Details of the Target

General Information of Target

Target ID LDTP07450
Target Name Protein lin-54 homolog (LIN54)
Gene Name LIN54
Gene ID 132660
Synonyms
CXCDC1; KIAA2037; Protein lin-54 homolog; CXC domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVVPAEVNSLLPEEIMDTGITLVDDDSIEAVIVSSPIPMETELEEIVNINSTGDSTATP
ISTEPITVYSNHTNQVAVNTTITKADSNTTVKPAFPSGLQKLGAQTPVTISANQIILNKV
SQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQLPQAQKVTTQAQSGDAKLPP
QQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSVLQTQQLKTVQIAKKPRTPTSGP
VITKLIFAKPINSKAVTGQTTQVSPPVIAGRVLSQSTPGTPSKTITISESGVIGSTLNST
TQTPNKIAISPLKSPNKAVKSTVQTITVGGVSTSQFKTIIPLATAPNVQQIQVPGSKFHY
VRLVTATSASSSTQPVSQNPSTNTQPLQQAKPVVVNTTPVRMSVPIVSAQAVKQVVPKPI
NPTSQIVTTSQPQQRLIMPATPLPQIQPNLTNLPPGTVLAPAPGTGNVGYAVLPAQYVTQ
LQQSSYVSIASNSTFTGTSGIQTQARLPFNGIIPSESASRPRKPCNCTKSLCLKLYCDCF
ANGEFCNNCNCTNCYNNLEHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCN
CKRSGCLKNYCECYEAKIMCSSICKCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKT
KLSSQISDLLTRPTPALNSGGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAER
MILEEFGRCLMSVINSAGKAKSDPCAMNC
Target Bioclass
Other
Family
Lin-54 family
Subcellular location
Nucleus
Function
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA.
Uniprot ID
Q6MZP7
Ensemble ID
ENST00000340417.8
HGNC ID
HGNC:25397

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G586E .
HCT15 SNV: p.A647V .
HEC1 Insertion: p.P96FfsTer14 .
IM95 Deletion: p.S742VfsTer6 .
KASUMI1 SNV: p.R520Q .
OCILY3 SNV: p.A746T .
SNU1 Deletion: p.Q385AfsTer11 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C525(1.37); C527(1.37)  LDD0531  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C525(1.37); C527(1.37)  LDD0531  [1]
 LDCM0215  AC10 PaTu 8988t C525(1.54); C527(1.54)  LDD1094  [1]
 LDCM0216  AC100 HCT 116 C525(0.75); C527(0.75)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C525(0.77); C527(0.77)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C525(0.86); C527(0.86)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C525(0.86); C527(0.86)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C525(0.81); C527(0.81)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C525(0.75); C527(0.75)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C525(0.80); C527(0.80)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C525(0.87); C527(0.87)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C525(0.55); C527(0.55)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C525(0.68); C527(0.68)  LDD0542  [1]
 LDCM0226  AC11 PaTu 8988t C525(1.56); C527(1.56)  LDD1105  [1]
 LDCM0227  AC110 HCT 116 C525(0.68); C527(0.68)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C525(0.78); C527(0.78)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C525(0.76); C527(0.76)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C525(0.89); C527(0.89)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C525(0.96); C527(0.74)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C525(0.92); C527(0.80)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C525(0.93); C527(0.90)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C525(1.06); C527(0.66)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C525(0.71); C527(0.67)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C525(0.86); C527(0.74)  LDD0553  [1]
 LDCM0237  AC12 PaTu 8988t C525(1.96); C527(1.96)  LDD1116  [1]
 LDCM0238  AC120 HCT 116 C525(0.80); C527(0.75)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C525(1.11); C527(0.85)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C525(0.81); C527(0.75)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C525(1.11); C527(0.81)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C525(1.26); C527(0.66)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C525(0.93); C527(0.75)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C525(0.82); C527(0.88)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C525(0.70); C527(0.70)  LDD0562  [1]
 LDCM0259  AC14 PaTu 8988t C525(1.57); C527(1.57)  LDD1138  [1]
 LDCM0263  AC143 HCT 116 C525(0.87); C527(0.87)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C525(0.98); C527(0.98)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C525(0.71); C527(0.71)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C525(0.81); C527(0.81)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C525(0.77); C527(0.77)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C525(0.91); C527(0.91)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C525(0.90); C527(0.90)  LDD0586  [1]
 LDCM0270  AC15 PaTu 8988t C525(2.45); C527(2.45)  LDD1149  [1]
 LDCM0271  AC150 HCT 116 C525(0.70); C527(0.70)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C525(0.79); C527(0.79)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C525(0.84); C527(0.84)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C525(0.65); C527(0.65)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C525(0.78); C527(0.78)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C525(0.66); C527(0.66)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C525(0.90); C527(0.90)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C525(0.76); C527(0.76)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C525(0.78); C527(0.78)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C525(1.22); C527(1.22)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C525(1.10); C527(1.10)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C525(1.10); C527(1.10)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C525(0.82); C527(0.82)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C525(1.16); C527(1.16)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C525(1.13); C527(1.13)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C525(0.91); C527(0.91)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C525(1.29); C527(1.29)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C525(0.93); C527(0.93)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C525(0.59); C527(0.59)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C525(0.70); C527(0.70)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C525(0.62); C527(0.62)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C525(0.53); C527(0.53)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C525(1.06); C527(1.06)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C525(0.51); C527(0.51)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C525(0.61); C527(0.61)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C525(0.54); C527(0.54)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C525(0.69); C527(0.69)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C525(0.65); C527(0.65)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C525(1.08); C527(1.08)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C525(1.13); C527(1.13)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C525(1.25); C527(1.25)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C525(0.96); C527(0.96)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C525(1.07); C527(1.07)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C525(1.05); C527(1.05)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C525(1.06); C527(1.06)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C525(1.03); C527(1.03)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C525(0.97); C527(0.97)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C525(1.00); C527(1.00)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C525(0.99); C527(0.99)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C525(1.09); C527(1.09)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C525(0.99); C527(0.99)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C525(1.29); C527(1.29)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C525(0.98); C527(0.98)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C525(0.87); C527(0.87)  LDD0909  [1]
 LDCM0312  AC5 HCT 116 C525(1.18); C527(1.18)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C525(0.88); C527(0.88)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C525(0.76); C527(0.76)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C525(0.80); C527(0.80)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C525(0.92); C527(0.92)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C525(0.90); C527(0.90)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C525(1.01); C527(1.01)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C525(0.96); C527(0.96)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C729(0.97)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C729(1.17)  LDD1560  [5]
 LDCM0323  AC6 PaTu 8988t C525(1.01); C527(1.01)  LDD1202  [1]
 LDCM0324  AC60 HEK-293T C729(1.07); C525(1.24)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C729(1.02); C525(1.00)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C729(1.09); C525(1.08)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C525(1.10)  LDD1566  [5]
 LDCM0332  AC68 HCT 116 C525(1.42); C527(1.42)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C525(1.30); C527(1.30)  LDD0650  [1]
 LDCM0334  AC7 PaTu 8988t C525(1.62); C527(1.62)  LDD1213  [1]
 LDCM0335  AC70 HCT 116 C525(0.97); C527(0.97)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C525(1.14); C527(1.14)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C525(1.03); C527(1.03)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C525(0.91); C527(0.91)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C525(0.94); C527(0.94)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C525(0.82); C527(0.82)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C525(0.93); C527(0.93)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C525(0.87); C527(0.87)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C525(0.74); C527(0.74)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C525(0.89); C527(0.89)  LDD0661  [1]
 LDCM0345  AC8 PaTu 8988t C525(1.87); C527(1.87)  LDD1224  [1]
 LDCM0346  AC80 HCT 116 C525(1.19); C527(1.19)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C525(1.21); C527(1.21)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C525(1.00); C527(1.00)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C525(0.90); C527(0.90)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C525(0.99); C527(0.99)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C525(0.64); C527(0.64)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C525(0.72); C527(0.72)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C525(0.78); C527(0.78)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C525(0.63); C527(0.63)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C525(0.82); C527(0.82)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C525(0.69); C527(0.69)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C525(1.03); C527(1.03)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C525(0.75); C527(0.75)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C525(0.96); C527(0.96)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C525(0.79); C527(0.79)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C525(0.58); C527(0.58)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C525(0.82); C527(0.82)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C525(0.76); C527(0.76)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C525(1.05); C527(1.05)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C525(0.74); C527(0.74)  LDD0683  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C525(1.96); C527(1.96)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C525(1.43); C527(1.43)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C525(1.80); C527(1.80)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C745(1.10)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C525(0.70); C527(0.70)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C525(0.57); C527(0.57)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C525(1.26); C527(1.26)  LDD0686  [1]
 LDCM0370  CL101 PaTu 8988t C525(0.95); C527(0.95)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C525(1.05); C527(1.05)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C525(2.01); C527(2.01)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C525(1.34); C527(1.34)  LDD1252  [1]
 LDCM0374  CL105 HCT 116 C525(0.77); C527(0.77)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C525(1.16); C527(1.16)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C525(1.17); C527(1.17)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C525(1.08); C527(1.08)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C525(1.14); C527(1.14)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C525(0.43); C527(0.43)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C525(1.00); C527(1.00)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C525(1.09); C527(1.09)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C525(0.55); C527(0.55)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C525(0.50); C527(0.50)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C525(0.46); C527(0.46)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C525(0.43); C527(0.43)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C525(0.73); C527(0.73)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C525(1.12); C527(1.12)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C525(1.01); C527(1.01)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C525(0.97); C527(0.97)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C525(0.83); C527(0.83)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C525(0.85); C527(0.85)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C525(0.82); C527(0.82)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C525(0.66); C527(0.66)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C525(0.59); C527(0.59)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C525(0.86); C527(0.86)  LDD0993  [1]
 LDCM0397  CL126 HEK-293T C525(1.05)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C613(0.90)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C729(0.96)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C525(0.70); C527(0.70)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C525(0.60); C527(0.60)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C525(0.46); C527(0.46)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C525(0.92); C527(0.92)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C525(1.15); C527(1.15)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C525(1.40); C527(1.40)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C525(0.90); C527(0.90)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C525(0.99); C527(0.99)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C525(0.89); C527(0.89)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C525(1.09); C527(1.09)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C525(1.50); C527(1.50)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C525(0.87); C527(0.87)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C525(0.99); C527(0.99)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C525(0.98); C527(0.98)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C525(0.92); C527(0.92)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C525(0.85); C527(0.85)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C525(0.89); C527(0.89)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C525(0.96); C527(0.96)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C525(0.79); C527(0.79)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C525(0.83); C527(0.83)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C525(1.14); C527(1.14)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C525(1.59); C527(1.59)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C525(1.15); C527(1.15)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C525(1.59); C527(1.59)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C525(1.35); C527(1.35)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C525(1.04); C527(1.04)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C525(1.39); C527(1.39)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C525(1.27); C527(1.27)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C525(0.65); C527(0.65)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C525(1.40); C527(1.40)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C525(1.21); C527(1.21)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C525(2.16); C527(2.16)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C525(1.59); C527(1.59)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C525(1.16); C527(1.16)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C525(1.29); C527(1.29)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C729(0.99); C525(0.98)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C525(1.05)  LDD1641  [5]
 LDCM0440  CL5 HCT 116 C525(0.92); C527(0.92)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C525(1.02)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C729(0.98)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C729(0.98)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C729(1.17)  LDD1648  [5]
 LDCM0447  CL56 HEK-293T C729(1.30); C525(0.96)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C729(0.96); C525(0.48)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C729(0.89); C525(1.04)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C525(1.02)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C525(0.86); C527(0.86)  LDD0768  [1]
 LDCM0454  CL62 HEK-293T C525(0.97)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C613(0.89)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C729(1.06)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C729(0.87)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C729(1.10)  LDD1661  [5]
 LDCM0460  CL68 HEK-293T C729(1.25); C525(1.02)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C729(1.21); C525(0.91)  LDD1664  [5]
 LDCM0462  CL7 HCT 116 C525(0.80); C527(0.80)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C729(0.96); C525(1.04)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C525(1.11)  LDD1667  [5]
 LDCM0467  CL74 HEK-293T C525(0.92)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C525(1.10); C527(1.10)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C525(0.95); C527(0.95)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C525(0.86); C527(0.86)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C525(0.94); C527(0.94)  LDD1070  [1]
 LDCM0473  CL8 HCT 116 C525(0.62); C527(0.62)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C525(1.28); C527(1.28)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C525(1.09); C527(1.09)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C525(0.84); C527(0.84)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C525(0.98); C527(0.98)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C525(0.68); C527(0.68)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C525(0.89); C527(0.89)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C525(0.70); C527(0.70)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C525(0.91); C527(0.91)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C525(0.85); C527(0.85)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C525(1.06); C527(1.06)  LDD1081  [1]
 LDCM0484  CL9 HCT 116 C525(0.63); C527(0.63)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C525(0.50); C527(0.50)  LDD1083  [1]
 LDCM0486  CL91 HCT 116 C525(1.09); C527(1.09)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C525(0.97); C527(0.97)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C525(1.36); C527(1.36)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C525(1.26); C527(1.26)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C525(1.10); C527(1.10)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C525(1.11); C527(1.11)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C525(1.00); C527(1.00)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C525(1.23); C527(1.23)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C525(0.92); C527(0.92)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C613(1.08)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C613(0.95)  LDD1671  [5]
 LDCM0427  Fragment51 HCT 116 C525(2.31); C527(2.31)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C525(0.95)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C525(1.00)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C525(1.02)  LDD1502  [5]
 LDCM0021  THZ1 HCT 116 C745(1.10)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 143 (ZNF143) GLI C2H2-type zinc-finger protein family P52747
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Transcription factor Sp3 (SP3) Sp1 C2H2-type zinc-finger protein family Q02447
Myb-related protein B (MYBL2) . P10244
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoblastoma-like protein 2 (RBL2) Retinoblastoma protein (RB) family Q08999
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402