C665(0.97)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C665(0.95)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C665(1.20)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C665(1.14)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C665(0.90)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C665(1.12)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C665(1.10)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C665(1.11)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C665(1.29)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C665(1.18)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C665(1.14)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C665(1.16)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C665(1.24)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C665(1.04)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C665(1.22)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C665(1.49)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C665(0.99)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C665(0.98)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C665(0.90)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C665(0.94)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C665(1.30)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C665(0.99)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C665(0.99)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C665(1.03)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C665(1.03)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C665(0.86)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C665(0.94)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C665(1.05)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C665(0.96)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C665(1.11)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C665(0.97)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C665(1.14)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C665(0.97)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C665(0.75)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C665(0.94)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C665(1.00)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C665(1.22)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C665(1.16)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C665(1.00)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C665(0.98)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C665(1.05)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C665(1.05)  LDD1092  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C438(3.73); C360(2.83)  LDD1702  [8]
 LDCM0468  Fragment33 HEK-293T C665(1.32)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C665(1.08)  LDD1025  [4]
 LDCM0022  KB02 42-MG-BA C346(1.46)  LDD2244  [9]
 LDCM0023  KB03 CAL-51 C346(3.19)  LDD2705  [9]
 LDCM0024  KB05 COLO792 C360(2.63)  LDD3310  [9]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840