Details of the Target

General Information of Target

Target ID LDTP00483
Target Name Phospholipase D2 (PLD2)
Gene Name PLD2
Gene ID 5338
Synonyms
Phospholipase D2; PLD 2; hPLD2; EC 3.1.4.4; Choline phosphatase 2; PLD1C; Phosphatidylcholine-hydrolyzing phospholipase D2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFA
PGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVL
MSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYR
NYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVV
KDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQAR
WWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIF
ITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRAL
MLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSE
SAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPW
RDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQ
CTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDE
IVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHR
LKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLL
GKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICD
DFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQ
GHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Phospholipase D family
Subcellular location
Cell membrane
Function Function as phospholipase selective for phosphatidylcholine. May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
TTD ID
T10383
Uniprot ID
O14939
DrugMap ID
TTRLMKF
Ensemble ID
ENST00000263088.11
HGNC ID
HGNC:9068
ChEMBL ID
CHEMBL2734

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.N181T DBIA    Probe Info 
HCC1395 Deletion: p.D663_K667del DBIA    Probe Info 
HEC1 SNV: p.R281W DBIA    Probe Info 
HEC1B SNV: p.R281W .
JURKAT SNV: p.A127V .
KMRC1 SNV: p.Q268Ter DBIA    Probe Info 
KYSE150 SNV: p.E660D DBIA    Probe Info 
LNCaP clone FGC SNV: p.P5H DBIA    Probe Info 
MCC13 SNV: p.Q900Ter .
NCIH1155 SNV: p.G140D .
PATU8988T SNV: p.S192I .
REH SNV: p.L824I .
SISO Substitution: p.G456V DBIA    Probe Info 
SUPT1 SNV: p.R608Ter .
SW837 SNV: p.A299G; p.I385V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C84(1.46)  LDD0532  [1]
ENE
 Probe Info  		N.A.  LDD0006  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
SF
 Probe Info  		N.A.  LDD0028  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
VSF
 Probe Info  		N.A.  LDD0007  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C224(1.79); C223(1.12); C84(1.23)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C84(1.46)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C84(0.94)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C84(0.89)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C84(0.92)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C84(0.90)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C84(0.83)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C84(0.89)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C84(0.81)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C84(0.69)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C84(0.82)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C84(0.75)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C84(0.91)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C84(0.84)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C84(0.62)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C84(0.85)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C223(0.93); C224(0.93)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C223(1.13); C224(1.13)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C223(1.74); C224(1.74)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C223(1.63); C224(1.63)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C223(0.93); C224(0.93)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C223(1.16); C224(1.16)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C223(1.44); C224(1.44)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C84(0.68)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C223(1.82); C224(1.82)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C223(1.30); C224(1.30)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C223(1.10); C224(1.10)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C223(0.97); C224(0.97)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C223(1.18); C224(1.18)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C223(1.69); C224(1.69)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C223(1.93); C224(1.93)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C223(1.89); C224(1.89)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C84(1.40)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C84(0.72)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C84(0.95)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C84(1.27)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C84(1.33)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C84(0.50)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C84(0.56)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C84(0.57)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C84(0.79)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C84(0.45)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C84(0.44)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C84(0.44)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C84(1.20)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C84(0.45)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C84(0.46)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C84(0.53)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C223(1.00); C224(1.00)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C223(1.03); C224(1.03)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C223(1.04); C224(1.04)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C223(1.14); C224(1.14)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C223(0.91); C224(0.91)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C223(2.64); C224(2.64)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C223(1.85); C224(1.85)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C84(0.97)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C223(1.01); C224(1.01)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C223(0.84); C224(0.84)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C223(1.08); C224(1.08)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C223(1.29); C224(1.29)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C223(0.93); C224(0.93)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C223(1.00); C224(1.00)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C223(0.96); C224(0.96)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C223(0.90); C224(0.90)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C84(0.64)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C84(1.23)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C84(0.92)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C224(1.00); C223(1.02); C84(0.92)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C84(0.95)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C84(1.15)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C84(0.64)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C84(1.13)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C84(1.01)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C223(1.22); C224(1.22)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C223(1.81); C224(1.81)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C223(1.43); C224(1.43)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C223(1.87); C224(1.87)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C223(1.71); C224(1.71)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C224(0.88); C223(1.11); C84(1.27)  LDD0888  [1]
 LDCM0291  AC30 HCT 116 C223(1.77); C224(1.77)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C223(1.38); C224(1.38)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C223(2.07); C224(2.07)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C223(1.16); C224(1.16)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C223(0.52); C224(0.52)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C223(0.90); C224(0.90)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C223(0.89); C224(0.89)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C223(0.90); C224(0.90)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C223(1.08); C224(1.08)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C223(1.02); C224(1.02)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C224(1.01); C223(1.37); C84(1.44)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C223(1.04); C224(1.04)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C223(1.19); C224(1.19)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C223(1.15); C224(1.15)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C223(1.12); C224(1.12)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C223(1.11); C224(1.11)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C223(1.13); C224(1.13)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C224(0.51); C223(1.00); C84(0.87)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C224(0.54); C223(1.18); C84(0.93)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C224(0.65); C223(1.12); C84(0.64)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C224(0.63); C223(1.26); C84(0.72)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C224(1.52); C223(0.94); C84(1.14)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C224(0.66); C223(1.48); C84(0.59)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C224(0.81); C223(1.46); C84(0.46)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C224(0.83); C223(1.65); C84(0.42)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C224(0.72); C223(2.56); C84(0.82)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C224(0.68); C223(1.39); C84(0.49)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C224(0.79); C223(1.11); C84(0.62)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C224(0.63); C223(1.01); C84(0.72)  LDD0917  [1]
 LDCM0320  AC57 HCT 116 C84(0.78)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C84(1.47)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C84(1.01)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C84(1.74)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C84(1.29)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C84(0.98)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C84(0.98)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C84(1.33)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C84(1.40)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C84(1.18)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C84(1.43)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C84(1.26)  LDD0648  [1]
 LDCM0332  AC68 HEK-293T C224(1.21); C223(0.96)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C224(1.17); C223(0.93)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C84(1.01)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C224(1.31); C223(0.88)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C224(1.34); C223(0.98)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C224(1.13); C223(1.06)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C224(1.21); C223(1.02)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C224(1.24); C223(0.91)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C224(1.07); C223(0.91)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C224(1.16); C223(0.99)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C224(1.23); C223(0.86)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C224(1.57); C223(0.97)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C224(1.08); C223(0.94)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C84(1.00)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C224(1.27); C223(0.89)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C224(1.44); C223(0.96)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C224(1.70); C223(0.94)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C84(1.23); C223(1.48); C224(1.48)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C223(1.20); C224(1.20); C84(1.53)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C84(1.02); C223(1.26); C224(1.26)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C84(0.96); C223(1.62); C224(1.62)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C223(1.25); C224(1.25); C84(1.35)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C223(1.41); C224(1.41); C84(2.17)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C223(1.34); C224(1.34); C84(4.21)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C223(1.42); C224(1.42); C84(1.74)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C223(1.17); C224(1.17); C84(1.68)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C223(1.26); C224(1.26); C84(1.92)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C223(1.00); C224(1.00); C84(1.43)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C223(1.04); C224(1.04); C84(1.36)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C223(1.31); C224(1.31); C84(2.95)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C223(0.89); C224(0.89); C84(1.74)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C223(1.52); C224(1.52); C84(2.66)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C84(1.20)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C84(0.96)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C84(0.86)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C84(0.88)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C84(0.97)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C84(1.19)  LDD2171  [1]
 LDCM0367  CL1 HEK-293T C224(0.90)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C224(1.20)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C224(0.96); C223(0.96); C84(0.87)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C84(1.40)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C84(1.76)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C84(1.59)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C84(1.23)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C84(0.53)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C84(0.50)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C84(0.42)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C84(0.52)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C84(0.39)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C224(0.99)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C84(0.40)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C84(0.65)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C223(1.12); C224(1.12)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C223(1.30); C224(1.30)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C223(1.06); C224(1.06)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C223(1.00); C224(1.00)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C223(0.81); C224(0.81)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C223(1.63); C224(1.63)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C223(0.99); C224(0.99)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C223(1.01); C224(1.01)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C224(0.73)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C223(0.95); C224(0.95)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C224(0.60); C223(2.92); C84(0.51)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C224(0.62); C223(1.55); C84(0.68)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C224(0.64); C223(1.78); C84(0.73)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C224(0.70); C223(0.92); C84(0.69)  LDD0993  [1]
 LDCM0396  CL125 HCT 116 C84(0.88)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C84(1.21)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C84(1.11)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C84(0.93)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C224(0.79)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C224(0.78)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C224(0.59)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C224(1.64); C84(1.29)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C224(0.97); C84(1.08)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C224(1.16); C84(0.69)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C224(1.12); C84(1.06)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C224(0.76)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C224(1.19); C84(0.93)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C224(1.06); C84(0.53)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C224(1.24); C84(0.61)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C224(0.80); C84(1.17)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C224(0.95); C84(1.00)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C224(1.13); C84(0.82)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C224(1.14); C84(1.12)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C224(1.02); C84(0.99)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C224(0.83); C84(1.14)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C224(1.19); C84(1.28)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C224(0.98)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C224(1.22); C84(0.46)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C224(20.00); C223(0.83); C84(0.60)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C224(0.74); C223(1.01); C84(0.53)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C224(1.00); C223(1.02); C84(0.46)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C224(0.57); C223(1.75); C84(0.65)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C224(0.76); C223(1.34); C84(0.49)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C224(0.77); C223(1.47); C84(0.48)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C224(0.75); C223(1.02); C84(0.57)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C224(0.91); C223(0.90); C84(0.11)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C224(0.87)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C224(0.70); C223(1.07); C84(0.34)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C224(1.31); C223(1.03); C84(0.14)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C224(0.69); C223(0.84); C84(0.13)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C224(0.99); C223(0.96); C84(0.14)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C224(0.94); C223(1.21); C84(0.40)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C224(0.75); C223(1.19); C84(0.18)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C84(0.92)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C84(1.13)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C84(1.25)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C84(1.11)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C224(0.81)  LDD1038  [1]
 LDCM0441  CL50 HCT 116 C84(1.06)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C84(0.91)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C84(1.05)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C84(1.52)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C84(1.40)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C84(1.21)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C84(1.55)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C84(1.26)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C84(1.37)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C84(1.21)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C224(0.76)  LDD1049  [1]
 LDCM0452  CL60 HCT 116 C84(1.23)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C84(0.92); C223(0.93); C224(0.93)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C84(0.72); C223(1.08); C224(1.08)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C84(1.28); C223(1.29); C224(1.29)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C84(0.92); C223(0.76); C224(0.76)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C84(1.17); C223(1.10); C224(1.10)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C84(0.95); C223(1.11); C224(1.11)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C84(1.62); C223(0.98); C224(0.98)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C84(1.45); C223(0.76); C224(0.76)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C84(1.42); C223(0.93); C224(0.93)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C224(0.86)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C84(1.29); C223(0.53); C224(0.53)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C84(1.26); C223(0.59); C224(0.59)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C84(1.53); C223(0.88); C224(0.88)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C84(1.49); C223(1.07); C224(1.07)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C84(1.58); C223(0.86); C224(0.86)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C224(1.41); C223(1.02)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C224(1.29); C223(0.96)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C224(2.44); C223(0.67)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C224(2.13); C223(0.82)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C224(0.96)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C224(1.16); C223(0.93)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C224(2.00); C223(0.91)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C224(1.09); C223(1.22)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C224(0.96); C223(1.33)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C224(2.77); C223(0.71)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C224(2.35); C223(0.86)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C224(2.03); C223(0.68)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C224(1.92); C223(0.93)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C224(1.26); C223(0.96)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C224(1.90); C223(1.15)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C224(1.10)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C224(1.97); C223(1.03)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C224(1.72); C223(1.06); C84(1.25)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C224(1.22); C223(0.95); C84(1.16)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C224(1.54); C223(0.91); C84(1.02)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C224(1.76); C223(0.86); C84(0.74)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C224(1.06); C223(0.83); C84(0.49)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C224(1.11); C223(1.05); C84(0.95)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C224(1.06); C223(0.96); C84(1.35)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C224(0.94); C223(1.14); C84(1.03)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C224(0.91); C223(1.04); C84(1.29)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C84(0.95); C863(0.78)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C84(1.05); C223(0.69); C224(0.69)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C224(1.41); C223(0.84); C84(0.94)  LDD1025  [1]
 LDCM0022  KB02 22RV1 C601(1.24)  LDD2243  [6]
 LDCM0023  KB03 22RV1 C601(1.06)  LDD2660  [6]
 LDCM0024  KB05 MIA PaCa-2 C601(1.99)  LDD3330  [6]
 LDCM0021  THZ1 HCT 116 C84(1.19)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related C3 botulinum toxin substrate 2 (RAC2) Rho family P15153
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-1 (CFL1) Actin-binding proteins ADF family P23528
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Choline Small molecular drug DB00122
Choline Salicylate Small molecular drug DB14006
Clinical trial
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vu0364739 Small molecular drug D03JRG
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pip2 Small molecular drug D07ZAJ

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840