Details of the Target

General Information of Target

Target ID LDTP06791
Target Name ADP-ribosylation factor-like protein 13B (ARL13B)
Gene Name ARL13B
Gene ID 200894
Synonyms
ARL2L1; ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1; ARL2-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSLMASCCGWFKRWREPVRKVTLLMVGLDNAGKTATAKGIQGEYPEDVAPTVGFSKINL
RQGKFEVTIFDLGGGIRIRGIWKNYYAESYGVIFVVDSSDEERMEETKEAMSEMLRHPRI
SGKPILVLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIK
KGLYWLLHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAEL
DGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIET
QGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVE
PLNIDDCAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRPN
SDAHDVIS
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Arf family
Subcellular location
Cell projection, cilium membrane
Function
Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data.
Uniprot ID
Q3SXY8
Ensemble ID
ENST00000303097.11
HGNC ID
HGNC:25419

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.V67G .
COLO679 SNV: p.R407K .
HCT116 Deletion: p.G182AfsTer16 DBIA    Probe Info 
PANC1 SNV: p.P392T .
RL SNV: p.E47D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.01  LDD0403  [1]
IA-alkyne
 Probe Info  		C287(20.00)  LDD0372  [2]
DBIA
 Probe Info  		C158(0.94); C165(0.94)  LDD0580  [3]
1d-yne
 Probe Info  		N.A.  LDD0358  [4]
IPM
 Probe Info  		C158(0.00); C165(0.00); C146(0.00); C287(0.00)  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C287(20.00)  LDD0372  [2]
 LDCM0214  AC1 HEK-293T C160(0.92); C158(1.26); C165(0.94)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C158(0.94); C165(0.94)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C160(0.95); C165(0.95)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C160(0.92); C165(0.92)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C160(0.93); C165(0.93)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C160(1.01); C165(1.01)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C160(1.00); C165(1.00)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C160(1.01); C165(1.01)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C160(0.90); C165(0.90)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C160(1.00); C165(1.00)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C160(1.07); C165(1.07)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C160(1.03); C165(1.03)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C158(0.88); C165(0.82)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C160(1.07); C165(1.07)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C160(1.10); C165(1.10)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C160(1.04); C165(1.04)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C158(1.44)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C158(1.29)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C158(1.69)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C158(1.59)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C158(1.31)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C158(1.85)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C158(1.82)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C158(0.86); C165(0.82)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C158(1.36)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C158(1.85)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C158(1.65)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C158(2.37)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C158(2.38)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C158(2.33)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C158(1.82)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C158(2.63)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C158(1.09); C165(1.11)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C158(1.06); C165(1.12)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C158(0.98); C165(1.12)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C158(0.96); C165(0.94)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C158(1.02); C165(1.08)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C158(1.05); C165(1.01)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C158(1.01); C165(1.13)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C158(1.04); C165(1.42)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C158(1.05); C165(1.11)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C158(1.11); C165(1.01)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C158(1.16); C165(1.07)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C158(1.14); C165(1.39)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C158(0.84); C165(0.86)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C158(1.12); C165(1.12)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C158(1.14); C165(1.29)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C158(1.27); C165(1.27)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C158(0.94); C165(0.94)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C158(0.76); C165(0.76)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C158(0.84); C165(0.84)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C158(1.28); C165(1.28)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C158(1.23); C165(1.23)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C158(0.89); C165(0.89)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C158(0.67); C165(0.67)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C158(0.83); C165(0.90)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C158(1.08); C165(1.08)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C158(1.13); C165(1.13)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C158(0.99); C165(0.99)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C158(0.59); C165(0.59)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C158(0.84); C165(0.84)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C158(1.38); C165(1.38)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C158(0.94); C165(0.94)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C158(1.11); C165(1.11)  LDD2161  [3]
 LDCM0276  AC17 PaTu 8988t C158(1.26); C165(1.26)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C158(1.39); C165(1.39)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C158(1.30); C165(1.30)  LDD1157  [3]
 LDCM0279  AC2 HEK-293T C160(1.49); C158(1.33); C165(1.34)  LDD0877  [3]
 LDCM0280  AC20 PaTu 8988t C158(1.14); C165(1.14)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C158(1.84); C165(1.84)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C158(1.59); C165(1.59)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C158(1.33); C165(1.33)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C158(1.47); C165(1.47)  LDD1163  [3]
 LDCM0285  AC25 HCT 116 C158(1.23); C165(1.23)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C158(1.11); C165(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C158(1.19); C165(1.19)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C158(1.22); C165(1.22)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C158(1.14); C165(1.14)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C160(0.57); C158(1.19); C165(0.75)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C158(1.06); C165(1.06)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C158(1.24); C165(1.24)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C158(1.31); C165(1.31)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C158(1.18); C165(1.18)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C158(1.40); C165(1.40)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C158(1.04); C165(1.04)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C158(1.09); C165(1.09)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C158(0.97); C165(0.97)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C158(1.01); C165(1.01)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C158(1.06); C165(1.06)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C160(1.23); C158(1.06); C165(1.13)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C158(1.05); C165(1.05)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C158(1.10); C165(1.10)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C158(0.97); C165(0.97)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C158(1.05); C165(1.05)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C158(0.95); C165(0.95)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C158(1.10); C165(1.10)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C160(0.98); C158(0.89); C165(0.91)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C160(0.98); C158(1.00); C165(1.13)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C160(0.91); C158(0.88); C165(0.83)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C160(0.74); C158(0.88); C165(0.97)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C160(0.82); C158(1.26); C165(0.86)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C160(0.97); C158(0.97); C165(0.94)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C160(1.15); C158(0.99); C165(1.12)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C160(0.86); C158(0.92); C165(0.99)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C160(1.15); C158(0.91); C165(0.91)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C160(0.73); C158(0.95); C165(0.99)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C160(0.80); C158(1.06); C165(1.05)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C160(1.05); C158(0.92); C165(0.87)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C158(1.08); C165(1.08)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C158(1.15); C165(1.15)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C158(1.12); C165(1.12)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C158(1.03); C165(0.97)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C158(1.19); C165(1.19)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C158(0.98); C165(0.98)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C158(1.33); C165(1.33)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C158(1.04); C165(1.04)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C158(1.16); C165(1.16)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C158(1.22); C165(1.22)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C158(1.26); C165(1.26)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C158(0.99); C165(0.99)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C158(1.10); C165(1.10)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C158(0.94); C165(0.94)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C158(1.03); C165(0.89)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C158(1.17); C165(1.17)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C158(1.12); C165(1.12)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C158(0.85); C165(0.85)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C158(1.16); C165(1.16)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C158(1.18); C165(1.18)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C158(1.08); C165(1.08)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C158(0.96); C165(0.96)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C158(1.04); C165(1.04)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C158(0.94); C165(0.94)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C158(1.32); C165(1.32)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C158(1.04); C165(0.93)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C158(1.09); C165(1.09)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C158(1.01); C165(1.01)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C158(1.30); C165(1.30)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C158(1.57); C165(1.57)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C158(1.56); C165(1.56)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C158(1.37); C165(1.37)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C158(1.26); C165(1.26)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C158(1.13); C165(1.13)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C158(1.21); C165(1.21)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C158(1.12); C165(1.12)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C158(1.22); C165(1.22)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C158(1.35); C165(1.35)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C158(1.20); C165(1.20)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C158(1.08); C165(1.08)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C158(1.34); C165(1.34)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C158(1.28); C165(1.28)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C158(1.30); C165(1.30)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C158(1.26); C165(1.26)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C160(0.93); C165(0.93)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C160(0.95); C165(0.95)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C158(0.88); C165(0.86)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C158(0.84); C165(0.99)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C158(0.87); C165(0.98)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 14.01  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C165(0.63)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C165(1.20)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C160(1.06); C158(1.13); C165(1.03)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C158(0.90); C165(1.04)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C158(1.00); C165(1.03)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C158(1.04); C165(1.10)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C158(1.05); C165(1.09)  LDD0971  [3]
 LDCM0374  CL105 PaTu 8988t C158(1.14); C165(1.14)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C158(1.46); C165(1.46)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C158(1.20); C165(1.20)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C158(1.29); C165(1.29)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C158(1.35); C165(1.35)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C165(1.37)  LDD0977  [3]
 LDCM0380  CL110 PaTu 8988t C158(1.28); C165(1.28)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C158(1.62); C165(1.62)  LDD1260  [3]
 LDCM0382  CL112 HCT 116 C158(1.20); C165(1.20)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C158(1.24); C165(1.24)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C158(1.17); C165(1.17)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C158(1.38); C165(1.38)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C158(1.37); C165(1.37)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C158(0.93); C165(0.93)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C158(1.25); C165(1.25)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C158(0.84); C165(0.84)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C165(1.16)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C158(0.97); C165(0.97)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C160(0.75); C158(0.90); C165(0.90)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C160(0.81); C158(0.95); C165(0.94)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C160(1.23); C158(1.11); C165(0.84)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C160(0.83); C158(0.91); C165(0.84)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C158(1.14); C165(1.14)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C158(1.20); C165(1.20)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C158(1.07); C165(1.07)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C158(1.04); C165(1.04)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C165(1.26)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C165(0.65)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C165(0.76)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C160(0.95); C165(0.85)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C160(1.09); C165(0.84)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C160(1.23); C165(1.21)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C160(0.86); C165(0.86)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C165(0.68)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C160(1.01); C165(0.88)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C160(1.58); C165(1.21)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C160(1.28); C165(1.02)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C160(1.02); C165(0.90)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C160(1.38); C165(1.11)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C160(1.44); C165(1.19)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C160(0.91); C165(0.94)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C160(1.55); C165(1.10)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C160(0.95); C165(0.86)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C160(0.98); C165(0.95)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C165(0.88)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C160(1.15); C165(1.07)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C160(1.00); C158(0.99); C165(0.89)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C160(1.00); C158(0.98); C165(1.00)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C160(1.27); C158(1.50); C165(1.28)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C160(1.05); C158(1.04); C165(1.10)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C160(1.00); C158(1.02); C165(1.03)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C160(0.90); C158(0.94); C165(1.06)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C160(0.98); C158(0.98); C165(1.14)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C160(0.94); C158(0.92); C165(0.93)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C165(0.98)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C160(0.88); C158(0.96); C165(1.08)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C160(0.98); C158(0.99); C165(1.09)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C160(1.00); C158(0.99); C165(1.11)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C160(0.98); C158(1.02); C165(1.21)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C160(0.98); C158(0.93); C165(0.97)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C160(0.88); C158(0.90); C165(0.95)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C160(1.07); C158(0.91); C165(1.00)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C160(1.05); C158(1.03); C165(1.00)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C160(1.12); C158(1.08); C165(0.97)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C160(1.05); C158(0.99); C165(0.94)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C165(0.77)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C160(1.09); C158(0.96); C165(1.03)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C160(1.15); C158(1.10); C165(1.05)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C160(0.95); C158(0.90); C165(0.81)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C160(1.87); C158(2.07); C165(1.41)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C160(1.15); C158(1.05); C165(0.97)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C160(1.16); C158(1.06); C165(1.06)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C160(1.12); C158(0.92); C165(0.89)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C160(1.06); C158(1.07); C165(0.99)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C160(1.09); C158(1.07); C165(0.98)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C160(1.08); C158(1.06); C165(1.04)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C165(1.04)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C160(1.13); C158(0.98); C165(1.07)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C160(1.35); C158(1.07); C165(1.35)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C160(1.23); C158(1.19); C165(1.23)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C160(1.12); C158(0.91); C165(1.12)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C160(4.18); C158(2.67); C165(4.18)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C160(1.32); C158(1.16); C165(1.32)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C160(1.46); C158(1.24); C165(1.46)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C160(1.41); C158(1.19); C165(1.41)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C160(1.08); C158(0.98); C165(1.08)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C160(1.12); C158(0.99); C165(1.12)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C165(1.20)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C160(1.28); C158(0.98); C165(1.28)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C160(1.44); C158(1.34); C165(1.44)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C160(1.62); C158(1.29); C165(1.62)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C160(1.85); C158(1.44); C165(1.85)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C160(1.21); C158(1.40); C165(1.21)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C160(1.07); C158(1.02); C165(0.90)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C160(1.76); C158(1.39); C165(1.06)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C160(1.09); C158(1.03); C165(0.92)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C160(1.01); C158(1.07); C165(0.94)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C165(2.00)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C160(0.90); C158(0.90); C165(0.78)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C160(1.17); C158(1.05); C165(0.97)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C160(1.54); C158(1.21); C165(1.11)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C160(1.05); C158(0.98); C165(0.93)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C160(1.03); C158(1.01); C165(0.91)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C160(1.16); C158(1.06); C165(0.95)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C160(1.22); C158(1.17); C165(0.98)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C160(0.84); C158(0.96); C165(0.81)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C160(1.09); C158(1.06); C165(0.92)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C160(0.86); C158(0.90); C165(0.87)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C165(1.22)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C160(2.04); C158(1.81); C165(1.68)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C160(0.92); C158(0.83); C165(0.93)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C160(0.88); C158(0.86); C165(0.84)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C160(0.69); C158(0.93); C165(0.73)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C160(0.96); C158(1.24); C165(0.92)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C160(1.36); C158(2.95); C165(2.30)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C160(0.70); C158(1.01); C165(0.73)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C160(1.03); C158(0.99); C165(0.92)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C160(0.63); C158(1.36); C165(0.72)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C160(0.74); C158(1.03); C165(0.79)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C287(1.03); C146(0.92)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C160(1.46); C158(1.67); C165(1.46)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C160(1.04); C158(0.97); C165(1.05)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C287(0.95); C367(0.99)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C287(0.98); C367(0.93)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C287(0.99); C367(1.02)  LDD1502  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 25 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) ATP-dependent AMP-binding enzyme family Q96CM8
N-acetyltransferase 8 (NAT8) Camello family Q9UHE5
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) Chondroitin N-acetylgalactosaminyltransferase family Q8N6G5
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) Isoprenylcysteine carboxyl methyltransferase family O60725
Amine oxidase [copper-containing] 3 (AOC3) Copper/topaquinone oxidase family Q16853
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4GALNT2) Glycosyltransferase 2 family Q8NHY0
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) Glycosyltransferase 58 family Q92685
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Phospholipid phosphatase 4 (PLPP4) PA-phosphatase related phosphoesterase family Q5VZY2
Phospholipid phosphatase-related protein type 2 (PLPPR2) PA-phosphatase related phosphoesterase family Q96GM1
Squalene synthase (FDFT1) Phytoene/squalene synthase family P37268
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transmembrane reductase CYB561D2 (CYB561D2) . O14569
Transporter and channel
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Monocyte to macrophage differentiation factor (MMD) ADIPOR family Q15546
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Claudin-4 (CLDN4) Claudin family O14493
Claudin-8 (CLDN8) Claudin family P56748
Gap junction beta-2 protein (GJB2) Connexin family P29033
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Inward rectifier potassium channel 2 (KCNJ2) Inward rectifier-type potassium channel family P63252
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) Sugar transporter (TC 2.A.1.1) family P22732
Aquaporin-10 (AQP10) MIP/aquaporin (TC 1.A.8) family Q96PS8
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
CMP-sialic acid transporter (SLC35A1) Nucleotide-sugar transporter family P78382
Solute carrier family 35 member B1 (SLC35B1) Nucleotide-sugar transporter family P78383
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Cardiac phospholamban (PLN) Phospholamban family P26678
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Na(+)/dicarboxylate cotransporter 3 (SLC13A3) SLC13A/DASS transporter family Q8WWT9
Vesicle-associated membrane protein 2 (VAMP2) Synaptobrevin family P63027
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-1A (STX1A) Syntaxin family Q16623
CD151 antigen (CD151) Tetraspanin (TM4SF) family P48509
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane 6 superfamily member 2 (TM6SF2) TM6SF family Q9BZW4
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Transmembrane protein 218 (TMEM218) TMEM218 family A2RU14
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) . Q9NWW5
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Transmembrane protein 187 (TMEM187) . Q14656
Transmembrane protein 65 (TMEM65) . Q6PI78
Transmembrane protein 79 (TMEM79) . Q9BSE2
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Cytokine and receptor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) Chemokine-like factor family Q96FZ5
C-C motif chemokine 4 (CCL4) Intercrine beta (chemokine CC) family P13236
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) . O14798
Other
Click To Hide/Show 44 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycodelin (PAEP) Lipocalin family P09466
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
MAL-like protein (MALL) MAL family Q13021
Myeloid-associated differentiation marker-like protein 2 (MYADML2) MAL family A6NDP7
Protein MAL2 (MAL2) MAL family Q969L2
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Nurim (NRM) Nurim family Q8IXM6
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
ORM1-like protein 3 (ORMDL3) ORM family Q8N138
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Protein NKG7 (NKG7) PMP-22/EMP/MP20 family Q16617
Protein S100-A2 (S100A2) S-100 family P29034
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Syntaxin-7 (STX7) Syntaxin family O15400
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Transmembrane protein 121 (TMEM121) TMEM121 family Q9BTD3
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Transmembrane protein 43 (TMEM43) TMEM43 family Q9BTV4
Transmembrane protein 54 (TMEM54) TMEM54 family Q969K7
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
C-type lectin domain family 4 member G (CLEC4G) . Q6UXB4
CD302 antigen (CD302) . Q8IX05
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6
Complement factor H-related protein 5 (CFHR5) . Q9BXR6
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) . Q96E93
Leukosialin (SPN) . P16150
Motile sperm domain-containing protein 3 (MOSPD3) . O75425
Mucin-like protein 1 (MUCL1) . Q96DR8
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Testis-expressed protein 264 (TEX264) . Q9Y6I9
Thrombospondin type-1 domain-containing protein 7A (THSD7A) . Q9UPZ6
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4
Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2) . Q71RG4
Transmembrane protein 190 (TMEM190) . Q8WZ59
Transmembrane protein 254 (TMEM254) . Q8TBM7
WAP four-disulfide core domain protein 2 (WFDC2) . Q14508

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402