Details of the Target

General Information of Target

Target ID LDTP03844
Target Name Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA)
Gene Name PIGA
Gene ID 5277
Synonyms
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A; EC 2.4.1.198; GlcNAc-PI synthesis protein; Phosphatidylinositol-glycan biosynthesis class A protein; PIG-A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACRGGAGNGHRASATLSRVSPGSLYTCRTRTHNICMVSDFFYPNMGGVESHIYQLSQCL
IERGHKVIIVTHAYGNRKGIRYLTSGLKVYYLPLKVMYNQSTATTLFHSLPLLRYIFVRE
RVTIIHSHSSFSAMAHDALFHAKTMGLQTVFTDHSLFGFADVSSVLTNKLLTVSLCDTNH
IICVSYTSKENTVLRAALNPEIVSVIPNAVDPTDFTPDPFRRHDSITIVVVSRLVYRKGI
DLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLV
QGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLE
KAIFQLKSGTLPAPENIHNIVKTFYTWRNVAERTEKVYDRVSVEAVLPMDKRLDRLISHC
GPVTGYIFALLAVFNFLFLIFLRWMTPDSIIDVAIDATGPRGAWTNNYSHSKRGGENNEI
SETR
Target Bioclass
Enzyme
Family
Glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Uniprot ID
P37287
Ensemble ID
ENST00000333590.6
HGNC ID
HGNC:8957

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MEWO SNV: p.Y398N .
RPMI7951 SNV: p.L310P DBIA    Probe Info 
SW403 SNV: p.F259S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C28(2.40)  LDD0169  [1]
DBIA
 Probe Info  		C28(3.40)  LDD0080  [2]
IA-alkyne
 Probe Info  		C28(0.00); C348(0.00)  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C28(2.40)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C28(1.03)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C28(1.12)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C28(1.47)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C28(1.25)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C28(0.82)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C28(1.37)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C28(1.33)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C28(1.01)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C28(0.74)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C28(1.40)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C28(0.81)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C28(0.98)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C28(1.34)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C28(1.24)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C28(1.99)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C28(1.64)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C28(0.98)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C28(1.53)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C28(1.11)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C28(1.16)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C28(1.57)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C28(1.58)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C28(1.50)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C28(1.29)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C28(1.40)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C28(1.49)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C28(1.84)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C28(1.65)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C28(1.51)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C28(1.76)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C28(2.50)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C28(2.48)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C28(1.02)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C28(1.23)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C28(1.23)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C28(1.44)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C28(1.05)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C28(1.30)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C28(1.43)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C28(1.29)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C28(0.75)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C28(0.98)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C28(1.21)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C28(1.17)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C28(1.00)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C28(1.14)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C28(0.98)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C28(1.19)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C28(1.01)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C28(1.01)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C28(1.45)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C28(1.03)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C28(1.16)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C28(1.37)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C28(0.71)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C28(1.07)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C28(1.64)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C28(1.50)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C28(0.95)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C28(0.94)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C28(1.06)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C28(1.14)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C28(1.16)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C28(0.92)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C28(1.24)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C28(1.28)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C28(1.15)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C28(0.93)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C28(1.06)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C28(1.15)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C28(0.97)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C28(1.01)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C28(1.00)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C28(0.87)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C28(0.99)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C28(0.86)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C28(0.72)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C28(1.06)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C28(0.96)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C28(1.27)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C28(0.97)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C28(1.23)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C28(0.73)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C28(0.90)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C28(1.06); C356(1.21)  LDD1535  [7]
 LDCM0298  AC37 HEK-293T C28(1.03)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C28(0.93)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C28(1.01)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C28(0.86)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C28(0.94)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C28(1.14)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C28(1.00)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C28(0.97); C356(1.25)  LDD1544  [7]
 LDCM0307  AC45 HEK-293T C28(1.09)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C28(1.13)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C28(1.29)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C28(1.15)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C28(1.12)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C28(0.91)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C28(1.22)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C28(1.06)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C28(1.15)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C28(1.05)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C28(1.16)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C28(1.26)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C28(1.10)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C28(1.07)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C28(1.21)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C28(1.16)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C28(0.87)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C28(1.14)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C28(1.05)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C28(1.11)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C28(1.49)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C28(1.08)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C28(1.20)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C28(1.33)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C28(1.31)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C28(1.21)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C28(0.81)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C28(1.30)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C28(0.86)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C28(1.15)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C28(1.02)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C28(1.37)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C28(1.11)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C28(1.57)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C28(1.81)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C28(1.01)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C28(1.06)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C28(1.17)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C28(1.34)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C28(2.24)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C28(2.27)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C28(1.01)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C28(1.26)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C28(0.82)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C28(0.92)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C28(0.87)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C28(1.34)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C28(1.01)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C28(0.95)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C28(1.11)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C28(0.96)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C28(0.81)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C28(0.84)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C28(0.75)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C28(1.01)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C28(0.87)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C28(0.80)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C28(1.07)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C28(1.14)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C28(1.62)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C28(1.09)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C28(1.33)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C28(1.20)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C28(1.02)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C28(1.05)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C28(1.12)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C28(1.59)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C28(1.07)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C28(1.27)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C28(0.94)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C28(1.32)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C28(1.11)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C28(1.11)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C28(1.01)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C28(1.29)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C28(0.96)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C28(0.97)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C28(0.95)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C28(1.23)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C28(1.02)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C28(0.86)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C28(0.82)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C28(0.96)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C28(0.97)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C28(1.00)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C28(1.16)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C28(1.06)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C28(1.15)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C28(1.04)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C28(1.30)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C28(1.04)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C28(1.05)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C28(1.14)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C28(1.15)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C28(1.05)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C28(1.03)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C28(0.93)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C28(1.21)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C28(0.94)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C28(0.95)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C28(0.99)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C28(0.96)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C28(1.07)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C28(1.12)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C28(1.00)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C28(1.11)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C28(1.13)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C28(1.12)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C28(1.19)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C28(1.21)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C28(0.91)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C28(1.35)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C28(1.03)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C28(0.95)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C28(1.06)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C28(1.20)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C28(1.06)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C28(0.85)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C28(1.13)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C28(1.11)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C28(1.04)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C28(1.17)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C28(1.31)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C28(1.07)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C28(1.09)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C28(1.27)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C28(1.55)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C28(1.29)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C28(1.13)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C28(1.23)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C28(0.98)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C28(1.03)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C28(1.30)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C28(1.05)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C28(1.27)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C28(1.32)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C28(1.23)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C28(1.30)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C28(1.15)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C28(1.04)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C28(1.00)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C28(1.35)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C28(1.22)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C28(1.58)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C28(1.10)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C28(1.19)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C28(1.50)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C28(0.97)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C28(1.02)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C28(1.00)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C28(0.81)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C28(0.99)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C28(0.90)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C28(1.13)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C28(0.96)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C28(1.14)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C28(0.98)  LDD1060  [2]
 LDCM0463  CL70 HCT 116 C28(1.08)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C28(0.78)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C28(1.10)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C28(1.06)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C28(1.14)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C28(1.23)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C28(1.28)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C28(0.96)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C28(1.18)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C28(0.68)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C28(1.28)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C28(0.99)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C28(0.90)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C28(0.96)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C28(1.30)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C28(1.07)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C28(1.39)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C28(1.02)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C28(1.57)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C28(0.87)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C28(0.70)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C28(1.04)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C28(0.89)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C28(1.02)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C28(0.89)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C28(0.91)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C28(0.91)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C28(1.00)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C28(0.77)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C28(0.94)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C28(1.11)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C28(0.91)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C28(1.03)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C28(1.10)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C28(3.40)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C28(1.59)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C28(1.96)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH) PIGH family Q14442
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP) PIGP family P57054
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (PIGQ) PIGQ family Q9BRB3
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (PIGY) . Q3MUY2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DPM2 family O94777

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402