Details of the Target

General Information of Target

Target ID LDTP01795
Target Name Coagulation factor X (F10)
Gene Name F10
Gene ID 2159
Synonyms
Coagulation factor X; EC 3.4.21.6; Stuart factor; Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Target Type
Successful
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
TTD ID
T84631
Uniprot ID
P00742
DrugMap ID
TTCIHJA
Ensemble ID
ENST00000375559.8
HGNC ID
HGNC:3528
ChEMBL ID
CHEMBL244

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C443(1.60)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C443(1.60)  LDD0531  [1]
 LDCM0216  AC100 PaTu 8988t C443(1.28)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C443(1.14)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C443(1.23)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C443(1.16)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C443(1.01)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C443(1.32)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C443(1.45)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C443(1.08)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C443(1.07)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C443(0.85)  LDD1104  [1]
 LDCM0226  AC11 HEK-293T C443(0.91)  LDD1509  [2]
 LDCM0227  AC110 PaTu 8988t C443(0.96)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C443(1.29)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C443(0.90)  LDD1108  [1]
 LDCM0230  AC113 HCT 116 C443(1.07)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C443(0.92)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C443(1.33)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C443(1.48)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C443(1.13)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C443(0.91)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C443(1.16)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C443(1.12)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C443(0.78)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C443(0.88)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C443(0.76)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C443(1.06)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C443(0.74)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C443(0.97)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C443(0.98)  LDD0562  [1]
 LDCM0259  AC14 HEK-293T C443(0.83)  LDD1512  [2]
 LDCM0278  AC19 HEK-293T C443(1.10)  LDD1517  [2]
 LDCM0279  AC2 HCT 116 C443(1.57)  LDD0596  [1]
 LDCM0282  AC22 HEK-293T C443(1.63)  LDD1521  [2]
 LDCM0284  AC24 HEK-293T C443(0.98)  LDD1523  [2]
 LDCM0285  AC25 HCT 116 C443(0.80)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C443(1.08)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C443(1.16)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C443(1.02)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C443(1.19)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C443(1.90)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C443(1.44)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C443(1.31)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C443(1.44)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C443(1.31)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C443(1.41)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C443(0.94)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C443(1.11)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C443(0.96)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C443(1.01)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C443(1.15)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C443(2.50)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C443(1.43)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C443(1.58)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C443(1.32)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C443(1.43)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C443(1.20)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C443(1.51)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C443(1.04)  LDD1547  [2]
 LDCM0310  AC48 HEK-293T C443(0.98)  LDD1549  [2]
 LDCM0312  AC5 HCT 116 C443(2.94)  LDD0629  [1]
 LDCM0314  AC51 HEK-293T C443(0.96)  LDD1553  [2]
 LDCM0317  AC54 HEK-293T C443(0.97)  LDD1556  [2]
 LDCM0319  AC56 HEK-293T C443(1.17)  LDD1558  [2]
 LDCM0322  AC59 HEK-293T C443(1.28)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C443(0.82)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C443(1.24)  LDD1565  [2]
 LDCM0328  AC64 HEK-293T C443(0.99)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C443(0.92)  LDD1569  [2]
 LDCM0349  AC83 HCT 116 C443(1.48)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C443(1.67)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C443(1.33)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C443(1.65)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C443(1.13)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C443(1.12)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C443(1.10)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C443(1.14)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C443(0.86)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C443(1.16)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C443(1.01)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C443(2.04)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C443(1.22)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C443(1.01)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C443(1.36)  LDD0681  [1]
 LDCM0365  AC98 PaTu 8988t C443(1.73)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C443(1.53)  LDD1245  [1]
 LDCM0275  AKOS034007705 HEK-293T C443(1.08)  LDD1514  [2]
 LDCM0367  CL1 HCT 116 C443(1.00)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C443(1.87)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C443(1.79)  LDD0686  [1]
 LDCM0379  CL11 HCT 116 C443(1.59)  LDD0696  [1]
 LDCM0382  CL112 HCT 116 C443(1.05)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C443(1.19)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C443(1.02)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C443(1.04)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C443(1.66)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C443(1.57)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C443(1.88)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C443(1.11)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C443(2.01)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C443(1.09)  LDD0708  [1]
 LDCM0400  CL13 HCT 116 C443(2.03)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C443(1.46)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C443(1.24)  LDD0719  [1]
 LDCM0403  CL16 PaTu 8988t C443(1.03)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C443(1.26)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C443(1.15)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C443(1.37)  LDD1285  [1]
 LDCM0407  CL2 HCT 116 C443(0.79)  LDD0724  [1]
 LDCM0408  CL20 PaTu 8988t C443(1.06)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C443(1.06)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C443(1.33)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C443(1.34)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C443(1.32)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C443(0.94)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C443(1.19)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C443(1.31)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C443(1.36)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C443(1.56)  LDD1296  [1]
 LDCM0418  CL3 HCT 116 C443(1.22)  LDD0735  [1]
 LDCM0419  CL30 PaTu 8988t C443(1.31)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C443(1.27)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C443(1.17)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C443(0.83)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C443(1.03)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C443(1.16)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C443(0.75)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C443(1.47)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C443(1.14)  LDD1307  [1]
 LDCM0429  CL4 HCT 116 C443(0.92)  LDD0746  [1]
 LDCM0430  CL40 PaTu 8988t C443(1.09)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C443(0.97)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C443(1.04)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C443(1.40)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C443(1.27)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C443(1.48)  LDD1314  [1]
 LDCM0436  CL46 HCT 116 C443(0.69)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C443(0.73)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C443(0.77)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C443(0.75)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C443(1.20)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C443(0.75)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C443(0.74)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C443(0.96)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C443(0.68)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C443(0.56)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C443(0.59)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C443(1.23)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C443(0.93)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C443(0.69)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C443(0.94)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C443(1.14)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C443(0.87)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C443(1.21)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C443(1.36)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C443(1.52)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C443(1.20)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C443(1.10)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C443(1.29)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C443(0.92)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C443(1.09)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C443(1.21)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C443(2.35)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C443(1.02)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C443(1.11)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C443(1.15)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C443(0.81)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C443(1.04)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C443(1.09)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C443(1.01)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C443(0.73)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C443(1.23)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C443(1.18)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C443(1.32)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C443(0.99)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C443(1.56)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C443(1.02)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C443(1.55)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C443(1.63)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C443(1.43)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C443(1.44)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C443(1.49)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C443(1.15)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C443(1.08)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C443(0.88)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C443(1.25)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C443(0.88)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C443(1.17)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C443(1.17)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C443(1.33)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C443(1.35)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C443(1.60)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C443(1.93)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C443(1.56)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C443(1.27)  LDD0785  [1]
 LDCM0427  Fragment51 PaTu 8988t C443(1.29)  LDD1306  [1]
 LDCM0022  KB02 HEK-293T C443(1.05)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C443(1.07)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C443(1.23)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Protein Z-dependent protease inhibitor (SERPINA10) Serpin family Q9UK55
Ubiquilin-2 (UBQLN2) . Q9UHD9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 35 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Emicizumab Antibody D09XTN
Antihemophilic Factor Human Recombinant BiotechDrug DB00025
Coagulation Factor Ix (Recombinant) BiotechDrug DB00100
Coagulation Factor Viia Recombinant Human BiotechDrug DB00036
Apixaban Small molecular drug D0I5HF
Betrixaban Small molecular drug D0J0BU
Betrixaban Small molecular drug DB12364
Du-176b Small molecular drug D0C3BS
Edoxaban Small molecular drug DB09075
Enoxaparin Small molecular drug DB01225
Fondaparinux Small molecular drug DB00569
Fondaparinux Sodium Small molecular drug D0NE9T
Heparin Small molecular drug DB01109
Kappadione Small molecular drug DB09332
Lmw Heparin Small molecular drug D08PSU
Rivaroxaban Small molecular drug D0KG3R
Albutrepenonacog Alfa . DB13884
Anti-inhibitor Coagulant Complex . DB13151
Antihemophilic Factor Human . DB13192
Antithrombin Alfa . DB11166
Bemiparin . DB09258
Certoparin Sodium . D0U7HJ
Coagulation Factor Ix . D0Q5KL
Coagulation Factor Ix Human . DB13152
Coagulation Factor Vii Human . DB13150
Danaparoid . D0P3SY
Lonoctocog Alfa . DB13998
Moroctocog Alfa . DB13999
Nadroparin Calcium . D0N2BX
Nonacog Beta Pegol . DB13933
Protamine Sulfate . DB09141
Protein S Human . DB13149
Prothrombin . DB11311
Turoctocog Alfa . DB09109
Turoctocog Alfa Pegol . DB14738
NDA/BLA
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Human Coagulation Factor X . D07JEW
Phase 3
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Melagatran Small molecular drug D01MUU
Prt4445 . D00ITC
Sr-123781a . D0VL4V
Ssr-126517e . D0P2RO
Phase 2
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ly-517717 Small molecular drug D07BRZ
Antistasin . D01FFG
Ep-217609 . D0UK1L
Gw-813893 . D0ID3W
Phase 1
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bibt986 Small molecular drug D0X2NN
Bi-11634 . D00ZPT
Ep-42675 . D0G6UQ
Gcc-4401 . D00RGF
R-1663 . D08UUD
Ssr-128428 . D02UIC
Preclinical
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Trimidox Small molecular drug D0X1ZV
Cs-3030 . D0K5WM
Investigative
Click To Hide/Show 66 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,2,3,4,6-penta-o-galloyl-beta-d-glucose Small molecular drug D00QDR
3-chlorophenyl 2-oxo-2h-chromene-3-carboxylate Small molecular drug D0P3OH
4-(4-benzyloxy-3-methoxy-benzylamino)-benzamidine Small molecular drug D02XPB
5-desgalloylstachyurin Small molecular drug D07HWB
Beta-hydroxy Aspartic Acid Small molecular drug D0Z8VP
Bms-269223 Small molecular drug D06HOI
Bms-344577 Small molecular drug D0J1QT
Bms-740808 Small molecular drug D0JU9N
Casuariin Small molecular drug D0I1UF
Ci-1031 Small molecular drug D0R5KV
D-pro-phe-arg Chloromethyl Ketone Small molecular drug D0M4VZ
Eribaxaban Small molecular drug DB06920
Gamma-carboxy-glutamic Acid Small molecular drug D06UUK
Gamma-carboxy-l-glutamic Acid Small molecular drug DB03847
Lefaxin Small molecular drug D09KKU
M55113 Small molecular drug D0I8WY
Molecule 11 Small molecular drug D0ES5A
Nafamostat Small molecular drug DB12598
Pedunculagin Small molecular drug D0Z2TG
Phso2-gly-(Me-gly)-arg-(2-thiazole) Small molecular drug D0FV9Y
Razaxaban Small molecular drug D0ON2Z
Sc-83157 Small molecular drug D06BPU
Sf303 Small molecular drug D01AUI
Sk509 Small molecular drug D00MZS
Sn429 Small molecular drug D03QAQ
Tellimagrandin Ii Small molecular drug D0E6SO
Ym-96765 Small molecular drug D07NYR
Zk-810388 Small molecular drug D0R9CH
Zk-813039 Small molecular drug D02AVL
Zk-814048 Small molecular drug D02PAU
(2r)-2-(5-chloro-2-thienyl)-n-{(3s)-1-[(1s)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}Propene-1-sulfonamide . DB07211
1-[[(1e)-2-(4-chlorophenyl)Ethenyl]Sulfonyl]-4-[[1-(4-pyridinyl)-4-piperidinyl]Methyl]Piperazine . DB08746
1-{2-[(4-chlorophenyl)Amino]-2-oxoethyl}-n-(1-isopropylpiperidin-4-yl)-1h-indole-2-carboxamide . DB07974
2-(5-chloro-2-thienyl)-n-{(3s)-1-[(1s)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}Ethanesulfonamide . DB07277
2-({4-[(5-chloro-1h-indol-2-yl)Sulfonyl]Piperazin-1-yl}Carbonyl)Thieno[32-b]Pyridine 4-oxide . DB07605
3-({4-[(6-chloro-1-benzothien-2-yl)Sulfonyl]-2-oxopiperazin-1-yl}Methyl)Benzenecarboximidamide . DB08487
4-({4-[(6-chloro-1-benzothien-2-yl)Sulfonyl]-2-oxopiperazin-1-yl}Methyl)Benzenecarboximidamide . DB08495
4-[(5-chloroindol-2-yl)Sulfonyl]-2-(2-methylpropyl)-1-[[5-(Pyridin-4-yl)Pyrimidin-2-yl]Carbonyl]Piperazine . DB04673
4-[[(1e)-2-(4-chlorophenyl)Ethenyl]Sulfonyl]-1-[[1-(4-pyridinyl)-4-piperidinyl]Methyl]Piperazinone . DB08745
4-{[(E)-2-(5-chlorothien-2-yl)Vinyl]Sulfonyl}-1-(1h-pyrrolo[32-c]Pyridin-2-ylmethyl)Piperazin-2-one . DB08488
5-(5-chloro-2-thienyl)-n-{(3s)-1-[(1s)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}-1h-124-triazole-3-sulfonamide . DB07804
5-chloro-n-((1r2s)-2-(4-(2-oxopyridin-1(2h)-yl)Benzamido) Cyclopentyl)Thiophene-2-carboxamide . DB08174
5-chloro-n-(2-(4-(2-oxopyridin-1(2h)-yl)Benzamido)Ethyl)Thiophene-2-carboxamide . DB08173
5-chloro-n-[(3r)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2h)-yl)Phenyl]Amino}-2-oxoethyl)Pyrrolidin-3-yl]Thiophene-2-carboxamide . DB07872
5-chloro-n-{(3s)-1-[(1s)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}-1-benzothiophene-2-sulfonamide . DB07843
5-chloro-n-{(3s)-1-[(2s)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1h-indole-2-sulfonamide . DB07848
5-chloro-thiophene-2-carboxylic Acid ((3s4s)-1-{[2-fluoro-4-(2-oxo-2h-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide . DB07875
5-chloro-thiophene-2-carboxylic Acid ((3s4s)-4-fluoro- 1-{[2-fluoro-4-(2-oxo-2h-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-yl)-amide . DB08143
6-chloro-n-{(3s)-1-[(1s)-1-methyl-2-(4-morpholinyl)-2-oxo Ethyl]-2-oxo-3-pyrrolidinyl}-2-naphthalenesulfonamide . DB07847
6-chloro-n-{(3s)-1-[(1s)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}-1-benzothiophene-2-sulfonamide . DB07844
Dt-831j . D09TXU
Ep-37 . D0Q2VA
Gc-2107 . D0QR3J
Lanoteplase . DB06245
N-((1r2r)-2-(5-chloro-1h-indole-2-carboxamido)Cyclohexyl)-5-methyl-4567-tetrahydrothiazolo[54-c]Pyridine-2-carboxamide . DB07630
N-((1r2s)-2-(5-chloro-1h-indole-2-carboxamido)Cyclohexyl)-5-methyl-4567-tetrahydrothiazolo[54-c]Pyridine-2-carboxamide . DB07629
N-(1-isopropylpiperidin-4-yl)-1-(3-methoxybenzyl)-1h-indole-2-carboxamide . DB07973
N-(2-(((5-chloro-2-pyridinyl)Amino)Sulfonyl)Phenyl)-4-(2-oxo-1(2h)-pyridinyl)Benzamide . DB07800
Prt-064445 . D0SP5Q
Recombinant Coagulation Factors . D0K7NJ
Recombinant Factor X . D08CEU
Rnapc2 . DB06552
Sk549 . D0Z9TY
Sk554 . D04QZF
Thieno[32-b]Pyridine-2-sulfonic Acid [1-(1-amino-isoquinolin-7-ylmethyl)-2-oxo-pyrroldin-3-yl]-amide . DB07261
Thieno[32-b]Pyridine-2-sulfonic Acid [2-oxo-1-(1h-pyrrolo[23-c]Pyridin-2-ylmethyl)-pyrrolidin-3-yl]-amide . DB08426
Discontinued
Click To Hide/Show 19 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Darexaban Maleate Small molecular drug D07OGZ
Dpc 423 Small molecular drug D03QJN
Dx-9065a Small molecular drug D0JH6W
Idraparinux Small molecular drug D0CY3A
Jtv-803 Small molecular drug D0N8JP
Octopamine Small molecular drug D0L9YS
Otamixaban Small molecular drug D0E2MJ
Pd-348292 Small molecular drug D0T4UL
R-68151 Small molecular drug D0G5GJ
Tak-442 Small molecular drug D0D5RH
Valspodar Small molecular drug D09TGX
Ym60828 Small molecular drug D0J9UI
Ave-3247 . D0L4PM
Draculin . D0K9KS
Dx-9065 . D0V2OS
Emd-503982 . D00CIF
Hirufaxin . D0Q1JW
Ym-75466 . D0G6UP
Zd-4927 . D0PG5J

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402