Details of the Target

General Information of Target

Target ID LDTP07604
Target Name Thioredoxin domain-containing protein 11 (TXNDC11)
Gene Name TXNDC11
Gene ID 51061
Synonyms
EFP1; Thioredoxin domain-containing protein 11; EF-hand-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMAR
QRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEY
VRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFY
FPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEPGVLGYF
EFSGSPQPPGYLTFFTSALHSLKKALESTSSPRALVSFTGEWHLETKIYVLDYLGTVRFG
VITNKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVLNYTAENICKWALENQETLFRWLRP
HGGKSLLLNNELKKGPALFLFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQHL
RRVDAPVLESLALEVPAQLPDPPTITASPCCNTVVLPQWHSFSRTHNVCELCVNQTSGGM
KPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVASDSIECSNFLTSYSPFSYYTACCRTIS
RGVSGFIDSEQGVFEAPTVAFSSLEKKCEVDAPSSVPHIEENRYLFPEVDMTSTNFTGLS
CRTNKTLNIYLLDSNLFWLYAERLGAPSSTQVKEFAAIVDVKEESHYILDPKQALMKLTL
ESFIQNFSVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCG
FCPSLNHIFIQLARNLPMDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYP
EDVPITLPNLLRFILHHSDPASSPQNVANSPTKECLQSEAVLQRGHISHLEREIQKLRAE
ISSLQRAQVQVESQLSSARRDEHRLRQQQRALEEQHSLLHAHSEQLQALYEQKTRELQEL
ARKLQELADASENLLTENTWLKILVATMERKLEGRDGAESLAAQREVHPKQPEPSATPQL
PGSSPPPANVSATLVSERNKENRTD
Target Bioclass
Enzyme
Family
Protein disulfide isomerase family
Subcellular location
Endoplasmic reticulum membrane
Function
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
Uniprot ID
Q6PKC3
Ensemble ID
ENST00000283033.10
HGNC ID
HGNC:28030
ChEMBL ID
CHEMBL4630840

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
IA-alkyne
 Probe Info  		C815(2.05)  LDD0304  [2]
DBIA
 Probe Info  		C770(1.00)  LDD0531  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C770(1.00)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C770(0.95)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C770(0.95)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C770(0.91)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C770(0.88)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C770(0.97)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C770(0.80)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C770(1.02)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C770(0.93)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C770(0.89)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C770(0.99)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C770(0.79)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C770(0.87)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C770(1.10)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C770(0.98)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C770(1.07)  LDD1108  [3]
 LDCM0237  AC12 HCT 116 C770(0.95)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C770(0.82)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C770(0.95)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C770(0.91)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C770(0.95)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C770(1.02)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C770(0.93)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C770(0.96)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C770(0.99)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C770(0.84)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C770(1.03)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C770(0.93)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C770(1.07)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C770(0.87)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C770(0.99)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C770(0.89)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C770(1.02)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C770(0.95)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C770(1.06)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C770(0.94)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C770(0.96)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C770(0.98)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C770(1.00)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C770(0.90)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C770(0.97)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C770(0.91)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C770(1.01)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C770(0.96)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C770(0.92)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C770(1.07)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C770(0.96)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C770(0.99)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C770(0.89)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C770(0.98)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C770(0.91)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C770(0.99)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C770(0.97)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C770(1.06)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C770(0.93)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C770(0.90)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C770(0.93)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C770(1.06)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C770(0.94)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C770(0.86)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C770(1.05)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C770(0.87)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C770(0.93)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C770(0.96)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C770(0.98)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C770(1.02)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C770(0.90)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C770(0.95)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C770(1.04)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C770(1.02)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C770(1.03)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C770(1.03)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C770(0.91)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C770(0.94)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C770(1.06)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C770(1.04)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C770(1.01)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C770(0.97)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C770(1.03)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C770(1.00)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C770(1.07)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C770(1.08)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C770(1.05)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C770(0.99)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C770(1.08)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C770(0.94)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C770(1.03)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C770(1.38)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C770(1.41)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C770(0.96)  LDD0648  [3]
 LDCM0332  AC68 PaTu 8988t C770(1.01)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C770(1.00)  LDD1212  [3]
 LDCM0334  AC7 HCT 116 C770(0.96)  LDD0651  [3]
 LDCM0335  AC70 PaTu 8988t C770(0.84)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C770(1.03)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C770(1.02)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C770(0.98)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C770(0.84)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C770(0.99)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C770(0.88)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C770(1.01)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C770(0.85)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C770(1.00)  LDD1223  [3]
 LDCM0345  AC8 HCT 116 C770(0.79)  LDD0662  [3]
 LDCM0346  AC80 PaTu 8988t C770(0.81)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C770(0.91)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C770(0.92)  LDD1227  [3]
 LDCM0349  AC83 HEK-293T C770(0.95)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C770(1.14)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C770(1.07)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C770(1.15)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C770(0.90)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C770(1.07)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C770(1.26)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C770(1.21)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C770(0.98)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C770(1.02)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C770(0.86)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C770(1.08)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C770(1.11)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C770(1.03)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C770(2.15)  LDD0962  [3]
 LDCM0365  AC98 PaTu 8988t C770(0.98)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C770(0.95)  LDD1245  [3]
 LDCM0248  AKOS034007472 HCT 116 C770(0.97)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C770(0.82)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C770(0.87)  LDD0592  [3]
 LDCM0367  CL1 PaTu 8988t C770(0.72)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C770(0.63)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C770(0.88)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C770(0.95)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C770(0.98)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C770(0.83)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C770(1.03)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C770(0.93)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C770(0.82)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C770(0.97)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C770(1.06)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C770(0.88)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C770(0.68)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C770(0.81)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C770(0.93)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C770(0.94)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C770(0.92)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C770(0.94)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C770(0.90)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C770(0.98)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C770(0.95)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C770(0.97)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C770(0.98)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C770(0.78)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C770(0.95)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C770(0.55)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C770(0.97)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C770(1.03)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C770(1.06)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C770(1.22)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C770(1.19)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C770(0.95)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C770(1.03)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C770(0.65)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C770(0.69)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C770(0.81)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C770(0.99)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C770(0.94)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C770(1.14)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C770(0.94)  LDD0723  [3]
 LDCM0407  CL2 PaTu 8988t C770(0.79)  LDD1286  [3]
 LDCM0408  CL20 HCT 116 C770(0.88)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C770(0.94)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C770(0.95)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C770(0.90)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C770(0.88)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C770(1.04)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C770(0.77)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C770(0.85)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C770(0.91)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C770(0.94)  LDD0734  [3]
 LDCM0418  CL3 PaTu 8988t C770(0.64)  LDD1297  [3]
 LDCM0419  CL30 HCT 116 C770(0.83)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C770(1.15)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C770(1.09)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C770(1.10)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C770(1.14)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C770(1.27)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C770(1.20)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C770(1.09)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C770(1.39)  LDD1026  [3]
 LDCM0429  CL4 PaTu 8988t C770(0.79)  LDD1308  [3]
 LDCM0430  CL40 HEK-293T C770(1.04)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C770(0.80)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C770(1.45)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C770(1.30)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C770(1.12)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C770(1.37)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C770(1.02)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C770(0.90)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C770(0.95)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C770(1.02)  LDD0756  [3]
 LDCM0440  CL5 PaTu 8988t C770(0.73)  LDD1319  [3]
 LDCM0441  CL50 HCT 116 C770(1.11)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C770(1.08)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C770(1.02)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C770(0.91)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C770(0.80)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C770(0.99)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C770(0.88)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C770(0.80)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C770(1.00)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C770(1.02)  LDD0767  [3]
 LDCM0451  CL6 PaTu 8988t C770(0.72)  LDD1330  [3]
 LDCM0452  CL60 HCT 116 C770(1.04)  LDD0769  [3]
 LDCM0453  CL61 PaTu 8988t C770(0.90)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C770(1.01)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C770(1.03)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C770(0.89)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C770(1.05)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C770(1.03)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C770(1.02)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C770(1.02)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C770(0.83)  LDD1340  [3]
 LDCM0462  CL7 PaTu 8988t C770(0.74)  LDD1341  [3]
 LDCM0463  CL70 PaTu 8988t C770(0.95)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C770(0.92)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C770(1.01)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C770(1.01)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C770(1.13)  LDD1346  [3]
 LDCM0469  CL76 HCT 116 C770(1.02)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C770(0.92)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C770(1.10)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C770(1.03)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C770(0.68)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C770(1.24)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C770(1.01)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C770(1.08)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C770(1.10)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C770(0.94)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C770(1.05)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C770(1.06)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C770(1.13)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C770(1.11)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C770(0.98)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C770(0.73)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C770(0.88)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C770(0.88)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C770(0.87)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C770(0.84)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C770(0.90)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C770(0.99)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C770(0.86)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C770(0.85)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C770(0.94)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C770(0.95)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C568(0.91); C770(1.11)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C770(0.94)  LDD1347  [3]
 LDCM0427  Fragment51 HEK-293T C770(1.07)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C568(1.04); C770(1.07); C815(1.11)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C568(0.97); C770(0.98); C815(1.01)  LDD1497  [5]
 LDCM0024  KB05 IGR37 C815(1.79)  LDD3314  [6]
 LDCM0131  RA190 MM1.R C815(2.05)  LDD0304  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-2B (RAB2B) Rab family Q8WUD1
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Kelch-like protein 38 (KLHL38) . Q2WGJ6

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840