Details of the Target

General Information of Target

Target ID LDTP00932
Target Name Adenylate cyclase type 3 (ADCY3)
Gene Name ADCY3
Gene ID 109
Synonyms
KIAA0511; Adenylate cyclase type 3; EC 4.6.1.1; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; AC3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE
SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDII
LFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVG
IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES
QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV
LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCD
YLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHS
SGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA
QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN
YVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM
LLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKY
SMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHV
ARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFD
SLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFA
LAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVM
GNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQV
VDNS
Target Bioclass
Enzyme
Family
Adenylyl cyclase class-4/guanylyl cyclase family
Subcellular location
Cell membrane
Function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Uniprot ID
O60266
Ensemble ID
ENST00000260600.9
HGNC ID
HGNC:234
ChEMBL ID
CHEMBL3164

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.D29H .
HCT15 SNV: p.L121I .
JURKAT Insertion: p.H251AfsTer39 .
KYSE410 SNV: p.V415L .
LNCaP clone FGC Insertion: p.M279NfsTer11 .
MOLT4 SNV: p.Y753H .
NCIH1155 SNV: p.R380Q; p.A758V .
SNU478 SNV: p.S153F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K862(5.34)  LDD0277  [1]
DBIA
 Probe Info  		C479(1.48)  LDD0532  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C169
 Probe Info  		21.71  LDD1849  [4]
C170
 Probe Info  		10.34  LDD1850  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C479(0.99)  LDD1507  [5]
 LDCM0215  AC10 HCT 116 C479(1.48)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C479(1.19)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C479(0.95)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C479(1.16)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C479(1.23)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C479(0.98)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C479(1.01)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C479(0.96)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C479(1.05)  LDD1518  [5]
 LDCM0280  AC20 HCT 116 C479(0.87)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C479(1.05)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C479(0.88)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C479(0.99)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C479(0.91)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C479(1.41)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C479(1.65)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C479(1.56)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C479(1.28)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C479(1.30)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C479(0.89)  LDD1529  [5]
 LDCM0291  AC30 HCT 116 C479(1.65)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C479(1.37)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C479(1.51)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C479(1.72)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C479(1.45)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C479(0.97)  LDD1535  [5]
 LDCM0298  AC37 HEK-293T C463(0.85)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C479(1.12)  LDD1538  [5]
 LDCM0302  AC40 HEK-293T C479(0.96); C369(0.77)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C479(1.03)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C479(1.14)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C479(0.96)  LDD1544  [5]
 LDCM0307  AC45 HEK-293T C463(1.17)  LDD1546  [5]
 LDCM0308  AC46 PaTu 8988t C479(1.15)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C479(1.33)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C479(1.61)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C479(1.34)  LDD1190  [2]
 LDCM0312  AC5 HEK-293T C463(0.87)  LDD1551  [5]
 LDCM0313  AC50 PaTu 8988t C479(1.40)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C479(1.20)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C479(1.30)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C479(1.72)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C479(1.97)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C479(1.53)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C479(1.13)  LDD1198  [2]
 LDCM0320  AC57 PaTu 8988t C479(1.01)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C479(1.14)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C479(0.92)  LDD1201  [2]
 LDCM0323  AC6 HCT 116 C479(1.41)  LDD0640  [2]
 LDCM0324  AC60 PaTu 8988t C479(1.21)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C479(1.01)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C479(1.28)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C479(1.06)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C479(0.89)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C479(1.04)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C479(1.17)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C479(1.12)  LDD1210  [2]
 LDCM0334  AC7 HCT 116 C479(1.03)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C479(1.00)  LDD0662  [2]
 LDCM0349  AC83 PaTu 8988t C479(1.06)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C479(0.90)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C479(1.46)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C479(1.32)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C479(1.46)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C479(0.94)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C479(1.08)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C479(1.03)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C479(1.09)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C479(1.36)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C479(0.76)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C479(1.01)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C479(1.21)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C479(1.25)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C479(0.96)  LDD1243  [2]
 LDCM0248  AKOS034007472 HCT 116 C479(1.24)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C479(1.43)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C479(1.60)  LDD0592  [2]
 LDCM0367  CL1 HEK-293T C479(1.12); C463(0.94); C369(1.24)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C479(1.38)  LDD1572  [5]
 LDCM0370  CL101 HCT 116 C479(1.53)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C479(1.21)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C479(1.19)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C479(1.17)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C479(1.11)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C479(1.44)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C479(1.31)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C479(1.02)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C479(0.97)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C479(1.29)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C479(1.09)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C479(1.00)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C479(1.33)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C479(1.28)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C479(1.15)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C479(1.72)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C479(1.26); C463(0.83); C369(1.32)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C479(1.16)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C479(1.14)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C479(1.22); C369(1.58)  LDD1594  [5]
 LDCM0392  CL121 PaTu 8988t C479(1.41)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C479(1.33)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C479(1.61)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C479(1.44)  LDD1274  [2]
 LDCM0396  CL125 PaTu 8988t C479(1.00)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C479(1.17)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C479(0.78)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C479(0.87)  LDD1278  [2]
 LDCM0400  CL13 HEK-293T C479(1.17); C463(0.86); C369(1.30)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C479(1.18)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C479(1.09)  LDD1606  [5]
 LDCM0403  CL16 PaTu 8988t C479(1.19)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C479(1.04)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C479(1.15)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C479(1.11)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C479(1.03)  LDD1611  [5]
 LDCM0408  CL20 PaTu 8988t C479(1.38)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C479(1.18)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C479(1.27)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C479(1.24)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C479(1.41)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C479(1.06)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C479(1.43)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C479(1.29)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C479(1.34)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C479(1.04)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C479(0.96)  LDD1622  [5]
 LDCM0419  CL30 PaTu 8988t C479(1.20)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C479(1.22)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C479(1.45)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C479(1.58)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C479(1.43)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C479(1.55)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C479(1.08)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C479(2.06)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C479(1.63)  LDD1307  [2]
 LDCM0430  CL40 PaTu 8988t C479(1.12)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C479(1.21)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C479(1.83)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C479(2.09)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C479(1.48)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C479(1.14)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C479(1.10)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C479(0.91)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C479(1.09)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C479(1.22)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C479(0.94)  LDD1644  [5]
 LDCM0441  CL50 PaTu 8988t C479(1.29)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C479(1.26)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C479(1.12)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C479(1.58)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C479(1.43)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C479(1.26)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C479(0.21)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C479(2.06)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C479(1.18)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C479(2.25)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C479(1.44)  LDD1654  [5]
 LDCM0452  CL60 PaTu 8988t C479(1.69)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C479(0.95)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C479(0.99)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C479(1.16)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C479(1.04)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C479(1.07)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C479(1.33)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C479(0.93)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C479(1.27)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C479(0.94)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C479(0.87)  LDD1665  [5]
 LDCM0463  CL70 HCT 116 C479(1.10)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C479(1.09)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C479(1.15)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C479(0.98)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C479(1.27)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C479(1.35)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C479(0.84)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C479(1.22)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C479(1.51)  LDD0789  [2]
 LDCM0474  CL80 HCT 116 C479(0.95)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C479(1.08)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C479(1.51)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C479(1.47)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C479(1.57)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C479(1.34)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C479(0.75)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C479(1.47)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C479(1.58)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C479(1.61)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C463(0.98)  LDD1687  [5]
 LDCM0485  CL90 HCT 116 C479(1.22)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C479(1.08)  LDD1689  [5]
 LDCM0488  CL93 HEK-293T C463(0.95)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C479(1.17)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C479(1.11); C369(1.87)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C479(1.07); C463(0.98); C369(1.09)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C479(1.13)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C479(0.94)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C479(1.01)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C479(1.00)  LDD0785  [2]
 LDCM0427  Fragment51 PaTu 8988t C479(1.68)  LDD1306  [2]
 LDCM0022  KB02 HEK-293T C479(0.85)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C479(1.03)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C479(0.74)  LDD1502  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Colforsin Small molecular drug DB02587

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402