Details of the Target

General Information of Target

Target ID LDTP04402
Target Name Ras-related protein Rab-28 (RAB28)
Gene Name RAB28
Gene ID 9364
Synonyms
Ras-related protein Rab-28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDSEEESQDRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNL
NVTLQIWDIGGQTIGGKMLDKYIYGAQGVLLVYDITNYQSFENLEDWYTVVKKVSEESET
QPLVALVGNKIDLEHMRTIKPEKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGI
KLNKAEIEQSQRVVKADIVNYNQEPMSRTVNPPRSSMCAVQ
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cell membrane
Uniprot ID
P51157
Ensemble ID
ENST00000288723.9
HGNC ID
HGNC:9768

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DEL SNV: p.E102D; p.V220I DBIA    Probe Info 
P31FUJ SNV: p.S8R .
SKOV3 SNV: p.V114A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C169(20.00); C31(1.85)  LDD2227  [1]
DBIA
 Probe Info  		C31(1.71)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C148(0.00); C169(0.00); C31(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C169(0.00); C31(0.00); C148(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C148(0.00); C31(0.00)  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
JW-RF-010
 Probe Info  		C31(0.00); C169(0.00)  LDD0026  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C169(0.97); C31(1.01)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C169(1.02)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C31(0.95); C169(1.30)  LDD1509  [7]
 LDCM0230  AC113 HCT 116 C31(0.95)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C31(1.08)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C31(1.02)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C31(0.98)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C31(1.02)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C31(1.09)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C31(1.31)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C31(1.08); C169(0.97)  LDD1510  [7]
 LDCM0238  AC120 HCT 116 C31(1.19)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C31(1.13)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C31(1.11)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C31(1.07)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C31(1.06)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C31(1.15)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C31(1.10)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C31(1.14)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C31(0.98)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C31(0.91)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C31(0.99)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C31(1.15)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C31(1.06)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C31(1.07)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C31(1.22)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C31(1.02)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C31(1.23)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C31(1.14)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C31(0.80)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C31(1.20)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C31(1.03)  LDD1512  [7]
 LDCM0260  AC140 HCT 116 C31(0.99)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C31(0.88)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C31(1.11)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C31(1.02)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C31(1.44)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C31(1.41)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C31(0.71)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C31(1.06)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C31(1.24)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C31(0.79)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C31(0.85)  LDD1513  [7]
 LDCM0271  AC150 HCT 116 C31(0.89)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C31(1.48)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C31(0.97)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C31(1.22)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C31(1.45)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C31(1.44)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C31(0.88)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C31(1.82)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C31(1.00)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C31(1.03)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C31(1.05)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C169(0.99); C31(1.25)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C31(0.99)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C31(0.95)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C31(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C31(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C31(1.00)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C31(1.08)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C31(1.17)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C31(1.17)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C31(1.17)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C31(1.11)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C169(0.97); C31(1.16)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C31(1.18)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C31(1.09)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C31(1.20)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C31(1.17)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C31(1.24)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C31(1.00)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C31(0.91)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C31(0.95)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C31(1.01)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C31(1.10)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C169(1.07); C31(1.08)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C31(1.22)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C31(1.04)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C31(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C31(1.08)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C31(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C31(1.23)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C169(0.99)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C169(1.03)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C169(0.97)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C169(0.97)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C169(1.07); C31(1.11)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C169(1.19)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C169(0.87)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C169(0.91)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C169(1.06)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C169(1.16)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C169(1.19)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C169(0.86)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C169(0.75); C31(1.11)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C169(0.92); C31(0.97)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C169(0.83); C31(0.91)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C31(0.92)  LDD1562  [7]
 LDCM0324  AC60 HCT 116 C169(0.77); C31(1.04)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C169(0.70); C31(1.14)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C169(0.88); C31(1.22)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C169(0.77); C31(1.02)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C169(0.85); C31(1.10)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C169(0.69); C31(1.19)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C169(0.70); C31(1.12)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C169(0.72); C31(1.07)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C169(0.99)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C169(1.04)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C31(1.02)  LDD1568  [7]
 LDCM0335  AC70 HCT 116 C169(1.81)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C169(1.54)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C169(1.67)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C169(1.43)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C169(1.48)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C169(1.25)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C169(1.38)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C169(1.05)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C169(1.09)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C169(1.35)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C31(1.03)  LDD1569  [7]
 LDCM0346  AC80 HCT 116 C169(1.19)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C169(1.26)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C169(1.40)  LDD0665  [2]
 LDCM0248  AKOS034007472 HEK-293T C31(1.02); C169(1.05)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C31(1.01); C169(1.04)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C31(0.99)  LDD1514  [7]
 LDCM0632  CL-Sc Hep-G2 C169(20.00); C31(1.85)  LDD2227  [1]
 LDCM0367  CL1 HCT 116 C31(0.94); C169(0.94)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C169(1.05); C31(1.05)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C169(0.86); C31(1.10)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C31(1.02); C169(0.98)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C31(1.11); C169(1.01)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C31(0.97); C169(0.96)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C31(0.94); C169(0.95)  LDD1577  [7]
 LDCM0374  CL105 HCT 116 C31(1.08)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C31(1.17)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C31(1.17)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C31(1.24)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C31(1.06)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C31(0.83); C169(1.17)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C31(1.09)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C31(1.10)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C31(0.98)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C31(1.26)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C31(1.00)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C31(1.13)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C31(1.12)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C31(1.35)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C31(1.03)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C31(1.00)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C31(0.93); C169(1.29)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C31(1.08)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C169(0.93)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C169(0.85)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C169(1.05)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C169(1.07)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C169(0.88); C31(0.95)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C169(0.74); C31(1.06)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C169(0.85); C31(0.89)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C169(0.80); C31(1.06)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C31(0.93); C169(1.17)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C169(0.97); C31(0.99)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C31(0.87); C169(1.11)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C31(1.06)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C31(0.78); C169(0.85)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C31(1.07); C169(1.07)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C31(0.93); C169(0.94)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C169(0.92); C31(0.97)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C31(0.95); C169(0.98)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C31(0.99); C169(1.04)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C31(0.95); C169(1.13)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C169(0.94); C31(1.07)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C169(1.17); C31(1.01)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C169(0.92); C31(0.95)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C169(1.00); C31(1.05)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C169(0.92); C31(0.93)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C169(0.96); C31(1.16)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C169(1.02); C31(1.17)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C169(1.20); C31(0.83)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C169(1.10); C31(1.09)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C169(1.09)  LDD0737  [2]
 LDCM0421  CL32 PaTu 8988t C169(0.82)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C169(0.81)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C169(0.81)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C169(0.86)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C169(0.88)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C169(0.82)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C169(0.79)  LDD1307  [2]
 LDCM0429  CL4 HCT 116 C169(0.90); C31(0.84)  LDD0746  [2]
 LDCM0430  CL40 PaTu 8988t C169(0.87)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C169(0.84)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C169(1.03)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C169(1.32)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C169(0.88)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C169(0.88)  LDD1314  [2]
 LDCM0436  CL46 HCT 116 C169(0.85); C31(0.96)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C169(0.89); C31(0.91)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C169(0.94); C31(0.90)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C169(1.05); C31(1.08)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C169(1.12); C31(0.80)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C169(1.09); C31(0.89)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C169(1.08); C31(0.94)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C169(0.92); C31(0.96)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C169(0.83); C31(0.96)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C169(0.94); C31(0.83)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C169(1.06); C31(0.91)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C169(0.85); C31(0.91)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C169(0.99); C31(0.91)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C169(0.98); C31(1.02)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C169(0.94); C31(0.88)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C169(1.06); C31(0.94)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C169(0.91); C31(0.92)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C169(1.08); C31(0.70)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C169(1.09); C31(0.43)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C169(0.88); C31(0.59)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C169(0.98); C31(0.66)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C169(1.05); C31(0.59)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C169(1.11); C31(0.54)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C169(1.06); C31(0.44)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C169(1.08); C31(0.94)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C169(1.00); C31(1.29)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C169(1.04); C31(1.09)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C169(0.85); C31(0.57)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C169(0.93); C31(0.76)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C169(1.15); C31(0.67)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C169(1.17); C31(0.51)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C169(0.93); C31(0.59)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C169(0.91)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C169(0.95)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C169(0.93)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C169(0.93)  LDD1351  [2]
 LDCM0473  CL8 HCT 116 C169(1.15); C31(0.80)  LDD0790  [2]
 LDCM0474  CL80 PaTu 8988t C169(0.92)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C169(1.05)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C169(0.90)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C169(0.85)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C169(1.12)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C169(0.90)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C169(0.98)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C169(1.15)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C169(1.12)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C169(1.19)  LDD1362  [2]
 LDCM0484  CL9 HCT 116 C169(0.82); C31(1.04)  LDD0801  [2]
 LDCM0485  CL90 PaTu 8988t C169(1.08)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C169(0.93); C31(0.90)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C169(1.11); C31(0.86)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C169(1.07); C31(1.11)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C169(0.90); C31(1.03)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C169(1.02); C31(1.09)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C169(1.00); C31(1.11)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C169(0.98); C31(1.06)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C169(0.94); C31(1.19)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C169(1.04); C31(0.96)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C31(0.92); C169(0.96)  LDD1698  [7]
 LDCM0625  F8 Ramos C169(0.92); C31(1.16); C148(3.48)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C169(2.52); C31(0.77); C148(0.52)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C169(7.22); C31(3.11); C148(1.59)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C169(2.45); C31(0.72); C148(2.04)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C169(1.26); C31(0.82); C148(0.42)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C169(1.25); C31(0.75); C148(1.29)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C169(1.99); C31(1.19)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C169(1.06); C31(0.94); C148(0.51)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C169(0.90); C31(0.85); C148(1.99)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C169(0.81); C31(0.69); C148(1.24)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C169(0.41); C31(0.43); C148(1.01)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C169(0.89); C31(0.73); C148(1.02)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C169(1.21); C31(0.78); C148(0.92)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C169(1.56); C31(0.81)  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C169(1.15); C31(0.47)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C169(1.39); C31(0.64); C148(1.12)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C169(1.76); C31(1.51)  LDD2184  [8]
 LDCM0427  Fragment51 PaTu 8988t C169(0.93)  LDD1306  [2]
 LDCM0610  Fragment52 Ramos C169(1.14); C31(0.63); C148(1.17)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C169(1.07); C31(0.52); C148(0.90)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C169(1.65); C31(1.09); C148(1.07)  LDD2186  [8]
 LDCM0022  KB02 HCT 116 C31(1.71)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C31(8.84)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C31(5.91)  LDD0082  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C169(1.75); C148(0.82)  LDD2206  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C148(0.64)  LDD2207  [9]
 LDCM0131  RA190 MM1.R C31(1.42)  LDD0304  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Malonate--CoA ligase ACSF3, mitochondrial (ACSF3) ATP-dependent AMP-binding enzyme family Q4G176
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.