Details of the Target

General Information of Target

Target ID LDTP04337
Target Name Double-strand break repair protein MRE11 (MRE11)
Gene Name MRE11
Gene ID 4361
Synonyms
HNGS1; MRE11A; Double-strand break repair protein MRE11; EC 3.1.-.-; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD
LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI
PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG
LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL
VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP
LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK
PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK
PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK
TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF
SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE
TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS
KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
Target Bioclass
Enzyme
Family
MRE11/RAD32 family
Subcellular location
Nucleus
Function
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point . The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Uniprot ID
P49959
Ensemble ID
ENST00000323929.8
HGNC ID
HGNC:7230
ChEMBL ID
CHEMBL3308929

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT1376 SNV: p.S613L .
ICC3 SNV: p.D491Y DBIA    Probe Info 
KNS42 Deletion: p.R191PfsTer5 DBIA    Probe Info 
LS180 Deletion: p.T481HfsTer43 DBIA    Probe Info 
MCC13 SNV: p.S563L DBIA    Probe Info 
NCIH1155 SNV: p.A551T DBIA    Probe Info 
NCIH358 SNV: p.G285C DBIA    Probe Info 
PATU8988T SNV: p.R576Ter DBIA    Probe Info 
SW1271 SNV: p.D468H .
TCCSUP SNV: p.E471Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.31  LDD0402  [1]
C-Sul
 Probe Info  		3.07  LDD0066  [2]
STPyne
 Probe Info  		K282(5.56); K293(1.61); K384(6.31); K393(9.47)  LDD0277  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
BTD
 Probe Info  		C75(2.58)  LDD1700  [4]
HHS-475
 Probe Info  		Y369(0.97); Y262(0.97)  LDD0264  [5]
HHS-465
 Probe Info  		Y369(8.93)  LDD2237  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
DBIA
 Probe Info  		C336(1.67)  LDD0080  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
CY-1
 Probe Info  		Q629(0.00); Q630(0.00)  LDD0246  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C75(0.00); C336(0.00); C249(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C249(0.00); C75(0.00); C336(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C336(0.00); C75(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0147  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		Y369(0.00); Y262(0.00)  LDD0028  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		9.00  LDD0443  [17]
NAIA_5
 Probe Info  		C75(0.00); C336(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y369(1.48)  LDD2239  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C336(1.38); C75(1.59)  LDD2117  [4]
 LDCM0214  AC1 HEK-293T C75(0.57)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C75(0.60)  LDD0813  [8]
 LDCM0226  AC11 HEK-293T C75(0.80)  LDD0824  [8]
 LDCM0230  AC113 HEK-293T C336(1.19)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C336(1.20)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C336(1.16)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C336(1.04)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C336(1.17)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C336(1.12)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C336(1.07)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C75(1.08)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C336(1.05)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C336(1.21)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C336(1.24)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C336(1.28)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C336(0.99)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C336(1.11)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C336(1.13)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C336(1.31)  LDD0843  [8]
 LDCM0246  AC128 PaTu 8988t C336(1.15); C75(0.93)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C336(1.25); C75(0.65)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C336(1.35); C75(0.82)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C336(1.33); C75(0.96)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C336(1.10); C75(0.85)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C336(1.07); C75(0.75)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C336(1.16); C75(0.79)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C336(1.11); C75(0.85)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C336(1.13); C75(0.82)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C336(1.22); C75(0.80)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C336(1.53); C75(0.80)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C336(1.08); C75(1.00)  LDD1137  [8]
 LDCM0259  AC14 HEK-293T C75(0.75)  LDD0857  [8]
 LDCM0260  AC140 PaTu 8988t C336(1.06); C75(1.06)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C336(1.43); C75(0.83)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C336(1.26); C75(0.73)  LDD1141  [8]
 LDCM0263  AC143 HEK-293T C336(1.17)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C336(1.37)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C336(1.26)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C336(1.36)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C336(1.33)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C336(1.32)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C336(1.27)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C75(0.54)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C336(0.96)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C336(0.98)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C336(1.18)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C336(1.28)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C336(1.07)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C336(1.53)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C336(1.10)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C336(2.16)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C336(0.78)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C336(0.78)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C336(0.68)  LDD0876  [8]
 LDCM0279  AC2 HEK-293T C75(0.47)  LDD0877  [8]
 LDCM0280  AC20 HEK-293T C336(0.74)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C336(0.79)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C336(0.73)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C336(0.77)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C336(0.80)  LDD0882  [8]
 LDCM0285  AC25 HEK-293T C336(0.71)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C336(0.61)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C336(0.60)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C336(0.66)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C336(0.55)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C75(0.67)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C336(0.53)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C336(0.68)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C336(0.60)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C336(0.69)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C336(0.58)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C75(0.99); C336(0.96)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C75(1.00); C83(1.01); C336(0.99)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C75(0.98); C83(1.23); C336(1.04)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C75(1.01); C83(1.06); C336(0.83)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C75(1.02); C83(1.07); C336(0.95)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C75(0.60)  LDD0899  [8]
 LDCM0302  AC40 HEK-293T C75(1.06); C83(1.06); C336(0.86); C146(0.95)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C75(1.02); C83(0.94)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C75(0.92); C83(1.03); C336(0.99)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C75(1.01); C336(0.95)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C75(0.96); C83(1.05); C336(1.00)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C75(1.04); C83(0.99); C336(1.04)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C336(0.92); C75(1.28)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C336(0.82); C75(1.13)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C336(0.74); C75(1.28)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C336(0.78); C75(1.00)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C75(0.52)  LDD0910  [8]
 LDCM0313  AC50 HEK-293T C336(0.88); C75(1.14)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C336(0.76); C75(1.58)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C336(0.78); C75(1.21)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C336(0.73); C75(1.11)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C336(0.72); C75(1.19)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C336(0.82); C75(1.22)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C336(0.82); C75(1.59)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C336(1.22); C75(1.14)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C336(0.97); C75(1.36)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C336(0.88); C75(1.70)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C75(0.69)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C336(0.66); C75(1.16)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C336(0.69); C75(1.41)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C336(0.83); C75(1.84)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C336(0.83); C75(2.23)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C336(0.75); C75(2.07)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C336(0.80); C75(1.90)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C336(0.92); C75(2.18)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C336(0.86); C75(1.67)  LDD0929  [8]
 LDCM0334  AC7 HEK-293T C75(0.76)  LDD0932  [8]
 LDCM0345  AC8 HEK-293T C75(0.64)  LDD0943  [8]
 LDCM0349  AC83 HEK-293T C336(0.91)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C336(0.72)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C336(0.85)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C336(0.71)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C336(0.59)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C336(0.70)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C336(0.75)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C336(0.71)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C336(1.02)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C336(0.96)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C336(0.89)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C336(0.85)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C336(0.93)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C336(1.07)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C336(0.98)  LDD0962  [8]
 LDCM0248  AKOS034007472 HEK-293T C75(0.76)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C75(0.53)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C75(0.78)  LDD0873  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C336(0.77)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C336(0.82)  LDD0966  [8]
 LDCM0369  CL100 HEK-293T C75(0.48)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C75(1.40)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C75(0.93)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C75(0.96)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C75(0.49)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C336(0.77)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C336(0.74)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C336(0.85)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C336(0.89)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C336(1.09)  LDD0976  [8]
 LDCM0379  CL11 HEK-293T C336(0.91)  LDD0977  [8]
 LDCM0380  CL110 HEK-293T C336(0.65)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C336(0.63)  LDD0979  [8]
 LDCM0382  CL112 HEK-293T C336(0.46)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C336(0.64)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C336(0.51)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C336(0.58)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C336(0.56)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C75(1.04); C83(1.06)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C75(0.92); C336(1.04)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C75(1.01); C83(1.02); C336(0.98)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C336(1.04)  LDD0988  [8]
 LDCM0391  CL120 HEK-293T C75(0.98); C83(0.96); C336(1.06)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C336(0.88); C75(1.10)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C336(0.78); C75(1.04)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C336(0.70); C75(1.07)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C336(0.84); C75(1.03)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C336(0.85); C75(1.09)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C336(0.96); C75(1.49)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C336(1.09); C75(1.44)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C336(0.96); C75(1.38)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C336(0.86)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C336(1.10)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C336(0.76)  LDD1000  [8]
 LDCM0403  CL16 HEK-293T C336(0.84)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C336(0.74)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C336(0.90)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C336(0.94)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C336(1.03)  LDD1005  [8]
 LDCM0408  CL20 HEK-293T C336(0.77)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C336(0.71)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C336(0.71)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C336(1.04)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C336(0.90)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C336(0.72)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C336(0.89)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C336(0.91)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C336(0.73)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C336(0.90)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C336(0.75)  LDD1016  [8]
 LDCM0419  CL30 HEK-293T C336(0.70)  LDD1017  [8]
 LDCM0420  CL31 PaTu 8988t C75(1.15)  LDD1299  [8]
 LDCM0421  CL32 PaTu 8988t C75(1.31)  LDD1300  [8]
 LDCM0422  CL33 PaTu 8988t C75(1.09)  LDD1301  [8]
 LDCM0423  CL34 PaTu 8988t C75(1.00)  LDD1302  [8]
 LDCM0424  CL35 PaTu 8988t C75(1.04)  LDD1303  [8]
 LDCM0425  CL36 PaTu 8988t C75(1.40)  LDD1304  [8]
 LDCM0426  CL37 PaTu 8988t C75(1.12)  LDD1305  [8]
 LDCM0428  CL39 PaTu 8988t C75(1.19)  LDD1307  [8]
 LDCM0429  CL4 HEK-293T C336(0.65)  LDD1027  [8]
 LDCM0430  CL40 PaTu 8988t C75(1.17)  LDD1309  [8]
 LDCM0431  CL41 PaTu 8988t C75(1.07)  LDD1310  [8]
 LDCM0432  CL42 PaTu 8988t C75(1.06)  LDD1311  [8]
 LDCM0433  CL43 PaTu 8988t C75(0.92)  LDD1312  [8]
 LDCM0434  CL44 PaTu 8988t C75(1.12)  LDD1313  [8]
 LDCM0435  CL45 PaTu 8988t C75(1.26)  LDD1314  [8]
 LDCM0436  CL46 HEK-293T C75(1.05); C83(0.93); C336(0.64)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C75(0.97); C83(0.90); C336(0.80)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C75(1.03); C83(1.00); C336(0.77); C146(0.86)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C75(0.89); C83(1.20)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C336(1.01)  LDD1038  [8]
 LDCM0441  CL50 HEK-293T C75(1.09); C336(0.94)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C75(1.03); C83(1.07); C336(0.92)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C75(0.99); C83(0.86)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C75(0.95); C83(1.06); C336(0.87)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C75(1.03); C336(0.81)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C75(1.00); C83(0.91); C336(0.83)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C75(0.96); C83(0.95); C336(0.82)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C75(1.05); C83(0.98); C336(0.63)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C75(0.99); C83(0.94); C336(0.73)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C336(0.81)  LDD1049  [8]
 LDCM0452  CL60 HEK-293T C75(1.21); C83(1.02); C336(0.76); C146(0.88)  LDD1655  [19]
 LDCM0453  CL61 PaTu 8988t C75(1.10)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C75(1.02)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C75(0.95)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C75(0.89)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C75(0.93)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C75(0.97)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C75(0.97)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C75(0.97)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C75(1.04)  LDD1340  [8]
 LDCM0462  CL7 HEK-293T C336(0.90)  LDD1060  [8]
 LDCM0463  CL70 PaTu 8988t C75(0.93)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C75(1.04)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C75(1.17)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C75(1.14)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C75(1.15)  LDD1346  [8]
 LDCM0469  CL76 PaTu 8988t C336(0.92); C75(1.15)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C336(0.94); C75(0.79)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C336(0.90); C75(0.84)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C336(0.96); C75(0.89)  LDD1351  [8]
 LDCM0473  CL8 HEK-293T C336(1.31)  LDD1071  [8]
 LDCM0474  CL80 PaTu 8988t C336(1.01); C75(0.97)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C336(0.96); C75(0.77)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C336(0.98); C75(0.89)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C336(0.91); C75(0.82)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C336(1.07); C75(0.75)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C336(0.96); C75(0.83)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C336(1.02); C75(0.94)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C336(0.92); C75(0.78)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C336(1.15); C75(0.77)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C336(1.03); C75(0.73)  LDD1362  [8]
 LDCM0484  CL9 HEK-293T C336(1.12)  LDD1082  [8]
 LDCM0485  CL90 PaTu 8988t C336(0.92); C75(0.77)  LDD1364  [8]
 LDCM0486  CL91 HEK-293T C75(0.52)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C75(0.44)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C75(0.93)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C75(0.37)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C75(0.38)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C75(0.43)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C75(0.41)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C75(0.37)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C75(0.42)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C75(1.02); C83(1.04); C336(0.91)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C75(1.70)  LDD1702  [4]
 LDCM0572  Fragment10 Ramos C75(0.68)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C75(12.58)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C75(0.57)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C75(0.91)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C75(0.41)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C75(0.48)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C75(0.63)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C75(1.13)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C75(0.94)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C75(1.32)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C75(0.60)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C75(1.09)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C75(0.44)  LDD2201  [20]
 LDCM0468  Fragment33 PaTu 8988t C75(0.85)  LDD1347  [8]
 LDCM0596  Fragment38 Ramos C75(3.58)  LDD2203  [20]
 LDCM0427  Fragment51 PaTu 8988t C75(1.11)  LDD1306  [8]
 LDCM0610  Fragment52 Ramos C75(1.06)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C75(0.77)  LDD2205  [20]
 LDCM0571  Fragment9 Ramos C75(0.54)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y369(0.97); Y262(0.97)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y262(0.77); Y369(1.13)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y262(0.72); Y369(1.06)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y262(0.79); Y369(1.02)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y262(0.62); Y369(0.97)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HCT 116 C336(1.67)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C336(2.37)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C336(2.73)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C75(1.86)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C75(1.18)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C75(1.15)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C336(2.06); C75(1.84)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C336(1.92); C75(1.83)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C75(0.83)  LDD2109  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C75(1.55)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C336(0.84); C75(1.21)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C75(0.73)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C336(1.27); C75(1.51)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C336(2.39)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C336(0.42)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C336(2.62)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C75(1.73)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C336(1.14); C75(0.59)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C75(2.58)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C336(1.04)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C336(1.64); C75(1.61)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C336(0.16)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C336(1.11)  LDD2146  [4]
 LDCM0131  RA190 MM1.R C336(1.96)  LDD0304  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA endonuclease RBBP8 (RBBP8) COM1/SAE2/CtIP family Q99708
Double-strand break repair protein MRE11 (MRE11) MRE11/RAD32 family P49959
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2AX (H2AX) Histone H2A family P16104
Cell cycle checkpoint protein RAD17 (RAD17) Rad17/RAD24 family O75943
Fanconi anemia group D2 protein (FANCD2) . Q9BXW9
Nibrin (NBN) . O60934

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.