Details of the Target

General Information of Target

Target ID LDTP07500
Target Name Mis18-binding protein 1 (MIS18BP1)
Gene Name MIS18BP1
Gene ID 55320
Synonyms
C14orf106; KIAA1903; KNL2; M18BP1; Mis18-binding protein 1; Kinetochore-associated protein KNL-2 homolog; HsKNL-2; P243
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIATPLKHSRIYLPPEASSQRRNLPMDAIFFDSIPSGTLTPVKDLVKYQNSSLKLNDHKK
NQFLKMTTFNNKNIFQSTMLTEATTSNSSLDISAIKPNKDGLKNKANYESPGKIFLRMKE
KVLRDKQEQPSRNSSLLEPQKSGNNETFTPNRVEKKKLQHTYLCEEKENNKSFQSDDSSL
RASVQGVPLESSNNDIFLPVKQKIQCQQEKKAPLHNLTYELPTLNQEQENFLAVEARNKT
LTRAQLAKQIFHSKESIVATTKSKKDTFVLESVDSADEQFQNTNAETLSTNCIPIKNGSL
LMVSDSERTTEGTSQQKVKEGNGKTVPGETGLPGSMKDTCKIVLATPRLHITIPRRSKRN
ISKLSPPRIFQTVTNGLKKNQVVQLQEWMIKSINNNTAICVEGKLIDVTNIYWHSNVIIE
RIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMFGFPENWKEHIDNFLEQLRA
GEKNREKTKQKQKTGRSVRDIRKSMKNDARENQTDTAQRATTTYDFDCDNLELKSNKHSE
SPGATELNMCHSNCQNKPTLRFPDDQVNNTIQNGGGDDLSNQELIGKKEYKMSSKKLKIG
ERTNERIIKSQKQETTEELDVSIDILTSREQFFSDEERKYMAINQKKAYILVTPLKSRKV
IEQRCMRYNLSAGTIKAVTDFVIPECQKKSPISKSMGTLENTFEGHKSKNKEDCDERDLL
TVNRKIKISNLEKEQMLTSDFKKNTRLLPKLKKIENQVAMSFYKHQSSPDLSSEESETEK
EIKRKAEVKKTKAGNTKEAVVHLRKSTRNTSNIPVILEPETEESENEFYIKQKKARPSVK
ETLQKSGVRKEFPITEAVGSDKTNRHPLECLPGLIQDKEWNEKELQKLHCAFASLPKHKP
GFWSEVAAAVGSRSPEECQRKYMENPRGKGSQKHVTKKKPANSKGQNGKRGDADQKQTIK
ITAKVGTLKRKQQMREFLEQLPKDDHDDFFSTTPLQHQRILLPSFQDSEDDDDILPNMDK
NPTTPSSVIFPLVKTPQCQHVSPGMLGSINRNDCDKYVFRMQKYHKSNGGIVWGNIKKKL
VETDFSTPTPRRKTPFNTDLGENSGIGKLFTNAVESLDEEEKDYYFSNSDSA
Target Bioclass
Other
Subcellular location
Nucleus
Function Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Uniprot ID
Q6P0N0
Ensemble ID
ENST00000310806.9
HGNC ID
HGNC:20190

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L55W; p.V758I .
HEC1 SNV: p.K883N .
HGC27 SNV: p.Q492H .
HUCCT1 SNV: p.E154Q .
IGROV1 SNV: p.S306N .
LN18 SNV: p.L731V .
LNCaP clone FGC SNV: p.K167N DBIA    Probe Info 
MOLT4 SNV: p.E827D .
NB1 SNV: p.Q513R .
OVCAR8 Deletion: p.L349_K379delinsQ .
OVK18 SNV: p.P867L .
PF382 SNV: p.N375I .
RKO Insertion: p.L232FfsTer12
SNV: p.A893T		 .
SNGM Deletion: p.R359EfsTer24 .
SUPT1 SNV: p.K709R .
T98G SNV: p.K156I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C164(2.27)  LDD0168  [1]
DBIA
 Probe Info  		C550(1.02); C554(1.02)  LDD0078  [2]
IA-alkyne
 Probe Info  		C400(0.00); C206(0.00)  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		C206(0.00); C890(0.00)  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C164(2.27)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C164(2.99)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C206(1.05)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C206(1.01)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C400(0.86)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C206(0.97); C164(0.99)  LDD1510  [10]
 LDCM0246  AC128 HCT 116 C890(1.30)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C890(0.84)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C890(1.31)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C890(1.04)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C890(0.92)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C890(1.04)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C890(1.25)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C890(1.36)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C890(1.08)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C890(0.95)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C890(1.08)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C890(1.14)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C206(1.08); C164(0.98)  LDD1512  [10]
 LDCM0260  AC140 HCT 116 C890(1.11)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C890(1.14)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C890(0.85)  LDD0579  [2]
 LDCM0270  AC15 HEK-293T C206(0.94)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C206(1.01)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C206(1.06)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C400(0.92)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C206(1.03)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C206(0.98); C164(0.98)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C164(0.94); C400(0.84); C292(1.44)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C206(0.97); C164(0.98)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C206(0.91)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C206(0.98)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C206(0.97)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C206(0.88)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C400(0.96)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C206(0.98); C164(0.98)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C164(0.98); C400(0.87); C292(1.16)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C400(0.70)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C206(1.01); C164(0.97)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C206(0.98)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C206(1.01)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C206(1.03)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C206(1.04)  LDD1534  [10]
 LDCM0296  AC35 HCT 116 C890(0.85)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C890(0.87)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C890(0.73)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C890(1.09)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C890(0.91)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C206(1.03); C164(1.02)  LDD1540  [10]
 LDCM0302  AC40 HCT 116 C890(0.98)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C890(0.81)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C890(1.00)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C890(0.82)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C890(0.74)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C890(0.77)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C206(1.02); C164(1.07)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C206(1.00)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C206(0.95)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C206(0.90)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C164(1.08); C400(0.75); C292(1.31)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C206(1.03)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C400(0.85)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C206(1.02); C164(1.03)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C164(0.91); C400(1.15); C292(1.33)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C206(1.05); C164(0.97)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C206(0.99)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C206(1.10)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C206(1.05)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C206(0.99)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C400(0.89)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C206(1.04); C164(1.10)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C206(1.02); C164(1.01)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C164(1.01); C400(0.95); C292(1.19)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C206(0.94); C164(1.05)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C206(1.02)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C206(1.03)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C206(1.00)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C206(1.04)  LDD1569  [10]
 LDCM0349  AC83 HCT 116 C890(0.88)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C890(0.95)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C890(0.88)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C890(0.96)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C890(0.82)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C890(0.83)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C890(0.80)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C890(0.92)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C890(0.66)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C890(0.76)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C890(0.94)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C890(0.75)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C890(0.94)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C890(0.66)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C890(0.89)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C164(0.91); C400(1.05); C292(1.28)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C206(1.06)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C206(1.05)  LDD1514  [10]
 LDCM0020  ARS-1620 HCC44 C550(1.02); C554(1.02)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C890(0.48)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C206(1.07)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C206(1.12); C164(0.98)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C206(0.98); C164(1.04)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C206(1.08)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C206(1.02)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C206(1.05)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C206(1.04); C164(1.09)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C206(1.02)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C206(0.98)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C206(0.94)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C206(0.99); C164(1.07)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C206(1.06)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C206(0.98)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C206(1.03)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C206(0.97)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C206(1.01); C164(1.01)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C206(1.09)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C206(1.00)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C206(0.99)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C206(1.08); C164(1.08)  LDD1590  [10]
 LDCM0387  CL117 HCT 116 C890(1.00)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C890(0.99)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C890(0.84)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C206(1.10)  LDD1594  [10]
 LDCM0391  CL120 HCT 116 C890(0.95)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C206(1.06)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C206(1.03)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C206(1.00)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C206(1.05); C164(1.13)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C206(1.04)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C206(1.02)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C206(0.99)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C206(1.04); C164(1.04)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C206(0.96)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C206(0.96)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C206(1.01)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C206(0.99); C164(1.10)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C206(0.92)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C206(0.98)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C400(1.29)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C206(1.03)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C206(0.97); C164(0.79)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C164(0.77); C400(1.40); C292(1.41)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C206(1.09); C164(1.16)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C206(0.93)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C206(1.02)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C206(1.14)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C206(1.07)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C206(0.98)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C206(1.00); C164(1.10)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C206(1.07)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C206(0.93)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C206(0.93)  LDD1623  [10]
 LDCM0420  CL31 HCT 116 C890(0.96)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C890(0.97)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C890(1.01)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C890(0.93)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C890(1.12)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C890(1.23)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C890(1.31)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C890(1.01)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C206(1.04); C164(1.15)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C890(1.79)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C890(1.11)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C890(1.30)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C890(0.75)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C890(1.10)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C890(1.06)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C206(1.01); C164(1.06)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C206(0.95)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C206(0.97)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C206(1.11)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C206(1.08)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C206(1.02)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C206(1.06); C164(1.23)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C206(1.10)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C206(0.93)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C400(1.06)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C206(1.08); C164(0.90)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C164(0.90); C400(1.17); C292(1.33)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C206(1.06); C164(1.01)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C206(0.98)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C206(0.98)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C206(1.04)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C206(1.11)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C206(1.05)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C206(1.02)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C206(1.02); C164(1.08)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C206(1.07)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C206(0.99)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C400(1.05)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C206(0.96); C164(0.90)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C164(0.99); C400(1.14); C292(1.36)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C400(0.91)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C206(1.10); C164(1.05)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C206(0.97)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C206(1.13)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C206(1.12)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C206(1.02)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C206(1.13); C164(1.14)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C206(1.07)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C206(1.00)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C400(0.77)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C206(0.89); C164(0.93)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C206(1.02); C164(0.97)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C164(0.96); C400(1.36); C292(1.05)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C206(1.05); C164(1.10)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C206(0.99)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C206(1.13)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C206(1.09)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C206(0.97)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C206(1.10)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C206(1.12); C164(1.11)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C206(1.04)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C164(0.92); C400(1.21); C292(1.55)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C206(1.00)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C400(0.87)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C206(1.10); C164(1.08)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C164(1.02); C400(1.28); C292(1.21)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C206(1.05); C164(1.14)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C206(1.14)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C206(1.17)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C206(1.14)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C206(1.00)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C206(1.04)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C206(1.02)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C206(2.40); C164(1.57); C870(1.28); C890(1.26)  LDD1702  [11]
 LDCM0468  Fragment33 HEK-293T C206(1.03)  LDD1671  [10]
 LDCM0427  Fragment51 HCT 116 C890(3.05)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C890(2.63)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C890(1.27)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C890(2.22)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C550(1.04); C554(1.04)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Mis18-beta (OIP5) Mis18 family O43482

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761