Details of the Target

General Information of Target

Target ID LDTP00341
Target Name Ubiquitin-conjugating enzyme E2 C (UBE2C)
Gene Name UBE2C
Gene ID 11065
Synonyms
UBCH10; Ubiquitin-conjugating enzyme E2 C; EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme C; EC 2.3.2.24; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF
KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE
KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
Target Bioclass
Enzyme
Family
Ubiquitin-conjugating enzyme family
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Uniprot ID
O00762
Ensemble ID
ENST00000335046.7
HGNC ID
HGNC:15937
ChEMBL ID
CHEMBL4105834

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MOLT4 SNV: p.N5T .
VCAP SNV: p.S87R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.69  LDD0402  [1]
STPyne
 Probe Info  		K163(10.00); K33(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		K33(10.00)  LDD0275  [2]
HHS-475
 Probe Info  		Y91(0.86); Y89(0.90); Y165(1.73)  LDD0264  [3]
IPM
 Probe Info  		C102(0.26)  LDD1702  [4]
HHS-465
 Probe Info  		Y165(1.45); Y91(3.06)  LDD2237  [5]
DBIA
 Probe Info  		C114(1.18)  LDD0080  [6]
5E-2FA
 Probe Info  		H104(0.00); H67(0.00)  LDD2235  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
Phosphinate-6
 Probe Info  		C102(0.00); C114(0.00)  LDD0018  [10]
1c-yne
 Probe Info  		K80(0.00); K61(0.00)  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C114(0.00); C102(0.00)  LDD2223  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C114(1.22)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C114(1.26)  LDD1508  [15]
 LDCM0216  AC100 HCT 116 C102(0.53); C114(0.53)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C102(0.59); C114(0.59)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C102(0.64); C114(0.64)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C102(0.54); C114(0.54)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C102(0.51); C114(0.51)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C102(0.51); C114(0.51)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C102(0.57); C114(0.57)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C102(0.57); C114(0.49)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C102(0.44); C114(0.66)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C102(0.52); C114(0.66)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C114(0.91)  LDD1509  [15]
 LDCM0227  AC110 HCT 116 C102(0.50); C114(0.67)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C102(0.43); C114(0.47)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C102(0.69); C114(0.43)  LDD0546  [6]
 LDCM0230  AC113 PaTu 8988t C102(1.24); C114(1.24)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C102(0.86); C114(0.86)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C102(0.96); C114(0.96)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C102(1.00); C114(1.00)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C102(0.99); C114(0.99)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C102(0.89); C114(0.89)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C102(1.41); C114(1.41)  LDD1115  [6]
 LDCM0237  AC12 HEK-293T C114(1.27)  LDD1510  [15]
 LDCM0238  AC120 PaTu 8988t C102(1.16); C114(1.16)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C102(1.12); C114(1.12)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C102(1.10); C114(1.10)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C102(1.43); C114(1.43)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C102(0.96); C114(0.96)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C102(0.85); C114(0.85)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C102(0.97); C114(0.97)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C102(1.11); C114(1.11)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C102(0.83); C114(0.83)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C102(0.92); C114(0.92)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C102(0.80); C114(0.80)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C102(0.72); C114(0.72)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C102(1.09); C114(1.09)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C102(0.58); C114(0.58)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C102(0.65); C114(0.65)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C102(0.50); C114(0.50)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C102(0.74); C114(0.74)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C102(0.71); C114(0.71)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C102(0.70); C114(0.70)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C102(0.49); C114(0.49)  LDD1137  [6]
 LDCM0259  AC14 HEK-293T C114(1.12)  LDD1512  [15]
 LDCM0260  AC140 PaTu 8988t C102(0.77); C114(0.77)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C102(1.08); C114(1.08)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C102(0.87); C114(0.87)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C102(0.67); C114(0.67)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C102(0.90); C114(0.90)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C102(0.84); C114(0.84)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C102(0.86); C114(0.86)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C102(0.95); C114(0.95)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C102(0.89); C114(0.89)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C102(1.00); C114(1.00)  LDD1148  [6]
 LDCM0270  AC15 HEK-293T C114(1.06)  LDD1513  [15]
 LDCM0271  AC150 PaTu 8988t C102(0.90); C114(0.90)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C102(0.91); C114(0.91)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C102(0.95); C114(0.95)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C102(0.78); C114(0.78)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C102(0.83); C114(0.83)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C102(0.91); C114(0.91)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C102(0.86); C114(0.86)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C102(1.15); C114(1.15)  LDD2169  [6]
 LDCM0276  AC17 HEK-293T C114(1.51)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C114(1.43)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C114(0.94)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C114(1.44)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C114(1.44)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C114(1.08)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C114(1.03)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C114(1.39)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C114(1.45)  LDD1523  [15]
 LDCM0285  AC25 PaTu 8988t C102(1.09); C114(1.09)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C102(1.14); C114(1.14)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C102(1.15); C114(1.15)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C102(1.12); C114(1.12)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C102(1.10); C114(1.10)  LDD1168  [6]
 LDCM0290  AC3 HEK-293T C114(1.01)  LDD1529  [15]
 LDCM0291  AC30 PaTu 8988t C102(1.09); C114(1.09)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C102(1.08); C114(1.08)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C102(0.89); C114(0.89)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C102(0.95); C114(0.95)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C102(1.14); C114(1.14)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C102(0.68); C114(0.68)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C102(0.65); C114(0.65)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C102(0.78); C114(0.78)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C102(0.72); C114(0.72)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C102(0.69); C114(0.69)  LDD1179  [6]
 LDCM0301  AC4 HEK-293T C114(0.82)  LDD1540  [15]
 LDCM0302  AC40 PaTu 8988t C102(0.66); C114(0.66)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C102(0.79); C114(0.79)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C102(0.73); C114(0.73)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C102(0.92); C114(0.92)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C102(0.78); C114(0.78)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C102(0.78); C114(0.78)  LDD1186  [6]
 LDCM0308  AC46 HEK-293T C114(1.16)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C114(1.24)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C114(1.41)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C114(1.51)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C114(0.93)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C114(1.13)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C114(1.04)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C114(1.23)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C114(1.25)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C114(1.16)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C114(1.45)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C114(1.02)  LDD1558  [15]
 LDCM0320  AC57 PaTu 8988t C102(0.98); C114(0.98)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C102(1.05); C114(1.05)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C102(1.06); C114(1.06)  LDD1201  [6]
 LDCM0323  AC6 HEK-293T C114(0.99)  LDD1562  [15]
 LDCM0324  AC60 PaTu 8988t C102(1.00); C114(1.00)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C102(1.07); C114(1.07)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C102(1.02); C114(1.02)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C102(0.99); C114(0.99)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C102(1.03); C114(1.03)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C102(1.08); C114(1.08)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C102(0.94); C114(0.94)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C102(1.14); C114(1.14)  LDD1210  [6]
 LDCM0332  AC68 HCT 116 C102(0.77); C114(0.77)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C102(0.68); C114(0.68)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C114(1.16)  LDD1568  [15]
 LDCM0335  AC70 HCT 116 C102(0.53); C114(0.53)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C102(0.84); C114(0.84)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C102(0.81); C114(0.81)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C102(0.53); C114(0.53)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C102(0.49); C114(0.49)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C102(0.42); C114(0.42)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C102(0.71); C114(0.71)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C102(0.66); C114(0.66)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C102(0.59); C114(0.59)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C102(0.87); C114(0.87)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C114(0.84)  LDD1569  [15]
 LDCM0346  AC80 HCT 116 C102(0.73); C114(0.73)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C102(0.80); C114(0.80)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C102(0.42); C114(0.42)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C102(0.74); C114(0.74)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C102(0.97); C114(0.97)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C102(0.85); C114(0.85)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C102(1.12); C114(1.12)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C102(0.99); C114(0.99)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C102(1.03); C114(1.03)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C102(0.93); C114(0.93)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C102(1.13); C114(1.13)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C102(0.81); C114(0.81)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C102(0.89); C114(0.89)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C102(1.00); C114(1.00)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C102(0.98); C114(0.98)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C102(0.62); C114(0.62)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C102(0.84); C114(0.84)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C102(1.07); C114(1.07)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C102(0.24); C114(0.24)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C102(0.62); C114(0.62)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C114(1.27)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C114(1.28)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C114(1.00)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 12.64  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C114(1.09)  LDD2171  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C102(1.63); C114(1.63)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C102(0.94); C114(0.94)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C114(1.24); C102(1.01); C114(1.01)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C102(1.20); C114(1.20)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C114(1.28)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C114(1.09)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C114(0.91); C102(1.07); C114(1.07)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C102(1.18); C114(1.18)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C114(1.05)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C114(1.08)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C114(1.04); C102(1.16); C114(1.16)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C102(1.10); C114(1.10)  LDD1582  [15]
 LDCM0379  CL11 HCT 116 C102(0.75); C114(0.75)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C114(0.96)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C114(0.76)  LDD1585  [15]
 LDCM0382  CL112 PaTu 8988t C102(0.86); C114(0.86)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C102(1.24); C114(1.24)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C102(0.94); C114(0.94)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C102(1.05); C114(1.05)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C102(0.57); C114(0.57)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C102(0.76); C114(0.76)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C102(0.61); C114(0.61)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C102(0.73); C114(0.73)  LDD1268  [6]
 LDCM0390  CL12 HCT 116 C102(1.02); C114(1.02)  LDD0707  [6]
 LDCM0391  CL120 PaTu 8988t C102(0.72); C114(0.72)  LDD1270  [6]
 LDCM0392  CL121 HEK-293T C102(1.31); C114(1.31)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C114(1.10)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C114(1.09)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C114(1.14); C102(1.23); C114(1.23)  LDD1599  [15]
 LDCM0396  CL125 PaTu 8988t C102(1.04); C114(1.04)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C102(1.00); C114(1.00)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C102(0.96); C114(0.96)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C102(0.93); C114(0.93)  LDD1278  [6]
 LDCM0400  CL13 HCT 116 C102(0.79); C114(0.79)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C102(0.86); C114(0.86)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C102(0.66); C114(0.66)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C102(1.51); C114(1.51)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C102(1.08); C114(1.08)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C102(0.95); C114(0.95)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C102(0.95); C114(0.95)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C102(0.94); C114(0.94)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C102(0.80); C114(0.80)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C102(0.87); C114(0.87)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C102(0.79); C114(0.79)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C102(0.85); C114(0.85)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C102(1.61); C114(1.61)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C102(0.68); C114(0.68)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C102(0.84); C114(0.84)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C102(1.12); C114(1.12)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C102(0.75); C114(0.75)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C102(0.83); C114(0.83)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C102(1.23); C114(1.23)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C102(0.80); C114(0.80)  LDD1298  [6]
 LDCM0420  CL31 HEK-293T C114(0.97)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C114(1.08)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C114(1.19)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C114(0.97)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C114(1.13)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C114(1.16)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C102(1.33); C114(1.33)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C114(0.93)  LDD1632  [15]
 LDCM0429  CL4 HCT 116 C102(1.03); C114(1.03)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C114(1.08); C102(1.14); C114(1.14)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C114(1.31)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C114(1.11)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C114(0.89)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C114(1.14)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C114(1.18)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C114(1.16)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C114(1.09)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C114(1.13)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C102(1.19); C114(1.19)  LDD1643  [15]
 LDCM0440  CL5 HCT 116 C102(0.91); C114(0.91)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C114(1.11)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C114(0.88); C102(1.03); C114(1.03)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C114(1.39)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C114(1.04)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C114(1.08)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C114(1.02)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C114(0.93)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C114(1.02)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C114(1.07)  LDD1653  [15]
 LDCM0451  CL6 HCT 116 C102(1.29); C114(1.29)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C114(1.15)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C102(1.40); C114(1.40)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C114(1.04)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C114(1.23)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C114(1.07); C102(1.19); C114(1.19)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C114(1.45)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C114(1.18)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C114(1.04)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C114(1.09)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C114(1.07)  LDD1664  [15]
 LDCM0462  CL7 HCT 116 C102(0.95); C114(0.95)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C114(1.01)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C114(1.09)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C114(1.39)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C102(1.15); C114(1.15)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C114(1.09)  LDD1670  [15]
 LDCM0469  CL76 HCT 116 C102(1.23); C114(1.23)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C102(0.94); C114(0.94)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C102(0.96); C114(0.96)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C102(1.30); C114(1.30)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C102(0.90); C114(0.90)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C102(0.81); C114(0.81)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C102(0.85); C114(0.85)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C102(0.92); C114(0.92)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C102(0.76); C114(0.76)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C102(0.95); C114(0.95)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C102(0.81); C114(0.81)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C102(1.52); C114(1.52)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C102(1.07); C114(1.07)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C102(0.77); C114(0.77)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C102(0.78); C114(0.78)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C102(1.14); C114(1.14)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C102(0.97); C114(0.97)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C114(0.92)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C114(1.42)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C114(1.17)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C114(1.25)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C114(1.45)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C114(1.15)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C102(1.19); C114(1.19)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C114(1.07)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C114(0.89)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C114(0.92)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C102(0.26)  LDD1702  [4]
 LDCM0625  F8 Ramos 0.61  LDD2187  [16]
 LDCM0573  Fragment11 Ramos 2.80  LDD2190  [16]
 LDCM0586  Fragment28 Ramos 0.91  LDD2198  [16]
 LDCM0468  Fragment33 HEK-293T C114(0.96)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C114(1.09)  LDD1631  [15]
 LDCM0116  HHS-0101 DM93 Y91(0.86); Y89(0.90); Y165(1.73)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y89(0.55); Y91(0.70); Y165(1.51)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y91(0.72); Y89(1.11); Y165(2.17)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y89(0.88); Y91(0.89); Y165(1.17)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y91(1.03); Y89(1.16); Y165(2.58)  LDD0268  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C114(1.18)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C114(1.28)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C114(2.18)  LDD0082  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C102(2.22)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C102(0.91); C102(0.18)  LDD2207  [17]
 LDCM0021  THZ1 HCT 116 C114(1.09)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 7 (MAPK7) CMGC Ser/Thr protein kinase family Q13164
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) WD repeat G protein beta family P62879

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.