Details of the Target

General Information of Target

Target ID LDTP00971
Target Name Ecotropic viral integration site 5 protein homolog (EVI5)
Gene Name EVI5
Gene ID 7813
Synonyms
NB4S; Ecotropic viral integration site 5 protein homolog; EVI-5; Neuroblastoma stage 4S gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS
SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS
SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ
SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE
VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE
HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL
QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT
KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA
LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ
RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH
LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA
VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP
PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET
EDSVLETRESNQVVQKERPPRRRESYSTTV
Target Bioclass
Other
Subcellular location
Nucleus
Function Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
Uniprot ID
O60447
Ensemble ID
ENST00000370331.5
HGNC ID
HGNC:3501

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K633(0.94)  LDD0277  [1]
m-APA
 Probe Info  		11.41  LDD0403  [2]
DBIA
 Probe Info  		C198(1.02)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
ENE
 Probe Info  		N.A.  LDD0006  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		C198(0.00); C479(0.00)  LDD0148  [7]
YN-1
 Probe Info  		N.A.  LDD0447  [8]
AOyne
 Probe Info  		14.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C198(1.02)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C198(0.63)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C177(1.77); C479(1.15)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C177(1.50); C479(1.16)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C177(1.53); C479(1.16)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C177(1.17); C479(1.14)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C177(1.65); C479(1.03)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C177(1.78); C479(1.07)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C177(1.22); C479(1.01)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C177(1.32); C479(1.06)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C177(1.46); C479(1.15)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C177(1.77); C479(1.33)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C198(0.58)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C177(1.77); C479(1.23)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C177(1.90); C479(0.61)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C177(1.78); C479(1.11)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C479(0.85)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C479(1.51)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C479(1.46)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C479(1.34)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C479(1.10)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C479(1.31)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C479(1.32)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C198(0.54)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C479(1.19)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C479(1.17)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C479(1.45)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C479(1.39)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C479(1.56)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C479(1.13)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C479(1.29)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C479(1.09)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C177(1.13)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C177(1.70)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C177(1.26)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C177(1.42)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C177(1.33)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C177(1.40)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C177(1.44)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C177(1.27)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C177(1.39)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C177(1.95)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C177(1.96)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C177(1.86)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C198(0.64)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C177(1.43)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C177(1.49)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C177(1.77)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C479(0.75)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C479(1.06)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C479(1.07)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C479(0.97)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C479(0.96)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C479(1.04)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C479(0.92)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C198(0.81)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C479(1.07)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C479(0.99)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C479(0.98)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C479(1.04)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C479(0.94)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C479(1.02)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C479(0.92)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C479(0.69)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C198(0.83)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C198(0.83)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C198(0.89)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C198(1.13)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C198(0.91)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C198(0.72)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C198(0.83)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C198(0.92)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C198(1.07)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C479(0.90)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C479(0.87)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C479(0.88)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C479(1.12)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C479(0.75)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C198(1.10)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C479(0.88)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C479(0.80)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C479(0.92)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C479(0.88)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C479(0.86)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C479(1.36)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C479(1.13)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C479(1.13)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C479(1.32)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C479(1.30)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C198(0.91)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C479(1.00)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C479(1.07)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C479(0.98)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C479(0.90)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C479(1.09)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C479(1.11)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C479(1.02)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C479(1.13)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C479(1.04)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C479(0.91)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C198(1.08)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C479(1.00)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C479(0.91)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C479(1.01)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C479(0.90)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C479(0.94)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C479(1.01)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C479(0.92)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C479(0.89)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C479(0.94)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C479(0.87)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C198(0.71)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C479(0.84)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C479(1.03)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C479(1.09)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C479(1.08)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C479(0.91)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C479(1.07)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C479(0.91)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C479(0.97)  LDD0929  [3]
 LDCM0334  AC7 HCT 116 C198(0.56)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C198(0.98)  LDD0662  [3]
 LDCM0349  AC83 HEK-293T C479(1.09)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C479(1.03)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C479(1.05)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C479(1.06)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C479(1.13)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C479(1.15)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C479(1.18)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C479(1.08)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C479(1.15)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C479(1.11)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C479(1.06)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C479(1.05)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C479(1.15)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C479(0.72)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C479(1.16)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C177(1.36); C479(1.16)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C177(1.04); C479(0.96)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C198(0.76)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C198(0.73)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C198(0.85)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.41  LDD0403  [2]
 LDCM0632  CL-Sc Hep-G2 C479(0.91)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C479(0.93)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C479(1.10)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C198(1.20)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C198(0.91)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C198(0.54)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C198(0.64)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C198(0.70)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C198(0.76)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C198(0.81)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C198(0.73)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C198(0.72)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C198(0.93)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C479(1.06)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C198(1.17)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C198(1.07)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C479(0.74)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C479(0.90)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C479(0.86)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C479(0.80)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C479(0.85)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C479(1.21)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C479(1.19)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C479(1.05)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C479(1.08)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C479(1.05)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C479(0.95)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C479(0.85)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C479(0.97)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C479(0.88)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C479(1.01)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C479(0.99)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C479(1.14)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C479(0.85)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C479(1.25)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C479(1.04)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C479(0.95)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C177(1.43); C479(0.63)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C177(1.59); C479(0.74)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C177(0.75); C479(0.76)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C177(1.09); C479(0.78)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C479(1.01)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C177(1.15); C479(0.87)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C177(0.88); C479(0.93)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C177(1.02); C479(0.89)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C177(0.80); C479(0.77)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C177(0.89); C479(1.25)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C177(1.32); C479(0.91)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C177(1.30); C479(0.86)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C177(1.42); C479(1.12)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C177(0.60); C479(0.78)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C177(0.73); C479(0.87)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C479(0.92)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C177(0.76); C479(0.97)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C177(1.80); C479(0.80)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C177(0.94); C479(1.04)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C177(0.96); C479(0.77)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C177(0.96); C479(0.84)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C177(0.90); C479(0.98)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C177(1.10); C479(1.04)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C177(0.98); C479(1.22)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C177(1.25); C479(1.08)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C479(1.14)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C177(0.75); C479(1.19)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C177(1.00); C479(1.06)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C177(0.89); C479(1.14)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C177(1.05); C479(0.96)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C177(1.05); C479(1.12)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C177(0.99); C479(0.99)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C479(0.92)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C479(1.07)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C479(0.88)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C479(1.06)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C479(1.06)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C479(0.99)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C479(1.12)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C479(0.97)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C479(1.10)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C479(0.97)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C479(1.09)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C479(1.06)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C479(0.98)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C479(1.19)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C479(1.17)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C479(0.96)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C479(1.32)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C479(0.88)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C479(0.93)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C479(0.94)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C479(0.91)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C479(1.14)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C479(0.97)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C479(1.09)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C479(1.08)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C479(1.03)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C479(1.25)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C479(1.04)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C479(1.23)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C479(0.97)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C479(1.08)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C479(1.19)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C198(1.11)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C198(1.37)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C198(1.04)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C198(1.15)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C479(1.18)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C198(1.00)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C198(1.49)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C198(1.02)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C198(1.05)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C198(0.90)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C198(1.19)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C198(1.35)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C198(0.98)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C198(1.13)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C198(0.88)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C479(0.87)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C198(1.18)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C198(1.02)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C198(1.18)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C198(1.27)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C198(1.08)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C198(1.07)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C198(1.12)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C198(1.08)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C198(1.16)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C198(0.94)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C641(1.05); C479(0.86); C177(0.98)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C479(0.76)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C177(0.73); C479(1.04)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C479(0.90); C177(1.02)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C479(0.98); C177(1.08)  LDD1497  [10]
 LDCM0024  KB05 MEL167 C652(1.51)  LDD3316  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleotidyltransferase MB21D2 (MB21D2) Mab-21 family Q8IYB1
Casein kinase I isoform delta (CSNK1D) CK1 Ser/Thr protein kinase family P48730
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
ADP-ribosylation factor-like protein 4A (ARL4A) Arf family P40617
Ras-related protein Rab-11A (RAB11A) Rab family P62491
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disks large homolog 1 (DLG1) MAGUK family Q12959
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Protein FAM161A (FAM161A) FAM161 family Q3B820
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNFAIP8L1) TNFAIP8 family Q8WVP5
U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3) Universal ribosomal protein uS4 family Q9NV31
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
Elongin-A (ELOA) . Q14241
F-box only protein 5 (FBXO5) . Q9UKT4
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Microspherule protein 1 (MCRS1) . Q96EZ8
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Rab15 effector protein (REP15) . Q6BDI9
Rhombotin-1 (LMO1) . P25800

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840