Details of the Target

General Information of Target

Target ID LDTP01207
Target Name Deformed epidermal autoregulatory factor 1 homolog (DEAF1)
Gene Name DEAF1
Gene ID 10522
Synonyms
SPN; ZMYND5; Deformed epidermal autoregulatory factor 1 homolog; Nuclear DEAF-1-related transcriptional regulator; NUDR; Suppressin; Zinc finger MYND domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERET
PRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGAAADNVFTTSVAN
AASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTP
LAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEF
EAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPY
KRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAV
ISESPAQGDVFAGATVQEASVQPPCRASHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVL
TSLPALAVPPPTPTKAAPPALVNGLELSEPRSWLYLEEMVNSLLNTAQQLKTLFEQAKHA
STYREAATNQAKIHADAERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHIC
GQSAAVTVQADEVHVAESVMEKVTV
Target Bioclass
Transcription factor
Subcellular location
Secreted; Nucleus; Cytoplasm
Function
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.
Uniprot ID
O75398
Ensemble ID
ENST00000382409.4
HGNC ID
HGNC:14677

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.I271T .
ETK1 SNV: p.E46K .
HCT116 SNV: p.A167T .
Ishikawa (Heraklio) 02 ER SNV: p.E475V .
KYSE30 SNV: p.V294I .
MDAMB453 SNV: p.E36K .
MOLT4 SNV: p.R303H; p.A436E .
OVK18 Deletion: p.F297LfsTer18
SNV: p.G155E		 .
SSP25 SNV: p.E46K .
YSCCC SNV: p.N443Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C504(1.08); C507(1.08)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0174  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C515(1.10); C507(1.06); C518(1.01); C528(1.36)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C515(0.61); C518(0.61)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C504(1.02); C528(1.04)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C504(1.08); C528(1.19)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C504(1.01); C528(0.93)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C504(0.87); C528(0.77)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C504(1.11); C528(1.01)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C504(0.93); C528(1.59)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C504(1.16); C528(0.62)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C504(0.97); C528(1.19)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C504(1.55); C528(0.64)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C504(1.42); C528(0.95)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C515(0.47); C518(0.47)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C504(1.02); C528(1.55)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C504(1.05); C528(1.55)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C504(0.98); C528(1.15)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C515(1.38); C504(1.10); C507(1.38); C528(0.61)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C515(0.99); C504(1.09); C507(0.99); C528(0.71)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C515(1.23); C504(0.88); C507(1.23); C528(0.57)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C515(1.08); C504(0.90); C507(1.08); C528(0.57)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C515(1.15); C504(0.85); C507(1.15); C528(0.75)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C515(1.45); C504(0.78); C507(1.45); C528(0.63)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C515(1.46); C504(0.60); C507(1.46); C528(0.74)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C515(0.55); C518(0.55)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C515(1.53); C504(0.76); C507(1.53); C528(0.50)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C515(2.58); C504(0.88); C507(2.58); C528(0.62)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C515(1.50); C504(0.70); C507(1.50); C528(0.59)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C515(1.80); C504(0.74); C507(1.80); C528(0.59)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C515(1.66); C504(0.65); C507(1.66); C528(0.83)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C515(1.36); C504(0.71); C507(1.36); C528(0.73)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C515(2.18); C504(0.67); C507(2.18); C528(0.77)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C515(2.56); C504(0.85); C507(2.56); C528(0.87)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C504(1.08); C528(0.95)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C504(0.91); C528(1.00)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C504(0.86); C528(0.94)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C504(0.78); C528(0.69)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C504(0.75); C528(0.88)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C504(0.74); C528(0.98)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C504(0.74); C528(1.02)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C504(1.03); C528(1.03)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C504(0.81); C528(1.21)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C504(0.92); C528(1.42)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C504(0.77); C528(1.02)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C504(0.90); C528(1.00)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C515(0.46); C518(0.46)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C504(0.67); C528(1.07)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C504(0.81); C528(1.79)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C504(0.90); C528(1.20)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C528(0.72)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C528(1.04)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C528(0.96)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C528(0.91)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C528(1.04)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C528(0.91)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C528(1.02)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C515(0.47); C518(0.47)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C528(1.01)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C528(0.98)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C528(0.91)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C528(0.74)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C528(1.96)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C528(0.96)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C528(0.94)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C528(2.04)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C504(0.86); C507(0.86)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C504(0.65); C507(0.65)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C504(0.77); C507(0.77)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C515(1.10); C507(1.06); C518(0.94); C528(1.21)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C504(1.04); C507(1.04)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C504(1.04); C507(1.04)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C504(0.80); C507(0.80)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C504(0.77); C507(0.77)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C504(0.98); C507(0.98)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C504(0.88); C528(1.53)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C504(0.79); C528(1.38)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C504(0.76); C528(1.33)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C504(1.40); C528(1.22)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C504(0.83); C528(1.42)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C515(1.13); C507(1.02); C518(0.99); C528(0.96)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C504(0.75); C528(1.62)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C504(1.15); C528(2.09)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C504(0.98); C528(1.62)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C504(1.07); C528(1.75)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C504(1.05); C528(1.83)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C504(0.76); C507(0.76)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C504(0.68); C507(0.68)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C504(0.93); C507(0.93)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C504(0.66); C507(0.66)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C504(0.85); C507(0.85)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C515(0.99); C507(0.91); C518(1.00); C528(1.28)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C504(1.20); C507(1.20)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C504(0.82); C507(0.82)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C504(0.77); C507(0.77)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C504(0.87); C507(0.87)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C504(1.07); C507(1.07)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C504(1.07); C507(1.07)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C515(1.11); C504(0.82); C507(1.21); C518(1.01)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C515(1.11); C504(0.73); C507(1.01); C518(1.21)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C515(1.03); C504(0.73); C507(0.99); C518(1.08)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C515(0.95); C504(0.72); C507(0.76); C518(1.13)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C515(1.07); C507(1.03); C518(1.05); C528(1.14)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C515(0.79); C504(0.97); C507(0.75); C518(0.84)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C515(1.08); C504(0.62); C507(1.06); C518(1.10)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C515(1.08); C504(0.72); C507(1.12); C518(1.04)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C515(0.92); C504(0.75); C507(0.83); C518(1.02)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C515(1.07); C504(0.55); C507(1.02); C518(1.13)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C515(1.03); C504(0.67); C507(0.97); C518(1.10)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C515(1.13); C504(0.64); C507(0.93); C518(1.34)  LDD0917  [1]
 LDCM0320  AC57 HCT 116 C504(1.11); C507(1.11); C515(1.91); C518(1.91)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C504(1.21); C507(1.21); C515(1.68); C518(1.68)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C504(1.08); C507(1.08); C515(1.85); C518(1.85)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C515(0.61); C518(0.61)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C504(1.08); C507(1.08); C515(2.67); C518(2.67)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C504(1.02); C507(1.02); C515(1.98); C518(1.98)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C504(1.02); C507(1.02); C515(2.44); C518(2.44)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C504(0.90); C507(0.90); C515(2.39); C518(2.39)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C504(1.03); C507(1.03); C515(3.13); C518(3.13)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C504(0.85); C507(0.85); C515(2.27); C518(2.27)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C504(0.83); C507(0.83); C515(1.67); C518(1.67)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C504(0.91); C507(0.91); C515(2.61); C518(2.61)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C504(0.86); C507(0.86); C515(1.15); C518(1.15)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C504(0.87); C507(0.87); C515(1.08); C518(1.08)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C515(0.57); C518(0.57)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C504(1.02); C507(1.02); C515(1.26); C518(1.26)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C504(0.79); C507(0.79); C515(0.94); C518(0.94)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C504(0.95); C507(0.95); C515(1.16); C518(1.16)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C504(0.95); C507(0.95); C515(1.26); C518(1.26)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C504(1.03); C507(1.03); C515(1.42); C518(1.42)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C504(1.00); C507(1.00); C515(1.50); C518(1.50)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C504(0.90); C507(0.90); C515(1.18); C518(1.18)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C504(0.98); C507(0.98); C515(1.17); C518(1.17)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C504(0.90); C507(0.90); C515(1.04); C518(1.04)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C504(0.77); C507(0.77); C515(1.09); C518(1.09)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C515(0.52); C518(0.52)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C504(0.96); C507(0.96); C515(1.11); C518(1.11)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C504(0.75); C507(0.75); C515(0.98); C518(0.98)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C504(1.06); C507(1.06); C515(1.44); C518(1.44)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C504(1.47); C507(1.47)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C504(1.43); C507(1.43)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C504(1.09); C507(1.09)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C504(0.99); C507(0.99)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C504(0.92); C507(0.92)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C504(1.01); C507(1.01)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C504(1.18); C507(1.18)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C504(1.18); C507(1.18)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C504(1.38); C507(1.38)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C504(1.39); C507(1.39)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C504(1.02); C507(1.02)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C504(1.05); C507(1.05)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C504(1.01); C507(1.01)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C504(1.20); C507(1.20)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C504(1.09); C507(1.09)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C504(1.11); C528(0.81)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C504(1.55); C528(0.84)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C515(0.64); C518(0.64)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C515(0.67); C518(0.67)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C515(0.70); C518(0.70)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C504(1.08); C507(1.08)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C515(0.77); C518(0.77); C528(1.15)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C515(0.82); C518(0.82); C528(1.62)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C515(1.01); C507(1.01); C518(1.03); C528(1.22)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C515(0.53); C518(0.53)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C515(0.36); C518(0.36)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C515(0.43); C518(0.43)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C515(0.47); C518(0.47)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C504(0.87); C507(0.87)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C504(0.95); C507(0.95)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C504(1.12); C507(1.12)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C504(1.12); C507(1.12)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C504(0.76); C507(0.76)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C515(0.94); C518(0.94); C528(1.02)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C504(1.20); C507(1.20)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C504(0.81); C507(0.81)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C504(0.92); C528(1.41)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C504(1.01); C528(1.49)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C504(1.31); C528(1.49)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C504(0.95); C528(1.86)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C504(0.88); C528(1.91)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C504(1.44); C507(1.44)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C504(0.97); C507(0.97)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C504(0.96); C507(0.96)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C515(1.19); C518(1.19); C528(0.88)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C504(0.98); C507(0.98)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C515(1.04); C504(0.67); C507(1.13); C518(0.96)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C515(1.03); C504(0.65); C507(1.04); C518(1.02)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C515(1.01); C504(1.01); C507(1.13); C518(0.89)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C515(0.99); C504(0.80); C507(0.84); C518(1.14)  LDD0993  [1]
 LDCM0396  CL125 HCT 116 C504(0.72); C507(0.72); C515(1.59); C518(1.59)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C504(1.03); C507(1.03); C515(2.65); C518(2.65)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C504(0.96); C507(0.96); C515(1.50); C518(1.50)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C504(1.30); C507(1.30); C515(2.38); C518(2.38)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C515(0.95); C518(0.95); C528(0.74)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C515(0.80); C518(0.80); C528(0.95)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C515(0.78); C518(0.78); C528(0.84)  LDD1000  [1]
 LDCM0403  CL16 PaTu 8988t C515(0.82); C518(0.82)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C515(1.09); C518(1.09)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C515(1.29); C518(1.29)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C515(1.16); C518(1.16)  LDD1285  [1]
 LDCM0407  CL2 HEK-293T C515(1.14); C518(1.14); C528(1.35)  LDD1005  [1]
 LDCM0408  CL20 PaTu 8988t C515(1.85); C518(1.85)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C515(2.25); C518(2.25)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C515(1.53); C518(1.53)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C515(2.03); C518(2.03)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C515(1.67); C518(1.67)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C515(0.99); C518(0.99)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C515(1.71); C518(1.71)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C515(0.96); C518(0.96)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C515(1.86); C518(1.86)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C515(1.33); C518(1.33)  LDD1296  [1]
 LDCM0418  CL3 HEK-293T C515(0.89); C518(0.89); C528(1.27)  LDD1016  [1]
 LDCM0419  CL30 PaTu 8988t C515(1.50); C518(1.50)  LDD1298  [1]
 LDCM0420  CL31 HEK-293T C515(0.82); C504(0.89); C507(0.82)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C515(1.02); C504(1.23); C507(1.02)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C515(0.87); C504(1.39); C507(0.87)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C515(0.95); C504(0.64); C507(0.95)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C515(0.97); C504(0.59); C507(0.97)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C515(0.94); C504(1.29); C507(0.94)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C515(0.86); C504(0.80); C507(0.86)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C515(1.04); C504(0.62); C507(1.04)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C515(1.04); C518(1.04); C528(0.98)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C515(1.03); C504(0.76); C507(1.03)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C515(0.92); C504(0.70); C507(0.92)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C515(0.99); C504(0.62); C507(0.99)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C515(1.16); C504(0.49); C507(1.16)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C515(0.97); C504(0.62); C507(0.97)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C515(0.92); C504(0.94); C507(0.92)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C515(1.39); C518(1.39)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C515(1.06); C518(1.06)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C515(1.23); C518(1.23)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C515(1.11); C518(1.11)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C515(1.01); C518(1.01); C528(1.17)  LDD1038  [1]
 LDCM0441  CL50 HCT 116 C515(0.91); C518(0.91)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C515(1.17); C518(1.17)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C515(0.89); C518(0.89)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C515(0.75); C518(0.75)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C515(0.77); C518(0.77)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C515(0.83); C518(0.83)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C515(1.05); C518(1.05)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C515(1.17); C518(1.17)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C515(1.06); C518(1.06)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C515(0.98); C518(0.98)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C515(0.95); C518(0.95); C528(0.73)  LDD1049  [1]
 LDCM0452  CL60 HCT 116 C515(1.15); C518(1.15)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C515(1.00); C518(1.00); C528(0.87)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C515(0.81); C518(0.81); C528(0.99)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C515(0.82); C518(0.82); C528(0.63)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C515(0.72); C518(0.72); C528(0.67)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C515(1.21); C518(1.21); C528(0.63)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C515(0.84); C518(0.84); C528(0.65)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C515(0.62); C518(0.62); C528(0.68)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C515(0.94); C518(0.94); C528(0.71)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C515(0.73); C518(0.73); C528(0.76)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C515(0.91); C518(0.91); C528(1.22)  LDD1060  [1]
 LDCM0463  CL70 HEK-293T C515(0.65); C518(0.65); C528(0.92)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C515(0.57); C518(0.57); C528(0.62)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C515(0.63); C518(0.63); C528(1.23)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C515(0.66); C518(0.66); C528(0.47)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C515(0.56); C518(0.56); C528(0.90)  LDD1065  [1]
 LDCM0469  CL76 HCT 116 C515(0.94); C518(0.94)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C515(1.12); C518(1.12)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C515(1.11); C518(1.11)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C515(1.11); C518(1.11)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C515(10.74); C518(1.26); C528(0.99)  LDD1071  [1]
 LDCM0474  CL80 HCT 116 C515(1.30); C518(1.30)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C515(1.19); C518(1.19)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C515(1.10); C518(1.10)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C515(0.95); C518(0.95)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C515(0.94); C518(0.94)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C515(1.03); C518(1.03)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C515(0.97); C518(0.97)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C515(0.92); C518(0.92)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C515(0.76); C518(0.76)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C515(0.94); C518(0.94)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C515(0.92); C518(1.12); C528(0.98)  LDD1082  [1]
 LDCM0485  CL90 HCT 116 C515(0.91); C518(0.91)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C515(0.94); C507(0.91); C518(1.02); C528(1.61)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C515(1.23); C507(1.06); C518(1.14); C528(1.28)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C515(1.10); C507(0.93); C518(1.12); C528(1.54)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C515(1.18); C507(0.88); C518(1.28); C528(1.62)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C515(1.05); C507(0.94); C518(1.26); C528(1.22)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C515(0.84); C507(0.78); C518(1.09); C528(1.50)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C515(1.06); C507(1.05); C518(0.98); C528(1.75)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C515(1.01); C507(0.93); C518(1.11); C528(1.11)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C515(1.14); C507(1.02); C518(1.16); C528(1.19)  LDD1092  [1]
 LDCM0468  Fragment33 HEK-293T C515(0.45); C518(0.45); C528(0.87)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C515(0.85); C504(1.13); C507(0.85)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C524(0.89)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C524(1.56)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C524(1.27)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
Glycogen synthase kinase-3 alpha (GSK3A) CMGC Ser/Thr protein kinase family P49840
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-synuclein (SNCA) Synuclein family P37840
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 2A (CDKN2A) CDKN2 cyclin-dependent kinase inhibitor family P42771
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Four and a half LIM domains protein 2 (FHL2) . Q14192
Methyl-CpG-binding protein 2 (MECP2) . P51608
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402