Details of the Target

General Information of Target

Target ID LDTP01799
Target Name Urokinase-type plasminogen activator (PLAU)
Gene Name PLAU
Gene ID 5328
Synonyms
Urokinase-type plasminogen activator; U-plasminogen activator; uPA; EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
Target Type
Successful
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
TTD ID
T17758
Uniprot ID
P00749
DrugMap ID
TTGY7WI
Ensemble ID
ENST00000372764.4
HGNC ID
HGNC:9052
ChEMBL ID
CHEMBL3286

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
L428 SNV: p.Q290Ter DBIA    Probe Info 
MDAMB453 SNV: p.H25Y .
MFE319 Insertion: p.P379TfsTer88 DBIA    Probe Info 
MOLT4 SNV: p.Q136K .
OCUG1 SNV: p.P160S DBIA    Probe Info 
RCC10RGB SNV: p.Q26Ter .
SNGM SNV: p.G117R .
SNU1 SNV: p.H61Y .
SW1573 Deletion: p.G392EfsTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.29  LDD0402  [1]
STPyne
 Probe Info  		K253(1.41); K66(2.98)  LDD0277  [2]
BTD
 Probe Info  		C345(0.61)  LDD2091  [3]
IPM
 Probe Info  		C345(1.43)  LDD1702  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C372(1.73); C382(1.73)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
NAIA_4
 Probe Info  		C70(0.00); C345(0.00)  LDD2226  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C345(0.68)  LDD2132  [3]
 LDCM0214  AC1 PaTu 8988t C382(0.30); C372(0.30); C299(0.84); C313(0.84)  LDD1093  [5]
 LDCM0215  AC10 PaTu 8988t C382(1.54); C372(1.54); C299(1.08); C313(1.08)  LDD1094  [5]
 LDCM0216  AC100 PaTu 8988t C299(1.25); C313(1.25)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C299(1.21); C313(1.21)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C299(1.29); C313(1.29)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C299(1.37); C313(1.37)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C299(1.37); C313(1.37)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C299(1.24); C313(1.24)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C299(1.24); C313(1.24)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C299(1.21); C313(1.21)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C299(1.36); C313(1.36)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C299(1.34); C313(1.34)  LDD1104  [5]
 LDCM0226  AC11 PaTu 8988t C382(1.61); C372(1.61); C299(0.99); C313(0.99)  LDD1105  [5]
 LDCM0227  AC110 PaTu 8988t C299(1.54); C313(1.54)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C299(1.30); C313(1.30)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C299(1.34); C313(1.34)  LDD1108  [5]
 LDCM0230  AC113 PaTu 8988t C299(0.90); C313(0.90)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C299(1.35); C313(1.35)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C299(1.05); C313(1.05)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C299(0.91); C313(0.91)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C299(1.18); C313(1.18)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C299(1.20); C313(1.20)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C299(1.17); C313(1.17)  LDD1115  [5]
 LDCM0237  AC12 PaTu 8988t C382(1.39); C372(1.39); C299(1.20); C313(1.20)  LDD1116  [5]
 LDCM0238  AC120 PaTu 8988t C299(1.15); C313(1.15)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C299(1.00); C313(1.00)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C299(1.19); C313(1.19)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C299(1.00); C313(1.00)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C299(1.18); C313(1.18)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C299(1.46); C313(1.46)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C299(1.00); C313(1.00)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C299(1.10); C313(1.10)  LDD1124  [5]
 LDCM0246  AC128 PaTu 8988t C53(1.10); C372(1.37); C51(1.10); C299(0.96)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C53(1.10); C372(0.98); C51(1.10); C299(1.10)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C53(1.20); C372(1.12); C51(1.20); C299(1.11)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C53(1.29); C372(1.17); C51(1.29); C299(1.09)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C53(1.09); C372(1.10); C51(1.09); C299(1.23)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C53(1.42); C372(0.95); C51(1.42); C299(1.33)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C53(1.05); C372(1.28); C51(1.05); C299(1.20)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C53(0.88); C372(1.01); C51(0.88); C299(1.11)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C53(1.24); C372(1.01); C51(1.24); C299(1.26)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C53(0.95); C372(0.96); C51(0.95); C299(1.17)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C53(1.30); C372(0.97); C51(1.30); C299(1.16)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C53(1.18); C372(0.99); C51(1.18); C299(1.04)  LDD1137  [5]
 LDCM0259  AC14 PaTu 8988t C382(2.10); C372(2.10); C299(1.01); C313(1.01)  LDD1138  [5]
 LDCM0260  AC140 PaTu 8988t C53(1.32); C372(0.96); C51(1.32); C299(1.17)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C53(1.22); C372(0.93); C51(1.22); C299(1.06)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C53(1.34); C372(0.83); C51(1.34); C299(1.17)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C372(1.69); C51(1.06); C299(1.24); C313(1.24)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C372(1.87); C51(1.09); C299(1.31); C313(1.31)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C372(1.40); C51(1.14); C299(1.22); C313(1.22)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C372(1.26); C51(0.77); C299(1.55); C313(1.55)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C372(1.00); C51(0.92); C299(1.21); C313(1.21)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C372(0.97); C51(1.37); C299(1.43); C313(1.43)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C372(1.57); C51(0.99); C299(1.39); C313(1.39)  LDD1148  [5]
 LDCM0270  AC15 PaTu 8988t C382(2.18); C372(2.18); C299(1.05); C313(1.05)  LDD1149  [5]
 LDCM0271  AC150 PaTu 8988t C372(1.99); C51(1.07); C299(1.25); C313(1.25)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C372(1.70); C51(1.19); C299(1.65); C313(1.65)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C372(0.98); C51(1.26); C299(1.40); C313(1.40)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C372(1.32); C51(1.46); C299(1.51); C313(1.51)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C372(1.52); C51(1.00); C299(1.54); C313(1.54)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C372(1.47); C51(1.00); C299(1.43); C313(1.43)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C372(0.99); C51(1.08); C299(1.33); C313(1.33)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C372(1.63); C51(0.91); C299(1.31); C313(1.31)  LDD2169  [5]
 LDCM0276  AC17 PaTu 8988t C51(0.99); C299(1.45); C313(1.45)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C51(1.56); C299(1.31); C313(1.31)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C51(1.13); C299(1.29); C313(1.29)  LDD1157  [5]
 LDCM0279  AC2 PaTu 8988t C382(0.22); C372(0.22); C299(0.71); C313(0.71)  LDD1158  [5]
 LDCM0280  AC20 PaTu 8988t C51(1.43); C299(1.44); C313(1.44)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C51(1.10); C299(1.26); C313(1.26)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C51(1.04); C299(1.31); C313(1.31)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C51(1.41); C299(1.46); C313(1.46)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C51(1.57); C299(1.35); C313(1.35)  LDD1163  [5]
 LDCM0285  AC25 PaTu 8988t C53(0.82); C299(0.89); C313(0.89)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C53(0.94); C299(0.93); C313(0.93)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C53(0.99); C299(0.87); C313(0.87)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C53(1.33); C299(1.04); C313(1.04)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C53(0.88); C299(0.90); C313(0.90)  LDD1168  [5]
 LDCM0290  AC3 PaTu 8988t C382(0.25); C372(0.25); C299(0.63); C313(0.63)  LDD1169  [5]
 LDCM0291  AC30 PaTu 8988t C53(0.98); C299(0.85); C313(0.85)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C53(0.90); C299(0.77); C313(0.77)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C53(0.93); C299(1.04); C313(1.04)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C53(1.18); C299(1.19); C313(1.19)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C53(1.04); C299(1.07); C313(1.07)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C53(1.29); C51(1.38); C299(1.09); C313(1.17)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C53(1.41); C51(1.52); C299(1.27); C313(1.33)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C53(1.13); C51(1.20); C299(1.15); C313(1.18)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C53(1.19); C51(1.28); C299(1.28); C313(1.27)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C53(1.42); C51(1.50); C299(1.34); C313(1.41)  LDD1179  [5]
 LDCM0301  AC4 PaTu 8988t C382(0.21); C372(0.21); C299(0.60); C313(0.60)  LDD1180  [5]
 LDCM0302  AC40 PaTu 8988t C53(1.45); C51(1.56); C299(1.57); C313(1.59)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C53(1.30); C51(1.40); C299(1.28); C313(1.30)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C53(1.36); C51(1.48); C299(1.35); C313(1.45)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C53(1.31); C51(1.41); C299(1.35); C313(1.31)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C53(1.35); C51(1.46); C299(1.47); C313(1.46)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C53(1.27); C51(1.38); C299(1.31); C313(1.33)  LDD1186  [5]
 LDCM0308  AC46 PaTu 8988t C53(1.29); C51(1.44); C299(1.37); C313(1.37)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C53(1.30); C51(1.58); C299(1.13); C313(1.13)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C53(1.27); C51(1.34); C299(1.27); C313(1.27)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C53(1.21); C51(1.32); C299(1.50); C313(1.50)  LDD1190  [5]
 LDCM0312  AC5 PaTu 8988t C382(0.24); C372(0.24); C299(0.75); C313(0.75)  LDD1191  [5]
 LDCM0313  AC50 PaTu 8988t C53(1.31); C51(1.43); C299(1.52); C313(1.52)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C53(1.23); C51(1.34); C299(2.66); C313(2.66)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C53(1.31); C51(1.36); C299(1.37); C313(1.37)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C53(1.33); C51(1.43); C299(1.68); C313(1.68)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C53(1.34); C51(1.37); C299(1.76); C313(1.76)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C53(1.02); C51(1.04); C299(1.28); C313(1.28)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C53(1.38); C51(1.26); C299(1.42); C313(1.42)  LDD1198  [5]
 LDCM0320  AC57 PaTu 8988t C299(1.71); C313(1.71)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C299(2.03); C313(2.03)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C299(1.39); C313(1.39)  LDD1201  [5]
 LDCM0323  AC6 PaTu 8988t C382(1.75); C372(1.75); C299(1.13); C313(1.13)  LDD1202  [5]
 LDCM0324  AC60 PaTu 8988t C299(1.45); C313(1.45)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C299(1.44); C313(1.44)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C299(1.56); C313(1.56)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C299(1.57); C313(1.57)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C299(1.38); C313(1.38)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C299(1.24); C313(1.24)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C299(1.74); C313(1.74)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C299(1.50); C313(1.50)  LDD1210  [5]
 LDCM0332  AC68 PaTu 8988t C51(1.33); C299(1.09); C313(1.09)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C51(1.22); C299(1.15); C313(1.15)  LDD1212  [5]
 LDCM0334  AC7 PaTu 8988t C382(1.14); C372(1.14); C299(1.17); C313(1.17)  LDD1213  [5]
 LDCM0335  AC70 PaTu 8988t C51(1.28); C299(1.17); C313(1.17)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C51(1.15); C299(1.01); C313(1.01)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C51(1.15); C299(1.15); C313(1.15)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C51(1.49); C299(1.17); C313(1.17)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C51(1.33); C299(1.04); C313(1.04)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C51(1.28); C299(1.18); C313(1.18)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C51(1.24); C299(1.14); C313(1.14)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C51(1.19); C299(1.11); C313(1.11)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C51(1.30); C299(1.10); C313(1.10)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C51(1.32); C299(1.19); C313(1.19)  LDD1223  [5]
 LDCM0345  AC8 PaTu 8988t C382(0.94); C372(0.94); C299(0.87); C313(0.87)  LDD1224  [5]
 LDCM0346  AC80 PaTu 8988t C51(1.14); C299(1.20); C313(1.20)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C51(1.30); C299(1.26); C313(1.26)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C51(1.34); C299(1.31); C313(1.31)  LDD1227  [5]
 LDCM0349  AC83 PaTu 8988t C382(1.38); C372(1.38); C51(0.92); C299(0.99)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C382(1.33); C372(1.33); C51(0.94); C299(1.28)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C382(1.59); C372(1.59); C51(0.90); C299(0.98)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C382(1.85); C372(1.85); C51(0.80); C299(1.01)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C382(1.38); C372(1.38); C51(0.95); C299(1.03)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C382(0.96); C372(0.96); C51(0.99); C299(1.14)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C382(0.98); C372(0.98); C51(0.86); C299(1.20)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C382(1.40); C372(1.40); C51(1.17); C299(1.29)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C382(1.06); C372(1.06); C51(1.03); C299(1.21)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C382(0.94); C372(0.94); C51(0.86); C299(0.99)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C382(1.28); C372(1.28); C51(0.89); C299(1.04)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C382(1.06); C372(1.06); C51(0.95); C299(1.31)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C382(1.09); C372(1.09); C51(0.96); C299(1.18)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C382(1.07); C372(1.07); C51(0.91); C299(1.15)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C382(1.26); C372(1.26); C51(0.86); C299(1.31)  LDD1243  [5]
 LDCM0365  AC98 PaTu 8988t C299(1.20); C313(1.20)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C299(1.18); C313(1.18)  LDD1245  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C345(0.79)  LDD2113  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C382(1.75); C372(1.75); C299(0.97); C313(0.97)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C382(1.51); C372(1.51); C299(1.11); C313(1.11)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C382(2.59); C372(2.59); C299(1.15); C313(1.15)  LDD1154  [5]
 LDCM0156  Aniline NCI-H1299 12.14  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C372(1.73); C382(1.73)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C345(0.61)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 PaTu 8988t C382(1.97); C372(1.97); C299(1.30); C313(1.17)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C382(3.28); C372(3.28); C299(1.09); C313(1.04)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C382(0.31); C372(0.31); C299(0.71); C313(0.71)  LDD1248  [5]
 LDCM0370  CL101 PaTu 8988t C382(1.31); C372(1.31); C299(1.10); C313(1.10)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C382(1.20); C372(1.20); C299(1.45); C313(1.45)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C382(1.75); C372(1.75); C299(1.20); C313(1.20)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C382(1.39); C372(1.39); C299(1.18); C313(1.18)  LDD1252  [5]
 LDCM0374  CL105 PaTu 8988t C51(1.46); C299(1.48); C313(1.48)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C51(1.45); C299(1.49); C313(1.49)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C51(1.23); C299(1.34); C313(1.34)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C51(1.22); C299(1.76); C313(1.76)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C51(1.35); C299(1.37); C313(1.37)  LDD1257  [5]
 LDCM0379  CL11 PaTu 8988t C382(3.19); C372(3.19); C299(1.49); C313(1.20)  LDD1258  [5]
 LDCM0380  CL110 PaTu 8988t C51(1.24); C299(1.59); C313(1.59)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C51(1.47); C299(1.63); C313(1.63)  LDD1260  [5]
 LDCM0382  CL112 PaTu 8988t C53(0.97); C299(1.15); C313(1.15)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C53(0.90); C299(1.01); C313(1.01)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C53(0.90); C299(1.20); C313(1.20)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C53(1.25); C299(1.09); C313(1.09)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C53(0.98); C299(1.08); C313(1.08)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C53(1.30); C51(1.38); C299(1.41); C313(1.41)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C53(1.44); C51(1.52); C299(1.48); C313(1.40)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C53(1.23); C51(1.35); C299(1.22); C313(1.28)  LDD1268  [5]
 LDCM0390  CL12 PaTu 8988t C382(2.46); C372(2.46); C299(1.35); C313(1.28)  LDD1269  [5]
 LDCM0391  CL120 PaTu 8988t C53(1.25); C51(1.38); C299(1.42); C313(1.41)  LDD1270  [5]
 LDCM0392  CL121 PaTu 8988t C53(1.64); C51(2.15); C299(1.37); C313(1.37)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C53(2.25); C51(1.67); C299(1.47); C313(1.47)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C53(1.46); C51(1.61); C299(1.77); C313(1.77)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C53(1.72); C51(2.21); C299(1.56); C313(1.56)  LDD1274  [5]
 LDCM0396  CL125 PaTu 8988t C299(1.87); C313(1.87)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C299(1.65); C313(1.65)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C299(1.98); C313(1.98)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C299(1.88); C313(1.88)  LDD1278  [5]
 LDCM0400  CL13 PaTu 8988t C382(2.47); C372(2.47); C299(1.56); C313(1.51)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C382(2.72); C372(2.72); C299(2.52); C313(2.20)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C382(2.87); C372(2.87); C299(1.94); C313(1.52)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C51(1.02); C299(1.41); C313(1.41)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C51(1.19); C299(1.30); C313(1.30)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C51(0.97); C299(1.30); C313(1.30)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C51(0.91); C299(1.25); C313(1.25)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C382(2.03); C372(2.03); C299(1.58); C313(1.41)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C51(1.02); C299(1.54); C313(1.54)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C51(0.84); C299(1.42); C313(1.42)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C51(1.18); C299(1.54); C313(1.54)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C51(1.14); C299(1.16); C313(1.16)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C51(0.86); C299(1.15); C313(1.15)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C51(0.83); C299(1.26); C313(1.26)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C51(0.85); C299(1.31); C313(1.31)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C51(1.12); C299(1.22); C313(1.22)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C51(0.87); C299(1.38); C313(1.38)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C51(1.07); C299(1.09); C313(1.09)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C382(1.73); C372(1.73); C299(1.43); C313(1.27)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C51(0.83); C299(1.28); C313(1.28)  LDD1298  [5]
 LDCM0420  CL31 PaTu 8988t C382(1.52); C372(0.89); C299(1.61); C313(1.61)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C382(2.17); C372(1.28); C299(1.41); C313(1.41)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C382(1.51); C372(1.33); C299(1.32); C313(1.32)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C382(1.42); C372(1.00); C299(1.74); C313(1.74)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C299(1.68); C313(1.68); C382(1.79); C372(1.21)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C382(1.51); C372(1.35); C299(1.28); C313(1.28)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C382(2.29); C372(1.39); C299(1.54); C313(1.54)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C382(2.62); C372(1.32); C299(1.37); C313(1.37)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C382(2.52); C372(2.52); C299(1.27); C313(1.32)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C382(1.46); C372(1.77); C299(1.40); C313(1.40)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C382(1.98); C372(1.48); C299(1.46); C313(1.46)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C382(2.40); C372(1.83); C299(1.46); C313(1.46)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C382(2.78); C372(1.65); C299(1.71); C313(1.71)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C382(2.08); C372(1.47); C299(1.30); C313(1.30)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C382(1.53); C372(1.46); C299(1.57); C313(1.57)  LDD1314  [5]
 LDCM0436  CL46 PaTu 8988t C299(1.22); C313(1.22)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C299(1.35); C313(1.35)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C299(1.30); C313(1.30)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C299(1.08); C313(1.08)  LDD1318  [5]
 LDCM0440  CL5 PaTu 8988t C382(1.74); C372(1.74); C299(1.46); C313(1.49)  LDD1319  [5]
 LDCM0441  CL50 PaTu 8988t C299(1.35); C313(1.35)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C299(1.18); C313(1.18)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C299(1.09); C313(1.09)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C299(1.37); C313(1.37)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C299(1.22); C313(1.22)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C299(1.31); C313(1.31)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C299(1.19); C313(1.19)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C299(1.36); C313(1.36)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C299(1.31); C313(1.31)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C299(1.29); C313(1.29)  LDD1329  [5]
 LDCM0451  CL6 PaTu 8988t C382(2.75); C372(2.75); C299(1.71); C313(1.51)  LDD1330  [5]
 LDCM0452  CL60 PaTu 8988t C299(1.30); C313(1.30)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C51(1.28); C299(1.23); C313(1.23)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C51(1.04); C299(1.35); C313(1.35)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C51(0.82); C299(1.49); C313(1.49)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C51(0.96); C299(1.40); C313(1.40)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C51(1.01); C299(1.17); C313(1.17)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C51(1.28); C299(1.46); C313(1.46)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C51(1.17); C299(1.47); C313(1.47)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C51(1.22); C299(1.60); C313(1.60)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C51(1.09); C299(1.68); C313(1.68)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C382(2.09); C372(2.09); C299(1.66); C313(1.46)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C51(1.62); C299(1.52); C313(1.52)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C51(0.78); C299(1.43); C313(1.43)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C51(0.64); C299(1.13); C313(1.13)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C51(1.05); C299(1.69); C313(1.69)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C51(0.94); C299(1.74); C313(1.74)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C382(1.31); C299(1.42); C313(1.42)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C382(1.79); C299(1.32); C313(1.32)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C382(1.62); C299(1.37); C313(1.37)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C382(1.43); C299(1.46); C313(1.46)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C382(2.72); C372(2.72); C299(1.35); C313(1.16)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C382(1.65); C299(1.43); C313(1.43)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C382(1.60); C299(1.61); C313(1.61)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C382(1.70); C299(1.60); C313(1.60)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C382(2.22); C299(1.47); C313(1.47)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C382(1.93); C299(1.37); C313(1.37)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C382(1.73); C299(1.26); C313(1.26)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C382(1.72); C299(1.84); C313(1.84)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C382(2.29); C299(1.69); C313(1.69)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C382(1.53); C299(1.43); C313(1.43)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C382(1.75); C299(1.23); C313(1.23)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C382(2.38); C372(2.38); C299(1.72); C313(1.58)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C382(1.62); C299(1.80); C313(1.80)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C382(0.23); C372(0.23); C299(0.68); C313(0.68)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C382(0.30); C372(0.30); C299(0.79); C313(0.79)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C382(0.31); C372(0.31); C299(0.83); C313(0.83)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C382(0.27); C372(0.27); C299(0.92); C313(0.92)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C382(0.31); C372(0.31); C299(0.92); C313(0.92)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C382(0.39); C372(0.39); C299(0.75); C313(0.75)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C382(0.42); C372(0.42); C299(0.79); C313(0.79)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C382(0.39); C372(0.39); C299(0.78); C313(0.78)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C382(0.24); C372(0.24); C299(0.76); C313(0.76)  LDD1373  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C345(1.43)  LDD1702  [3]
 LDCM0468  Fragment33 PaTu 8988t C51(1.06); C299(1.58); C313(1.58)  LDD1347  [5]
 LDCM0427  Fragment51 PaTu 8988t C382(2.23); C372(1.58); C299(1.34); C313(1.34)  LDD1306  [5]
 LDCM0022  KB02 8305C C433(2.13); C361(2.23)  LDD2248  [8]
 LDCM0023  KB03 8305C C433(5.19); C361(3.15)  LDD2665  [8]
 LDCM0024  KB05 COLO792 C345(1.86); C361(3.28); C70(2.42)  LDD3310  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C345(0.66)  LDD2121  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C345(1.43)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C345(0.78)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C345(1.14)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C345(1.05)  LDD2104  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C345(0.89)  LDD2115  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C345(1.08)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C345(1.00)  LDD2127  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C345(0.98)  LDD2134  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C345(1.49)  LDD2137  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C345(1.99)  LDD2145  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C345(0.84)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C345(0.48)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disintegrin and metalloproteinase domain-containing protein 28 (ADAM28) . Q9UKQ2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amiloride Small molecular drug DB00594
Pro-urokinase . D03VNX
Urokinase . D0E8UO
Phase 4
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pai-1 Small molecular drug D03ZJE
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amediplase Small molecular drug D0G6ZG
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Upamostat Small molecular drug D03KGH
Htu-pa . D01HHJ
Saruplase . D0G5UW
Clinical trial
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid18163548c4 Small molecular drug D00EPS
Uk-356202 Small molecular drug D0G0YZ
Investigative
Click To Hide/Show 57 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2r)-1-(2,6-dimethylphenoxy)Propan-2-amine Small molecular drug D03NLL
(2r)-1-(26-dimethylphenoxy)Propan-2-amine Small molecular drug DB07129
(3,4-dichlorophenyl)(1h-pyrazol-1-yl)Methanone Small molecular drug D0X1OY
(3-nitro-1h-pyrazol-1-yl)(P-tolyl)Methanone Small molecular drug D08OCS
(4-bromo-1h-pyrazol-1-yl)(P-tolyl)Methanone Small molecular drug D05ZIP
(4-guanidino-benzyl)-carbamic Acid Benzyl Ester Small molecular drug D0F6EZ
(4-nitro-1h-pyrazol-1-yl)(O-tolyl)Methanone Small molecular drug D00WFQ
(4-nitro-1h-pyrazol-1-yl)(Phenyl)Methanone Small molecular drug D06LPR
1-benzoyl-n-phenyl-1h-pyrazole-3-carboxamide Small molecular drug D0IU5E
1-guanidino-7-isoquinolinesulphonamide Small molecular drug D0K4PK
1-guanidino-n-phenyl-7-isoquinolinesulphonamide Small molecular drug D00PEJ
1-[4-(2-oxo-2-phenylethyl)Phenyl]Guanidine Small molecular drug D0ZM9M
2-(2-hydroxy-phenyl)-1h-indole-5-carboxamidine Small molecular drug D08OLP
2-amino-1h-benzimidazol-5-ol Small molecular drug DB03729
2-amino-5-hydroxy-benzimidazole Small molecular drug D09KKF
2-nas-phe(3-am)-4-(2-guanidinoethyl)Piperidine Small molecular drug D0SP2I
4-chloro-1-guanidino-7-isoquinolinesulphonamide Small molecular drug D06CJP
4-iodobenzo[B]Thiophene 2-carboxamidine Small molecular drug D05MJU
4-iodobenzo[B]Thiophene-2-carboxamidine Small molecular drug DB03136
4-methoxy-n'-(2-phenylacetyl)Benzohydrazide Small molecular drug D02AKP
5-methylsulfanyl-thiophene-2-carboxamidine Small molecular drug D02XJW
6-(N-phenylcarbamyl)-2-naphthalenecarboxamidine Small molecular drug D0A8WP
Benzamidine Small molecular drug D07SFI
Cra_10655 Small molecular drug D01LCS
Cra_8696 Small molecular drug D0K7YL
Fucose Small molecular drug D0G6XS
N-(1-adamantyl)-n'-(4-guanidinobenzyl)Urea Small molecular drug D0EV6B
N-(1-adamantyl)-n'-(4-guanidinobenzyl)Urea Small molecular drug DB03782
Thieno[2,3-b]Pyridine-2-carboxamidine Small molecular drug D0B1AK
Thieno[23-b]Pyridine-2-carboxamidine Small molecular drug DB03876
2-(2-hydroxy-5-methoxy-phenyl)-1h-benzoimidazole-5-carboxamidine . DB01905
2-(2-hydroxy-phenyl)-3h-benzoimidazole-5-carboxamidine . DB02287
2-{2-hydroxy-[11'-biphenyl]-3-yl}-1h-13-benzodiazole-5-carboximidamide . DB01725
4-(2-aminoethoxy)-35-dichloro-n-[3-(1-methylethoxy)Phenyl]Benzamide . DB08072
4-(2-aminoethoxy)-n-(25-diethoxyphenyl)-35-dimethylbenzamide . DB07625
4-(2-aminoethoxy)-n-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-35-dimethylbenzamide . DB07626
4-(2-aminoethoxy)-n-(3-chloro-5-piperidin-1-ylphenyl)-35-dimethylbenzamide . DB08697
6-chloro-2-(2-hydroxy-biphenyl-3-yl)-1h-indole-5-carboxamidine . DB03865
6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1h-benzoimidazole-5-carboxamidine . DB06855
6-fluoro-2-[2-hydroxy-3-(2-methyl-cyclohexyloxy)-phenyl]-1h-indole-5-carboxamidine . DB06856
6-[(Z)-amino(Imino)Methyl]-n-[3-(Cyclopentyloxy)Phenyl]-2-naphthamide . DB07076
6-[(Z)-amino(Imino)Methyl]-n-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-ylamino)-2-naphthamide . DB03082
6-[N-(1-isopropyl-1234-tetrahydro-7-isoquinolinyl)Carbamyl]-2-naphthalenecarboxamidine . DB02705
6-[N-(1-isopropyl-34-dihydro-7-isoquinolinyl)Carbamyl]-2-naphthalenecarboxamidine . DB02473
6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-naphthalenecarboxamidine . DB02398
6-[N-(4-ethyl-1234-tetrahydro-6-isoquinolinyl)Carbamyl]-2-naphthalenecarboxamidine . DB02551
7-methoxy-8-[1-(Methylsulfonyl)-1h-pyrazol-4-yl]Naphthalene-2-carboximidamide . DB03046
8-(Pyrimidin-2-ylamino)Naphthalene-2-carboximidamide . DB04059
Atf-hi-8 . D05ABK
Atn-658 . D03BWQ
B-623 . D05DNW
Fibrinolysin . DB05254
N-(4-carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide . DB06857
Recombinant Human Pro-urokinase . D0D1TX
Trans-6-(2-phenylcyclopropyl)-naphthalene-2-carboxamidine . DB03476
Upa-targeted Oncolytic Sendai Virus . D00LDI
[246-triisopropyl-phenylsulfonyl-l-[3-amidino-phenylalanine]]-piperazine-n'-beta-alanine . DB04172
Discontinued
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pai-2 Small molecular drug D0D3VA
Wx-uk1 Small molecular drug D08INO
B-428 . D0K1PR

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840