Details of the Target

General Information of Target

Target ID LDTP00640
Target Name ATP-binding cassette sub-family C member 5 (ABCC5)
Gene Name ABCC5
Gene ID 10057
Synonyms
MRP5; ATP-binding cassette sub-family C member 5; EC 7.6.2.-; EC 7.6.2.2; Multi-specific organic anion transporter C; MOAT-C; Multidrug resistance-associated protein 5; SMRP; pABC11
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS
LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR
VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI
LSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW
ALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG
PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNE
VLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSV
HMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK
NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQA
VLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG
KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS
CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG
NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI
FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS
VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS
VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPM
KFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP
LVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQEL
LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT
GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM
RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD
IGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLE
SEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCT
MLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Subcellular location
Basolateral cell membrane
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) . Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells.
Uniprot ID
O15440
Ensemble ID
ENST00000265586.10
HGNC ID
HGNC:56
ChEMBL ID
CHEMBL2046258

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.V293I .
HEC1B SNV: p.W633R .
HGC27 SNV: p.L152M DBIA    Probe Info 
IM95 SNV: p.A1132T .
KMRC1 SNV: p.V133M DBIA    Probe Info 
MEWO SNV: p.S1056F DBIA    Probe Info 
MFE319 SNV: p.K885N; p.S904N DBIA    Probe Info 
MM1S Deletion: p.N783CfsTer34; p.L785CfsTer33 .
NCIH196 Deletion: p.G720TfsTer33 .
NCIH3122 SNV: p.M287T DBIA    Probe Info 
RKO SNV: p.S64P DBIA    Probe Info 
SUPT1 SNV: p.T208I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1339(2.35)  LDD3310  [1]
BTD
 Probe Info  		C46(1.74)  LDD2117  [2]
AHL-Pu-1
 Probe Info  		C46(2.01)  LDD0171  [3]
IA-alkyne
 Probe Info  		C46(0.95)  LDD2182  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		N.A.  LDD0005  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C46(1.74)  LDD2117  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C46(2.01)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C760(0.98); C46(0.99); C1250(0.84); C1311(1.03)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C760(1.02); C46(1.03); C1250(0.98); C1311(1.03)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C760(1.11); C46(1.03); C1250(1.06); C1311(0.94)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C760(1.04); C46(0.97); C1250(1.12); C1311(0.93)  LDD1510  [6]
 LDCM0246  AC128 PaTu 8988t C661(0.90); C662(0.90)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C661(0.73); C662(0.73)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C661(0.85); C662(0.85)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C661(0.91); C662(0.91)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C661(1.03); C662(1.03)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C661(0.75); C662(0.75)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C661(0.84); C662(0.84)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C661(0.68); C662(0.68)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C661(0.81); C662(0.81)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C661(0.67); C662(0.67)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C661(0.87); C662(0.87)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C661(0.97); C662(0.97)  LDD1137  [7]
 LDCM0259  AC14 HEK-293T C760(1.01); C46(1.03); C1250(0.93); C1311(0.96)  LDD1512  [6]
 LDCM0260  AC140 PaTu 8988t C661(0.90); C662(0.90)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C661(1.09); C662(1.09)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C661(0.93); C662(0.93)  LDD1141  [7]
 LDCM0263  AC143 PaTu 8988t C661(0.85); C662(0.85)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C661(0.89); C662(0.89)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C661(0.90); C662(0.90)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C661(0.48); C662(0.48)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C661(0.78); C662(0.78)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C661(0.58); C662(0.58)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C661(0.47); C662(0.47)  LDD1148  [7]
 LDCM0270  AC15 HEK-293T C760(1.01); C46(0.96); C1250(0.94); C1311(1.06)  LDD1513  [6]
 LDCM0271  AC150 PaTu 8988t C661(0.41); C662(0.41)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C661(0.30); C662(0.30)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C661(0.53); C662(0.53)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C661(0.37); C662(0.37)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C661(0.35); C662(0.35)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C661(0.38); C662(0.38)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C661(0.45); C662(0.45)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C661(0.35); C662(0.35)  LDD2169  [7]
 LDCM0276  AC17 HEK-293T C760(0.98); C46(1.11); C1250(1.05); C1311(0.84)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C760(1.02); C46(1.05); C1250(1.07); C1311(0.93)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C760(1.13); C46(1.19); C1250(0.99); C1311(0.93)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C760(1.05); C46(1.07); C1250(1.05); C1311(1.08)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C760(0.98); C46(0.90); C1250(1.03); C1311(1.01)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C46(0.98); C1250(1.06); C1311(1.04); C280(0.92)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C760(0.96); C46(0.99); C1250(0.86); C1311(0.96)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C760(0.96); C46(0.99); C1250(0.96); C1311(0.92)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C760(0.95); C46(1.00); C1250(0.88); C1311(1.01)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C760(0.97); C46(1.06); C1250(1.09); C1311(0.83)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C760(0.97); C46(1.05); C1250(1.13); C1311(1.06)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C760(1.09); C46(0.97); C1250(0.96); C1311(0.93)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C760(1.00); C46(0.95); C1250(0.99); C1311(1.07)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C46(0.93); C1250(1.05); C1311(1.02); C280(1.17)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C760(1.02); C46(1.05); C1250(1.01); C1311(0.93)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C760(1.04); C46(0.97); C1250(0.99); C1311(0.99)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C760(0.99); C46(1.01); C1250(0.93); C1311(0.98)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C760(0.90); C46(0.95); C1250(0.96); C1311(1.13)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C760(0.97); C46(1.16); C1250(1.00); C1311(0.91)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C760(0.95); C46(1.07); C1250(0.96); C1311(0.93)  LDD1534  [6]
 LDCM0296  AC35 PaTu 8988t C661(0.63); C662(0.63)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C661(0.53); C662(0.53)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C661(0.78); C662(0.78)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C661(0.60); C662(0.60)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C661(0.52); C662(0.52)  LDD1179  [7]
 LDCM0301  AC4 HEK-293T C760(0.99); C46(0.91); C1250(0.99); C1311(0.98)  LDD1540  [6]
 LDCM0302  AC40 PaTu 8988t C661(0.55); C662(0.55)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C661(0.81); C662(0.81)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C661(0.83); C662(0.83)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C661(0.69); C662(0.69)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C661(0.84); C662(0.84)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C661(0.94); C662(0.94)  LDD1186  [7]
 LDCM0308  AC46 HEK-293T C760(1.02); C46(0.99); C1250(0.93); C1311(0.99)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C760(0.97); C46(0.99); C1250(0.98); C1311(1.04)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C760(0.98); C46(1.02); C1250(1.08); C1311(1.06)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C760(0.95); C46(1.07); C1250(1.05); C1311(0.92)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C46(0.98); C1250(1.00); C1311(1.09); C280(1.09)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C760(1.04); C46(1.00); C1250(0.89); C1311(0.97)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C760(1.07); C46(1.01); C1250(1.01); C1311(0.93)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C760(1.05); C46(0.92); C1250(1.00); C1311(0.98)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C46(0.92); C1250(1.04); C1311(1.02); C280(1.00)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C760(1.01); C46(1.01); C1250(0.90); C1311(1.00)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C760(0.98); C46(0.95); C1250(0.98); C1311(0.94)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C760(0.97); C46(1.02); C1250(0.88); C1311(1.01)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C760(0.93); C46(1.07); C1250(0.96); C1311(0.87)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C760(1.10); C46(0.96); C1250(1.07); C1311(0.98)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C760(1.03); C46(0.96); C1250(0.93); C1311(0.92)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C760(1.05); C46(1.11); C1250(0.92); C1311(0.96)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C760(0.99); C46(0.99); C1250(0.95); C1311(0.95)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C46(0.94); C1250(1.08); C1311(0.95); C280(1.00)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C760(1.02); C46(0.96); C1250(0.93); C1311(1.05)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C760(0.93); C46(0.98); C1250(1.04); C1311(0.96)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C760(0.94); C46(1.02); C1250(0.91); C1311(1.07)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C760(0.97); C46(0.95); C1250(1.02); C1311(0.98)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C760(0.97); C46(1.02); C1250(0.83); C1311(1.06)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C46(0.95); C1250(1.07); C1311(1.01); C280(1.02)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C760(1.03); C46(1.09); C1250(1.00); C1311(0.87)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C760(0.99); C46(1.05); C1250(0.93); C1311(1.02)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C760(0.95); C46(0.97); C1250(1.17); C1311(1.13)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C760(1.21); C46(1.02); C1250(1.41); C1311(1.06)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C46(1.08); C1250(1.03); C1311(0.96); C347(0.95)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C760(0.94); C46(1.00); C1250(0.97); C1311(1.09)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C760(0.98); C46(1.01); C1250(1.14); C1311(0.99)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C760(0.92); C46(0.97); C1250(0.89); C1311(0.94)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C46(1.00); C1250(1.00); C1311(0.98); C347(0.99)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C760(0.91); C46(0.96); C1250(1.12); C1311(1.06)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C760(1.06); C46(0.95); C1250(1.01); C1311(1.03)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C760(0.76); C46(1.01); C1250(0.88); C1311(0.97)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C46(1.06); C1250(0.98); C1311(0.91); C347(1.02)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C760(0.90); C46(0.92); C1250(1.05); C1311(1.09)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C760(1.14); C46(1.05); C1250(1.20); C1311(1.11)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C760(1.03); C46(0.97); C1250(1.09); C1311(0.98)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C760(0.91); C46(1.02); C1250(1.02); C1311(1.00)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C46(0.99); C1250(1.02); C1311(0.94); C347(1.04)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C760(1.04); C46(0.96); C1250(0.95); C1311(1.00)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C760(0.98); C46(1.00); C1250(1.17); C1311(0.97)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C760(0.80); C46(1.07); C1250(1.00); C1311(1.06)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C46(0.97); C1250(0.98); C1311(1.00); C347(0.96)  LDD1590  [6]
 LDCM0387  CL117 PaTu 8988t C661(0.83); C662(0.83)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C661(1.11); C662(1.11)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C661(0.77); C662(0.77)  LDD1268  [7]
 LDCM0390  CL12 HEK-293T C760(0.98); C46(1.09); C1250(1.20); C1311(1.30)  LDD1594  [6]
 LDCM0391  CL120 PaTu 8988t C661(0.59); C662(0.59)  LDD1270  [7]
 LDCM0392  CL121 HEK-293T C760(0.98); C46(0.98); C1250(1.03); C1311(1.12)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C760(1.07); C46(1.00); C1250(1.07); C1311(0.95)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C760(0.92); C46(0.93); C1250(0.92); C1311(0.96)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C46(1.06); C1250(0.99); C1311(1.01); C347(1.15)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C760(0.78); C46(0.95); C1250(0.91); C1311(1.16)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C760(0.98); C46(1.07); C1250(1.06); C1311(0.95)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C760(0.87); C46(0.99); C1250(1.02); C1311(1.02)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C46(1.08); C1250(0.85); C1311(0.99); C347(0.96)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C760(1.04); C46(0.95); C1250(1.06); C1311(1.22)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C760(1.00); C46(0.96); C1250(0.98); C1311(0.95)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C760(0.86); C46(0.93); C1250(0.86); C1311(1.09)  LDD1606  [6]
 LDCM0403  CL16 PaTu 8988t C661(0.85); C662(0.85)  LDD1282  [7]
 LDCM0404  CL17 PaTu 8988t C661(0.62); C662(0.62)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C661(0.63); C662(0.63)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C661(0.65); C662(0.65)  LDD1285  [7]
 LDCM0407  CL2 HEK-293T C760(1.13); C46(1.04); C1250(1.04); C1311(0.94)  LDD1611  [6]
 LDCM0408  CL20 PaTu 8988t C661(0.63); C662(0.63)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C661(0.62); C662(0.62)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C661(0.62); C662(0.62)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C661(0.66); C662(0.66)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C661(0.87); C662(0.87)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C661(0.67); C662(0.67)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C661(0.57); C662(0.57)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C661(0.69); C662(0.69)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C661(0.64); C662(0.64)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C661(0.74); C662(0.74)  LDD1296  [7]
 LDCM0418  CL3 HEK-293T C760(1.03); C46(1.12); C1250(0.95); C1311(0.96)  LDD1622  [6]
 LDCM0419  CL30 PaTu 8988t C661(0.60); C662(0.60)  LDD1298  [7]
 LDCM0420  CL31 PaTu 8988t C661(0.77); C662(0.77)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C661(0.50); C662(0.50)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C661(0.49); C662(0.49)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C661(0.72); C662(0.72)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C661(0.52); C662(0.52)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C661(0.35); C662(0.35)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C661(0.41); C662(0.41)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C661(0.42); C662(0.42)  LDD1307  [7]
 LDCM0429  CL4 HEK-293T C46(1.00); C1250(1.03); C1311(1.14); C347(1.15)  LDD1633  [6]
 LDCM0430  CL40 PaTu 8988t C661(0.61); C662(0.61)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C661(0.46); C662(0.46)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C661(0.35); C662(0.35)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C661(0.33); C662(0.33)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C661(0.44); C662(0.44)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C661(0.36); C662(0.36)  LDD1314  [7]
 LDCM0436  CL46 PaTu 8988t C661(0.81); C662(0.81)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C661(0.82); C662(0.82)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C661(0.67); C662(0.67)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C661(0.76); C662(0.76)  LDD1318  [7]
 LDCM0440  CL5 HEK-293T C760(1.00); C46(1.10); C1250(1.12); C1311(0.94)  LDD1644  [6]
 LDCM0441  CL50 PaTu 8988t C661(0.65); C662(0.65)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C661(0.84); C662(0.84)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C661(0.67); C662(0.67)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C661(0.55); C662(0.55)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C661(0.62); C662(0.62)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C661(0.64); C662(0.64)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C661(0.40); C662(0.40)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C661(0.57); C662(0.57)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C661(0.64); C662(0.64)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C661(0.56); C662(0.56)  LDD1329  [7]
 LDCM0451  CL6 HEK-293T C760(1.01); C46(1.00); C1250(1.21); C1311(0.94)  LDD1654  [6]
 LDCM0452  CL60 PaTu 8988t C661(0.69); C662(0.69)  LDD1331  [7]
 LDCM0453  CL61 HEK-293T C760(1.03); C46(0.95); C1250(1.00); C1311(1.22)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C760(1.08); C46(1.02); C1250(0.97); C1311(0.92)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C760(0.93); C46(0.95); C1250(0.97); C1311(0.96)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C46(1.07); C1250(1.06); C1311(1.04); C347(1.36)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C760(0.96); C46(0.98); C1250(1.12); C1311(0.96)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C760(1.05); C46(0.94); C1250(0.95); C1311(1.00)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C760(1.14); C46(1.09); C1250(1.07); C1311(1.10)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C760(1.14); C46(0.94); C1250(1.18); C1311(1.02)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C46(0.93); C1250(1.22); C1311(1.04); C280(1.04)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C760(1.18); C46(1.11); C1250(1.23); C1311(1.04)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C760(1.18); C46(1.06); C1250(1.27); C1311(1.06)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C760(1.12); C46(1.10); C1250(1.16); C1311(1.07)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C760(1.14); C46(1.12); C1250(1.23); C1311(0.97)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C760(1.08); C46(1.02); C1250(0.99); C1311(1.12)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C760(0.97); C46(0.93); C1250(1.02); C1311(0.97)  LDD1670  [6]
 LDCM0469  CL76 PaTu 8988t C661(0.99); C662(0.99)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C661(1.26); C662(1.26)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C661(0.88); C662(0.88)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C661(1.08); C662(1.08)  LDD1351  [7]
 LDCM0473  CL8 HEK-293T C760(1.19); C46(1.09); C1250(1.38); C1311(0.99)  LDD1676  [6]
 LDCM0474  CL80 PaTu 8988t C661(0.73); C662(0.73)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C661(0.99); C662(0.99)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C661(0.89); C662(0.89)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C661(0.92); C662(0.92)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C661(0.78); C662(0.78)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C661(1.02); C662(1.02)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C661(0.74); C662(0.74)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C661(0.78); C662(0.78)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C661(0.65); C662(0.65)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C661(0.77); C662(0.77)  LDD1362  [7]
 LDCM0484  CL9 HEK-293T C46(1.00); C1250(1.24); C1311(1.12); C280(1.08)  LDD1687  [6]
 LDCM0485  CL90 PaTu 8988t C661(0.81); C662(0.81)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C760(1.13); C46(1.06); C1250(1.20); C1311(1.05)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C760(1.05); C46(1.00); C1250(1.09); C1311(0.97)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C46(0.95); C1250(1.23); C1311(1.08); C280(1.16)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C760(1.13); C46(1.03); C1250(1.05); C1311(1.03)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C760(1.05); C46(1.06); C1250(1.23); C1311(1.19)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C760(0.90); C46(1.16); C1250(1.20); C1311(1.38)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C760(0.92); C46(0.87); C1250(0.97); C1311(1.13)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C760(0.95); C46(0.99); C1250(1.20); C1311(0.93)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C760(0.82); C46(1.06); C1250(0.99); C1311(1.03)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C760(0.98); C46(1.00); C1250(0.97); C1311(1.02)  LDD1698  [6]
 LDCM0625  F8 Ramos C46(1.87)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C46(0.89)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C46(0.43)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C46(1.90)  LDD2191  [4]
 LDCM0576  Fragment14 Ramos C46(1.55)  LDD2193  [4]
 LDCM0580  Fragment21 Ramos C46(1.11)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C46(1.45)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C46(0.92)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C46(0.81)  LDD2198  [4]
 LDCM0589  Fragment31 Ramos C46(1.47)  LDD2200  [4]
 LDCM0468  Fragment33 HEK-293T C760(0.94); C46(0.91); C1250(0.91); C1311(1.02)  LDD1671  [6]
 LDCM0596  Fragment38 Ramos C46(2.95)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C46(0.91)  LDD2184  [4]
 LDCM0427  Fragment51 PaTu 8988t C661(0.34); C662(0.34)  LDD1306  [7]
 LDCM0610  Fragment52 Ramos C46(1.08)  LDD2204  [4]
 LDCM0569  Fragment7 Ramos C46(1.01)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C46(1.44)  LDD2188  [4]
 LDCM0022  KB02 HEK-293T C146(1.00); C760(0.95); C46(1.01); C1379(0.98)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C146(0.92); C760(0.93); C46(1.09); C1379(0.94)  LDD1497  [6]
 LDCM0024  KB05 COLO792 C1339(2.35)  LDD3310  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C46(0.09)  LDD2145  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C46(1.08)  LDD2153  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C46(1.08)  LDD2207  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 17 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adefovir Dipivoxil Small molecular drug DB00718
Alprostadil Small molecular drug DB00770
Atorvastatin Small molecular drug DB01076
Cisplatin Small molecular drug DB00515
Curcumin Small molecular drug DB11672
Dinoprostone Small molecular drug DB00917
Dipyridamole Small molecular drug DB00975
Fluorouracil Small molecular drug DB00544
Glutathione Small molecular drug DB00143
Hyaluronic Acid Small molecular drug DB08818
Mercaptopurine Small molecular drug DB01033
Pemetrexed Small molecular drug DB00642
Probenecid Small molecular drug DB01032
Rifampicin Small molecular drug DB01045
Sildenafil Small molecular drug DB00203
Sulfinpyrazone Small molecular drug DB01138
Zidovudine Small molecular drug DB00495
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyclic Adenosine Monophosphate Small molecular drug DB02527
Curcumin Sulfate . DB14635

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.