Details of the Target

General Information of Target

Target ID LDTP00531
Target Name Centrosomal protein of 290 kDa (CEP290)
Gene Name CEP290
Gene ID 80184
Synonyms
BBS14; KIAA0373; NPHP6; Centrosomal protein of 290 kDa; Cep290; Bardet-Biedl syndrome 14 protein; Cancer/testis antigen 87; CT87; Nephrocystin-6; Tumor antigen se2-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMK
MKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQL
EKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI
IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMR
KNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDD
PIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER
DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT
KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE
ILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLK
EIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLK
NMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE
MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELR
ESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQ
NEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTI
KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQY
TTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS
ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEK
LHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMY
EHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILE
LEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI
AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA
KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE
MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS
EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG
SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK
VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ
RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF
IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEV
KKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQ
QKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLK
LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSG
LQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQA
KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRAL
ESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT
YSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMC
EFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS
EKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAA
EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK
ELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRE
LQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ
HLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPV
AASEEFEDEEESPVNFPIY
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. Required for efficient recruitment of RAB8A to primary cilium. In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5. Activates ATF4-mediated transcription.
TTD ID
T01674
Uniprot ID
O15078
DrugMap ID
TT3XBOV
Ensemble ID
ENST00000552810.6
HGNC ID
HGNC:29021

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C383(1.61)  LDD3342  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		48.84  LDD1884  [4]
STS-1
 Probe Info  		N.A.  LDD0137  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C2055(0.64)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C383(1.06); C998(0.97); C929(0.98)  LDD1508  [7]
 LDCM0216  AC100 HEK-293T C2055(1.59)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C2055(1.54)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C2055(1.53)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C2055(1.12)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C2055(1.44)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C2055(1.31)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C2055(1.01)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C2055(1.56)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C2055(1.27)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C2055(1.39)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C2055(1.11); C383(1.07); C998(1.01); C929(1.17)  LDD1509  [7]
 LDCM0227  AC110 HEK-293T C2055(0.60)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C2055(0.16)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C2055(0.38)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C2055(0.97)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C2055(1.45)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C2055(1.09)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C2055(1.70)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C2055(1.16)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C2055(1.14)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C2055(1.55)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C2055(0.91); C383(1.08); C998(0.98); C929(1.09)  LDD1510  [7]
 LDCM0238  AC120 HEK-293T C2055(1.60)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C2055(1.36)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C2055(1.24)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C2055(1.29)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C2055(1.36)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C2055(1.15)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C2055(0.58)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C2055(0.43)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C2055(0.79)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C2055(1.33)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C2055(1.13)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C2055(1.17)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C2055(1.06)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C2055(1.11)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C2055(1.50)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C2055(0.91)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C2055(1.13)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C2055(0.88)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C2055(0.53)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C2055(0.80)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C383(1.08); C118(1.12); C929(1.11)  LDD1512  [7]
 LDCM0260  AC140 HEK-293T C2055(1.07)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C2055(0.79)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C2055(1.28)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C2055(1.03)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C2055(1.62)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C2055(1.24)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C2055(0.90)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C2055(0.92)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C2055(0.81)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C2055(1.13)  LDD0867  [6]
 LDCM0270  AC15 HEK-293T C2055(0.76); C383(1.12); C998(1.02); C929(1.15)  LDD1513  [7]
 LDCM0271  AC150 HEK-293T C2055(1.09)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C2055(1.28)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C2055(1.56)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C2055(1.36)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C2055(1.46)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C2055(1.40)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C2055(1.33)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C2055(0.50)  LDD2165  [6]
 LDCM0276  AC17 HEK-293T C2055(1.05)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C2055(1.09)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C2055(1.35)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C2055(0.73)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C2055(0.73)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C2055(0.57)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C2055(0.99)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C2055(1.07)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C2055(1.43)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C2055(1.25)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C2055(1.13)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C2055(1.18)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C2055(1.12)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C2055(1.25)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C2055(1.02)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C2055(1.59)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C2055(1.63)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C2055(1.45)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C2055(1.24)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C2055(1.64)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C2055(0.85)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C2055(1.21)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C2055(1.13)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C2055(1.21)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C2055(1.01)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C2055(0.70)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C2055(1.40)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C2055(0.96)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C2055(1.30)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C2055(1.10)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C2055(1.18)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C2055(1.12)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C383(1.06); C118(1.22); C929(1.09)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C2055(0.88); C383(1.06); C998(1.07); C929(1.05)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C2055(0.83); C383(1.14)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C383(1.08); C998(1.09); C929(1.40)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C2055(0.96)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C383(1.10); C998(1.01); C929(1.14)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C2055(0.85); C383(1.04); C998(1.06); C929(1.11)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C2055(0.95); C383(1.02); C998(0.99); C929(1.00)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C2055(1.32); C383(1.09); C998(0.95); C929(1.23)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C383(1.10); C118(1.12); C929(1.14)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C2055(0.90); C383(1.18); C998(1.02); C929(1.02)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C2055(0.87); C383(1.11)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C2055(0.93)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C2055(1.36)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C2055(1.26)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C383(1.02); C118(1.08); C929(1.15)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C2055(1.09)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C2055(1.02)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C2055(1.17)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C2055(1.11)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C2055(1.25)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C2055(1.17)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C2055(1.36)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C2055(1.46)  LDD0929  [6]
 LDCM0334  AC7 HEK-293T C2055(0.79); C383(1.10); C998(1.07); C929(1.02)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C2055(0.89); C383(1.04)  LDD1569  [7]
 LDCM0365  AC98 HEK-293T C2055(0.86)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C2055(1.55)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C2055(1.03); C383(1.07); C998(0.96); C929(0.98)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C383(1.04); C998(1.07); C929(1.45)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C2055(1.08); C383(1.11)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C383(0.97); C998(0.87)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C383(0.79); C118(0.86); C929(0.85)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C2055(0.64)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C383(1.00); C998(1.05)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C383(0.92); C998(0.91); C929(1.02)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C383(1.05); C998(1.08)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C383(1.13); C998(0.99); C929(1.03)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C2055(0.97)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C2055(0.81)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C2055(1.28)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C2055(0.95)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C2055(1.03)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C2055(0.94); C383(0.99); C998(1.07); C929(1.10)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C2055(0.82)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C2055(1.55)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C2055(1.29)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C2055(1.30)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C2055(1.37)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C2055(1.37)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C2055(1.51)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C2055(1.17)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C2055(0.96)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C2055(1.18)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C2055(1.14); C383(1.32)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C2055(0.96)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C383(1.04); C998(1.01)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C383(1.08); C998(0.73); C929(1.03)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C383(1.04); C998(0.90)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C383(1.42); C998(1.02); C929(1.07)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C2055(1.25)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C2055(1.01)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C2055(1.09)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C2055(1.06)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C383(1.03); C998(0.97)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C383(1.00); C998(0.76); C929(1.10)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C383(0.98); C998(1.02)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C383(1.16); C998(0.96); C929(1.00)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C383(1.10); C998(1.04); C929(1.10)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C383(1.07); C998(0.99); C929(1.05)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C2055(0.95); C383(1.12); C998(1.17); C929(1.39)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C383(1.00); C998(0.83); C929(0.99)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C2055(1.00); C383(1.08); C998(1.18); C929(1.05)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C2055(1.96); C383(0.96); C998(1.15); C929(1.22)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C383(1.05); C118(1.04); C929(1.18)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C2055(0.90); C383(1.15); C998(1.06); C929(1.24)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C2055(1.11); C383(1.15)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C383(0.91); C998(0.99)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C383(1.03); C998(0.93); C929(0.93)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C383(1.11); C998(1.06)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C383(1.11); C998(0.95); C929(1.00)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C383(1.09); C998(1.07); C929(1.05)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C383(1.03); C998(1.10)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C383(1.07); C998(1.04); C929(1.11)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C2055(1.62)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C2055(1.27)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C2055(1.10)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C2055(0.95)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C2055(1.30)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C2055(1.03)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C2055(1.24)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C2055(0.87)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C383(1.00); C998(0.96); C929(1.00)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C2055(1.15)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C2055(0.97)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C2055(0.99)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C2055(1.02)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C2055(1.32)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C2055(1.04)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C2055(1.28)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C2055(1.32)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C2055(1.45)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C2055(1.15)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C383(1.02); C998(1.15); C929(1.06)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C2055(0.66)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C2055(0.87)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C2055(1.12)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C2055(1.08)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C2055(0.93)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C2055(0.96)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C2055(1.53)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C2055(0.98)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C2055(0.78)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C2055(1.08)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C383(0.95); C998(0.98); C929(0.99)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C2055(0.72)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C2055(1.64)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C2055(1.41)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C2055(1.39)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C2055(1.15)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C2055(1.09)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C2055(1.01)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C2055(1.13)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C2055(0.94)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C2055(1.33)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C2055(1.07); C383(1.05); C998(1.03); C929(1.25)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C2055(1.21)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C2055(1.18)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C2055(1.32)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C2055(1.04)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C2055(0.85)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C2055(1.25)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C2055(1.02)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C2055(1.99)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C2055(1.72)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C2055(0.78); C383(0.87); C998(0.91); C929(0.83)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C2055(1.33)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C2055(1.09)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C2055(0.80)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C2055(0.81)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C2055(1.77)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C2055(1.55)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C2055(1.43)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C2055(1.26)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C2055(1.07)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C2055(1.14)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C2055(0.93); C383(0.97); C998(1.07); C929(1.33)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C2055(0.90)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C2055(1.39)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C2055(1.06)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C2055(1.07)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C2055(0.96)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C2055(0.80)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C2055(1.48)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C2055(1.14)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C2055(0.84)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C2055(0.72)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C383(0.97); C998(0.95)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C2055(0.70)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C2055(1.03)  LDD1025  [6]
 LDCM0022  KB02 HEK-293T C2055(1.06); C383(1.01); C118(0.92)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C2055(1.15); C383(1.08); C118(0.97)  LDD1497  [7]
 LDCM0024  KB05 NCI-H1155 C383(1.61)  LDD3342  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 423 (ZNF423) Krueppel C2H2-type zinc-finger protein family Q2M1K9
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 131 kDa (CEP131) CEP131 family Q9UPN4
Centrosomal protein of 162 kDa (CEP162) CEP162 family Q5TB80
Bublin coiled-coil protein (BBLN) UPF0184 (EST00098) family Q9BUW7
Centriolar coiled-coil protein of 110 kDa (CCP110) . O43303
Centrosomal protein of 290 kDa (CEP290) . O15078
IQ calmodulin-binding motif-containing protein 1 (IQCB1) . Q15051
PRKCA-binding protein (PICK1) . Q9NRD5
Protein hinderin (KIAA1328) . Q86T90

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sepofarsen Oligonucleotide DS14FO

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402