Details of the Target

General Information of Target

Target ID LDTP04421
Target Name Probable global transcription activator SNF2L2 (SMARCA2)
Gene Name SMARCA2
Gene ID 6595
Synonyms
BAF190B; BRM; SNF2A; SNF2L2; Probable global transcription activator SNF2L2; EC 3.6.4.-; ATP-dependent helicase SMARCA2; BRG1-associated factor 190B; BAF190B; Protein brahma homolog; hBRM; SNF2-alpha; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTPTDPGAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPMPTM
GSTDFPQEGMHQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGY
MSPHPSPLGAPEHVSSPMSGGGPTPPQMPPSQPGALIPGDPQAMSQPNRGPSPFSPVQLH
QLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGLQQQQQQQQQQQQQQQQQQQQQQQPQ
QQPPQPQTQQQQQPALVNYNRPSGPGPELSGPSTPQKLPVPAPGGRPSPAPPAAAQPPAA
AVPGPSVPQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQE
LENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKR
QTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAV
ATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANL
TNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDLPVKVTHT
ETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESDSDYEEEDEEEESSRQETEEKI
LLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLI
NGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV
PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHIL
AKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLP
TIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPE
KVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPY
MFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMT
IMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADT
VVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQ
AGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDR
RREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDAL
TEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGRPPAEKLSPNP
PKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKELPEYY
ELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFK
SARQKIAKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLNKKDDKGRDKGKGKKRPNR
GKAKPVVSDFDSDEEQDEREQSEGSGTDDE
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family
Subcellular location
Nucleus
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Uniprot ID
P51531
Ensemble ID
ENST00000349721.8
HGNC ID
HGNC:11098
ChEMBL ID
CHEMBL2362979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.R424K DBIA    Probe Info 
CCK81 SNV: p.R979H DBIA    Probe Info 
CHL1 SNV: p.N1113S .
COLO792 SNV: p.H466Y DBIA    Probe Info 
DU145 SNV: p.P808L DBIA    Probe Info 
HCT116 SNV: p.R855Q .
HCT15 SNV: p.P244Q; p.E1578G DBIA    Probe Info 
HSC4 SNV: p.E362K DBIA    Probe Info 
IGROV1 SNV: p.P101Q DBIA    Probe Info 
IM95 Deletion: p.Q235_Q242del DBIA    Probe Info 
KYM1 SNV: p.G92V .
LNCaP clone FGC Insertion: p.M1242NfsTer10
SNV: p.P889H		 DBIA    Probe Info 
MCC13 SNV: p.Y1489N DBIA    Probe Info 
NALM6 SNV: p.P243Q DBIA    Probe Info 
NCIH716 SNV: p.V537L .
OE33 SNV: p.Q520E DBIA    Probe Info 
OVTOKO SNV: p.R1162C .
PATU8988T SNV: p.L946S DBIA    Probe Info 
PF382 SNV: p.K951T DBIA    Probe Info 
SBC5 SNV: p.W892L DBIA    Probe Info 
SNGM SNV: p.R1349Ter DBIA    Probe Info 
SUPT1 SNV: p.P58L; p.K1191R DBIA    Probe Info 
SW620 SNV: p.Q162K DBIA    Probe Info 
TC71 SNV: p.Y642H .
TOV21G Deletion: p.Q253del .
UMUC3 SNV: p.Q1074H .
WM2664 Insertion: p.Q1504AfsTer10 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.02  LDD0402  [1]
STPyne
 Probe Info  		K190(4.86); K209(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y689(76.74); Y693(14.16); Y964(20.82); Y1316(8.40)  LDD3495  [3]
BTD
 Probe Info  		C1401(0.74)  LDD2092  [4]
AHL-Pu-1
 Probe Info  		C1296(3.53)  LDD0168  [5]
DBIA
 Probe Info  		C91(1.04); C399(1.01)  LDD0078  [6]
CY4
 Probe Info  		N.A.  LDD0247  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
IPM
 Probe Info  		N.A.  LDD0005  [12]
TFBX
 Probe Info  		C1175(0.00); C861(0.00); C968(0.00); C1296(0.00)  LDD0148  [13]
Acrolein
 Probe Info  		C1296(0.00); C91(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		H870(0.00); C1296(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1296(3.53)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1296(3.35)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C399(0.73)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C399(0.75)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C399(0.91)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C399(1.05)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C399(0.97)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C399(0.74)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C399(0.94)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C399(1.01)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C399(1.13)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C399(0.95)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C399(1.25)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C399(1.00)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C399(0.95)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C399(0.77)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C399(0.85)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C399(0.76)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C399(0.73); C906(1.16)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C399(1.08); C906(1.23)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C399(0.96); C906(0.83)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C399(0.74); C906(0.89)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C399(0.73); C906(1.21)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C399(0.59); C906(1.45)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C399(0.83); C906(0.79)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C399(0.89)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C399(0.75); C906(1.31)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C399(0.64); C906(1.02)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C399(0.55); C906(0.72)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C399(0.71); C906(0.69)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C399(0.70); C906(1.15)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C399(0.66); C906(0.93)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C399(0.69); C906(0.53)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C399(0.74); C906(0.48)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C399(0.89)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C399(1.03)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C399(0.91)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C399(1.07)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C399(0.89)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C399(0.92)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C399(1.06)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C399(0.90)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C399(0.75)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C399(0.86)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C399(0.79)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C399(0.93)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C399(0.76)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C399(0.89)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C399(0.75)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C399(0.92)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C399(0.58)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C399(1.03)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C399(1.02)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C399(0.83)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C399(0.87)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C399(0.67)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C399(0.82)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C399(0.61)  LDD0868  [6]
 LDCM0271  AC150 HEK-293T C399(0.91)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C399(0.98)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C399(0.66)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C399(0.89)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C399(0.75)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C399(0.77)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C399(0.99)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C399(0.88)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C399(0.59)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C399(0.72)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C399(0.78)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C399(0.61)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C399(0.59)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C399(0.78)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C399(0.68)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C399(0.66)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C399(0.83)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C906(0.95)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C906(0.82)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C906(1.01)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C906(0.62)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C906(0.77)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C399(0.79)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C906(0.86)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C906(0.89)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C906(0.91)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C906(1.04)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C906(1.10)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C399(0.68)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C399(0.91)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C399(0.79)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C399(0.93)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C399(0.75)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C399(0.90)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C399(1.06)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C399(0.76)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C399(0.98)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C399(0.69)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C399(0.76)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C399(0.79)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C399(0.69); C906(1.16)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C399(0.62); C906(0.94)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C399(0.58); C906(1.05)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C399(0.72); C906(0.81)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C399(1.17)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C399(0.70); C906(0.86)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C399(0.61); C906(0.77)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C399(0.66); C906(0.72)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C399(0.78); C906(1.08)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C399(0.59); C906(0.88)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C399(0.62); C906(0.89)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C399(0.74); C906(1.01)  LDD0917  [6]
 LDCM0320  AC57 PaTu 8988t C906(1.04)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C906(0.97)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C906(0.91)  LDD1201  [6]
 LDCM0323  AC6 HEK-293T C399(1.50)  LDD0921  [6]
 LDCM0324  AC60 PaTu 8988t C906(0.86)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C906(1.02)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C906(1.07)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C906(1.14)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C906(0.86)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C906(0.90)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C906(1.03)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C906(0.94)  LDD1210  [6]
 LDCM0332  AC68 HEK-293T C399(0.90)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C399(0.79)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C399(0.92)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C399(0.81)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C399(0.75)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C399(0.61)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C399(0.56)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C399(0.63)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C399(0.68)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C399(0.84)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C399(0.66)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C399(0.68)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C399(0.76)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C399(1.01)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C399(0.58)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C399(0.62)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C399(0.61)  LDD0946  [6]
 LDCM0349  AC83 PaTu 8988t C91(0.75)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C91(0.88)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C91(0.82)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C91(0.81)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C91(0.82)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C91(0.79)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C91(0.84)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C91(0.85)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C91(0.86)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C91(0.90)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C91(0.83)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C91(0.79)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C91(0.90)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C91(0.81)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C91(0.81)  LDD1243  [6]
 LDCM0365  AC98 HEK-293T C399(1.07)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C399(1.12)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C399(0.92)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C399(0.64)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C399(0.75)  LDD0873  [6]
 LDCM0020  ARS-1620 HCC44 C91(1.04); C399(1.01)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C1296(1.84)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C906(0.77)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C906(0.50)  LDD0966  [6]
 LDCM0369  CL100 HEK-293T C399(0.68)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C399(0.90)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C399(0.78)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C399(0.82)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C399(0.73)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C399(1.01)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C399(0.88)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C399(1.18)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C399(0.64)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C399(0.78)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C906(0.65)  LDD0977  [6]
 LDCM0380  CL110 HEK-293T C399(0.67)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C399(1.13)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C906(0.98)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C906(0.96)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C906(0.88)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C906(0.85)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C906(0.97)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C399(1.05)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C399(0.76)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C399(0.93)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C906(1.38)  LDD0988  [6]
 LDCM0391  CL120 HEK-293T C399(0.80)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C399(0.60); C906(0.85)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C399(0.64); C906(0.81)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C399(0.63); C906(0.91)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C399(0.79); C906(1.02)  LDD0993  [6]
 LDCM0396  CL125 PaTu 8988t C906(1.03)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C906(0.92)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C906(0.92)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C906(1.00)  LDD1278  [6]
 LDCM0400  CL13 HEK-293T C906(1.00)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C906(0.99)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C906(0.74)  LDD1000  [6]
 LDCM0403  CL16 HEK-293T C399(1.81)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C399(0.94)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C399(1.16)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C399(0.83)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C906(0.85)  LDD1005  [6]
 LDCM0408  CL20 HEK-293T C399(0.92)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C399(0.73)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C399(0.93)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C399(0.91)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C399(1.11)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C399(1.00)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C399(0.91)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C399(0.97)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C399(0.86)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C399(1.00)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C906(0.73)  LDD1016  [6]
 LDCM0419  CL30 HEK-293T C399(0.80)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C399(1.61)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C399(1.43)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C399(1.15)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C399(0.91)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C399(0.93)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C399(0.83)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C399(0.98)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C399(0.76)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C906(0.94)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C399(0.90)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C399(0.74)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C399(0.78)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C399(0.63)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C399(0.99)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C399(0.70)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C399(1.29)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C399(1.16)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C399(1.27)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C399(0.89)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C906(1.02)  LDD1038  [6]
 LDCM0441  CL50 HEK-293T C399(0.82)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C399(0.82)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C399(1.34)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C399(1.00)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C399(0.80)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C399(1.07)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C399(1.29)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C399(0.90)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C399(0.80)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C399(0.94)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C906(0.96)  LDD1049  [6]
 LDCM0452  CL60 HEK-293T C399(0.92)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C399(1.14)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C399(1.06)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C399(2.08)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C399(1.17)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C399(0.91)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C399(0.99)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C399(0.86)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C399(0.65)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C399(1.07)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C906(1.09)  LDD1060  [6]
 LDCM0463  CL70 HEK-293T C399(1.24)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C399(0.86)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C399(1.07)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C399(0.58)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C399(0.78)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C399(0.97)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C399(1.08)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C399(1.92)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C399(1.22)  LDD1070  [6]
 LDCM0473  CL8 PaTu 8988t C91(1.09); C906(1.10)  LDD1352  [6]
 LDCM0474  CL80 HEK-293T C399(1.03)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C399(1.08)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C399(0.78)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C399(0.72)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C399(1.25)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C399(0.98)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C399(1.16)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C399(1.08)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C399(0.84)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C399(0.88)  LDD1081  [6]
 LDCM0484  CL9 PaTu 8988t C91(1.24); C906(2.06)  LDD1363  [6]
 LDCM0485  CL90 HEK-293T C399(0.82)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C399(1.38)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C399(1.07)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C399(1.15)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C399(0.84)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C399(0.65)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C399(0.96)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C399(1.04)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C399(0.86)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C399(0.73)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C399(0.93); C968(1.12); C91(1.06); C906(0.92)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C91(1.19)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C399(0.60)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C399(1.02)  LDD1025  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 HEK-293T C399(1.08); C91(1.02); C968(0.92)  LDD1492  [16]
 LDCM0023  KB03 Jurkat C906(4.97)  LDD0209  [17]
 LDCM0024  KB05 IGR37 C399(3.72)  LDD3314  [18]
 LDCM0109  NEM HeLa H870(0.00); H458(0.00)  LDD0223  [14]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1401(0.74)  LDD2092  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1401(1.28)  LDD2096  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1401(0.95)  LDD2100  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1401(1.06)  LDD2114  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1401(1.67)  LDD2118  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1401(1.36)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1401(1.25)  LDD2124  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1401(1.23)  LDD2126  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1401(0.53)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1401(0.73)  LDD2135  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1296(2.68)  LDD2141  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF complex subunit SMARCC2 (SMARCC2) SMARCC family Q8TAQ2
AT-rich interactive domain-containing protein 1A (ARID1A) . O14497
AT-rich interactive domain-containing protein 1B (ARID1B) . Q8NFD5
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) KHDRBS family Q07666
Methyl-CpG-binding protein 2 (MECP2) . P51608
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840