Details of the Target

General Information of Target

Target ID LDTP00549
Target Name Importin subunit alpha-6 (KPNA5)
Gene Name KPNA5
Gene ID 3841
Synonyms
Importin subunit alpha-6; Karyopherin subunit alpha-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAMASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDE
SMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPID
QVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLN
SEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNL
CRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCR
RLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEAC
WTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYL
VALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLD
KIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL
Target Bioclass
Transporter and channel
Family
Importin alpha family
Subcellular location
Cytoplasm
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Uniprot ID
O15131
Ensemble ID
ENST00000356348.6
HGNC ID
HGNC:6398

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.99  LDD0402  [1]
DBIA
 Probe Info  		C357(1.22)  LDD0532  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
IA-alkyne
 Probe Info  		C299(0.00); C338(0.00); C256(0.00); C241(0.00)  LDD0165  [4]
WYneN
 Probe Info  		C299(0.00); C241(0.00)  LDD0021  [5]
TFBX
 Probe Info  		C299(0.00); C256(0.00); C241(0.00)  LDD0148  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
AOyne
 Probe Info  		12.70  LDD0443  [8]
NAIA_5
 Probe Info  		C299(0.00); C241(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		N309(0.00); H308(0.00)  LDD2240  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C253(1.22); C357(1.22); C422(0.85)  LDD0812  [2]
 LDCM0215  AC10 HCT 116 C357(1.22)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C253(1.10); C357(1.10); C422(0.87)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C253(1.03); C357(1.03); C422(0.95)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C253(1.15); C357(1.15); C422(1.08)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C253(1.26); C357(1.26); C422(1.02)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C253(1.50); C357(1.50); C422(0.89)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C253(0.78); C357(0.78); C422(1.07)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C253(0.96); C357(0.96); C422(1.17)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C253(0.95); C357(0.95); C422(0.98)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C253(0.77); C357(0.77); C422(0.99)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C253(1.00); C357(1.00); C422(1.01)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C357(1.30)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C253(1.10); C357(1.10); C422(0.83)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C253(0.91); C357(0.91); C422(0.72)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C253(1.10); C357(1.10); C422(0.93)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C357(1.28)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C357(1.05)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C357(1.03)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C357(1.09)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C357(1.01)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C357(1.12)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C357(1.14)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C357(0.94)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C357(0.28)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C357(0.99)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C357(1.24)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C357(0.84)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C357(0.98)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C357(0.47)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C357(1.15)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C357(0.80)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C253(0.63); C357(0.63); C422(0.94)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C253(0.87); C357(0.87); C422(0.96)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C253(0.81); C357(0.81); C422(0.99)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C253(1.03); C357(1.03); C422(0.99)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C253(0.79); C357(0.79); C422(0.91)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C253(1.00); C357(1.00); C422(0.94)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C253(0.99); C357(0.99); C422(0.98)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C253(1.02); C357(1.02); C422(0.90)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C253(0.92); C357(0.92); C422(0.88)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C253(0.89); C357(0.89); C422(0.83)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C253(0.70); C357(0.70); C422(0.79)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C253(1.02); C357(1.02); C422(0.85)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C357(1.18)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C253(0.99); C357(0.99); C422(0.89)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C253(1.16); C357(1.16); C422(0.82)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C253(0.71); C357(0.71); C422(0.89)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C253(1.00); C357(1.06); C422(0.94)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C253(1.06); C357(1.03); C422(0.64)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C253(1.12); C357(1.25); C422(0.63)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C253(0.94); C357(0.91); C422(0.63)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C253(1.07); C357(1.00); C422(0.56)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C253(1.05); C357(1.07); C422(0.58)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C253(0.87); C357(0.93); C422(0.87)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C357(1.20)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C253(1.03); C357(1.09); C422(0.73)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C253(1.02); C357(1.13); C422(0.73)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C253(0.95); C357(0.91); C422(0.78)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C253(0.95); C357(0.89); C422(0.71)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C253(1.00); C357(0.97); C422(0.91)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C253(1.01); C357(1.12); C422(0.81)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C253(1.05); C357(1.17); C422(0.51)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C253(1.03); C357(0.99); C422(0.38)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C253(0.98)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C253(0.79)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C253(0.86)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C253(1.04); C357(1.04); C422(0.88)  LDD0877  [2]
 LDCM0280  AC20 HCT 116 C253(1.00)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C253(0.75)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C253(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C253(0.87)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C253(0.96)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C253(0.78)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C253(0.92)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C253(0.85)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C253(0.90)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C253(0.94)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C253(0.91); C357(0.91); C422(0.89)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C253(0.84)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C253(0.81)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C253(0.98)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C253(0.92)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C253(1.04)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C253(1.14); C357(2.23)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C253(0.97); C357(1.08)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C357(0.72); C253(0.99)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C253(1.11); C357(1.24)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C253(1.09); C357(1.23)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C253(0.92); C357(0.92); C422(0.92)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C357(0.94); C253(0.99)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C253(0.96); C357(1.07)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C253(0.97); C357(1.59)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C253(0.91); C357(1.18)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C253(1.02); C357(1.36)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C357(1.14); C253(1.17)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C253(1.24); C357(1.24); C422(0.99)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C253(1.07); C357(1.07); C422(0.85)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C253(0.86); C357(0.86); C422(0.78)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C253(0.91); C357(0.91); C422(1.04)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C253(1.17); C357(1.17); C422(1.02)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C253(1.22); C357(1.22); C422(0.95)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C253(0.83); C357(0.83); C422(0.78)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C253(1.17); C357(1.17); C422(0.83)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C253(1.06); C357(1.06); C422(0.94)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C253(0.84); C357(0.84); C422(0.71)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C253(1.12); C357(1.12); C422(0.81)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C253(1.00); C357(1.00); C422(0.71)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C253(1.18)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C253(1.60)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C253(1.39)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C357(0.99)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C253(1.34)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C253(0.94)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C253(1.34)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C253(1.27)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C253(1.09)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C253(1.30)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C253(0.96)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C253(1.41)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C253(1.08); C357(1.08); C422(1.04)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C253(1.14); C357(1.14); C422(1.05)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C357(1.11)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C253(1.32); C357(1.32); C422(1.01)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C253(1.24); C357(1.24); C422(0.99)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C253(1.07); C357(1.07); C422(1.17)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C253(0.86); C357(0.86); C422(0.95)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C253(1.33); C357(1.33); C422(1.07)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C253(1.21); C357(1.21); C422(1.01)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C253(0.86); C357(0.86); C422(0.94)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C253(0.97); C357(0.97); C422(0.90)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C253(1.07); C357(1.07); C422(0.98)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C253(1.36); C357(1.36); C422(1.14)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C357(1.03)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C253(1.32); C357(1.32); C422(0.85)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C253(1.06); C357(1.06); C422(0.92)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C253(1.03); C357(1.03); C422(0.71)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C357(0.79); C253(1.01)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C357(0.65); C253(0.82)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C357(0.72); C253(0.79)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C253(0.86); C357(0.95)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C253(0.86); C357(1.08)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C253(0.79); C357(1.08)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C253(0.86); C357(0.86)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C253(0.90); C357(1.01)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C357(0.71); C253(0.98)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C253(0.90); C357(0.96)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C253(0.74); C357(0.90)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C357(0.66); C253(0.71)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C253(0.83); C357(1.04)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C253(0.75); C357(0.83)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C357(0.75); C253(0.87)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C253(1.21); C357(1.21); C422(0.96)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C253(1.02); C357(1.02); C422(0.95)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C357(1.35)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C357(1.33)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C357(1.01)  LDD0592  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C253(0.97)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C253(0.86)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C253(0.88); C357(0.88); C422(0.77)  LDD0967  [2]
 LDCM0370  CL101 HCT 116 C357(1.09)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C357(1.23)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C357(1.21)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C357(1.09)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C253(0.86)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C253(0.93)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C253(0.96)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C253(1.00)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C253(0.80)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C253(0.96)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C253(0.68)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C253(0.80)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C253(0.82)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C253(1.01)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C253(0.87)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C253(1.07)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C253(0.83)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C253(1.02); C357(1.59)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C253(0.96); C357(1.54)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C253(0.93); C357(1.12)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C253(0.93)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C253(0.96); C357(1.18)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C253(0.95); C357(0.95); C422(0.70)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C253(1.01); C357(1.01); C422(0.88)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C253(1.20); C357(1.20); C422(0.93)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C253(1.64); C357(1.64); C422(0.90)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C253(0.84)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C253(0.83)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C253(1.24)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C253(1.34)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C253(1.08)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C253(0.92)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C253(1.04)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C422(1.02)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C422(0.84)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C422(0.93)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C422(0.92)  LDD1004  [2]
 LDCM0407  CL2 HCT 116 C253(0.91)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C422(0.95)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C422(0.82)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C422(0.87)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C422(0.81)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C422(0.87)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C422(0.84)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C422(0.87)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C422(1.00)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C422(0.90)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C422(0.92)  LDD1015  [2]
 LDCM0418  CL3 HCT 116 C253(0.94)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C422(0.80)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C422(0.93)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C422(0.91)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C422(0.60)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C422(0.72)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C422(0.70)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C422(0.75)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C422(0.89)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C422(0.50)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C253(1.08)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C422(0.78)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C422(0.61)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C422(0.49)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C422(0.56)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C422(0.77)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C422(0.56)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C253(0.80)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C253(0.79)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C253(0.84)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C253(0.92)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C253(1.11)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C253(0.97)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C253(0.95)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C253(0.93)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C253(0.86)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C253(0.92)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C253(0.96)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C253(0.89)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C253(0.82)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C253(0.90)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C253(0.97)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C253(0.89)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C253(0.90)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C253(1.44)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C253(1.21)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C253(1.15)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C253(1.24)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C253(1.19)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C253(1.22)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C253(1.07)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C253(1.09)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C253(0.98)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C253(1.00)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C253(1.12)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C253(1.46)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C253(1.51)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C253(1.04)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C253(1.18)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C422(1.05)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C422(0.78)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C422(0.63)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C422(0.84)  LDD1070  [2]
 LDCM0473  CL8 HCT 116 C253(0.84)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C422(0.89)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C422(0.74)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C422(1.10)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C422(1.04)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C422(0.69)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C422(0.77)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C422(0.59)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C422(0.68)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C422(0.91)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C422(0.84)  LDD1081  [2]
 LDCM0484  CL9 HCT 116 C253(1.00)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C422(0.89)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C253(1.15); C357(1.15); C422(1.16)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C253(0.96); C357(0.96); C422(0.99)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C253(0.94); C357(0.94); C422(0.89)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C253(0.90); C357(0.90); C422(0.81)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C253(1.07); C357(1.07); C422(0.78)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C253(1.16); C357(1.16); C422(0.88)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C253(1.02); C357(1.02); C422(0.89)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C253(0.80); C357(0.80); C422(0.80)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C253(0.86); C357(0.86); C422(0.90)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C253(1.07); C296(1.05); C139(1.12); C340(1.04)  LDD1698  [12]
 LDCM0468  Fragment33 HCT 116 C253(1.25)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C422(1.09)  LDD1025  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C253(1.00); C139(1.11); C340(1.00)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C253(1.05); C139(0.98); C340(1.02)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C240(5.51)  LDD3310  [13]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Single-stranded DNA cytosine deaminase (AICDA) Cytidine and deoxycytidylate deaminase family Q9GZX7
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
m7GpppX diphosphatase (DCPS) HIT family Q96C86
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
tRNA-splicing endonuclease subunit Sen54 (TSEN54) SEN54 family Q7Z6J9
Speckle-type POZ protein-like (SPOPL) Tdpoz family Q6IQ16
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore complex protein Nup50 (NUP50) . Q9UKX7
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DBIRD complex subunit ZNF326 (ZNF326) AKAP95 family Q5BKZ1
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) ANP32 family Q92688
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Lamin-B1 (LMNB1) Intermediate filament family P20700
DNA repair protein RAD52 homolog (RAD52) RAD52 family P43351
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840