Details of the Target

General Information of Target

Target ID LDTP07010
Target Name Tight junction-associated protein 1 (TJAP1)
Gene Name TJAP1
Gene ID 93643
Synonyms
PILT; TJP4; Tight junction-associated protein 1; Protein incorporated later into tight junctions; Tight junction protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT
RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA
SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK
CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE
SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS
PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL
SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD
RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP
REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL
HRKDSLTQAQEQGNLLN
Target Bioclass
Other
Subcellular location
Golgi apparatus, trans-Golgi network
Function Plays a role in regulating the structure of the Golgi apparatus.
Uniprot ID
Q5JTD0
Ensemble ID
ENST00000259751.5
HGNC ID
HGNC:17949

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A4T DBIA    Probe Info 
HT SNV: p.A4P .
NCIH358 SNV: p.K94T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K160(0.71); K183(4.90); K204(8.11); K94(10.00)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C76(5.41)  LDD0170  [3]
IA-alkyne
 Probe Info  		C350(5.24)  LDD1703  [4]
DBIA
 Probe Info  		C350(1.12); C196(1.04)  LDD0078  [5]
NAIA_4
 Probe Info  		C76(0.00); C196(0.00); C350(0.00)  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
W1
 Probe Info  		C172(0.00); C350(0.00)  LDD0236  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C172(0.00); C181(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C76(5.41)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C76(4.51)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C196(0.96)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C350(1.34); C172(1.00); C196(0.97); C76(0.83)  LDD1508  [13]
 LDCM0216  AC100 HEK-293T C196(1.73)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C196(1.25)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C196(1.41)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C196(1.58)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C196(1.41)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C196(0.87)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C196(0.86)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C196(1.41)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C196(0.99)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C196(1.13)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C350(1.03); C172(1.03); C196(1.07)  LDD1509  [13]
 LDCM0227  AC110 HEK-293T C196(2.64)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C196(3.99)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C196(2.68)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C196(1.00)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C196(1.04)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C196(1.02)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C196(0.90)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C196(0.84)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C196(0.95)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C196(1.16)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C350(1.15); C172(1.02); C196(0.99); C76(1.03)  LDD1510  [13]
 LDCM0238  AC120 HCT 116 C196(0.90)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C196(1.00)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C196(0.96)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C196(0.80)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C196(0.97)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C196(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C196(0.87)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C196(0.98)  LDD0562  [5]
 LDCM0259  AC14 HEK-293T C350(1.06); C172(0.98); C196(1.02); C76(1.07)  LDD1512  [13]
 LDCM0263  AC143 HCT 116 C196(1.32)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C196(1.03)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C196(1.01)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C196(1.24)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C196(0.93)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C196(1.56)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C196(1.45)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C350(1.13); C172(1.03); C196(0.94); C76(1.01)  LDD1513  [13]
 LDCM0271  AC150 HCT 116 C196(1.18)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C196(1.11)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C196(1.14)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C196(1.36)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C196(1.11)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C196(1.15)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C196(1.19)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C196(1.08)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C196(0.93)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C196(0.78)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C196(0.82)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C196(1.01)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C196(1.07)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C196(0.82)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C196(0.85)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C196(0.82)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C196(1.13)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C196(1.19)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C196(1.28)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C196(1.37)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C196(1.03)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C196(1.38)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C196(0.98)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C196(1.26)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C196(1.01)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C196(1.28)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C196(1.22)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C196(1.13)  LDD0893  [5]
 LDCM0296  AC35 PaTu 8988t C196(1.36)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C196(1.50)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C196(1.38)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C196(1.32)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C196(1.63)  LDD1179  [5]
 LDCM0301  AC4 HCT 116 C196(1.20)  LDD0618  [5]
 LDCM0302  AC40 PaTu 8988t C196(1.64)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C196(1.10)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C196(1.11)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C196(1.28)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C196(1.42)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C196(1.19)  LDD1186  [5]
 LDCM0308  AC46 HEK-293T C350(1.03); C172(0.98); C196(0.95); C76(1.35)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C350(1.16); C172(0.98); C196(0.96); C76(0.89)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C350(1.02); C172(0.99); C196(1.00)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C350(1.07); C172(0.97); C196(1.04)  LDD1550  [13]
 LDCM0312  AC5 HCT 116 C196(1.12)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C350(1.11); C172(1.00); C196(0.99); C76(0.96)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C350(1.05); C172(0.97); C196(1.05)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C350(1.12); C172(1.00); C196(0.99); C76(1.14)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C350(0.99); C172(0.93); C196(1.03)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C350(1.12); C172(0.94); C196(1.00); C76(1.07)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C350(1.12); C172(1.02); C196(0.95); C76(0.92)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C350(1.03); C172(0.95); C196(1.04)  LDD1558  [13]
 LDCM0320  AC57 PaTu 8988t C196(1.24)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C196(1.15)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C196(1.18)  LDD1201  [5]
 LDCM0323  AC6 HEK-293T C350(1.07); C172(0.98); C196(0.97); C76(1.49)  LDD1562  [13]
 LDCM0324  AC60 PaTu 8988t C196(1.31)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C196(1.04)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C196(1.08)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C196(1.12)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C196(1.09)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C196(0.97)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C196(1.09)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C196(1.05)  LDD1210  [5]
 LDCM0332  AC68 PaTu 8988t C172(0.95); C196(0.95)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C172(1.09); C196(1.10)  LDD1212  [5]
 LDCM0334  AC7 HEK-293T C350(1.12); C172(1.00); C196(0.92); C76(1.04)  LDD1568  [13]
 LDCM0335  AC70 PaTu 8988t C172(1.08); C196(0.98)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C172(1.01); C196(0.92)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C172(1.05); C196(0.87)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C172(1.00); C196(0.82)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C172(1.02); C196(0.94)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C172(1.02); C196(1.08)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C172(0.97); C196(0.96)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C172(1.00); C196(0.88)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C172(1.06); C196(0.90)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C172(0.97); C196(1.08)  LDD1223  [5]
 LDCM0345  AC8 HEK-293T C350(1.08); C172(1.04); C196(1.05)  LDD1569  [13]
 LDCM0346  AC80 PaTu 8988t C172(1.06); C196(1.00)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C172(1.03); C196(0.99)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C172(1.20); C196(0.99)  LDD1227  [5]
 LDCM0349  AC83 PaTu 8988t C196(0.91)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C196(0.89)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C196(0.94)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C196(0.96)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C196(0.89)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C196(0.91)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C196(0.89)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C196(0.86)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C196(0.84)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C196(0.94)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C196(0.74)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C196(0.80)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C196(0.95)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C196(0.77)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C196(0.81)  LDD1243  [5]
 LDCM0365  AC98 HEK-293T C196(1.17)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C196(1.15)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C350(0.94); C172(1.00); C196(0.98)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C350(1.02); C172(0.99); C196(1.02)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C350(1.08); C172(0.99); C196(1.00)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 12.12  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C350(1.12); C196(1.04)  LDD0078  [5]
 LDCM0630  CCW28-3 231MFP C350(1.27)  LDD2214  [14]
 LDCM0632  CL-Sc Hep-G2 C196(1.21)  LDD2227  [6]
 LDCM0367  CL1 PaTu 8988t C196(0.89)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C196(1.59)  LDD1247  [5]
 LDCM0369  CL100 HCT 116 C196(1.00)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C350(1.11); C172(1.00); C196(0.98)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C350(1.09); C172(1.08); C196(0.90)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C350(1.08); C172(0.93); C196(0.95)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C350(1.14); C172(1.01); C196(0.99)  LDD1577  [13]
 LDCM0374  CL105 HCT 116 C196(0.71)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C196(0.63)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C196(0.67)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C196(0.81)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C196(0.83)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C196(0.96)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C196(0.78)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C196(0.86)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C196(1.46)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C196(1.12)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C196(2.23)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C196(1.47)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C196(1.71)  LDD0984  [5]
 LDCM0387  CL117 PaTu 8988t C196(1.07)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C196(1.01)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C196(1.36)  LDD1268  [5]
 LDCM0390  CL12 PaTu 8988t C196(1.03)  LDD1269  [5]
 LDCM0391  CL120 PaTu 8988t C196(1.40)  LDD1270  [5]
 LDCM0392  CL121 HEK-293T C350(1.20); C172(0.98); C196(0.93)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C350(1.14); C172(0.99); C196(1.06)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C350(1.20); C172(1.65); C196(0.90)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C350(1.21); C172(1.05); C196(1.04)  LDD1599  [13]
 LDCM0396  CL125 PaTu 8988t C196(1.06)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C196(1.01)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C196(1.06)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C196(1.18)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C196(1.92)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C196(2.52)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C196(1.23)  LDD1281  [5]
 LDCM0403  CL16 HEK-293T C350(1.15); C172(0.94); C196(1.05)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C350(1.08); C172(1.17); C196(1.16)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C350(1.08); C172(1.09); C196(1.07); C76(0.96)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C350(1.16); C172(1.24); C196(1.08)  LDD1610  [13]
 LDCM0407  CL2 PaTu 8988t C196(0.98)  LDD1286  [5]
 LDCM0408  CL20 HEK-293T C350(0.98); C172(1.16); C196(1.02); C76(1.30)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C350(0.83); C172(1.45); C196(1.11)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C350(0.88); C172(1.13); C196(1.03); C76(1.03)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C350(0.99); C172(1.33); C196(1.08); C76(1.29)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C350(0.99); C172(1.26); C196(1.01)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C350(1.06); C172(1.09); C196(0.96)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C350(0.97); C172(0.99); C196(0.97)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C350(0.98); C172(1.02); C196(0.90)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C350(1.10); C172(1.05); C196(1.09)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C350(0.99); C172(1.00); C196(0.99)  LDD1621  [13]
 LDCM0418  CL3 PaTu 8988t C196(1.40)  LDD1297  [5]
 LDCM0419  CL30 HEK-293T C350(0.96); C172(1.11); C196(0.98); C76(1.22)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C350(1.22); C172(1.12); C196(1.12)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C350(1.07); C172(1.05); C196(0.94); C76(1.26)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C350(0.97); C172(1.58); C196(0.99)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C350(0.82); C172(1.44); C196(0.97); C76(0.99)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C350(0.95); C172(1.26); C196(0.95); C76(1.12)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C350(0.95); C172(1.25); C196(1.00)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C350(1.15); C172(0.97); C196(0.90)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C350(1.15); C172(0.97); C196(0.93)  LDD1632  [13]
 LDCM0429  CL4 PaTu 8988t C196(1.15)  LDD1308  [5]
 LDCM0430  CL40 HEK-293T C350(1.00); C172(0.99); C196(1.10)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C350(0.99); C172(1.09); C196(0.95)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C350(0.99); C172(1.08); C196(1.08); C76(0.92)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C350(0.83); C172(1.14); C196(0.89)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C350(1.04); C172(1.08); C196(1.00); C76(1.28)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C350(1.31); C172(1.26); C196(1.15)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C196(1.16)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C196(1.11)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C196(0.87)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C196(1.06)  LDD1037  [5]
 LDCM0440  CL5 PaTu 8988t C196(1.85)  LDD1319  [5]
 LDCM0441  CL50 HEK-293T C196(1.28)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C196(0.99)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C196(0.72)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C196(1.10)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C196(0.95)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C196(1.11)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C196(1.27)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C196(1.55)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C196(1.50)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C196(1.48)  LDD1048  [5]
 LDCM0451  CL6 PaTu 8988t C196(1.29)  LDD1330  [5]
 LDCM0452  CL60 HEK-293T C196(1.69)  LDD1050  [5]
 LDCM0453  CL61 PaTu 8988t C172(1.07)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C172(0.91)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C172(0.97)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C172(0.94)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C172(0.94)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C172(1.05)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C172(1.10)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C172(1.24)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C172(1.11)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C196(1.63)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C172(1.09)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C172(0.93)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C172(0.92)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C172(1.13)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C172(1.08)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C196(1.00)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C196(1.12)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C196(1.31)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C196(1.05)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C196(1.47)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C196(1.32)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C196(1.44)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C196(1.05)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C196(1.16)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C196(1.87)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C196(1.07)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C196(1.25)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C196(1.76)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C196(1.54)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C196(1.73)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C196(1.53)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C196(1.60)  LDD1364  [5]
 LDCM0486  CL91 HCT 116 C196(1.17)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C196(1.08)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C196(1.17)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C196(1.44)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C196(1.28)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C196(1.12)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C196(0.94)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C196(1.07)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C196(1.09)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C350(1.14); C172(0.89); C196(0.92)  LDD1698  [13]
 LDCM0625  F8 Ramos C350(2.66)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C350(1.11)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C350(20.00)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C350(0.92)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C350(0.72)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C350(0.87)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C350(0.78)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C350(1.03)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C350(1.73)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C350(1.18)  LDD2197  [15]
 LDCM0588  Fragment30 Ramos C350(1.10)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C350(1.02)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C350(1.41)  LDD2201  [15]
 LDCM0468  Fragment33 PaTu 8988t C172(1.01)  LDD1347  [5]
 LDCM0596  Fragment38 Ramos C350(1.08)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C350(0.78)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C350(1.21); C172(0.93); C196(0.92)  LDD1631  [13]
 LDCM0614  Fragment56 Ramos C350(1.23)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C350(0.86)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C350(0.88)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C350(0.76); C172(0.89); C196(0.94)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C350(1.14); C172(0.87); C196(1.00)  LDD1497  [13]
 LDCM0024  KB05 UACC257 C350(2.13)  LDD3325  [16]
 LDCM0628  OTUB2-COV-1 HEK-293T C350(2.04)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.