Details of the Target

General Information of Target

Target ID LDTP01448
Target Name SAM and SH3 domain-containing protein 1 (SASH1)
Gene Name SASH1
Gene ID 23328
Synonyms
KIAA0790; PEPE1; SAM and SH3 domain-containing protein 1; Proline-glutamate repeat-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNID
DLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSA
VSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVAS
EITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSS
NCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL
DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESR
GLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHV
GSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGL
DGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVK
SEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN
KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYE
DLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGC
SPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQ
GQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSL
DDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF
SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGT
HHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLP
VKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPA
LTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERD
VAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST
AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
Uniprot ID
O94885
Ensemble ID
ENST00000367467.8
HGNC ID
HGNC:19182

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HHS-475
 Probe Info  		Y307(1.68)  LDD0264  [2]
DBIA
 Probe Info  		C1170(2.08)  LDD0080  [3]
IA-alkyne
 Probe Info  		C727(0.00); C406(0.00)  LDD0165  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
NAIA_4
 Probe Info  		C406(0.00); C720(0.00); C1170(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		C1120(0.00); C1018(0.00)  LDD2224  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1170(0.36)  LDD1093  [3]
 LDCM0215  AC10 HCT 116 C727(1.16)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C1170(0.82); C727(1.02)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1170(0.92); C727(0.84)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1170(1.03); C727(0.94)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1170(1.14); C727(1.15)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1170(1.07); C727(1.19)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1170(1.02); C727(1.18)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1170(1.07); C727(1.15)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1170(1.19); C727(0.85)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1170(1.09); C727(1.00)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1170(0.83); C727(1.28)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C727(0.94)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C1170(0.99); C727(1.17)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1170(1.02); C727(1.38)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1170(0.94); C727(0.72)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1170(1.49)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1170(1.23)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1170(1.57)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1170(0.92)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1170(0.95)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1170(1.33)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1170(1.28)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C727(0.93)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1170(1.40)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1170(2.08)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1170(1.25)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1170(1.12)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1170(1.04)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1170(0.96)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1170(1.85)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1170(1.37)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C727(0.83)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C727(0.95)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C727(0.95)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C727(0.99)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C727(0.93)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C727(1.03)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C727(1.21)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C727(1.08)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C727(1.04)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C727(1.17)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C727(1.26)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C727(1.20)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C727(1.13)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C727(1.24)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C727(1.43)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C727(1.00)  LDD0579  [3]
 LDCM0263  AC143 PaTu 8988t C1170(1.35)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C1170(1.38)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C1170(1.36)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C1170(1.09)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C1170(1.27)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C1170(1.63)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C1170(2.38)  LDD1148  [3]
 LDCM0270  AC15 HCT 116 C727(1.01)  LDD0587  [3]
 LDCM0271  AC150 PaTu 8988t C1170(1.77)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C1170(2.57)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C1170(1.83)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C1170(2.09)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C1170(2.35)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C1170(2.09)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C1170(2.09)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C1170(2.20)  LDD2169  [3]
 LDCM0276  AC17 HCT 116 C1170(0.44); C727(0.82)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1170(0.52); C727(0.81)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1170(0.38); C727(1.05)  LDD0595  [3]
 LDCM0279  AC2 PaTu 8988t C1170(0.29)  LDD1158  [3]
 LDCM0280  AC20 HCT 116 C1170(0.49); C727(0.59)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1170(0.42); C727(0.86)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1170(0.50); C727(0.67)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1170(0.46); C727(0.81)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1170(0.59); C727(0.96)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1170(1.37)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1170(1.05)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1170(1.14)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1170(1.11)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1170(1.43)  LDD0606  [3]
 LDCM0290  AC3 PaTu 8988t C1170(0.34)  LDD1169  [3]
 LDCM0291  AC30 HCT 116 C1170(1.11)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1170(1.00)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1170(0.98)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1170(1.32)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1170(0.91)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C1170(1.30)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C1170(1.64)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C1170(1.45)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C1170(1.40)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C1170(1.87)  LDD1179  [3]
 LDCM0301  AC4 PaTu 8988t C1170(0.35)  LDD1180  [3]
 LDCM0302  AC40 PaTu 8988t C1170(1.63)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C1170(1.29)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C1170(1.56)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C1170(1.46)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C1170(1.49)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C1170(1.25)  LDD1186  [3]
 LDCM0308  AC46 HEK-293T C727(1.02)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C727(1.62)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C727(1.15)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C727(1.08)  LDD0909  [3]
 LDCM0312  AC5 PaTu 8988t C1170(0.42)  LDD1191  [3]
 LDCM0313  AC50 HEK-293T C727(1.03)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C727(1.11)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C727(1.41)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C727(1.11)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C727(1.01)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C727(1.15)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C727(1.16)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C727(1.38)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C727(1.19)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C727(1.13)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C727(1.19)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C727(1.05)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C727(1.08)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C727(1.05)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C727(1.14)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C727(1.01)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C727(1.24)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C727(1.20)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C727(1.08)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C727(0.94)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C727(1.24)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C727(1.00)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C727(1.10)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C727(1.24)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C727(1.00)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C727(1.40)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C727(1.91)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C727(1.42)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C727(1.74)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C727(1.53)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C727(1.28)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C727(1.36)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C727(0.85)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C727(2.24)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C727(1.44)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C727(1.82)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C727(0.96)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C727(0.97)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C727(1.03)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C727(0.98)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C727(1.11)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C727(0.88)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C727(1.07)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C727(0.99)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C727(0.98)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C727(0.81)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C727(0.81)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C727(1.00)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C727(0.93)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C727(0.87)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C727(0.67)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C1170(1.51); C727(1.63)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C727(0.79); C1170(0.83)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C727(1.11)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C727(1.00)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C727(1.12)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.49  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C1018(0.83)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C799(1.07); C1170(1.86); C927(1.07)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C799(1.47); C1170(1.29); C927(0.89)  LDD1572  [7]
 LDCM0369  CL100 PaTu 8988t C1170(0.26)  LDD1248  [3]
 LDCM0370  CL101 HCT 116 C727(0.87)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C727(1.00)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C727(1.31)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C727(1.11)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C1170(0.47); C727(0.85)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1170(0.52); C727(0.95)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1170(0.51); C727(0.67)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1170(0.48); C727(0.76)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1170(0.63); C727(0.73)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C799(1.07); C1170(1.26); C927(1.11)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C1170(0.46); C727(0.74)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1170(0.48); C727(0.99)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1170(0.86)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1170(1.00)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1170(0.78)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1170(1.01)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1170(1.00)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C1170(1.10)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C1170(0.96)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C1170(1.56)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C799(2.47); C1170(1.09); C927(1.16); C1120(1.68)  LDD1594  [7]
 LDCM0391  CL120 PaTu 8988t C1170(1.61)  LDD1270  [3]
 LDCM0392  CL121 HEK-293T C727(1.24)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C727(1.14)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C727(1.10)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C727(1.27)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C727(0.95)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C727(1.12)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C727(1.11)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C727(0.93)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C799(1.36); C1170(1.22); C927(1.20)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C799(1.22)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C799(0.96); C927(1.02); C1120(1.64)  LDD1606  [7]
 LDCM0403  CL16 PaTu 8988t C1170(1.08); C727(0.84)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C1170(0.82); C727(0.72)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C1170(1.27); C727(1.14)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C1170(0.90); C727(0.99)  LDD1285  [3]
 LDCM0407  CL2 HEK-293T C799(1.34)  LDD1611  [7]
 LDCM0408  CL20 PaTu 8988t C1170(0.96); C727(0.62)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C1170(1.23); C727(0.86)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C1170(1.25); C727(1.24)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C1170(1.28); C727(0.73)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C1170(1.17); C727(0.84)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C1170(0.99); C727(0.79)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C1170(1.13); C727(0.88)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C1170(1.35); C727(1.23)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C1170(1.23); C727(0.63)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C1170(1.23); C727(0.68)  LDD1296  [3]
 LDCM0418  CL3 HEK-293T C799(1.05); C927(0.99); C1120(1.37)  LDD1622  [7]
 LDCM0419  CL30 PaTu 8988t C1170(1.55); C727(0.99)  LDD1298  [3]
 LDCM0420  CL31 PaTu 8988t C1170(1.12); C727(0.92)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C1170(1.27); C727(1.24)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C1170(1.41); C727(1.01)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C1170(1.32); C727(1.57)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C1170(1.43); C727(1.66)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C1170(1.57); C727(1.19)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C1170(1.65); C727(1.65)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C1170(1.22); C727(1.14)  LDD1307  [3]
 LDCM0429  CL4 HEK-293T C799(0.97)  LDD1633  [7]
 LDCM0430  CL40 PaTu 8988t C1170(1.01); C727(1.61)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C1170(1.46); C727(1.61)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C1170(1.94); C727(2.04)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C1170(2.35); C727(2.27)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C1170(1.77); C727(1.66)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C1170(1.44); C727(0.99)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C1170(1.17); C727(1.12)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C1170(0.93); C727(1.14)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C1170(1.11); C727(1.20)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C1170(1.15); C727(1.14)  LDD1318  [3]
 LDCM0440  CL5 HEK-293T C799(1.03); C927(1.13); C1120(1.21); C406(0.99)  LDD1644  [7]
 LDCM0441  CL50 PaTu 8988t C1170(1.18); C727(1.28)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C1170(1.23); C727(1.39)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C1170(1.24); C727(1.21)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C1170(1.44); C727(1.55)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C1170(1.32); C727(1.20)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C1170(1.32); C727(1.21)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C1170(0.68); C727(0.71)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C1170(2.48); C727(1.87)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C1170(1.46); C727(1.27)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C1170(2.16); C727(1.91)  LDD1329  [3]
 LDCM0451  CL6 HEK-293T C799(1.06); C1170(1.02); C927(1.12); C1120(1.49)  LDD1654  [7]
 LDCM0452  CL60 PaTu 8988t C1170(1.71); C727(1.57)  LDD1331  [3]
 LDCM0453  CL61 PaTu 8988t C727(1.02)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C727(0.91)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C727(0.90)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C727(1.21)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C727(0.98)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C727(0.51)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C727(1.27)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C727(1.71)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C727(1.52)  LDD1340  [3]
 LDCM0462  CL7 HEK-293T C799(0.88); C1120(1.12)  LDD1665  [7]
 LDCM0463  CL70 PaTu 8988t C727(1.16)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C727(0.91)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C727(0.71)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C727(1.30)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C727(1.01)  LDD1346  [3]
 LDCM0469  CL76 HEK-293T C727(1.11)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C727(0.98)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C727(1.77)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C727(1.44)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C927(1.09); C1120(1.21); C406(1.26)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C727(1.24)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C727(1.24)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C727(0.90)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C727(0.97)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C727(1.58)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C727(1.57)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C727(1.82)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C727(1.29)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C727(1.17)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C727(1.30)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C927(1.09); C1120(1.21)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C727(0.98)  LDD1083  [3]
 LDCM0486  CL91 PaTu 8988t C1170(0.23)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C1170(0.22)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C1170(0.26)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C1170(0.26)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C1170(0.26)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C1170(0.23)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C1170(0.24)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C1170(0.35)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C1170(0.23)  LDD1373  [3]
 LDCM0495  E2913 HEK-293T C799(1.05); C927(1.03); C1120(1.11)  LDD1698  [7]
 LDCM0468  Fragment33 PaTu 8988t C727(1.03)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C1170(1.52); C727(2.23)  LDD1306  [3]
 LDCM0116  HHS-0101 DM93 Y307(1.68)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y307(0.74)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y307(0.48)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y307(0.81)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y307(0.91)  LDD0268  [2]
 LDCM0022  KB02 HCT 116 C1170(2.08)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C1170(1.38)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C1170(1.53)  LDD0082  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402