Details of the Target

General Information of Target

Target ID LDTP05088
Target Name E3 ubiquitin-protein ligase RNF4 (RNF4)
Gene Name RNF4
Gene ID 6047
Synonyms
SNURF; E3 ubiquitin-protein ligase RNF4; EC 2.3.2.27; RING finger protein 4; Small nuclear ring finger protein; Protein SNURF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTRKRRGGAINSRQAQKRTREATSTPEISLEAEPIELVETAGDEIVDLTCESLEPVVVD
LTHNDSVVIVDERRRPRRNARRLPQDHADSCVVSSDDEELSRDRDVYVTTHTPRNARDEG
ATGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCPTCRKKI
NHKRYHPIYI
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.
Uniprot ID
P78317
Ensemble ID
ENST00000314289.13
HGNC ID
HGNC:10067

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMCH1 SNV: p.M1? .
UMUC3 SNV: p.S127Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C173(1.22); C176(1.22); C132(1.02); C135(1.02)  LDD0078  [1]
IA-alkyne
 Probe Info  		C173(0.00); C176(0.00)  LDD2241  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C132(1.78); C135(1.78)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C132(1.35); C135(1.35)  LDD1094  [1]
 LDCM0216  AC100 PaTu 8988t C132(1.24); C135(1.24)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C132(2.16); C135(2.16)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C132(1.38); C135(1.38)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C132(0.84); C135(0.84)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C132(1.44); C135(1.44)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C132(1.16); C135(1.16)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C132(1.25); C135(1.25)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C132(1.18); C135(1.18)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C132(1.27); C135(1.27)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C132(2.01); C135(2.01)  LDD1104  [1]
 LDCM0226  AC11 PaTu 8988t C132(1.43); C135(1.43)  LDD1105  [1]
 LDCM0227  AC110 PaTu 8988t C132(1.16); C135(1.16)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C132(1.70); C135(1.70)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C132(1.31); C135(1.31)  LDD1108  [1]
 LDCM0237  AC12 PaTu 8988t C132(1.30); C135(1.30)  LDD1116  [1]
 LDCM0259  AC14 PaTu 8988t C132(1.07); C135(1.07)  LDD1138  [1]
 LDCM0263  AC143 HCT 116 C132(0.92); C135(0.92)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C135(0.97); C132(1.12)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C135(0.79); C132(1.09)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C132(0.66); C135(0.82)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C135(1.04); C132(1.06)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C132(0.62); C135(0.73)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C132(0.60); C135(0.73)  LDD0586  [1]
 LDCM0270  AC15 PaTu 8988t C132(1.39); C135(1.39)  LDD1149  [1]
 LDCM0271  AC150 HCT 116 C132(0.79); C135(0.89)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C135(0.85); C132(0.97)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C132(0.75); C135(0.76)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C135(0.59); C132(0.67)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C132(0.82); C135(0.81)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C132(0.86); C135(0.72)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C132(0.75); C135(0.84)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C132(0.88); C135(0.94)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C132(0.89); C135(0.89)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C132(0.83); C135(0.83)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C132(0.89); C135(0.89)  LDD0595  [1]
 LDCM0279  AC2 PaTu 8988t C132(1.48); C135(1.48)  LDD1158  [1]
 LDCM0280  AC20 HCT 116 C132(1.05); C135(1.05)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C132(0.97); C135(0.97)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C132(1.10); C135(1.10)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C132(0.82); C135(0.82)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C132(1.01); C135(1.01)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C132(0.92); C135(0.92)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C132(0.73); C135(0.73)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C132(0.85); C135(0.85)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C132(1.08); C135(1.08)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C132(0.92); C135(0.92)  LDD0606  [1]
 LDCM0290  AC3 PaTu 8988t C132(1.22); C135(1.22)  LDD1169  [1]
 LDCM0291  AC30 HCT 116 C132(0.89); C135(0.89)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C132(0.97); C135(0.97)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C132(0.72); C135(0.72)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C132(1.09); C135(1.09)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C132(0.87); C135(0.87)  LDD0612  [1]
 LDCM0296  AC35 PaTu 8988t C132(1.20); C135(1.20)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C132(1.11); C135(1.11)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C132(1.10); C135(1.10)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C132(1.18); C135(1.18)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C132(1.62); C135(1.62)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C132(1.27); C135(1.27)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C132(2.01); C135(2.01)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C132(1.08); C135(1.08)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C132(1.83); C135(1.83)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C132(1.48); C135(1.48)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C132(1.81); C135(1.81)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C132(1.38); C135(1.38)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C132(1.02); C135(1.02)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C132(1.01); C135(1.01)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C132(0.96); C135(0.96)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C132(1.34); C135(1.34)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C132(1.39); C135(1.39)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C132(1.58); C135(1.58)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C132(0.46); C135(0.46)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C132(1.02); C135(1.02)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C132(1.65); C135(1.65)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C132(2.06); C135(2.06)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C132(1.05); C135(1.05)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C132(1.31); C135(1.31)  LDD1198  [1]
 LDCM0323  AC6 PaTu 8988t C132(1.26); C135(1.26)  LDD1202  [1]
 LDCM0324  AC60 HEK-293T C91(1.09)  LDD1563  [3]
 LDCM0326  AC62 HEK-293T C91(0.84)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C91(0.95)  LDD1566  [3]
 LDCM0332  AC68 PaTu 8988t C132(1.01); C135(1.01)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C132(0.87); C135(0.87)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C132(1.07); C135(1.07)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C132(0.97); C135(0.97)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C132(1.17); C135(1.17)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C132(0.91); C135(0.91)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C132(0.71); C135(0.71)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C132(0.85); C135(0.85)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C132(0.92); C135(0.92)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C132(0.80); C135(0.80)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C132(0.83); C135(0.83)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C132(0.98); C135(0.98)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C132(0.90); C135(0.90)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C132(1.03); C135(1.03)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C132(0.99); C135(0.99)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C132(0.95); C135(0.95)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C132(0.95); C135(0.95)  LDD1227  [1]
 LDCM0365  AC98 PaTu 8988t C132(1.28); C135(1.28)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C132(1.22); C135(1.22)  LDD1245  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C132(1.13); C135(1.13)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C132(2.11); C135(2.11)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C132(1.18); C135(1.18)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C173(1.22); C176(1.22); C132(1.02); C135(1.02)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C132(0.78); C135(0.78)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C132(0.85); C135(0.85)  LDD0685  [1]
 LDCM0369  CL100 PaTu 8988t C132(1.24); C135(1.24)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C132(1.42); C135(1.42)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C132(1.28); C135(1.28)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C132(1.38); C135(1.38)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C132(1.23); C135(1.23)  LDD1252  [1]
 LDCM0374  CL105 HCT 116 C132(0.88); C135(0.88)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C132(1.07); C135(1.07)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C132(1.27); C135(1.27)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C132(0.98); C135(0.98)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C132(0.90); C135(0.90)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C132(0.65); C135(0.65)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C132(1.39); C135(1.39)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C132(0.82); C135(0.82)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C132(0.70); C135(0.70)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C132(1.05); C135(1.05)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C132(0.49); C135(0.49)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C132(0.72); C135(0.72)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C132(0.71); C135(0.71)  LDD0703  [1]
 LDCM0387  CL117 PaTu 8988t C132(1.09); C135(1.09)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C132(1.35); C135(1.35)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C132(1.31); C135(1.31)  LDD1268  [1]
 LDCM0390  CL12 HCT 116 C132(1.13); C135(1.13)  LDD0707  [1]
 LDCM0391  CL120 PaTu 8988t C132(1.15); C135(1.15)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C132(1.61); C135(1.61)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C132(1.13); C135(1.13)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C132(1.00); C135(1.00)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C132(1.11); C135(1.11)  LDD1274  [1]
 LDCM0396  CL125 HEK-293T C91(1.02)  LDD1600  [3]
 LDCM0400  CL13 HCT 116 C132(0.78); C135(0.78)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C132(0.88); C135(0.88)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C132(0.83); C135(0.83)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C132(0.92); C135(0.92)  LDD0720  [1]
 LDCM0407  CL2 HCT 116 C132(0.96); C135(0.96)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C91(1.08)  LDD1612  [3]
 LDCM0410  CL22 HEK-293T C91(1.15)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C91(1.05)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C91(1.03)  LDD1617  [3]
 LDCM0418  CL3 HCT 116 C132(1.02); C135(1.02)  LDD0735  [1]
 LDCM0421  CL32 HCT 116 C132(1.04); C135(1.04)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C132(0.96); C135(0.96)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C132(1.05); C135(1.05)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C132(0.90); C135(0.90)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C132(1.35); C135(1.35)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C132(1.03); C135(1.03)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C132(0.98); C135(0.98)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C132(0.91); C135(0.91)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C132(0.96); C135(0.96)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C132(1.22); C135(1.22)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C132(1.16); C135(1.16)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C132(0.95); C135(0.95)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C132(0.93); C135(0.93)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C132(1.05); C135(1.05)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C132(0.89); C135(0.89)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C132(0.86); C135(0.86)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C132(0.81); C135(0.81)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C132(0.86); C135(0.86)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C132(0.93); C135(0.93)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C132(0.97); C135(0.97)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C132(0.92); C135(0.92)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C132(0.86); C135(0.86)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C132(0.96); C135(0.96)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C132(0.99); C135(0.99)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C132(0.96); C135(0.96)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C132(1.03); C135(1.03)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C132(1.24); C135(1.24)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C132(0.99); C135(0.99)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C132(1.23); C135(1.23)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C132(0.98); C135(0.98)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C132(1.02); C135(1.02)  LDD0769  [1]
 LDCM0453  CL61 PaTu 8988t C132(0.83); C135(0.83)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C132(1.21); C135(1.21)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C132(1.01); C135(1.01)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C132(0.99); C135(0.99)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C132(1.10); C135(1.10)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C132(1.21); C135(1.21)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C132(0.91); C135(0.91)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C132(1.10); C135(1.10)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C132(1.09); C135(1.09)  LDD1340  [1]
 LDCM0462  CL7 HCT 116 C132(0.83); C135(0.83)  LDD0779  [1]
 LDCM0463  CL70 PaTu 8988t C132(1.21); C135(1.21)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C132(1.13); C135(1.13)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C132(1.16); C135(1.16)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C132(1.45); C135(1.45)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C132(1.21); C135(1.21)  LDD1346  [1]
 LDCM0473  CL8 HCT 116 C132(0.70); C135(0.70)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C91(1.02)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C91(0.82)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C91(1.09)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C91(0.92)  LDD1682  [3]
 LDCM0484  CL9 HCT 116 C132(0.90); C135(0.90)  LDD0801  [1]
 LDCM0486  CL91 PaTu 8988t C132(0.84); C135(0.84)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C132(1.10); C135(1.10)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C132(1.04); C135(1.04)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C132(1.26); C135(1.26)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C132(1.19); C135(1.19)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C132(0.92); C135(0.92)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C132(1.13); C135(1.13)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C132(1.49); C135(1.49)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C132(1.22); C135(1.22)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C132(1.13); C135(1.13)  LDD1347  [1]
 LDCM0427  Fragment51 HCT 116 C132(0.97); C135(0.97)  LDD0744  [1]
 LDCM0022  KB02 HEL C91(0.74)  LDD2351  [4]
 LDCM0023  KB03 Jurkat C91(13.44)  LDD0209  [5]
 LDCM0024  KB05 HEL C91(0.65)  LDD3185  [4]
 LDCM0021  THZ1 HCT 116 C132(1.48); C135(1.48)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Actin, cytoplasmic 1 (ACTB) Actin family P60709
ATP-dependent RNA helicase DDX39A (DDX39A) DEAD box helicase family O00148
Spliceosome RNA helicase DDX39B (DDX39B) DEAD box helicase family Q13838
Desumoylating isopeptidase 1 (DESI1) DeSI family Q6ICB0
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) SAICAR synthetase family; AIR carboxylase family P22234
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Neuronal-specific septin-3 (SEPTIN3) Septin GTPase family Q9UH03
BTB/POZ domain-containing protein 1 (BTBD1) . Q9H0C5
BTB/POZ domain-containing protein 3 (BTBD3) . Q9Y2F9
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
E3 ubiquitin-protein ligase TRIM38 (TRIM38) . O00635
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Protein ARK2N (ARK2N) . Q96B23
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Ubiquitin domain-containing protein 2 (UBTD2) . Q8WUN7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Transcription factor
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 1 (CREB1) BZIP family P16220
Zinc finger protein 275 (ZNF275) Krueppel C2H2-type zinc-finger protein family Q9NSD4
Zinc finger protein 319 (ZNF319) Krueppel C2H2-type zinc-finger protein family Q9P2F9
Zinc finger protein 42 homolog (ZFP42) Krueppel C2H2-type zinc-finger protein family Q96MM3
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Homeobox protein Nkx-3.1 (NKX3-1) NK-3 homeobox family Q99801
Steroid hormone receptor ERR1 (ESRRA) Nuclear hormone receptor family P11474
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
AT-rich interactive domain-containing protein 3C (ARID3C) . A6NKF2
Homeobox protein VENTX (VENTX) . O95231
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 34 (ZBTB34) . Q8NCN2
Zinc finger and BTB domain-containing protein 6 (ZBTB6) . Q15916
Zinc finger transcription factor Trps1 (TRPS1) . Q9UHF7
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
C-C motif chemokine 2 (CCL2) Intercrine beta (chemokine CC) family P13500
Other
Click To Hide/Show 38 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-2 (CFL2) Actin-binding proteins ADF family Q9Y281
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Protein FAM118A (FAM118A) FAM118 family Q9NWS6
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
Desmin (DES) Intermediate filament family P17661
Late cornified envelope protein 1B (LCE1B) LCE family Q5T7P3
Late cornified envelope protein 1D (LCE1D) LCE family Q5T752
Late cornified envelope protein 1E (LCE1E) LCE family Q5T753
Late cornified envelope protein 1F (LCE1F) LCE family Q5T754
Late cornified envelope protein 2B (LCE2B) LCE family O14633
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Late cornified envelope protein 3B (LCE3B) LCE family Q5TA77
Late cornified envelope protein 5A (LCE5A) LCE family Q5TCM9
Latexin (LXN) Protease inhibitor I47 (latexin) family Q9BS40
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1) RRM HNRPC family O60812
Heterogeneous nuclear ribonucleoprotein C-like 2 (HNRNPCL2) RRM HNRPC family B2RXH8
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
Sex comb on midleg-like protein 2 (SCML2) SCM family Q9UQR0
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
A-kinase anchor protein 17A (AKAP17A) . Q02040
FAS-associated death domain protein (FADD) . Q13158
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Kelch-like protein 12 (KLHL12) . Q53G59
Myeloid differentiation primary response protein MyD88 (MYD88) . Q99836
Polyhomeotic-like protein 1 (PHC1) . P78364
Protein TFG (TFG) . Q92734
Protein ZNRD2 (ZNRD2) . O60232
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9
Zinc finger CCCH domain-containing protein 10 (ZC3H10) . Q96K80
Zinc finger CCHC domain-containing protein 17 (ZCCHC17) . Q9NP64

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.