Details of the Target

General Information of Target

Target ID LDTP02671
Target Name Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)
Gene Name ATP1A3
Gene ID 478
Synonyms
Sodium/potassium-transporting ATPase subunit alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; EC 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQE
ILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNL
YLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDL
VEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCV
EGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILS
LILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGST
STICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNR
AVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQL
SIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGE
RVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAG
IKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDL
KDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADI
GVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPF
LLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLI
SMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQ
RKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSY
CPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
Subcellular location
Cell membrane
Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Uniprot ID
P13637
Ensemble ID
ENST00000543770.5
HGNC ID
HGNC:801
ChEMBL ID
CHEMBL2095186

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.Q157R DBIA    Probe Info 
CCK81 SNV: p.T272M .
DU145 SNV: p.K615N DBIA    Probe Info 
GB1 Insertion: p.N787QfsTer19 .
HEC1 SNV: p.I945V .
HGC27 SNV: p.A587E .
HT SNV: p.Y105C .
KYSE180 SNV: p.G699D .
LN229 SNV: p.A527V .
LS123 SNV: p.A98V DBIA    Probe Info 
MCC13 SNV: p.G938S
Substitution: p.A244T		 .
MDST8 SNV: p.G66R DBIA    Probe Info 
MOLT4 SNV: p.M168I IA-alkyne    Probe Info 
NCIH1155 SNV: p.R930Q DBIA    Probe Info 
OVK18 SNV: p.M579V DBIA    Probe Info 
PC14 SNV: p.K81M DBIA    Probe Info 
PC9 SNV: p.K81M .
SNU1 SNV: p.P273S DBIA    Probe Info 
TE8 SNV: p.E540K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C521(3.60); C62(1.05)  LDD3311  [1]
AHL-Pu-1
 Probe Info  		C364(2.27)  LDD0169  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C653(0.00); C449(0.00); C508(0.00); C546(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C449(0.00); C418(0.00); C49(0.00); C695(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C449(0.00); C508(0.00); C418(0.00); C49(0.00)  LDD0037  [3]
Compound 11
 Probe Info  		N.A.  LDD2213  [4]
IPM
 Probe Info  		C49(0.00); C653(0.00)  LDD2156  [5]
Acrolein
 Probe Info  		C364(0.00); C695(0.00); C418(0.00)  LDD0217  [6]
Cinnamaldehyde
 Probe Info  		C418(0.00); C695(0.00)  LDD0220  [6]
Crotonaldehyde
 Probe Info  		C418(0.00); C364(0.00); C695(0.00)  LDD0219  [6]
Methacrolein
 Probe Info  		C695(0.00); C364(0.00)  LDD0218  [6]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe6
 Probe Info  		6.77  LDD0467  [7]
STS-2
 Probe Info  		N.A.  LDD0138  [8]
LD-F
 Probe Info  		E352(0.00); A353(0.00); V354(0.00); E355(0.00)  LDD0015  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C364(2.27)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C49(1.06); C653(0.99); C221(1.06); C546(0.78)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C49(0.99); C653(1.04); C221(0.91); C546(1.00)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C49(0.98); C653(0.87); C221(0.99); C546(1.19)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C49(0.94); C653(0.82); C221(1.01); C546(0.92)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C49(1.10); C653(1.15); C546(0.96)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C49(0.90); C653(0.92); C221(1.01); C546(0.86)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C49(0.98); C653(1.04); C221(0.92); C546(0.88)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C49(0.92); C653(1.00); C221(0.82); C546(0.98)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C49(1.35); C653(1.04); C221(0.75); C546(0.99)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C49(0.90); C653(1.04); C221(0.95); C546(1.27)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C49(0.91); C653(0.86); C221(0.86); C546(0.79)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C49(0.98); C653(0.95); C546(0.84)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C49(1.06); C653(1.07); C546(1.08)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C49(0.90); C653(1.00); C221(1.00); C546(1.10)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C49(0.96); C653(0.98)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C49(1.03); C653(1.04); C221(0.87); C546(0.75)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C49(0.91); C653(1.01); C221(0.97); C546(0.96)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C49(0.97); C653(0.95); C221(0.96); C546(1.15)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C49(0.91); C653(1.00); C221(0.90); C546(0.91)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C49(0.97); C653(0.99); C546(1.20)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C49(1.03); C653(0.89); C221(0.93); C546(1.15)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C49(1.06); C653(1.07); C546(0.92)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C49(0.98); C653(1.00); C221(0.82); C546(0.94)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C49(0.94); C653(1.06)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C49(0.99); C653(1.02); C221(1.08); C546(0.81)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C49(0.99); C653(0.99); C221(0.92); C546(1.11)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C49(1.03); C653(0.93); C221(0.94); C546(1.21)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C49(0.95); C653(0.89); C221(0.90); C546(0.91)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C49(0.95); C653(0.91); C546(0.90)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C49(1.00); C653(0.99); C546(0.95)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C49(0.98); C653(1.02); C221(0.90); C546(0.93)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C49(0.99); C653(0.80); C221(1.03); C546(1.18)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C49(1.03); C653(1.01)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C49(1.02); C653(1.05); C221(1.03); C546(0.80)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C49(1.00); C653(0.95); C221(0.90); C546(1.22)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C49(1.00); C653(0.86); C221(0.92); C546(1.28)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C49(0.88); C653(0.77); C221(0.94); C546(0.96)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C49(0.93); C653(0.99); C546(1.03)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C49(1.03); C653(0.95); C546(1.06)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C49(1.00); C653(0.90); C221(0.92); C546(0.90)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C49(1.06); C653(0.89)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C49(1.03); C653(0.93); C221(1.02); C546(0.80)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C49(0.93); C653(0.93); C546(0.87)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C49(0.95); C653(1.01); C221(1.02); C546(0.92)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C49(1.00); C653(0.93); C221(1.00); C546(1.19)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C49(0.91); C653(0.80); C221(0.99); C546(0.93)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C49(0.97); C653(0.93); C546(0.95)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C49(0.96); C653(0.91); C546(1.10)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C49(1.01); C653(0.95); C221(0.93); C546(0.97)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C49(0.99); C653(0.91)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C49(1.01); C653(0.95); C221(1.02); C546(1.15)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C49(1.01); C653(0.92); C221(0.96); C546(1.04)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C49(1.00); C653(0.87); C221(0.97); C546(1.27)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C49(0.99); C653(0.97); C546(1.12)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C49(1.00); C653(0.88); C221(0.90); C546(0.78)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C49(0.95); C653(0.88); C546(1.07)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C49(1.02); C653(0.86); C546(1.03)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C49(1.03); C653(0.95); C221(1.00); C546(0.99)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C49(1.04); C653(0.92)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C49(0.90); C653(0.98); C221(1.03); C546(0.96)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C49(1.01); C653(1.01)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C49(0.99); C653(0.90); C546(0.88)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C49(1.01); C653(1.05); C221(1.02); C546(0.98)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C49(1.01); C653(0.98)  LDD1514  [10]
 LDCM0108  Chloroacetamide HeLa C364(0.00); C418(0.00); C346(0.00); C695(0.00)  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C49(0.86); C653(0.97); C221(1.16); C546(1.35)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C49(1.32); C653(1.15); C546(0.83)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C49(0.99); C653(0.93); C546(1.45)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C49(0.94); C653(0.93); C221(0.87); C546(1.20)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C49(1.04); C653(0.90); C221(1.08)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C49(0.92); C653(1.09); C221(1.00); C546(0.86)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C49(0.99); C653(0.92); C546(0.99)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C49(0.99); C653(0.92); C221(1.06); C546(0.96)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C49(0.83); C653(0.96); C221(1.02)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C49(0.97); C653(1.02); C221(0.98); C546(0.93)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C49(1.05); C653(0.92); C546(1.15)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C49(0.95); C653(0.96); C221(1.00); C546(0.94)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C49(0.96); C653(1.10); C221(1.15); C546(0.69)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C49(0.87); C653(1.02); C221(0.94)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C49(0.94); C653(1.06); C221(0.92); C546(1.04)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C49(1.16); C653(0.98); C546(0.84)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C49(0.91); C653(1.04); C221(0.94); C546(1.26)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C49(0.95); C653(1.02); C221(0.97)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C49(0.95); C653(1.05); C221(1.03); C546(1.26)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C49(0.96); C653(0.97); C546(1.46)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C49(0.95); C653(0.94); C221(1.07); C546(1.48)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C49(0.97); C653(0.88); C221(1.04)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C49(0.94); C653(1.01); C221(1.02); C546(1.03)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C49(1.08); C653(1.16)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C49(1.00); C653(0.94); C546(1.35)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C49(0.92); C653(0.83); C221(1.04); C546(1.28)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C49(0.99); C653(0.86); C221(0.99)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C49(0.81); C653(0.99); C221(0.90); C546(0.76)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C49(1.03); C653(0.83); C546(1.28)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C49(0.88); C653(0.73); C221(1.09); C546(1.03)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C49(1.09); C653(0.79); C221(0.98)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C49(1.04); C653(0.87); C221(0.83); C546(1.28)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C49(1.08); C653(0.88); C546(1.13)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C49(0.95); C653(0.85); C221(1.04); C546(1.12)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C49(0.95); C653(0.91); C221(1.04)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C49(0.78); C653(1.06); C221(1.01); C546(0.84)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C49(0.97); C653(0.99); C546(1.08)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C49(0.88); C653(0.98); C221(1.06); C546(0.66)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C49(0.96); C653(0.97); C221(0.99); C546(1.24)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C49(1.07); C653(0.82); C221(1.05); C546(0.75)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C49(1.02); C653(0.92); C221(1.14)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C49(0.99); C653(0.82); C221(1.14); C546(0.97)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C49(0.96); C653(0.90); C546(0.75)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C49(1.11); C653(1.11); C546(0.87)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C49(1.10); C653(1.06); C221(1.23); C546(0.85)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C49(1.08); C653(1.07)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C49(0.89); C653(0.84); C221(1.04); C546(1.18)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C49(0.96); C653(0.95); C221(1.10)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C49(0.97); C653(1.02); C221(0.95); C546(1.10)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C49(0.99); C653(0.97); C546(1.13)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C49(0.95); C653(0.99); C221(1.04); C546(0.89)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C49(0.92); C653(1.02); C221(1.10); C546(0.92)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C49(1.04); C653(0.99); C221(0.99); C546(1.05)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C49(0.99); C653(0.84); C221(1.04); C546(0.87)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C49(0.90); C653(0.81); C221(1.02); C546(0.96)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C49(0.85); C653(0.98); C546(0.86)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C49(1.16); C653(1.02); C546(0.84)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C49(1.10); C653(1.02); C221(1.18); C546(0.68)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C49(1.10); C653(1.03)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C49(0.79); C653(0.89); C221(1.00); C546(1.31)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C49(0.92); C653(0.91); C221(0.96); C546(1.10)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C49(0.91); C653(0.90); C546(0.85)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C49(0.98); C653(1.01); C546(1.20)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C49(1.29); C653(1.04); C221(0.95); C546(0.81)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C49(0.99); C653(0.92); C221(0.88); C546(1.33)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C49(0.95); C653(0.88); C221(0.91); C546(1.01)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C49(0.95); C653(0.79); C221(1.12); C546(0.71)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C49(0.97); C653(0.94); C546(0.86)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C49(1.14); C653(0.89); C546(0.93)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C49(1.07); C653(1.00); C221(1.08); C546(0.67)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C49(1.16); C653(1.03)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C49(0.91); C653(0.81); C221(1.13); C546(1.91)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C49(0.99); C653(0.89); C221(1.01); C546(0.90)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C49(1.08); C653(0.92); C221(1.05)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C49(1.01); C653(1.01); C546(1.01)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C49(1.09); C653(1.00); C221(1.07); C546(0.62)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C49(0.86); C653(0.98); C221(0.90); C546(0.76)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C49(1.06); C653(0.93); C221(0.94); C546(1.06)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C49(0.94); C653(0.76); C221(1.08); C546(0.78)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C49(0.94); C653(0.95); C546(0.92)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C49(1.02); C653(1.01); C546(0.75)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C49(0.99); C653(0.94); C221(1.14); C546(0.82)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C49(0.86); C653(0.95); C221(0.93); C546(0.89)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C49(1.12); C653(1.02)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C49(0.89); C653(0.91); C221(0.98); C546(1.15)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C49(0.99); C653(0.96); C221(1.19)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C49(1.01); C653(0.99); C221(1.02); C546(1.20)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C49(0.90); C653(0.97); C546(1.24)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C49(1.02); C653(1.01); C221(1.14); C546(0.99)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C49(0.95); C653(0.88); C221(1.00); C546(1.04)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C49(0.96); C653(0.89); C221(1.05); C546(0.89)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C49(0.95); C653(0.76); C221(1.25); C546(0.70)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C49(1.02); C653(0.86); C546(0.79)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C49(1.15); C653(0.87); C221(1.05); C546(0.94)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C49(1.20); C653(0.95); C546(0.90)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C49(1.10); C653(0.93); C221(1.18); C546(0.89)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C49(1.04); C653(1.02)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C49(0.86); C653(0.85); C221(1.04); C546(1.30)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C49(1.11); C653(0.86); C221(1.08)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C49(1.03); C653(0.93); C546(1.08)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C49(0.97); C653(0.91); C221(1.00); C546(0.64)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C49(0.96); C653(0.97); C221(1.05); C546(1.23)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C49(0.95); C653(0.88); C221(0.95); C546(1.11)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C49(1.06); C653(0.82); C221(0.83); C546(0.83)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C49(0.91); C653(0.76); C221(1.00); C546(0.81)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C49(0.96); C653(0.90); C546(0.94)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C49(1.07); C653(0.97); C546(0.90)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C49(1.10); C653(0.92); C221(0.98); C546(0.89)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C49(0.99); C653(0.98)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C49(0.93); C653(0.83); C221(1.01); C546(1.78)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C49(1.18); C653(0.80); C221(0.99)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C49(0.89); C653(0.82); C221(0.94); C546(1.08)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C49(1.05); C653(0.79); C546(1.13)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C49(1.02); C653(0.84); C221(1.08); C546(0.99)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C49(0.90); C653(0.90); C546(0.90)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C49(0.85); C653(0.95); C221(0.71); C546(0.97)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C49(0.94); C653(0.68); C221(0.93); C546(1.19)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C49(0.95); C653(0.73); C221(0.97); C546(0.89)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C49(0.91); C653(0.87); C546(0.96)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C49(1.02); C653(0.90); C546(1.09)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C49(0.90); C653(0.93); C221(0.97); C546(0.67)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C49(1.08); C653(0.90)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C49(0.98); C653(0.88); C221(1.00); C546(1.60)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C49(1.07); C653(0.96); C221(1.12)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C49(0.97); C653(0.95); C221(0.91); C546(0.91)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C49(0.84); C653(1.01); C221(1.15); C546(0.89)  LDD1698  [10]
 LDCM0625  F8 Ramos C201(1.87); C695(1.43); C49(2.43); C546(0.73)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C201(0.66); C695(2.89); C49(1.86); C546(0.53)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C201(0.80); C695(0.18); C49(1.18); C546(0.15)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C201(1.09); C695(5.62); C49(0.78); C546(0.73)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C201(1.59); C695(1.17); C49(0.70); C546(0.92)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C201(1.17); C695(6.15); C49(1.35); C546(1.78)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C201(1.14); C695(8.24); C49(0.72); C546(0.90)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C201(1.37); C695(1.40); C49(0.95); C546(1.22)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C201(0.51); C695(1.07); C49(1.14); C546(0.69)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C201(1.47); C695(0.98); C49(0.98); C546(1.06)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C201(0.54); C695(0.92); C49(0.79); C546(1.14)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C201(1.98); C695(1.19); C49(0.77); C546(0.51)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C201(1.81); C695(1.77); C49(1.00); C546(0.91)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C201(1.09); C695(5.77); C49(1.11); C546(0.43)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C49(0.94); C653(0.92); C221(1.09); C546(0.99)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C201(1.84); C695(1.65); C49(1.28); C546(3.37)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C201(0.82); C695(5.20); C49(1.03); C546(0.84)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C49(1.00); C653(0.99); C221(1.11)  LDD1631  [10]
 LDCM0610  Fragment52 Ramos C201(2.47); C695(1.10); C49(0.45); C546(0.52)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C201(3.91); C695(1.07); C49(1.06); C546(1.24)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C201(0.59); C695(4.16); C49(2.57); C546(0.83)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C201(0.77); C695(10.79); C49(0.80); C546(0.79)  LDD2188  [11]
 LDCM0107  IAA HeLa C364(0.00); H610(0.00); C695(0.00); C418(0.00)  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C221(1.09); C49(0.93); C653(1.03)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C221(0.96); C49(1.00); C653(0.85)  LDD1497  [10]
 LDCM0024  KB05 G361 C521(3.60); C62(1.05)  LDD3311  [1]
 LDCM0109  NEM HeLa C695(0.00); H610(0.00)  LDD0223  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C346(1.05)  LDD2206  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C364(0.85); C695(0.78); C346(0.61)  LDD2207  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eyes absent homolog 3 (EYA3) EYA family Q99504
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-related ovarian killer protein (BOK) Bcl-2 family Q9UMX3
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 49 (ZBTB49) Krueppel C2H2-type zinc-finger protein family Q6ZSB9
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Achaete-scute homolog 4 (ASCL4) . Q6XD76
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuropeptide FF receptor 1 (NPFFR1) G-protein coupled receptor 1 family Q9GZQ6
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Protein INCA1 (INCA1) INCA family Q0VD86
Syncoilin (SYNC) Intermediate filament family Q9H7C4
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Ski-like protein (SKIL) SKI family P12757
Protein spire homolog 1 (SPIRE1) Spire family Q08AE8
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
TP53-binding protein 1 (TP53BP1) . Q12888

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ouabain Small molecular drug DB01092
Bisacodyl . DB09020

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.