Details of the Target

General Information of Target

Target ID LDTP05656
Target Name EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)
Gene Name EFEMP1
Gene ID 2202
Synonyms
FBLN3; FBNL; EGF-containing fibulin-like extracellular matrix protein 1; Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK
CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA
SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG
THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS
PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT
SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY
PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA
NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS
VLRLTIIVGPFSF
Target Bioclass
Other
Family
Fibulin family
Subcellular location
Secreted, extracellular space
Function
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Uniprot ID
Q12805
Ensemble ID
ENST00000355426.8
HGNC ID
HGNC:3218

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HGC27 Deletion: p.C305FfsTer21 .
HT115 SNV: p.T485A .
IPC298 SNV: p.G474R .
KMCH1 SNV: p.I423M .
LNCaP clone FGC SNV: p.Q211Ter .
MSTO211H SNV: p.R299K .
RL SNV: p.A186S .
T98G SNV: p.E337K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]
DBIA
 Probe Info  		C159(0.99); C184(0.99); C377(0.95); C379(0.95)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C190(0.00); C350(0.00); C365(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C190(0.00); C350(0.00); C365(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Methacrolein
 Probe Info  		C190(0.00); C48(0.00)  LDD0218  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C318(1.21)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C318(1.39)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C386(0.90)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C386(1.22)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C386(1.26)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C386(1.30)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C386(1.39)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C386(1.02)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C386(0.92)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C386(1.05)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C386(0.99)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C386(1.17)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C318(1.82)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C386(1.02)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C386(0.97)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C386(1.00)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C318(0.90); C320(0.27)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C318(1.08); C320(1.00)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C318(1.00); C320(1.16)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C318(0.90); C320(0.68)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C318(1.22); C320(1.02)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C318(1.02); C320(0.94)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C318(1.03); C320(0.87)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C318(1.64)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C318(1.04); C320(0.83)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C318(1.19); C320(1.20)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C318(1.07); C320(0.82)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C318(0.96); C320(0.42)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C318(0.98); C320(0.78)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C318(1.20); C320(0.86)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C318(0.96); C320(0.94)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C318(1.00); C320(0.91)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C386(0.78)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C386(0.83)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C386(0.90)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C386(0.86)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C386(0.79)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C386(0.81)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C386(1.05)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C386(0.85)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C386(0.93)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C386(0.73)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C386(0.88)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C386(0.93)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C318(1.19)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C386(0.99)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C386(0.91)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C386(0.92)  LDD0579  [2]
 LDCM0270  AC15 HCT 116 C318(1.36)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C320(1.00); C318(1.16)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C320(0.86); C318(0.92)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C320(1.02); C318(1.09)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C318(0.97)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C320(0.65); C318(0.72)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C320(0.78); C318(0.84)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C318(0.79); C320(0.79)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C320(0.85); C318(0.99)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C320(1.06); C318(1.20)  LDD0601  [2]
 LDCM0290  AC3 HCT 116 C318(1.47)  LDD0607  [2]
 LDCM0296  AC35 HEK-293T C332(0.75)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C332(0.62)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C332(0.75)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C332(0.73)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C332(0.81)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C318(1.26)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C332(0.67)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C332(0.77)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C332(0.73)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C332(0.77)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C332(0.82)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C332(0.69)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C332(1.27); C379(1.32); C386(1.32)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C332(1.24); C379(1.13); C386(1.13)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C332(1.41); C379(1.19); C386(1.19)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C332(1.24); C379(1.13); C386(1.13)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C318(1.20)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C332(0.83); C379(1.29); C386(1.29)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C332(1.18); C379(1.34); C386(1.34)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C332(1.18); C379(1.27); C386(1.27)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C332(1.12); C379(1.58); C386(1.58)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C332(1.45); C379(1.41); C386(1.41)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C332(1.24); C379(1.22); C386(1.22)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C332(1.57); C379(1.38); C386(1.38)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C332(0.99); C379(0.97); C386(0.97)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C332(1.16); C379(1.25); C386(1.25)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C332(1.26); C379(1.22); C386(1.22)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C318(1.14)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C332(2.17); C379(0.83); C386(0.83)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C332(1.24); C379(1.07); C386(1.07)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C332(1.20); C379(1.17); C386(1.17)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C332(1.27); C379(1.18); C386(1.18)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C332(1.06); C379(1.22); C386(1.22)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C332(0.98); C379(1.08); C386(1.08)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C332(1.06); C379(1.12); C386(1.12)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C332(1.00); C379(1.09); C386(1.09)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C318(1.01); C320(1.01)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C318(1.26); C320(1.26)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C318(1.29)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C318(1.02); C320(1.02)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C318(1.95); C320(1.95)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C318(1.55); C320(1.55)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C318(1.12); C320(1.12)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C318(1.56); C320(1.56)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C318(1.10); C320(1.10)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C318(1.09); C320(1.09)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C318(1.21); C320(1.21)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C318(1.09); C320(1.09)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C318(1.19); C320(1.19)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C318(1.40)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C318(1.06); C320(1.06)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C318(1.62); C320(1.62)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C318(0.90); C320(0.90)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C332(1.06)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C332(1.13)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C332(0.82)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C332(1.02)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C332(1.14)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C332(0.78)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C332(1.50)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C332(0.94)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C332(1.06)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C332(0.78)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C332(0.96)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C332(0.84)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C332(1.11)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C332(1.13)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C332(1.93)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C386(1.35)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C386(1.17)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C318(1.38)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C318(1.25)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C318(1.48)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C159(0.99); C184(0.99); C377(0.95); C379(0.95)  LDD0078  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0367  CL1 HCT 116 C318(1.12); C320(1.12)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C318(1.51); C320(1.51)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C318(1.34)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C318(1.54)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C318(1.55)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C318(1.37)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C318(1.40)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C318(0.92); C320(0.96)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C320(1.09); C318(1.29)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C320(1.02); C318(1.12)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C320(1.02); C318(1.11)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C320(1.01); C318(1.11)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C318(1.11); C320(1.11)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C320(0.97); C318(1.01)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C320(0.99); C318(1.01)  LDD0698  [2]
 LDCM0387  CL117 HEK-293T C332(0.80)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C332(1.04)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C332(0.65)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C318(1.59); C320(1.59)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C332(0.89)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C332(1.76); C379(1.55); C386(1.55)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C332(1.01); C379(1.90); C386(1.90)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C332(1.15); C379(1.54); C386(1.54)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C332(1.59); C379(1.79); C386(1.79)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C332(0.96); C379(1.16); C386(1.16)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C332(1.32); C379(0.86); C386(0.86)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C332(0.91); C379(1.18); C386(1.18)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C332(1.06); C379(1.14); C386(1.14)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C318(2.38); C320(2.38)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C318(0.86); C320(0.86)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C318(1.96); C320(1.96)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C318(1.24)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C318(1.21)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C318(1.16)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C318(1.14)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C318(1.13); C320(1.13)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C318(1.28)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C318(1.26)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C318(1.34)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C318(1.19)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C318(0.91)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C318(1.02)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C318(1.40)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C318(1.07)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C318(1.12)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C318(1.20)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C318(1.12); C320(1.12)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C318(1.11)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C318(0.98)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C332(0.69); C379(0.86); C386(0.86)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C332(0.64); C379(0.72); C386(0.72)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C332(0.80); C379(0.81); C386(0.81)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C332(0.83); C379(1.06); C386(1.06)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C332(0.73); C379(0.91); C386(0.91)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C332(0.61); C379(0.81); C386(0.81)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C332(1.10); C379(0.89); C386(0.89)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C318(1.33); C320(1.33)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C332(0.73); C379(1.26); C386(1.26)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C332(1.01); C379(0.71); C386(0.71)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C332(0.88); C379(1.13); C386(1.13)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C332(0.90); C379(1.20); C386(1.20)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C332(0.81); C379(0.80); C386(0.80)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C332(0.86); C379(1.23); C386(1.23)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C318(1.23); C320(1.23); C386(1.06)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C318(1.21); C320(1.21); C386(1.42)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C318(1.24); C320(1.24); C386(1.30)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C318(1.21); C320(1.21); C386(1.43)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C318(1.65); C320(1.65)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C318(1.31); C320(1.31); C386(1.30)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C318(1.38); C320(1.38); C386(1.56)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C318(1.18); C320(1.18); C386(0.93)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C318(1.09); C320(1.09); C386(0.87)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C318(1.15); C320(1.15); C386(0.79)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C318(1.24); C320(1.24); C386(1.02)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C318(1.22); C320(1.22); C386(0.90)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C318(1.36); C320(1.36); C386(1.19)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C318(1.30); C320(1.30); C386(1.02)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C318(1.32); C320(1.32); C386(1.24)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C318(1.45); C320(1.45)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C318(1.27); C320(1.27); C386(1.40)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C386(0.81)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C386(0.88)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C386(0.92)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C386(1.40)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C386(1.08)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C386(1.10)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C386(1.14)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C386(1.26)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C386(0.94)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C318(1.58); C320(1.58)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C386(1.06)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C386(0.98)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C386(0.96)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C386(0.88)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C386(0.81)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C318(1.46); C320(1.46)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C318(1.68); C320(1.68)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C318(1.40); C320(1.40)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C318(1.27); C320(1.27)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C318(1.22); C320(1.22)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C318(1.29); C320(1.29)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C318(1.94); C320(1.94)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C318(1.84); C320(1.84)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C318(1.13); C320(1.13)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C318(1.03); C320(1.03)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C318(1.02); C320(1.02)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C318(0.99); C320(0.99)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C318(1.69); C320(1.69)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C318(1.52); C320(1.52)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C318(1.15); C320(1.15)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C318(1.20); C320(1.20)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C318(1.19); C320(1.19)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C318(1.04)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C318(1.13)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C318(1.20)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C318(1.17)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C318(1.30)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C318(1.03)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C318(1.33)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C318(0.84)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C318(1.08)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C386(1.14)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C332(0.76); C379(1.13); C386(1.13)  LDD1025  [2]
 LDCM0022  KB02 A-549 C190(2.14)  LDD2260  [5]
 LDCM0023  KB03 ABC-1 C190(2.77)  LDD2679  [5]
 LDCM0024  KB05 SKMEL24 C190(1.96)  LDD3323  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Nuclear receptor subfamily 4 group A member 3 (NR4A3) Nuclear hormone receptor family Q92570
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Homeobox protein MOX-2 (MEOX2) . P50222
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-crystallin A4 (CRYBA4) Beta/gamma-crystallin family P53673
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Keratin-associated protein 19-2 (KRTAP19-2) KRTAP type 19 family Q3LHN2
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Late cornified envelope protein 1C (LCE1C) LCE family Q5T751
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 3A (LCE3A) LCE family Q5TA76
Late cornified envelope protein 3D (LCE3D) LCE family Q9BYE3
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Antileukoproteinase (SLPI) . P03973
Atrophin-1 (ATN1) . P54259
BAG family molecular chaperone regulator 4 (BAG4) . O95429
BAG family molecular chaperone regulator 5 (BAG5) . Q9UL15
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592
Keratin-associated protein 21-2 (KRTAP21-2) . Q3LI59
Large proline-rich protein BAG6 (BAG6) . P46379
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840