Details of the Target

General Information of Target

Target ID LDTP01746
Target Name E3 SUMO-protein ligase ZBED1 (ZBED1)
Gene Name ZBED1
Gene ID 9189
Synonyms
ALTE; DREF; hDREF; KIAA0785; TRAMP; E3 SUMO-protein ligase ZBED1; EC 2.3.2.-; DNA replication-related element-binding factor; Putative Ac-like transposable element; Zinc finger BED domain-containing protein 1; dREF homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENKSLESSQTDLKLVAHPRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNT
SNLSYHLEKNHPEEFCEFVKSNTEQMREAFATAFSKLKPESSQQPGQDALAVKAGHGYDS
KKQQELTAAVLGLICEGLYPASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAV
REVILKELAEATWCGISTDMWRSENQNRAYVTLAAHFLGLGAPNCLSMGSRCLKTFEVPE
ENTAETITRVLYEVFIEWGISAKVFGATTNYGKDIVKACSLLDVAVHMPCLGHTFNAGIQ
QAFQLPKLGALLSRCRKLVEYFQQSAVAMYMLYEKQKQQNVAHCMLVSNRVSWWGSTLAM
LQRLKEQQFVIAGVLVEDSNNHHLMLEASEWATIEGLVELLQPFKQVAEMLSASRYPTIS
MVKPLLHMLLNTTLNIKETDSKELSMAKEVIAKELSKTYQETPEIDMFLNVATFLDPRYK
RLPFLSAFERQQVENRVVEEAKGLLDKVKDGGYRPAEDKIFPVPEEPPVKKLMRTSTPPP
ASVINNMLAEIFCQTGGVEDQEEWHAQVVEELSNFKSQKVLGLNEDPLKWWSDRLALFPL
LPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLYENARSGAEAEPE
DQDEGEWGLDQEQVFSLGDGVSGGFFGIRDSSFL
Target Bioclass
Enzyme
Subcellular location
Nucleus, PML body
Function
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins.; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
Uniprot ID
O96006
Ensemble ID
ENST00000381218.8
HGNC ID
HGNC:447

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C76(2.02)  LDD0168  [1]
DBIA
 Probe Info  		C610(6.68)  LDD0204  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
W1
 Probe Info  		N.A.  LDD0236  [6]
AOyne
 Probe Info  		13.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C76(2.02)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C76(3.53)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C194(0.79); C38(0.79); C76(1.09)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C194(0.82); C38(0.82)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C194(0.57); C38(0.57)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C194(0.93); C38(0.93)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C194(0.52); C38(0.52)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C194(0.41); C38(0.41)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C194(0.49); C38(0.49)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C194(1.34); C38(1.34)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C194(1.92); C38(1.92)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C194(0.50); C38(0.50)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C194(0.94); C38(0.94)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C194(0.73); C38(0.73)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C194(0.83); C38(0.83)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C194(0.51); C38(0.51)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C194(0.64); C38(0.64)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C194(0.48); C38(0.48)  LDD0827  [8]
 LDCM0230  AC113 PaTu 8988t C38(0.92)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C38(1.03)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C38(0.98)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C38(1.00)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C38(0.95)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C38(0.97)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C38(1.04)  LDD1115  [8]
 LDCM0237  AC12 HEK-293T C194(0.96); C38(0.96)  LDD0835  [8]
 LDCM0238  AC120 PaTu 8988t C38(0.90)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C38(1.08)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C38(0.89)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C38(0.94)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C38(1.03)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C38(1.01)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C38(0.93)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C38(1.11)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C38(1.27)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C38(1.31)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C38(1.20)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C38(1.21)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C38(1.27)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C38(1.46)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C38(1.38)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C38(1.51)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C38(1.46)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C38(1.50)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C38(1.37)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C38(1.28)  LDD1137  [8]
 LDCM0259  AC14 HEK-293T C194(0.71); C38(0.71)  LDD0857  [8]
 LDCM0260  AC140 PaTu 8988t C38(1.36)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C38(1.23)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C38(1.35)  LDD1141  [8]
 LDCM0263  AC143 PaTu 8988t C38(1.18)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C38(1.28)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C38(0.93)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C38(1.31)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C38(1.00)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C38(1.61)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C38(1.77)  LDD1148  [8]
 LDCM0270  AC15 HEK-293T C194(0.70); C38(0.70)  LDD0868  [8]
 LDCM0271  AC150 PaTu 8988t C38(1.42)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C38(2.04)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C38(1.37)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C38(1.77)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C38(2.03)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C38(1.73)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C38(1.75)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C38(1.80)  LDD2169  [8]
 LDCM0276  AC17 HEK-293T C76(1.13)  LDD1515  [9]
 LDCM0279  AC2 HEK-293T C194(0.50); C38(0.50); C76(1.19)  LDD0877  [8]
 LDCM0281  AC21 HEK-293T C76(1.11); C38(1.10)  LDD1520  [9]
 LDCM0283  AC23 HEK-293T C76(1.09)  LDD1522  [9]
 LDCM0285  AC25 HEK-293T C76(1.26)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C76(1.32)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C76(1.29)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C76(1.57)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C76(1.36)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C194(0.70); C38(0.70); C76(1.05)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C76(1.29)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C76(1.07)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C76(1.17)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C76(1.21)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C76(1.19)  LDD0893  [8]
 LDCM0296  AC35 PaTu 8988t C38(1.23)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C38(1.55)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C38(1.48)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C38(1.32)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C38(1.59)  LDD1179  [8]
 LDCM0301  AC4 HEK-293T C194(0.96); C38(0.96); C76(1.13)  LDD0899  [8]
 LDCM0302  AC40 PaTu 8988t C38(1.73)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C38(1.45)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C38(1.51)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C38(1.34)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C38(1.72)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C38(1.48)  LDD1186  [8]
 LDCM0308  AC46 HEK-293T C194(0.68); C38(0.68)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C194(0.70); C38(0.70)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C194(0.66); C38(0.66)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C194(0.58); C38(0.58)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C194(0.74); C38(0.74); C76(1.09)  LDD0910  [8]
 LDCM0313  AC50 HEK-293T C194(0.63); C38(0.63)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C194(0.46); C38(0.46)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C194(0.41); C38(0.41)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C194(0.59); C38(0.59)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C194(0.42); C38(0.42)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C194(0.55); C38(0.55)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C194(0.56); C38(0.56)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C194(1.11); C38(1.11)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C194(1.09); C38(1.09)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C194(1.04); C38(1.04)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C194(1.03); C38(1.03)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C194(1.11); C38(1.11)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C194(0.63); C38(0.63)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C194(1.04); C38(1.04)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C194(0.77); C38(0.77)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C194(0.89); C38(0.89)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C194(0.60); C38(0.60)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C194(0.79); C38(0.79)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C194(0.70); C38(0.70)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C194(0.98); C38(0.98)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C194(0.83); C38(0.83)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C194(0.85); C38(0.85)  LDD0932  [8]
 LDCM0335  AC70 HEK-293T C194(0.85); C38(0.85)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C194(0.82); C38(0.82)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C194(0.82); C38(0.82)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C194(0.99); C38(0.99)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C194(2.04); C38(2.04)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C194(0.82); C38(0.82)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C194(0.94); C38(0.94)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C194(0.92); C38(0.92)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C194(0.84); C38(0.84)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C194(1.03); C38(1.03)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C194(0.50); C38(0.50)  LDD0943  [8]
 LDCM0346  AC80 HEK-293T C194(0.85); C38(0.85)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C194(0.95); C38(0.95)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C194(0.53); C38(0.53)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C194(2.24); C38(2.24)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C194(0.77); C38(0.77)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C194(0.89); C38(0.89)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C194(1.07); C38(1.07)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C194(0.95); C38(0.95)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C194(0.70); C38(0.70)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C194(0.62); C38(0.62)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C194(0.57); C38(0.57)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C194(0.94); C38(0.94)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C194(0.81); C38(0.81)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C194(0.81); C38(0.81)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C194(0.51); C38(0.51)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C194(0.79); C38(0.79)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C194(0.83); C38(0.83)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C194(0.51); C38(0.51)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C194(1.23); C38(1.23)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C194(0.94); C38(0.94)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C194(1.39); C38(1.39)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C194(0.57); C38(0.57)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C194(0.61); C38(0.61)  LDD0873  [8]
 LDCM0102  BDHI 8 Jurkat C610(6.68)  LDD0204  [2]
 LDCM0367  CL1 PaTu 8988t C38(1.29)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C38(2.20)  LDD1247  [8]
 LDCM0369  CL100 HEK-293T C194(0.57); C38(0.57); C76(1.25)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C194(0.47); C38(0.47)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C194(0.55); C38(0.55)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C194(0.53); C38(0.53)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C194(0.64); C38(0.64)  LDD0971  [8]
 LDCM0376  CL107 HEK-293T C76(0.94); C38(0.97)  LDD1580  [9]
 LDCM0379  CL11 PaTu 8988t C38(1.11)  LDD1258  [8]
 LDCM0381  CL111 HEK-293T C76(0.94); C38(1.10)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C76(1.31)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C76(1.14)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C76(1.45)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C76(1.33)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C76(1.35)  LDD0984  [8]
 LDCM0387  CL117 PaTu 8988t C38(1.29)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C38(1.21)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C38(1.47)  LDD1268  [8]
 LDCM0390  CL12 PaTu 8988t C38(1.19)  LDD1269  [8]
 LDCM0391  CL120 PaTu 8988t C38(1.38)  LDD1270  [8]
 LDCM0392  CL121 HEK-293T C194(0.48); C38(0.48)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C194(0.58); C38(0.58)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C194(0.56); C38(0.56)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C194(0.58); C38(0.58)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C194(0.95); C38(0.95)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C194(1.10); C38(1.10)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C194(1.22); C38(1.22)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C194(1.03); C38(1.03)  LDD0997  [8]
 LDCM0400  CL13 PaTu 8988t C38(2.02)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C38(2.35)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C38(1.81)  LDD1281  [8]
 LDCM0403  CL16 HEK-293T C194(0.69); C38(0.69)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C194(1.14); C38(1.14)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C194(0.85); C38(0.85)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C194(1.14); C38(1.14)  LDD1004  [8]
 LDCM0407  CL2 PaTu 8988t C38(1.08)  LDD1286  [8]
 LDCM0408  CL20 HEK-293T C194(0.62); C38(0.62)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C194(0.86); C38(0.86)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C194(0.74); C38(0.74)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C194(1.06); C38(1.06)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C194(0.93); C38(0.93)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C194(0.64); C38(0.64)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C194(1.38); C38(1.38)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C194(1.17); C38(1.17)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C194(1.15); C38(1.15)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C194(0.86); C38(0.86)  LDD1015  [8]
 LDCM0418  CL3 PaTu 8988t C38(1.16)  LDD1297  [8]
 LDCM0419  CL30 HEK-293T C194(0.66); C38(0.66)  LDD1017  [8]
 LDCM0420  CL31 PaTu 8988t C38(1.23)  LDD1299  [8]
 LDCM0421  CL32 PaTu 8988t C38(1.25)  LDD1300  [8]
 LDCM0422  CL33 PaTu 8988t C38(2.78)  LDD1301  [8]
 LDCM0423  CL34 PaTu 8988t C38(1.44)  LDD1302  [8]
 LDCM0424  CL35 PaTu 8988t C38(1.65)  LDD1303  [8]
 LDCM0425  CL36 PaTu 8988t C38(3.39)  LDD1304  [8]
 LDCM0426  CL37 PaTu 8988t C38(1.52)  LDD1305  [8]
 LDCM0428  CL39 PaTu 8988t C38(1.74)  LDD1307  [8]
 LDCM0429  CL4 PaTu 8988t C38(1.28)  LDD1308  [8]
 LDCM0430  CL40 PaTu 8988t C38(1.32)  LDD1309  [8]
 LDCM0431  CL41 PaTu 8988t C38(1.62)  LDD1310  [8]
 LDCM0432  CL42 PaTu 8988t C38(1.39)  LDD1311  [8]
 LDCM0433  CL43 PaTu 8988t C38(1.54)  LDD1312  [8]
 LDCM0434  CL44 PaTu 8988t C38(1.58)  LDD1313  [8]
 LDCM0435  CL45 PaTu 8988t C38(2.46)  LDD1314  [8]
 LDCM0436  CL46 HEK-293T C76(1.06)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C76(0.87)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C76(0.84)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C76(1.13)  LDD1037  [8]
 LDCM0440  CL5 PaTu 8988t C38(1.86)  LDD1319  [8]
 LDCM0441  CL50 HEK-293T C76(1.24)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C76(0.98)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C76(0.90)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C76(0.93)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C76(0.94)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C76(0.92)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C76(0.76)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C76(1.04)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C76(0.94)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C76(1.05)  LDD1048  [8]
 LDCM0451  CL6 PaTu 8988t C38(1.51)  LDD1330  [8]
 LDCM0452  CL60 HEK-293T C76(1.15)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C194(0.62); C38(0.62)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C194(0.59); C38(0.59)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C194(0.41); C38(0.41)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C194(0.60); C38(0.60)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C194(0.64); C38(0.64)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C194(0.60); C38(0.60)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C194(0.84); C38(0.84)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C194(0.60); C38(0.60)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C194(0.77); C38(0.77)  LDD1059  [8]
 LDCM0462  CL7 PaTu 8988t C38(1.62)  LDD1341  [8]
 LDCM0463  CL70 HEK-293T C194(0.85); C38(0.85)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C194(0.59); C38(0.59)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C194(0.75); C38(0.75)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C194(0.58); C38(0.58)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C194(0.28); C38(0.28)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C76(1.01)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C76(1.05)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C76(0.82)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C76(1.00)  LDD1070  [8]
 LDCM0473  CL8 PaTu 8988t C38(2.51)  LDD1352  [8]
 LDCM0474  CL80 HEK-293T C76(0.98)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C76(0.98)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C76(1.14)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C76(1.20)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C76(0.88)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C76(0.89)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C76(0.84)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C76(0.91)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C76(1.00)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C76(1.07)  LDD1081  [8]
 LDCM0484  CL9 PaTu 8988t C38(1.46)  LDD1363  [8]
 LDCM0485  CL90 HEK-293T C76(1.13)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C194(0.72); C38(0.72); C76(1.03)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C194(0.52); C38(0.52); C76(1.05)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C194(0.65); C38(0.65); C76(1.09)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C194(0.40); C38(0.40); C76(1.38)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C194(0.25); C38(0.25); C76(1.55)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C194(0.44); C38(0.44); C76(1.21)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C194(0.73); C38(0.73); C76(1.11)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C194(0.61); C38(0.61); C76(1.19)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C194(0.87); C38(0.87); C76(1.18)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C76(0.88); C38(1.38)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C194(0.41); C38(0.41)  LDD1066  [8]
 LDCM0427  Fragment51 PaTu 8988t C38(1.66)  LDD1306  [8]
 LDCM0022  KB02 A2058 C610(2.27)  LDD2253  [10]
 LDCM0023  KB03 A2058 C610(2.99)  LDD2670  [10]
 LDCM0024  KB05 WM266-4 C610(2.95)  LDD3328  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
DNA polymerase epsilon subunit 2 (POLE2) DNA polymerase epsilon subunit B family P56282
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Gamma-glutamylaminecyclotransferase (GGACT) Gamma-glutamylcyclotransferase family Q9BVM4
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) Peptidase C12 family Q9Y5K5
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
E3 SUMO-protein ligase PIAS2 (PIAS2) PIAS family O75928
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
3-mercaptopyruvate sulfurtransferase (MPST) . P25325
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Probable E3 ubiquitin-protein ligase TRIML2 (TRIML2) . Q8N7C3
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Prosaposin (PSAP) . P07602
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Neurochondrin (NCDN) Neurochondrin family Q9UBB6
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Protein SSX2 (SSX2; SSX2B) SSX family Q16385
Molecular chaperone MKKS (MKKS) TCP-1 chaperonin family Q9NPJ1
Alpha-catulin (CTNNAL1) Vinculin/alpha-catenin family Q9UBT7
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
Leucine-rich repeat-containing protein 20 (LRRC20) . Q8TCA0
Melanoma-associated antigen B2 (MAGEB2) . O15479
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) . Q9UI95
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840