Details of the Target

General Information of Target

Target ID LDTP05042
Target Name Calcineurin subunit B type 1 (PPP3R1)
Gene Name PPP3R1
Gene ID 5534
Synonyms
CNA2; CNB; Calcineurin subunit B type 1; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVID
IFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMV
GNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
Target Bioclass
Other
Family
Calcineurin regulatory subunit family
Subcellular location
Cytoplasm, cytosol
Function Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Uniprot ID
P63098
Ensemble ID
ENST00000234310.8
HGNC ID
HGNC:9317
ChEMBL ID
CHEMBL2082

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
NAIA_5
 Probe Info  		C12(1.20); C12(0.87)  LDD2227  [2]
IPM
 Probe Info  		C12(1.80)  LDD1702  [3]
DBIA
 Probe Info  		C154(1.35)  LDD0531  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C154(1.35)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C154(1.31)  LDD0532  [4]
 LDCM0216  AC100 PaTu 8988t C154(1.00)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C154(1.02)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C154(0.92)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C154(1.10)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C154(0.87)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C154(0.84)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C154(0.95)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C154(0.85)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C154(0.99)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C154(1.20)  LDD1104  [4]
 LDCM0226  AC11 HCT 116 C154(1.21)  LDD0543  [4]
 LDCM0227  AC110 PaTu 8988t C154(1.10)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C154(1.02)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C154(0.94)  LDD1108  [4]
 LDCM0230  AC113 HCT 116 C154(0.89)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C154(0.93)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C154(1.14)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C154(1.21)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C154(1.19)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C154(1.04)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C154(1.04)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C154(1.09)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C154(1.30)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C154(1.13)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C154(1.09)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C154(0.94)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C154(0.85)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C154(0.96)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C154(1.27)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C154(1.17)  LDD0562  [4]
 LDCM0246  AC128 PaTu 8988t C154(1.26)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C154(1.14)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C154(0.97)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C154(1.00)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C154(1.00)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C154(0.96)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C154(1.14)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C154(1.17)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C154(1.11)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C154(0.99)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C154(1.06)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C154(1.18)  LDD1137  [4]
 LDCM0259  AC14 HCT 116 C154(1.42)  LDD0576  [4]
 LDCM0260  AC140 PaTu 8988t C154(1.23)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C154(0.98)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C154(1.10)  LDD1141  [4]
 LDCM0270  AC15 HCT 116 C154(1.26)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C154(0.86)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C154(0.92)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C154(0.87)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C154(1.46)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C154(0.89)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C154(0.84)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C154(0.83)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C154(0.77)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C154(0.93)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C154(0.95)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C154(1.08)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C154(1.09)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C154(1.05)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C154(0.99)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C154(1.17)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C154(1.09)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C154(1.06)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C154(1.17)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C154(1.07)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C154(1.09)  LDD0612  [4]
 LDCM0301  AC4 HCT 116 C154(1.45)  LDD0618  [4]
 LDCM0312  AC5 HCT 116 C154(1.37)  LDD0629  [4]
 LDCM0320  AC57 PaTu 8988t C154(1.22)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C154(1.03)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C154(0.97)  LDD1201  [4]
 LDCM0323  AC6 HCT 116 C154(1.32)  LDD0640  [4]
 LDCM0324  AC60 PaTu 8988t C154(1.01)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C154(1.01)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C154(1.15)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C154(1.00)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C154(1.23)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C154(0.86)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C154(1.05)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C154(1.09)  LDD1210  [4]
 LDCM0334  AC7 HCT 116 C154(1.16)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C154(1.25)  LDD0662  [4]
 LDCM0365  AC98 PaTu 8988t C154(0.96)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C154(0.79)  LDD1245  [4]
 LDCM0248  AKOS034007472 HCT 116 C154(1.28)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C154(1.19)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C154(1.39)  LDD0592  [4]
 LDCM0632  CL-Sc Hep-G2 C12(1.20); C12(0.87)  LDD2227  [2]
 LDCM0369  CL100 HCT 116 C154(1.21)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C154(1.53)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C154(1.25)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C154(1.30)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C154(1.14)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C154(0.98)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C154(1.10)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C154(0.94)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C154(1.16)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C154(1.02)  LDD0695  [4]
 LDCM0380  CL110 HCT 116 C154(1.03)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C154(0.89)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C154(0.87)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C154(1.00)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C154(0.84)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C154(1.01)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C154(1.05)  LDD0703  [4]
 LDCM0396  CL125 PaTu 8988t C154(0.95)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C154(0.99)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C154(0.96)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C154(1.06)  LDD1278  [4]
 LDCM0403  CL16 HCT 116 C154(1.12)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C154(1.09)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C154(1.36)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C154(1.31)  LDD0723  [4]
 LDCM0408  CL20 HCT 116 C154(1.33)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C154(1.31)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C154(1.83)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C154(1.18)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C154(1.43)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C154(1.34)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C154(1.17)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C154(1.34)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C154(1.31)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C154(1.36)  LDD0734  [4]
 LDCM0419  CL30 HCT 116 C154(1.25)  LDD0736  [4]
 LDCM0420  CL31 PaTu 8988t C154(1.40)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C154(1.60)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C154(1.59)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C154(1.87)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C154(2.01)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C154(0.44)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C154(2.04)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C154(2.04)  LDD1307  [4]
 LDCM0430  CL40 PaTu 8988t C154(1.21)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C154(1.50)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C154(1.33)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C154(1.33)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C154(1.97)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C154(1.41)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C154(1.01)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C154(1.09)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C154(1.05)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C154(1.09)  LDD1318  [4]
 LDCM0441  CL50 PaTu 8988t C154(1.11)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C154(1.10)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C154(1.20)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C154(1.14)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C154(1.13)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C154(1.11)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C154(0.26)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C154(2.09)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C154(1.29)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C154(2.03)  LDD1329  [4]
 LDCM0452  CL60 PaTu 8988t C154(1.61)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C154(0.88)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C154(0.98)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C154(1.22)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C154(1.20)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C154(0.96)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C154(1.20)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C154(1.13)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C154(1.19)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C154(1.44)  LDD1340  [4]
 LDCM0463  CL70 PaTu 8988t C154(1.19)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C154(1.05)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C154(1.30)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C154(1.29)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C154(1.07)  LDD1346  [4]
 LDCM0469  CL76 HCT 116 C154(1.13)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C154(0.81)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C154(1.14)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C154(1.30)  LDD0789  [4]
 LDCM0474  CL80 HCT 116 C154(1.06)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C154(1.31)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C154(1.69)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C154(1.28)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C154(1.56)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C154(1.18)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C154(1.09)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C154(1.17)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C154(1.40)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C154(1.93)  LDD0800  [4]
 LDCM0485  CL90 HCT 116 C154(0.90)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C154(1.35)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C154(1.18)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C154(1.10)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C154(1.09)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C154(1.37)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C154(1.74)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C154(1.25)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C154(1.20)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C154(1.42)  LDD0811  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C12(1.80)  LDD1702  [3]
 LDCM0468  Fragment33 PaTu 8988t C154(1.31)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C154(1.65)  LDD1306  [4]
 LDCM0022  KB02 A204 C154(1.12)  LDD2252  [7]
 LDCM0023  KB03 A204 C154(1.47)  LDD2669  [7]
 LDCM0024  KB05 MSTO-211H C154(1.11)  LDD3337  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) PPP phosphatase family Q08209
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC) PPP phosphatase family P48454
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Voclosporin Small molecular drug DB11693
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Myristic Acid Small molecular drug DB08231

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840