Details of the Target

General Information of Target

Target ID LDTP04311
Target Name Regulator of G-protein signaling 19 (RGS19)
Gene Name RGS19
Gene ID 10287
Synonyms
GAIP; GNAI3IP; Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein; GAIP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQ
ASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFW
LACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDA
QLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
Target Bioclass
Other
Subcellular location
Membrane
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Uniprot ID
P49795
Ensemble ID
ENST00000332298.9
HGNC ID
HGNC:13735
ChEMBL ID
CHEMBL3707468

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C73, C76(20.00)  LDD1705  [1]
DBIA
 Probe Info  		C73(3.98); C76(3.98)  LDD0080  [2]
AOyne
 Probe Info  		11.40  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C73(1.41); C76(1.41)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C73(1.20); C76(1.20)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C73(1.26); C76(1.26)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C73(1.10); C76(1.10)  LDD0554  [2]
 LDCM0246  AC128 PaTu 8988t C73(1.22); C76(1.22)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C73(1.33); C76(1.33)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C73(1.17); C76(1.17)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C73(1.37); C76(1.37)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C73(1.27); C76(1.27)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C73(2.22); C76(2.22)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C73(1.70); C76(1.70)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C73(1.94); C76(1.94)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C73(1.98); C76(1.98)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C73(2.06); C76(2.06)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C73(1.33); C76(1.33)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C73(1.50); C76(1.50)  LDD1137  [2]
 LDCM0259  AC14 HCT 116 C73(1.57); C76(1.57)  LDD0576  [2]
 LDCM0260  AC140 PaTu 8988t C73(1.33); C76(1.33)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C73(1.14); C76(1.14)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C73(1.60); C76(1.60)  LDD1141  [2]
 LDCM0263  AC143 PaTu 8988t C73(1.39); C76(1.39)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C73(1.14); C76(1.14)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C73(1.23); C76(1.23)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C73(0.90); C76(0.90)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C73(1.10); C76(1.10)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C73(1.48); C76(1.48)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C73(1.65); C76(1.65)  LDD1148  [2]
 LDCM0270  AC15 HCT 116 C73(1.21); C76(1.21)  LDD0587  [2]
 LDCM0271  AC150 PaTu 8988t C73(0.99); C76(0.99)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C73(1.28); C76(1.28)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C73(1.34); C76(1.34)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C73(1.53); C76(1.53)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C73(1.31); C76(1.31)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C73(1.22); C76(1.22)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C73(1.35); C76(1.35)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C73(0.95); C76(0.95)  LDD2169  [2]
 LDCM0276  AC17 PaTu 8988t C73(1.27); C76(1.27)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C73(1.67); C76(1.67)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C73(1.24); C76(1.24)  LDD1157  [2]
 LDCM0279  AC2 HCT 116 C73(1.31); C76(1.31)  LDD0596  [2]
 LDCM0280  AC20 PaTu 8988t C73(1.55); C76(1.55)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C73(1.55); C76(1.55)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C73(1.53); C76(1.53)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C73(2.02); C76(2.02)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C73(1.68); C76(1.68)  LDD1163  [2]
 LDCM0285  AC25 HCT 116 C73(1.10); C76(1.10)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C73(1.31); C76(1.31)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C73(1.29); C76(1.29)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C73(1.33); C76(1.33)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C73(1.02); C76(1.02)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C73(1.24); C76(1.24)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C73(1.09); C76(1.09)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C73(1.19); C76(1.19)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C73(1.82); C76(1.82)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C73(1.74); C76(1.74)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C73(1.73); C76(1.73)  LDD0612  [2]
 LDCM0296  AC35 PaTu 8988t C73(1.28); C76(1.28)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C73(1.45); C76(1.45)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C73(1.48); C76(1.48)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C73(1.50); C76(1.50)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C73(1.45); C76(1.45)  LDD1179  [2]
 LDCM0301  AC4 HCT 116 C73(1.35); C76(1.35)  LDD0618  [2]
 LDCM0302  AC40 PaTu 8988t C73(1.75); C76(1.75)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C73(1.37); C76(1.37)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C73(1.42); C76(1.42)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C73(1.38); C76(1.38)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C73(1.93); C76(1.93)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C73(1.48); C76(1.48)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C73(1.16); C76(1.16)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C73(1.30); C76(1.30)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C73(1.53); C76(1.53)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C73(1.47); C76(1.47)  LDD1190  [2]
 LDCM0312  AC5 HCT 116 C73(1.41); C76(1.41)  LDD0629  [2]
 LDCM0313  AC50 PaTu 8988t C73(1.74); C76(1.74)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C73(1.40); C76(1.40)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C73(1.61); C76(1.61)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C73(1.99); C76(1.99)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C73(2.27); C76(2.27)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C73(1.41); C76(1.41)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C73(1.69); C76(1.69)  LDD1198  [2]
 LDCM0320  AC57 PaTu 8988t C73(1.21); C76(1.21)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C73(1.34); C76(1.34)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C73(1.14); C76(1.14)  LDD1201  [2]
 LDCM0323  AC6 HCT 116 C73(1.15); C76(1.15)  LDD0640  [2]
 LDCM0324  AC60 PaTu 8988t C73(1.30); C76(1.30)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C73(1.19); C76(1.19)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C73(1.19); C76(1.19)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C73(1.13); C76(1.13)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C73(1.12); C76(1.12)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C73(1.13); C76(1.13)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C73(1.23); C76(1.23)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C73(1.07); C76(1.07)  LDD1210  [2]
 LDCM0332  AC68 PaTu 8988t C73(0.96); C76(0.96)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C73(1.05); C76(1.05)  LDD1212  [2]
 LDCM0334  AC7 HCT 116 C73(1.06); C76(1.06)  LDD0651  [2]
 LDCM0335  AC70 PaTu 8988t C73(1.10); C76(1.10)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C73(0.96); C76(0.96)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C73(0.96); C76(0.96)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C73(0.95); C76(0.95)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C73(1.04); C76(1.04)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C73(1.21); C76(1.21)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C73(1.11); C76(1.11)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C73(1.02); C76(1.02)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C73(1.07); C76(1.07)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C73(1.14); C76(1.14)  LDD1223  [2]
 LDCM0345  AC8 HCT 116 C73(1.39); C76(1.39)  LDD0662  [2]
 LDCM0346  AC80 PaTu 8988t C73(1.08); C76(1.08)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C73(1.07); C76(1.07)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C73(1.09); C76(1.09)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C73(0.92); C76(0.92)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C73(0.82); C76(0.82)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C73(0.93); C76(0.93)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C73(0.86); C76(0.86)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C73(0.75); C76(0.75)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C73(0.72); C76(0.72)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C73(0.83); C76(0.83)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C73(0.69); C76(0.69)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C73(0.70); C76(0.70)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C73(0.83); C76(0.83)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C73(0.90); C76(0.90)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C73(0.81); C76(0.81)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C73(0.85); C76(0.85)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C73(0.73); C76(0.73)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C73(0.76); C76(0.76)  LDD1243  [2]
 LDCM0248  AKOS034007472 HCT 116 C73(1.06); C76(1.06)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C73(1.11); C76(1.11)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C73(2.02); C76(2.02)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C73(1.19); C76(1.19)  LDD2171  [2]
 LDCM0367  CL1 PaTu 8988t C73(1.16); C76(1.16)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C73(2.04); C76(2.04)  LDD1247  [2]
 LDCM0369  CL100 HCT 116 C73(1.47); C76(1.47)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C73(1.42); C76(1.42)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C73(1.02); C76(1.02)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C73(1.14); C76(1.14)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C73(1.26); C76(1.26)  LDD0690  [2]
 LDCM0374  CL105 PaTu 8988t C73(1.27); C76(1.27)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C73(1.35); C76(1.35)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C73(1.25); C76(1.25)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C73(1.32); C76(1.32)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C73(1.52); C76(1.52)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C73(1.26); C76(1.26)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C73(1.79); C76(1.79)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C73(2.13); C76(2.13)  LDD1260  [2]
 LDCM0382  CL112 HCT 116 C73(1.21); C76(1.21)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C73(1.43); C76(1.43)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C73(1.23); C76(1.23)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C73(1.22); C76(1.22)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C73(1.36); C76(1.36)  LDD0703  [2]
 LDCM0387  CL117 PaTu 8988t C73(1.30); C76(1.30)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C73(1.34); C76(1.34)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C73(1.35); C76(1.35)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C73(1.53); C76(1.53)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C73(1.41); C76(1.41)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C73(1.20); C76(1.20)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C73(1.38); C76(1.38)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C73(2.27); C76(2.27)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C73(2.13); C76(2.13)  LDD1274  [2]
 LDCM0396  CL125 PaTu 8988t C73(1.26); C76(1.26)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C73(1.09); C76(1.09)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C73(1.03); C76(1.03)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C73(1.12); C76(1.12)  LDD1278  [2]
 LDCM0400  CL13 PaTu 8988t C73(2.38); C76(2.38)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C73(2.33); C76(2.33)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C73(2.51); C76(2.51)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C73(1.14); C76(1.14)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C73(1.22); C76(1.22)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C73(1.16); C76(1.16)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C73(1.37); C76(1.37)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C73(1.12); C76(1.12)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C73(1.59); C76(1.59)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C73(2.29); C76(2.29)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C73(3.25); C76(3.25)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C73(1.28); C76(1.28)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C73(1.81); C76(1.81)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C73(1.96); C76(1.96)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C73(1.28); C76(1.28)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C73(1.26); C76(1.26)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C73(1.74); C76(1.74)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C73(1.53); C76(1.53)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C73(1.73); C76(1.73)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C73(1.24); C76(1.24)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C73(1.30); C76(1.30)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C73(1.31); C76(1.31)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C73(1.71); C76(1.71)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C73(1.53); C76(1.53)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C73(1.48); C76(1.48)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C73(6.73); C76(6.73)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C73(1.55); C76(1.55)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C73(1.44); C76(1.44)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C73(1.43); C76(1.43)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C73(1.58); C76(1.58)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C73(1.50); C76(1.50)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C73(1.44); C76(1.44)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C73(1.63); C76(1.63)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C73(1.80); C76(1.80)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C73(1.82); C76(1.82)  LDD1314  [2]
 LDCM0436  CL46 HCT 116 C73(0.66); C76(0.66)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C73(0.75); C76(0.75)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C73(0.79); C76(0.79)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C73(0.86); C76(0.86)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C73(2.49); C76(2.49)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C73(0.82); C76(0.82)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C73(0.73); C76(0.73)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C73(0.83); C76(0.83)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C73(0.78); C76(0.78)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C73(0.95); C76(0.95)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C73(0.66); C76(0.66)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C73(0.85); C76(0.85)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C73(0.85); C76(0.85)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C73(0.72); C76(0.72)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C73(0.83); C76(0.83)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C73(2.78); C76(2.78)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C73(0.93); C76(0.93)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C73(1.10); C76(1.10)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C73(1.17); C76(1.17)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C73(1.48); C76(1.48)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C73(1.81); C76(1.81)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C73(1.24); C76(1.24)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C73(2.44); C76(2.44)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C73(1.71); C76(1.71)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C73(1.49); C76(1.49)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C73(1.39); C76(1.39)  LDD0778  [2]
 LDCM0462  CL7 PaTu 8988t C73(2.11); C76(2.11)  LDD1341  [2]
 LDCM0463  CL70 HCT 116 C73(1.34); C76(1.34)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C73(1.66); C76(1.66)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C73(1.31); C76(1.31)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C73(1.47); C76(1.47)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C73(1.53); C76(1.53)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C73(1.22); C76(1.22)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C73(1.20); C76(1.20)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C73(1.19); C76(1.19)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C73(1.80); C76(1.80)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C73(2.64); C76(2.64)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C73(1.10); C76(1.10)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C73(1.35); C76(1.35)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C73(2.10); C76(2.10)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C73(1.90); C76(1.90)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C73(3.30); C76(3.30)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C73(1.38); C76(1.38)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C73(1.10); C76(1.10)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C73(1.52); C76(1.52)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C73(2.01); C76(2.01)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C73(3.44); C76(3.44)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C73(2.05); C76(2.05)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C73(1.22); C76(1.22)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C73(1.17); C76(1.17)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C73(1.13); C76(1.13)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C73(1.05); C76(1.05)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C73(1.77); C76(1.77)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C73(1.66); C76(1.66)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C73(1.56); C76(1.56)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C73(1.47); C76(1.47)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C73(1.44); C76(1.44)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C73(1.54); C76(1.54)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C73(1.56); C76(1.56)  LDD0785  [2]
 LDCM0427  Fragment51 PaTu 8988t C73(1.51); C76(1.51)  LDD1306  [2]
 LDCM0022  KB02 HCT 116 C73(3.98); C76(3.98)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C73(1.83); C76(1.83)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C73(20.00); C76(20.00)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C73(1.19); C76(1.19)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alkaline phosphatase, placental type (ALPP) Alkaline phosphatase family P05187
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
POU domain, class 4, transcription factor 2 (POU4F2) POU transcription factor family Q12837
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 5-6 (KRTAP5-6) KRTAP type 5 family Q6L8G9
Late cornified envelope protein 4A (LCE4A) LCE family Q5TA78
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417
Vasorin (VASN) . Q6EMK4

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.