Details of the Target

General Information of Target

Target ID LDTP03704
Target Name Glypican-1 (GPC1)
Gene Name GPC1
Gene ID 2817
Synonyms
Glypican-1 [Cleaved into: Secreted glypican-1]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLR
ICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSER
TLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHP
QLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV
PLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLI
TDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRR
RGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMA
RGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQD
ASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTF
LLPLLLFLALTVARPRWR
Target Bioclass
Other
Family
Glypican family
Subcellular location
Lipid-anchor, GPI-anchor; Secreted, extracellular space; Extracellular side; Cell membrane
Function
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
Uniprot ID
P35052
Ensemble ID
ENST00000264039.7
HGNC ID
HGNC:4449

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.D496H .
HUCCT1 SNV: p.S395R .
JURKAT SNV: p.A129T .
MFE319 SNV: p.S316N .
OCIAML2 SNV: p.Q385K .
SKMEL28 SNV: p.A220G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K358(1.32); K383(1.73); K461(1.89); K277(2.26)  LDD3494  [1]
BTD
 Probe Info  		C343(0.90)  LDD2107  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C268(1.02)  LDD0531  [4]
IA-alkyne
 Probe Info  		C343(0.00); C401(0.00)  LDD0162  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
IPM
 Probe Info  		C343(0.00); C191(0.00)  LDD2156  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
NAIA_5
 Probe Info  		C246(0.00); C343(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C343(0.37)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C268(1.02)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C343(0.93)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C343(0.88)  LDD0543  [4]
 LDCM0237  AC12 HCT 116 C343(0.88)  LDD0554  [4]
 LDCM0259  AC14 HCT 116 C343(0.80)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C268(1.19)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C268(0.88)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C268(0.94)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C268(0.81)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C268(0.90)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C268(0.78)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C268(0.58)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C343(0.83)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C268(1.06)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C268(1.15)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C268(0.83)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C268(0.78)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C268(0.83)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C268(0.90)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C268(0.86)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C268(0.99)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C343(1.09)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C343(1.29)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C343(1.21)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C268(0.97)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C343(1.16)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C343(0.97)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C343(1.02)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C343(0.99)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C343(1.06)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C343(0.85)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C343(0.87)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C343(0.95)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C343(0.96)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C343(0.90)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C268(1.03)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C343(0.98)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C343(0.83)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C343(1.15)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C343(0.96)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C343(0.94)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C343(0.98); C268(1.03)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C268(0.89); C343(0.98)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C268(0.84); C343(0.85)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C268(0.85); C343(1.03)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C268(1.05); C343(1.16)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C268(1.25)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C268(0.77); C343(0.93)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C343(0.87); C268(0.91)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C268(0.77); C343(0.96)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C268(0.76); C343(0.90)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C268(0.79); C343(0.96)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C343(0.92); C268(0.96)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C343(1.08); C268(1.26)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C343(1.02); C268(1.20)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C343(1.07); C268(1.17)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C268(1.24); C343(1.39)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C268(0.95)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C343(1.06); C268(1.30)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C343(1.00); C268(1.38)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C343(0.90); C268(1.21)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C268(1.10); C343(1.44)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C343(0.91); C268(1.25)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C343(0.95); C268(1.16)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C343(0.94); C268(1.30)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C343(0.90)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C343(0.81)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C343(0.79)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C343(0.89)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C343(0.87)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C343(0.88)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C343(0.86)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C343(0.87)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C343(0.93)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C343(0.88)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C343(0.90)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C343(0.80)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C343(1.02); C268(1.11)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C343(0.92); C268(1.01)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C343(0.99)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C268(0.89); C343(0.94)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C343(1.09); C268(1.43)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C343(0.90); C268(0.94)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C343(0.91); C268(1.27)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C268(0.64); C343(0.80)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C343(0.90); C268(0.97)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C343(1.00); C268(1.16)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C343(0.96); C268(1.81)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C268(0.84); C343(1.01)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C343(1.06); C268(1.08)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C343(0.87)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C268(0.74); C343(0.93)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C268(0.68); C343(1.00)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C268(0.65); C343(0.83)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C343(0.77)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C343(0.73)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C343(0.74)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C343(0.80)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C343(0.91)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C343(0.92)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C343(0.81)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C343(0.93)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C343(0.82)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C343(0.89)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C343(0.84)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C343(0.75)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C343(0.86)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C343(0.86)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C343(0.81)  LDD0681  [4]
 LDCM0248  AKOS034007472 HCT 116 C343(0.96)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C343(0.91)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C343(0.77)  LDD0592  [4]
 LDCM0367  CL1 HCT 116 C343(0.87)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C343(0.75)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C268(1.02)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C343(0.86)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C343(0.90)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C343(0.91)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C343(0.91)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C343(1.08)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C343(1.04)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C343(1.18)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C343(1.12)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C343(1.10)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C343(0.81)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C343(1.02)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C343(1.01)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C343(1.13)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C343(0.93)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C343(0.94)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C343(0.93)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C343(1.07)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C268(0.67); C343(0.94)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C343(0.95); C268(1.00)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C343(0.93); C268(1.06)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C343(0.94)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C268(0.78); C343(0.94)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C268(0.97); C343(1.61)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C343(0.82); C268(1.00)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C343(0.82); C268(0.96)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C268(1.05); C343(1.18)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C343(1.03)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C343(0.76)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C343(0.92)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C343(0.86)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C343(0.66)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C343(0.82)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C343(0.76)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C343(0.92)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C343(1.07)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C343(0.90)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C343(1.07)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C343(1.05)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C343(1.00)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C343(0.97)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C343(1.02)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C343(1.00)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C343(1.01)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C343(0.75)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C343(0.95)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C343(1.05)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C343(0.80)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C343(0.94)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C343(1.04)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C343(0.99)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C268(0.84); C343(0.67)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C268(1.09); C343(0.62)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C268(0.98); C343(0.40)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C268(1.02); C343(0.64)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C268(1.11); C343(0.52)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C268(0.88); C343(0.56)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C268(1.12); C343(0.57)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C268(1.09); C343(0.63)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C343(0.74)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C268(0.79); C343(0.60)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C268(0.95); C343(0.66)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C268(0.89); C343(0.81)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C268(1.12); C343(0.52)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C268(1.02); C343(0.61)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C268(1.02); C343(0.68)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C343(1.22); C191(0.95); C401(1.03)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C343(1.37); C191(1.00); C401(1.08)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C191(0.98); C401(1.07)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C343(0.94); C279(1.08); C191(0.88); C401(1.05)  LDD1643  [10]
 LDCM0440  CL5 HCT 116 C343(1.03)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C343(1.07); C279(1.15); C191(0.98); C401(1.01)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C343(1.12); C191(0.85); C401(0.96)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C343(1.28); C279(1.05); C191(1.20); C401(1.11)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C279(1.17); C191(1.10); C401(1.10)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C343(1.55); C279(1.11); C191(0.97)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C343(1.38); C279(1.23); C191(1.07); C401(1.11)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C343(1.55); C279(2.16); C191(1.11); C401(1.08)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C343(1.20); C191(1.02); C401(1.02)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C343(1.33); C191(0.97); C401(1.21)  LDD1653  [10]
 LDCM0451  CL6 HCT 116 C343(0.79)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C191(0.98); C401(1.10)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C343(0.91); C279(1.03); C191(0.97); C401(0.79)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C343(0.96); C279(0.98); C191(0.98); C401(1.02)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C343(0.98); C279(1.00); C191(0.99); C401(0.94)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C343(1.08); C191(1.09); C401(0.96)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C343(1.14); C279(0.99); C191(0.97); C401(1.08)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C279(0.88); C191(1.04); C401(1.09)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C343(1.35); C279(1.02); C191(1.07)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C343(1.27); C279(1.20); C191(0.99); C401(1.07)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C343(1.24); C279(1.50); C191(0.94); C401(1.11)  LDD1664  [10]
 LDCM0462  CL7 HCT 116 C343(0.91)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C343(1.19); C191(1.09); C401(1.06)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C343(1.47); C191(1.02); C401(1.13)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C191(1.02); C401(1.00)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C343(0.97); C279(0.92); C191(0.99); C401(1.04)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C343(0.92); C279(1.03); C191(0.99); C401(1.04)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C343(1.03); C191(0.99); C401(0.99)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C343(1.15); C279(0.91); C191(1.14); C401(1.05)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C279(0.82); C191(1.06); C401(1.09)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C343(1.38); C279(0.99); C191(1.14)  LDD1675  [10]
 LDCM0473  CL8 HCT 116 C343(0.67)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C343(1.15); C279(1.40); C191(1.00); C401(1.07)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C343(1.23); C279(1.51); C191(1.05); C401(1.04)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C343(1.17); C191(1.18); C401(1.07)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C343(1.37); C191(0.99); C401(1.23)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C191(1.01); C401(1.08)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C343(0.95); C279(1.03); C191(0.99); C401(1.03)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C343(0.95); C279(0.67); C191(0.87); C401(1.00)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C343(0.96); C279(1.12); C191(1.04); C401(1.05)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C343(0.86); C191(1.05); C401(0.91)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C343(1.10); C279(1.08); C191(1.01); C401(0.96)  LDD1686  [10]
 LDCM0484  CL9 HCT 116 C343(1.13)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C279(2.10); C191(1.16); C401(1.21)  LDD1688  [10]
 LDCM0486  CL91 HCT 116 C268(1.15)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C268(1.13)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C268(1.03)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C268(0.87)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C268(0.92)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C268(1.00)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C268(0.98)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C268(1.29)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C268(1.16)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C343(0.99); C279(1.04); C191(0.95); C401(0.98)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C343(0.93); C279(1.05); C191(1.08); C401(1.07)  LDD1671  [10]
 LDCM0427  Fragment51 HCT 116 C268(0.71); C343(0.75)  LDD0744  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 A2058 C343(2.48)  LDD2253  [11]
 LDCM0023  KB03 A2058 C343(4.48)  LDD2670  [11]
 LDCM0024  KB05 SKMEL3 C191(1.40)  LDD3324  [11]
 LDCM0109  NEM HeLa H58(0.00); H82(0.00)  LDD0223  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C343(0.90)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C343(1.03)  LDD2109  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C343(0.72)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C343(0.48)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C343(0.41)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C343(0.91)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C343(0.83)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 179 (GPR179) G-protein coupled receptor 3 family Q6PRD1

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840