Details of the Target

General Information of Target

Target ID LDTP06443
Target Name Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)
Gene Name PTPN14
Gene ID 5784
Synonyms
PEZ; PTPD2; Tyrosine-protein phosphatase non-receptor type 14; EC 3.1.3.48; Protein-tyrosine phosphatase pez
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETH
YFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYL
QVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLE
ELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIF
VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHK
FYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFH
GNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI
MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQP
EDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTP
ELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTR
KVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKS
LHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPES
VPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARV
LRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSI
IEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTL
KKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNT
GYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSH
RYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDH
GCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC
LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class subfamily
Subcellular location
Cytoplasm
Function
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
TTD ID
T82848
Uniprot ID
Q15678
DrugMap ID
TTNIR6C
Ensemble ID
ENST00000366956.10
HGNC ID
HGNC:9647
ChEMBL ID
CHEMBL3317332

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1029(5.26); K639(8.31)  LDD0277  [1]
BTD
 Probe Info  		C133(0.79); C20(1.17)  LDD2099  [2]
IPM
 Probe Info  		C20(1.76)  LDD1701  [2]
DBIA
 Probe Info  		C133(1.20)  LDD0532  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C133(0.87)  LDD2117  [2]
 LDCM0215  AC10 HCT 116 C133(1.20)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C133(0.95)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C133(0.91)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C133(0.95)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C133(1.16)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C133(0.89)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C133(0.95)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C133(1.00)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C133(1.05)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C133(1.36)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C133(1.22)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C133(1.52)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C133(1.05)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C133(1.14)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C133(1.17)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C1050(1.46)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C1050(0.95)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C1050(1.58)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C1050(1.26)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C1050(1.41)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C1050(0.99)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C1050(1.57)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C133(1.02)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C1050(1.06)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C1050(1.08)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C1050(1.05)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C1050(1.23)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C1050(1.18)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C1050(0.90)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C1050(1.29)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C1050(1.84)  LDD1124  [3]
 LDCM0259  AC14 HCT 116 C133(1.20)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C133(1.13)  LDD0587  [3]
 LDCM0285  AC25 HCT 116 C133(0.72)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C133(0.67)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C133(0.82)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C133(0.78)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C133(0.70)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C133(0.82)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C133(0.90)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C133(0.95)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C133(0.92)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C133(0.86)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C133(0.90)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C133(0.83)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C133(1.13)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C133(0.78)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C133(0.78)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C133(0.77)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C133(0.88)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C133(0.85)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C133(0.66)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C133(1.00)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C133(1.00)  LDD0624  [3]
 LDCM0323  AC6 HCT 116 C133(0.93)  LDD0640  [3]
 LDCM0334  AC7 HCT 116 C133(0.81)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C133(0.89)  LDD0662  [3]
 LDCM0365  AC98 HCT 116 C133(1.14)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C133(1.16)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C133(1.19)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C133(1.19)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C133(0.85)  LDD0592  [3]
 LDCM0367  CL1 PaTu 8988t C1050(0.71)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C1050(0.68)  LDD1247  [3]
 LDCM0370  CL101 HCT 116 C133(1.06)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C133(1.10)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C133(1.08)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C133(1.09)  LDD0690  [3]
 LDCM0375  CL106 HEK-293T C1082(1.17)  LDD1579  [4]
 LDCM0379  CL11 PaTu 8988t C1050(0.68)  LDD1258  [3]
 LDCM0380  CL110 HEK-293T C1082(0.58)  LDD1584  [4]
 LDCM0382  CL112 HCT 116 C133(0.89)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C133(0.82)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C133(0.71)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C133(0.77)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C133(0.77)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C133(0.79)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C133(0.85)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C133(0.92)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C1050(0.79)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C133(0.95)  LDD0708  [3]
 LDCM0393  CL122 HEK-293T C1082(1.26)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C1082(1.07)  LDD1601  [4]
 LDCM0400  CL13 PaTu 8988t C1050(0.71)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C1050(0.65)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C1050(0.68)  LDD1281  [3]
 LDCM0403  CL16 PaTu 8988t C1050(1.81)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C1050(1.81)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C1050(1.69)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C1050(1.87)  LDD1285  [3]
 LDCM0407  CL2 PaTu 8988t C1050(0.71)  LDD1286  [3]
 LDCM0408  CL20 PaTu 8988t C1050(2.01)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C1050(1.67)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C1050(1.90)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C1050(1.83)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C1050(1.99)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C1050(1.61)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C1050(1.81)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C1050(1.66)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C1050(1.84)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C1050(1.97)  LDD1296  [3]
 LDCM0418  CL3 PaTu 8988t C1050(0.66)  LDD1297  [3]
 LDCM0419  CL30 PaTu 8988t C1050(1.62)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C133(0.76)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C133(1.23)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C133(1.13)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C133(1.05)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C133(0.92)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C133(0.94)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C133(1.01)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C133(1.17)  LDD0745  [3]
 LDCM0429  CL4 PaTu 8988t C1050(0.72)  LDD1308  [3]
 LDCM0430  CL40 HCT 116 C133(0.88)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C133(0.90)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C133(1.05)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C133(0.90)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C133(1.02)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C133(0.65)  LDD0752  [3]
 LDCM0440  CL5 PaTu 8988t C1050(0.70)  LDD1319  [3]
 LDCM0441  CL50 HEK-293T C1082(1.22)  LDD1645  [4]
 LDCM0451  CL6 PaTu 8988t C1050(0.71)  LDD1330  [3]
 LDCM0453  CL61 HCT 116 C133(1.14)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C133(0.92)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C133(0.94)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C133(1.11)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C133(1.00)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C133(0.96)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C133(0.93)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C133(0.65)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C133(0.90)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C1050(0.72)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C133(0.86)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C133(0.76)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C133(0.96)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C133(0.93)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C133(0.79)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C133(1.04)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C133(0.65)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C133(0.83)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C133(0.97)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C1050(0.65)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C133(1.12)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C133(0.93)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C133(0.71)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C133(0.74)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C133(0.91)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C133(0.86)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C133(0.86)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C133(0.78)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C133(0.84)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C133(0.74)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C1050(0.70)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C133(0.58)  LDD0802  [3]
 LDCM0493  CL98 HEK-293T C1082(0.95)  LDD1696  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C20(1.18)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C133(1.08)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C133(0.74)  LDD0744  [3]
 LDCM0022  KB02 42-MG-BA C133(1.96)  LDD2244  [5]
 LDCM0023  KB03 MDA-MB-231 C20(1.76)  LDD1701  [2]
 LDCM0024  KB05 G361 C133(3.04)  LDD3311  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C133(0.79); C20(1.17)  LDD2099  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C133(1.62)  LDD2105  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C133(1.02); C20(1.04)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C133(0.50)  LDD2109  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C133(1.08)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C133(0.68)  LDD2120  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C133(0.73)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C133(0.63)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C133(1.10); C20(0.88)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C133(0.86)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C133(1.43)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C133(0.95)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C20(1.04)  LDD2137  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C133(0.56)  LDD2143  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C133(0.56)  LDD2146  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C133(2.18)  LDD2147  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840