Details of the Target

General Information of Target

Target ID LDTP06164
Target Name Inositol polyphosphate-5-phosphatase A (INPP5A)
Gene Name INPP5A
Gene ID 3632
Synonyms
5PTASE; Inositol polyphosphate-5-phosphatase A; EC 3.1.3.56; 43 kDa inositol polyphosphate 5-phosphatase; Type I inositol 1,4,5-trisphosphate 5-phosphatase; 5PTase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN
YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF
DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL
VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK
SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT
ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL
VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
Target Bioclass
Enzyme
Family
Inositol 1,4,5-trisphosphate 5-phosphatase type I family
Subcellular location
Cell membrane
Function
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells.
Uniprot ID
Q14642
Ensemble ID
ENST00000368594.8
HGNC ID
HGNC:6076
ChEMBL ID
CHEMBL4243

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C159(0.96)  LDD0531  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C159(0.96)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C159(1.20)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C159(0.85)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C159(0.99)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C159(0.92)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C159(0.92)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C159(0.82)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C159(0.83)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C159(0.76)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C159(0.83)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C159(0.83)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C159(0.83)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C159(1.30)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C159(1.04)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C159(0.91)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C159(0.85)  LDD0546  [1]
 LDCM0237  AC12 HCT 116 C159(1.10)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C159(1.30)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C159(1.21)  LDD0587  [1]
 LDCM0276  AC17 HEK-293T C159(1.04); C381(1.08)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C159(1.04); C381(1.19); C172(0.86); C344(1.10)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C159(0.93); C381(0.88)  LDD1517  [4]
 LDCM0279  AC2 HCT 116 C159(1.08)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C159(0.96); C381(1.03); C172(1.14)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C159(0.98); C381(0.93); C172(1.10)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C159(1.05)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C159(1.10)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C159(1.15); C381(1.12)  LDD1523  [4]
 LDCM0285  AC25 HCT 116 C159(1.08)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C159(1.29)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C159(1.27)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C159(1.19)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C159(1.22)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C159(1.25)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C159(1.38)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C159(1.35)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C159(1.48)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C159(1.42)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C159(1.54)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C159(0.79)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C159(0.91)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C159(0.76)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C159(1.65)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C159(1.65)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C159(1.08)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C159(1.86)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C159(1.08)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C159(1.74)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C159(1.08)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C159(1.48)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C159(1.67)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C159(1.22)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C159(1.23)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C159(1.23)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C159(1.33)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C159(1.11)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C159(1.17)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C159(0.92)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C159(0.94)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C159(1.11)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C159(1.11)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C159(1.32)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C159(1.34)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C159(1.05); C381(1.05)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C159(0.99); C381(1.17); C172(0.84); C344(1.08)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C159(0.98); C381(1.05)  LDD1561  [4]
 LDCM0323  AC6 HCT 116 C159(1.26)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C159(1.01); C381(0.97); C172(0.97)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C159(1.14); C381(1.12); C172(0.93)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C159(0.97)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C159(1.10)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C159(1.06); C381(1.07)  LDD1567  [4]
 LDCM0334  AC7 HCT 116 C159(1.11)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C159(1.23)  LDD0662  [1]
 LDCM0365  AC98 HCT 116 C159(1.09)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C159(1.07)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C159(1.13)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C159(1.13)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C159(1.59)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C159(0.97); C381(0.89); C172(0.84)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C159(1.18)  LDD1572  [4]
 LDCM0369  CL100 HCT 116 C159(0.94)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C159(1.36)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C159(1.11)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C159(1.11)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C159(1.08)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C159(0.88); C381(0.86); C172(0.99)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C159(0.97); C381(0.69)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C159(1.05); C381(0.86); C172(0.95)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C159(1.02); C381(1.02); C172(0.75)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C159(1.12); C381(0.88); C172(1.04)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C159(0.81)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C159(0.96); C381(0.88)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C159(0.97); C381(1.00); C172(0.89)  LDD1585  [4]
 LDCM0382  CL112 HCT 116 C159(1.11)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C159(1.29)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C159(1.17)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C159(1.30)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C159(1.10)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C159(1.17)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C159(1.11)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C159(1.69)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C159(0.76); C381(0.87)  LDD1594  [4]
 LDCM0391  CL120 HCT 116 C159(1.80)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C159(0.94)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C159(1.19)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C159(1.28)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C159(1.26)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C159(1.04); C381(0.85); C172(0.89)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C159(1.06); C381(1.01)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C159(1.03); C381(0.95); C172(0.86)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C159(1.03); C381(1.02); C172(0.92)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C159(0.98); C381(0.84); C172(0.92)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C159(1.08); C381(1.05)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C159(1.07); C381(0.89); C172(0.69)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C159(1.08); C381(1.02); C172(0.93)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C159(1.17); C381(1.00)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C159(1.07); C381(1.26); C172(0.83); C344(1.04)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C159(1.02); C381(1.08)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C159(1.05); C381(1.01)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C159(0.95); C381(1.15); C172(1.10)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C159(0.85); C381(0.77); C172(0.68)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C159(1.11)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C159(0.79)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C159(0.70); C381(0.80)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C159(0.91); C381(0.89); C172(1.01)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C159(1.03); C381(1.04)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C159(1.06); C381(1.03); C172(1.02)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C159(1.04); C381(1.04); C172(0.98)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C159(1.14); C381(0.95)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C159(1.03); C381(1.00); C172(1.04)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C159(1.07); C381(1.18); C172(0.93); C344(1.02)  LDD1623  [4]
 LDCM0420  CL31 HCT 116 C159(1.00)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C159(1.13)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C159(1.09)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C159(1.12)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C159(1.12)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C159(1.14)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C159(1.06)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C159(1.15)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C159(1.09); C381(1.05); C172(0.74)  LDD1633  [4]
 LDCM0430  CL40 HCT 116 C159(1.08)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C159(1.01)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C159(1.00)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C159(1.36)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C159(1.20)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C159(1.42)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C159(1.10)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C159(0.79)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C159(0.63); C381(0.80)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C159(0.90); C381(0.95); C172(1.08)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C159(1.09); C381(1.11)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C159(1.07); C381(0.93)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C159(1.17); C381(1.00); C172(1.36)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C159(1.13); C381(0.90)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C159(1.15); C381(1.16); C172(0.68); C344(1.22)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C159(1.01); C381(1.07)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C159(1.06); C381(1.08); C172(2.08)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C159(1.10); C381(0.89); C172(1.35)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C159(1.05)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C159(0.79)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C159(1.00); C381(1.20); C172(0.67); C344(1.04)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C159(0.71); C381(0.73)  LDD1655  [4]
 LDCM0453  CL61 HCT 116 C159(1.16)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C159(1.18)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C159(1.24)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C159(1.24)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C159(1.19)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C159(1.75)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C159(1.39)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C159(1.37)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C159(1.06)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C159(1.08); C381(1.04)  LDD1665  [4]
 LDCM0463  CL70 HCT 116 C159(1.37)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C159(1.36)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C159(1.15)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C159(1.33)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C159(1.26)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C159(1.00); C381(1.00); C172(1.04)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C159(1.02); C381(0.96)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C159(0.98); C381(1.15); C172(0.91); C344(1.09)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C159(0.99); C381(1.04)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C159(1.23); C381(0.85); C172(0.99)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C159(1.00); C381(1.18); C172(1.06)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C159(0.92); C381(0.79); C172(0.78)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C159(1.00)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C159(0.84)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C159(0.86); C381(0.88)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C159(0.87); C381(0.91); C172(1.08)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C159(1.07); C381(1.06)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C159(1.06); C381(1.03); C172(0.90)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C159(1.09); C381(1.03); C172(0.93)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C159(1.10); C381(1.00)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C159(0.84); C381(0.82); C172(0.83)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C159(1.04); C381(1.02); C172(0.66); C344(1.06)  LDD1688  [4]
 LDCM0486  CL91 HCT 116 C159(1.18)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C159(0.86)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C159(0.88)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C159(0.89)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C159(1.03)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C159(1.20)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C159(1.16)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C159(1.09)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C159(1.05)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C159(1.12); C381(1.00); C172(1.19)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C159(1.18)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C159(1.08)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C159(1.13)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C159(1.19)  LDD1497  [4]
 LDCM0024  KB05 MONO-MAC-6 C159(1.59)  LDD3335  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin (PLEK) . P08567

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840