Details of the Target

General Information of Target

Target ID LDTP00410
Target Name tRNA (cytosine(38)-C(5))-methyltransferase (TRDMT1)
Gene Name TRDMT1
Gene ID 1787
Synonyms
DNMT2; tRNA; cytosine(38)-C(5))-methyltransferase; EC 2.1.1.204; DNA; cytosine-5)-methyltransferase-like protein 2; Dnmt2; DNA methyltransferase homolog HsaIIP; DNA MTase homolog HsaIIP; M.HsaIIP; PuMet
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGI
TLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLEN
VKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPG
QVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHR
KNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSY
IEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGF
PEKITVKQRYRLLGNSLNVHVVAKLIKILYE
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Subcellular location
Cytoplasm
Function Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Has higher activity on tRNA(Asp) modified with queuosine at position 34.
Uniprot ID
O14717
Ensemble ID
ENST00000377799.8
HGNC ID
HGNC:2977
ChEMBL ID
CHEMBL4523124

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: . .
AGS SNV: p.L352I .
DU145 SNV: p.C79F .
HCT15 SNV: p.I137T .
ICC137 SNV: p.Q145H .
OVK18 SNV: p.A227T .
SNU308 SNV: p.N242D .
SW403 SNV: p.G180C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C287(0.96)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		C222(0.00); C287(0.00)  LDD2156  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C287(2.34)  LDD0372  [6]
 LDCM0214  AC1 HCT 116 C287(1.19)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C222(0.98)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C287(1.11)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C287(1.11)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C287(0.80)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C287(0.96)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C287(1.07)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C287(0.84)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C287(0.83)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C287(1.09)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C287(0.97)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C287(1.07)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C222(0.78)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C287(0.92)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C287(1.16)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C287(0.94)  LDD0827  [1]
 LDCM0230  AC113 HCT 116 C287(1.28)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C287(1.40)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C287(2.14)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C287(1.94)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C287(1.37)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C287(1.35)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C287(1.28)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C222(1.02)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C287(1.41)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C287(1.16)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C287(1.09)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C287(1.26)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C287(1.31)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C287(1.33)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C287(1.64)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C287(1.61)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C222(0.66)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C222(1.05)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C222(0.98)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C222(0.92)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C222(1.33)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C222(0.95)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C222(1.06)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C222(1.40)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C222(0.85)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C222(1.63)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C222(1.63)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C222(1.71)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C222(1.02)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C222(1.38)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C222(1.81)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C222(1.46)  LDD0860  [1]
 LDCM0270  AC15 HEK-293T C222(1.74)  LDD0868  [1]
 LDCM0276  AC17 HCT 116 C287(1.37)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C287(1.56)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C287(1.40)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C287(1.02)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C287(1.20)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C287(1.10)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C287(1.01)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C287(1.24)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C287(1.15)  LDD0601  [1]
 LDCM0285  AC25 PaTu 8988t C287(0.83)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C287(0.98)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C287(1.23)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C287(1.36)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C287(0.97)  LDD1168  [1]
 LDCM0290  AC3 HCT 116 C287(1.00)  LDD0607  [1]
 LDCM0291  AC30 PaTu 8988t C287(0.94)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C287(0.91)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C287(0.91)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C287(1.37)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C287(1.09)  LDD1174  [1]
 LDCM0301  AC4 HCT 116 C287(1.32)  LDD0618  [1]
 LDCM0308  AC46 HCT 116 C287(0.98)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C287(0.95)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C287(0.80)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C287(1.26)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C287(1.27)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C287(1.19)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C287(0.75)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C287(1.03)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C287(1.24)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C287(1.14)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C287(1.43)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C287(1.67)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C287(0.58)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C287(0.69)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C287(0.94)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C222(1.05)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C287(3.61)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C287(0.87)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C287(0.93)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C287(0.96)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C287(3.61)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C287(1.14)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C287(0.88)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C287(0.82)  LDD0929  [1]
 LDCM0334  AC7 HEK-293T C222(1.24)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C222(1.69)  LDD0943  [1]
 LDCM0349  AC83 HEK-293T C222(0.82)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C222(1.60)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C222(1.42)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C222(1.10)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C222(1.02)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C222(1.16)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C222(1.89)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C222(1.44)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C222(1.37)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C222(1.21)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C222(1.24)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C222(1.43)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C222(1.65)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C222(1.48)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C222(2.68)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C287(0.96)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C287(1.84)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C222(0.79)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C222(1.38)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C222(1.44)  LDD0873  [1]
 LDCM0020  ARS-1620 HCC44 C287(0.96)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C287(1.03)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C287(1.68)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C287(1.54)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C222(1.26)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C222(1.28)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C222(1.54)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C222(1.40)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C287(2.20)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C287(2.15)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C287(1.61)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C287(2.24)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C287(2.50)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C287(1.43)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C287(2.21)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C287(2.00)  LDD0698  [1]
 LDCM0382  CL112 PaTu 8988t C287(1.79)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C287(0.88)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C287(1.30)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C287(1.11)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C287(1.03)  LDD1265  [1]
 LDCM0390  CL12 HCT 116 C287(1.99)  LDD0707  [1]
 LDCM0392  CL121 HCT 116 C287(0.72)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C287(1.23)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C287(1.55)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C287(1.57)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C287(0.67)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C287(1.41)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C287(0.81)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C287(0.78)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C287(1.23)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C287(1.70)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C287(1.33)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C222(1.47); C287(1.47)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C222(1.59); C287(2.15)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C222(1.41); C287(1.16)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C222(1.23); C287(1.13)  LDD1004  [1]
 LDCM0407  CL2 HCT 116 C287(0.96)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C222(1.56); C287(1.66)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C222(1.24); C287(2.00)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C222(1.20); C287(1.78)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C222(0.87); C287(1.54)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C222(1.09); C287(1.41)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C222(1.23); C287(1.78)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C222(1.19); C287(1.23)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C222(1.08); C287(1.34)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C222(1.01); C287(1.94)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C222(1.13); C287(1.57)  LDD1015  [1]
 LDCM0418  CL3 HCT 116 C287(1.08)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C222(1.66); C287(1.74)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C222(1.38); C287(1.07)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C222(1.27); C287(0.89)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C222(1.77); C287(1.60)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C222(1.05); C287(1.45)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C222(1.34); C287(1.00)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C222(1.33); C287(0.70)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C222(1.18); C287(0.90)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C222(2.69); C287(1.46)  LDD1026  [1]
 LDCM0429  CL4 HCT 116 C287(0.95)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C222(1.29); C287(1.62)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C222(1.81); C287(1.05)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C222(1.72); C287(0.86)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C222(1.79); C287(0.84)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C222(1.18); C287(1.09)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C222(1.44); C287(1.61)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C222(2.13)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C222(1.43)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C222(1.45)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C222(1.26)  LDD1037  [1]
 LDCM0440  CL5 HCT 116 C287(0.96)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C222(2.07)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C222(1.50)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C222(1.08)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C222(1.12)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C222(1.42)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C222(1.26)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C222(1.18)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C222(0.99)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C222(1.07)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C222(1.56)  LDD1048  [1]
 LDCM0451  CL6 HCT 116 C287(1.11)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C222(1.97)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C222(1.28)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C222(1.32)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C222(2.21)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C222(1.31)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C222(1.52)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C222(1.31)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C222(1.33)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C222(1.44)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C222(1.24)  LDD1059  [1]
 LDCM0462  CL7 HCT 116 C287(1.30)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C222(1.09)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C222(1.23)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C222(1.35)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C222(1.16)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C222(2.28)  LDD1065  [1]
 LDCM0469  CL76 HCT 116 C287(1.26)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C287(1.58)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C287(1.28)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C287(2.17)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C287(2.51)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C287(1.46)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C287(1.46)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C287(2.35)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C287(2.56)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C287(2.82)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C287(1.60)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C287(1.29)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C287(2.05)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C287(1.88)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C287(2.42)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C287(1.11)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C287(1.43)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C287(1.17)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C287(1.21)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C287(1.04)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C287(1.86)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C287(2.02)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C287(1.25)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C287(1.65)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C287(1.53)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C287(1.35)  LDD0811  [1]
 LDCM0468  Fragment33 HEK-293T C222(2.54)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C222(1.13); C287(0.86)  LDD1025  [1]
 LDCM0022  KB02 T cell C287(8.33)  LDD1703  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pentamidine Small molecular drug DB00738
Glycerin . DB09462
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-adenosyl-l-homocysteine Small molecular drug DB01752

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.