Details of the Target

General Information of Target

Target ID LDTP06864
Target Name GRIP1-associated protein 1 (GRIPAP1)
Gene Name GRIPAP1
Gene ID 56850
Synonyms
KIAA1167; GRIP1-associated protein 1; GRASP-1) [Cleaved into: GRASP-1 C-terminal chain; 30kDa C-terminus form)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS
KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG
AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGLA
PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE
SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ
GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR
EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ
EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK
KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQ
QEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ
RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ
TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQ
EKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDL
VKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGPPDPDLEPGET
S
Target Bioclass
Other
Subcellular location
Early endosome membrane
Function
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity.; [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
Uniprot ID
Q4V328
Ensemble ID
ENST00000376423.8
HGNC ID
HGNC:18706

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K615R DBIA    Probe Info 
HEC1 SNV: p.A129D .
HEC1B SNV: p.A129D .
NCIH1155 SNV: p.A146T .
NCIH23 SNV: p.A4G .
SKMEL28 SNV: p.P181S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K238(9.92); K249(6.46); K352(1.49); K460(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y47(22.57); Y377(17.47)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C744(2.77)  LDD0169  [4]
HHS-475
 Probe Info  		Y753(0.75); Y25(2.95)  LDD0264  [5]
DBIA
 Probe Info  		C744(1.22)  LDD0078  [6]
IA-alkyne
 Probe Info  		C744(0.00); C243(0.00); C104(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
BTD
 Probe Info  		N.A.  LDD0004  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		N.A.  LDD0005  [8]
NHS
 Probe Info  		N.A.  LDD0010  [8]
W1
 Probe Info  		N.A.  LDD0236  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C243(0.95)  LDD2103  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C744(2.77)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C243(0.32)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C243(0.84); C744(0.93)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C243(1.14); C744(0.88)  LDD0543  [6]
 LDCM0230  AC113 HCT 116 C744(1.00)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C744(0.96)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C744(1.37)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C744(1.63)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C744(1.41)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C744(1.20)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C744(1.15)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C243(0.89); C744(0.82)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C744(1.11)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C744(0.97)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C744(0.89)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C744(1.18)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C744(1.06)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C744(1.12)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C744(1.58)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C744(1.45)  LDD0562  [6]
 LDCM0259  AC14 HCT 116 C243(0.99); C744(0.91)  LDD0576  [6]
 LDCM0263  AC143 HCT 116 C744(1.87)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C744(2.04)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C744(1.32)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C744(1.74)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C744(1.87)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C744(2.50)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C744(3.18)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C243(0.78); C744(0.94)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C744(1.78)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C744(1.34)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C744(1.65)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C744(3.54)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C744(2.40)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C744(1.94)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C744(2.25)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C744(2.12)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C243(1.00)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C243(0.85)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C243(1.36)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C243(0.31)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C243(1.63)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C243(1.38)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C243(0.73)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C243(0.59)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C243(0.86)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C243(1.39)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C243(1.27)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C243(1.48)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C243(1.65)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C243(1.22)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C243(0.29)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C243(1.59)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C243(1.46)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C243(1.72)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C243(1.69)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C243(1.86)  LDD0612  [6]
 LDCM0296  AC35 PaTu 8988t C744(1.42)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C744(1.49)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C744(1.33)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C744(1.43)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C744(1.87)  LDD1179  [6]
 LDCM0301  AC4 HCT 116 C243(0.26)  LDD0618  [6]
 LDCM0302  AC40 PaTu 8988t C744(2.32)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C744(2.04)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C744(1.44)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C744(1.55)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C744(2.38)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C744(1.61)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C744(1.29)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C744(1.15)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C744(1.16)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C744(1.33)  LDD1190  [6]
 LDCM0312  AC5 HCT 116 C243(0.27)  LDD0629  [6]
 LDCM0313  AC50 PaTu 8988t C744(1.67)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C744(0.72)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C744(1.36)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C744(1.76)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C744(2.51)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C744(0.80)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C744(2.06)  LDD1198  [6]
 LDCM0320  AC57 HCT 116 C243(1.88)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C243(2.60)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C243(2.27)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C243(0.97); C744(1.00)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C243(1.60)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C243(1.58)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C243(2.42)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C243(1.55)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C243(2.03)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C243(1.29)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C243(1.23)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C243(1.73)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C744(0.89); C243(1.09)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C744(0.82); C243(0.90)  LDD0662  [6]
 LDCM0349  AC83 HCT 116 C744(2.12)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C744(1.82)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C744(1.59)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C744(1.75)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C744(1.51)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C744(1.47)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C744(1.35)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C744(1.02)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C744(2.75)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C744(1.79)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C744(1.72)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C744(1.46)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C744(1.65)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C744(2.22)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C744(2.11)  LDD0681  [6]
 LDCM0248  AKOS034007472 HCT 116 C243(0.90); C744(0.95)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C744(0.86); C243(1.17)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C243(0.84); C744(0.86)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C744(1.22)  LDD0078  [6]
 LDCM0632  CL-Sc Hep-G2 C744(1.34); C744(1.07); C744(0.83)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C744(0.93); C104(1.04)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C744(0.97); C104(0.91)  LDD1572  [14]
 LDCM0369  CL100 HCT 116 C243(0.34)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C243(0.83); C744(0.93)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C744(0.78); C243(0.89)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C744(0.80); C243(0.88)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C744(0.88); C243(0.93)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C243(1.01)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C243(1.25)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C243(1.25)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C243(3.24)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C243(0.87)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C744(1.33); C104(0.97); C243(0.23)  LDD1583  [14]
 LDCM0380  CL110 HCT 116 C243(1.34)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C243(1.64)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C243(1.32)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C243(1.83)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C243(1.06)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C243(1.88)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C243(1.50)  LDD0703  [6]
 LDCM0387  CL117 PaTu 8988t C744(1.47)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C744(1.30)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C744(1.45)  LDD1268  [6]
 LDCM0390  CL12 HEK-293T C744(1.28); C104(0.90); C243(0.36)  LDD1594  [14]
 LDCM0391  CL120 PaTu 8988t C744(1.18)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C744(0.93)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C744(1.80)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C744(1.17)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C744(1.25)  LDD1274  [6]
 LDCM0396  CL125 HCT 116 C243(1.22)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C243(1.37)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C243(1.42)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C243(1.93)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C744(1.04); C104(1.04)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C744(1.01); C104(1.00); C243(0.97)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C744(0.97); C104(0.95); C243(0.78)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C744(1.00); C104(1.11); C243(0.82)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C744(1.03); C104(0.78); C243(0.78)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C744(0.97); C104(1.06); C243(0.70)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C744(1.25); C104(1.12); C243(0.82)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C744(1.04); C104(1.00); C243(0.92)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C744(1.29); C104(0.95)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C744(0.96); C104(0.89); C243(0.81)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C744(1.14); C104(0.95)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C744(1.32); C104(1.04); C243(0.20)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C744(1.03); C104(1.01); C243(0.33)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C744(0.88); C104(1.00)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C744(1.00); C104(1.05); C243(1.00)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C744(1.00); C104(0.93); C243(0.81)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C744(0.95); C104(1.08); C243(0.83)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C744(1.07); C104(0.99); C243(1.00)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C744(1.04); C104(0.91); C243(0.93)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C744(0.98); C104(1.03); C243(0.71)  LDD1623  [14]
 LDCM0420  CL31 PaTu 8988t C744(0.87)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C744(1.17)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C744(0.81)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C744(0.91)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C744(0.93)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C744(0.75)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C744(1.17)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C744(0.95)  LDD1307  [6]
 LDCM0429  CL4 HEK-293T C744(1.10); C104(1.02); C243(0.97)  LDD1633  [14]
 LDCM0430  CL40 PaTu 8988t C744(0.97)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C744(0.98)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C744(1.29)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C744(1.20)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C744(1.24)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C744(1.27)  LDD1314  [6]
 LDCM0436  CL46 HCT 116 C744(0.85)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C744(0.87)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C744(0.87)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C744(0.88)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C744(1.04); C104(0.92); C243(0.71)  LDD1644  [14]
 LDCM0441  CL50 HCT 116 C744(0.90)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C744(0.86)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C744(0.93)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C744(0.84)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C744(0.75)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C744(0.85)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C744(0.74)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C744(1.02)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C744(0.72)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C744(0.73)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C744(0.99); C104(1.04); C243(0.81)  LDD1654  [14]
 LDCM0452  CL60 HCT 116 C744(1.00)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C243(1.03)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C243(0.66)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C243(0.80)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C243(0.86)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C243(0.65)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C243(0.54)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C243(0.52)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C243(0.61)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C243(0.48)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C744(1.20); C104(1.00); C243(0.87)  LDD1665  [14]
 LDCM0463  CL70 HCT 116 C243(0.55)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C243(0.58)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C243(0.62)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C243(0.56)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C243(0.53)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C744(0.93); C104(1.09); C243(0.87)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C744(1.09); C104(0.89); C243(1.07)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C744(0.94); C104(1.11); C243(0.94)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C744(1.16); C104(1.02); C243(0.73)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C744(0.81); C104(0.87)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C744(1.09); C104(1.08)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C744(0.95); C104(0.99); C243(0.86)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C744(1.06); C104(0.96)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C744(1.09); C104(1.01); C243(0.28)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C744(1.12); C104(0.90); C243(0.43)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C744(0.89); C104(1.06)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C744(1.00); C104(1.08); C243(1.13)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C744(1.01); C104(0.49); C243(0.88)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C744(0.97); C104(1.14); C243(0.89)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C744(0.97); C104(0.91); C243(1.07)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C744(1.05); C104(0.90); C243(0.84)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C744(0.81); C104(0.82); C243(1.29)  LDD1688  [14]
 LDCM0486  CL91 HCT 116 C243(0.80)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C243(0.90)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C243(0.50)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C243(0.57)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C243(0.39)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C243(0.38)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C243(0.32)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C243(0.38)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C243(0.35)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C744(0.93); C104(0.95); C243(0.79)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C243(0.47)  LDD0785  [6]
 LDCM0427  Fragment51 PaTu 8988t C744(1.29)  LDD1306  [6]
 LDCM0116  HHS-0101 DM93 Y753(0.75); Y25(2.95)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y753(0.79); Y25(2.32)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y753(0.72); Y25(0.76)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y753(1.03); Y25(4.55)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y753(1.21); Y25(3.78)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C243(1.67)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C243(0.94)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C243(1.18)  LDD0082  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C243(1.24)  LDD2094  [13]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C243(0.92)  LDD2098  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C243(1.05)  LDD2099  [13]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C243(1.78)  LDD2105  [13]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C243(1.58)  LDD2136  [13]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C243(1.75); C581(1.17)  LDD2153  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
NUAK family SNF1-like kinase 2 (NUAK2) CAMK Ser/Thr protein kinase family Q9H093
Dual specificity protein phosphatase 26 (DUSP26) Protein-tyrosine phosphatase family Q9BV47
Ras-related protein Rab-4A (RAB4A) Rab family P20338
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 219 (ZNF219) Krueppel C2H2-type zinc-finger protein family Q9P2Y4
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Teashirt homolog 2 (TSHZ2) Teashirt C2H2-type zinc-finger protein family Q9NRE2
Protein AF-17 (MLLT6) . P55198
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Other
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy protein 5 (ATG5) ATG5 family Q9H1Y0
Bystin (BYSL) Bystin family Q13895
Coiled-coil domain-containing protein 103 (CCDC103) CCDC103/PR46b family Q8IW40
Cilia- and flagella-associated protein 53 (CFAP53) CFAP53 family Q96M91
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cyclin-H (CCNH) Cyclin family P51946
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Inhibitor of growth protein 4 (ING4) ING family Q9UNL4
Inhibitor of growth protein 5 (ING5) ING family Q8WYH8
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
SNW domain-containing protein 1 (SNW1) SNW family Q13573
T-complex protein 10A homolog 1 (TCP10L) TCP10 family Q8TDR4
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Translin-associated protein X (TSNAX) Translin family Q99598
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
Alanine and arginine-rich domain-containing protein (AARD) . Q4LEZ3
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Elongin-A (ELOA) . Q14241
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Phostensin (PPP1R18) . Q6NYC8
Signal-transducing adaptor protein 1 (STAP1) . Q9ULZ2
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402