Details of the Target

General Information of Target

Target ID LDTP03914
Target Name Cyclin-F (CCNF)
Gene Name CCNF
Gene ID 899
Synonyms
FBX1; FBXO1; Cyclin-F; F-box only protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHILKWLSVEDILAVRAVHS
QLKDLVDNHASVWACASFQELWPSPGNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSD
EARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVSGSCCKAVVHESLRAECQLQR
THKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGCLTSSYLLWESDRRTDVSDPGRC
LHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQAVSKQQVFS
VQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACM
VICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTL
VPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGF
SYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEVLSYSQLCAAL
GVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGSFVTTPTAELSSQEETL
LGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDVTVVYLNPEQHCCQESSDEEACP
EDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVTTSGYSSVSTASPTSSVDGGLGA
LPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPESSVPQQQVKRINLCIHSEEEDMN
LGLVRL
Target Bioclass
Other
Family
Cyclin family, Cyclin AB subfamily
Subcellular location
Nucleus
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle. Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability. Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity. In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability. Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry. May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB.
Uniprot ID
P41002
Ensemble ID
ENST00000397066.9
HGNC ID
HGNC:1591

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C14(0.92); C16(0.92)  LDD0078  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]
VSF
 Probe Info  		N.A.  LDD0007  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C176(0.99)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C176(1.36)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C176(0.92)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C176(1.35)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C176(1.45)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C176(1.08)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C176(1.91)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C176(0.94)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C176(1.16)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C176(1.37)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C176(1.97)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C176(1.34)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C176(1.67)  LDD0546  [1]
 LDCM0246  AC128 HEK-293T C14(1.04); C16(1.04)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C14(0.94); C16(0.94)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C14(0.97); C16(0.97)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C14(0.94); C16(0.94)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C14(1.03); C16(1.03)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C14(0.90); C16(0.90)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C14(0.98); C16(0.98)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C14(0.90); C16(0.90)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C14(1.15); C16(1.15)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C14(0.94); C16(0.94)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C14(0.97); C16(0.97)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C14(0.94); C16(0.94)  LDD0856  [1]
 LDCM0260  AC140 HEK-293T C14(1.05); C16(1.05)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C14(1.07); C16(1.07)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C14(0.94); C16(0.94)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C14(1.04); C16(1.04); C176(1.15)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C14(0.89); C16(0.89); C176(1.09)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C176(0.83); C14(0.99); C16(0.99)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C176(0.93); C14(1.00); C16(1.00)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C14(0.83); C16(0.83); C176(1.02)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C14(1.05); C16(1.05); C176(2.71)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C14(0.90); C16(0.90); C176(1.38)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C14(0.89); C16(0.89); C176(1.02)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C14(0.88); C16(0.88); C176(1.24)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C14(0.84); C16(0.84); C176(1.66)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C14(0.89); C16(0.89); C176(1.68)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C14(0.97); C16(0.97); C176(1.10)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C14(1.11); C16(1.11); C176(2.95)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C14(0.87); C16(0.87); C176(0.88)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C14(0.93); C16(0.93); C176(1.18)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C255(1.17)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C255(2.28)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C255(1.12)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C255(1.13)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C255(1.11)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C255(0.99)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C255(1.36)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C255(1.01)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C176(0.85)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C176(0.81)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C176(0.71)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C176(0.82)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C176(0.89)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C176(0.99)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C176(1.49)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C176(1.33)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C176(0.91)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C176(0.95)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C14(0.54); C16(0.54); C255(0.83); C496(0.99)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C14(0.66); C16(0.66); C255(0.88); C496(1.02)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C255(0.80); C14(1.05); C16(1.05); C496(1.07)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C255(1.03); C14(1.06); C16(1.06); C496(1.13)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C14(0.81); C16(0.81); C255(0.96); C496(1.03)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C14(0.84); C16(0.84); C255(0.97); C496(1.03)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C14(0.61); C16(0.61); C496(0.93); C255(0.93)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C14(0.76); C16(0.76); C255(1.01); C496(1.10)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C14(0.72); C16(0.72); C255(0.91); C496(1.04)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C255(0.86); C14(1.05); C16(1.05); C496(1.07)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C255(0.83); C14(0.89); C16(0.89); C496(0.99)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C14(0.93); C16(0.93)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C14(1.10); C16(1.10)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C14(0.93); C16(0.93)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C14(0.96); C16(0.96)  LDD0909  [1]
 LDCM0313  AC50 HEK-293T C14(0.95); C16(0.95)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C14(0.92); C16(0.92)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C14(0.93); C16(0.93)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C14(1.00); C16(1.00)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C14(0.89); C16(0.89)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C14(0.89); C16(0.89)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C14(1.14); C16(1.14)  LDD0917  [1]
 LDCM0320  AC57 HCT 116 C496(0.73); C176(1.06); C255(1.07)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C496(0.86); C255(0.99); C176(1.02)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C496(0.87); C255(1.04); C176(1.18)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C496(0.82); C176(1.02); C255(1.11)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C255(0.88); C496(0.90); C176(0.93)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C496(0.85); C255(1.07); C176(1.16)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C496(1.02); C176(1.12); C255(1.26)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C496(0.94); C176(1.09); C255(1.27)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C255(1.02); C176(1.06); C496(1.10)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C176(0.72); C496(1.03); C255(1.09)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C496(1.02); C176(1.02); C255(1.19)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C176(0.77); C14(0.89); C16(0.89)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C176(0.69); C14(0.82); C16(0.82)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C176(1.08); C14(1.11); C16(1.11)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C176(0.77); C14(0.81); C16(0.81)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C14(0.99); C16(0.99); C176(1.06)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C176(1.02); C14(1.14); C16(1.14)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C176(0.80); C14(0.98); C16(0.98)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C14(1.08); C16(1.08); C176(1.16)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C14(0.97); C16(0.97); C176(1.27)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C14(0.87); C16(0.87); C176(0.99)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C176(0.95); C14(0.97); C16(0.97)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C176(0.84); C14(1.03); C16(1.03)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C176(1.03); C14(1.06); C16(1.06)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C176(0.81); C14(0.91); C16(0.91)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C176(0.91); C14(0.94); C16(0.94)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C255(2.38)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C255(2.22)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C255(1.58)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C255(1.55)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C255(1.25)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C255(1.11)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C255(1.89)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C255(0.88)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C255(3.15)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C255(1.67)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C255(1.15)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C255(1.12)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C255(1.34)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C255(1.30)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C255(1.79)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C176(1.59)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C176(1.27)  LDD0683  [1]
 LDCM0020  ARS-1620 HCC44 C14(0.92); C16(0.92)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C496(0.93)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C496(1.08)  LDD0685  [1]
 LDCM0374  CL105 HCT 116 C255(1.38)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C255(1.61)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C255(1.51)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C255(1.65)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C255(1.39)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C496(0.89)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C255(2.36)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C255(1.55)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C176(0.55)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C176(0.93)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C176(0.85)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C176(1.06)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C176(0.88)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C255(0.97); C14(1.02); C16(1.02); C496(1.07)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C14(0.62); C16(0.62); C255(0.99); C496(1.02)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C14(0.75); C16(0.75); C496(0.90); C255(0.92)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C496(1.16)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C14(0.77); C16(0.77); C255(1.01); C496(1.04)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C14(1.14); C16(1.14)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C14(1.15); C16(1.15)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C14(1.24); C16(1.24)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C14(1.05); C16(1.05)  LDD0993  [1]
 LDCM0396  CL125 HCT 116 C496(0.78); C255(1.10); C176(1.18)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C496(0.80); C255(1.24); C176(1.28)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C496(0.83); C176(0.87); C255(1.00)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C496(0.88); C255(0.93); C176(1.05)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C496(1.03)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C496(1.10)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C496(1.19)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C255(0.90); C176(1.59)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C176(0.84); C255(0.96)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C255(0.98); C176(1.84)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C255(0.95); C176(1.74)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C496(1.08)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C255(1.17); C176(1.54)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C176(2.29); C255(2.44)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C176(1.91); C255(1.98)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C255(0.99); C176(1.11)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C255(1.29); C176(2.78)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C176(3.32); C255(1.39)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C176(2.00); C255(1.14)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C176(3.02); C255(0.93)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C176(2.02); C255(1.31)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C176(2.14); C255(1.19)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C496(0.97)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C176(2.56); C255(0.86)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C14(0.85); C16(0.85)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C14(0.91); C16(0.91)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C14(1.36); C16(1.36)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C14(1.01); C16(1.01)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C14(0.91); C16(0.91)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C14(0.92); C16(0.92)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C14(1.06); C16(1.06)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C14(1.13); C16(1.13)  LDD1026  [1]
 LDCM0429  CL4 HCT 116 C496(0.99)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C14(0.93); C16(0.93)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C14(0.95); C16(0.95)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C14(0.95); C16(0.95)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C14(0.85); C16(0.85)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C14(1.09); C16(1.09)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C14(1.10); C16(1.10)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C14(1.13); C16(1.13); C255(0.80)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C14(0.91); C16(0.91); C255(0.89)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C14(0.83); C16(0.83); C255(0.65)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C14(1.07); C16(1.07); C255(0.96)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C496(1.09)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C14(0.85); C16(0.85); C255(0.85)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C14(0.92); C16(0.92); C255(0.80)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C14(1.06); C16(1.06); C255(0.72)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C14(0.93); C16(0.93); C255(1.01)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C14(0.94); C16(0.94); C255(0.71)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C14(1.03); C16(1.03); C255(0.71)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C14(1.01); C16(1.01); C255(0.54)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C14(0.97); C16(0.97); C255(1.29)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C14(1.01); C16(1.01); C255(0.78)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C14(1.19); C16(1.19); C255(0.76)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C496(1.11)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C14(0.96); C16(0.96); C255(0.85)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C14(1.29); C16(1.29)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C14(0.76); C16(0.76)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C14(0.87); C16(0.87)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C14(0.87); C16(0.87)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C14(0.89); C16(0.89)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C14(0.99); C16(0.99)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C14(1.26); C16(1.26)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C14(1.01); C16(1.01)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C14(0.92); C16(0.92)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C496(1.03)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C14(0.71); C16(0.71)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C14(0.80); C16(0.80)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C14(0.93); C16(0.93)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C14(0.95); C16(0.95)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C14(0.92); C16(0.92)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C14(0.84); C16(0.84); C176(1.79); C496(0.88)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C14(0.71); C16(0.71); C176(0.92); C496(0.85)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C14(0.93); C16(0.93); C176(1.32); C496(0.92)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C14(0.87); C16(0.87); C176(1.18); C496(0.91)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C496(1.65)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C14(0.85); C16(0.85); C176(1.89); C496(0.78)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C14(0.83); C16(0.83); C176(2.71); C496(0.81)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C14(0.85); C16(0.85); C176(2.43); C496(0.94)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C14(0.81); C16(0.81); C176(1.30); C496(0.94)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C14(0.81); C16(0.81); C176(0.87); C496(1.00)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C14(0.95); C16(0.95); C176(1.35); C496(0.98)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C14(0.81); C16(0.81); C176(2.35); C496(0.87)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C14(0.89); C16(0.89); C176(1.06); C496(0.83)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C14(0.98); C16(0.98); C176(1.30); C496(0.92)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C14(0.82); C16(0.82); C176(0.90); C496(1.12)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C496(0.97)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C14(0.74); C16(0.74); C176(1.25); C496(0.98)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C14(1.03); C16(1.03)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C14(1.02); C16(1.02)  LDD1025  [1]
 LDCM0023  KB03 Jurkat C496(35.75)  LDD0209  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-1 (CUL1) Cullin family Q13616
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) Ribonucleoside diphosphate reductase small chain family P31350
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centriolar coiled-coil protein of 110 kDa (CCP110) . O43303

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.