Details of the Target

General Information of Target

Target ID LDTP20001
Target Name Uncharacterized protein C2orf42 (C2orf42)
Gene Name C2orf42
Gene ID 54980
Synonyms
Uncharacterized protein C2orf42
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRLKVGFQGGGCFRKDALCLEGGVSARWARAPHSAPLRPPRELHAAPPPATPTQTVVRPA
GFPRRTRLMVRSAPPTQRPPTGSGCVSGLWRKGLGLRPQTLLRVGSVVLSSAPALRPRLG
PCLRPPPSD
Target Bioclass
Other
Uniprot ID
Q9NWW7
Ensemble ID
ENST00000264434.7
HGNC ID
HGNC:26056

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C115(0.55); C120(0.55); C286(0.67); C295(0.67)  LDD0533  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C115(0.55); C120(0.55); C286(0.67); C295(0.67)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C115(0.58); C120(0.58); C286(0.78); C295(0.78)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C115(0.56); C120(0.56); C286(0.80); C295(0.80)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C115(0.55); C120(0.55); C286(0.91); C295(0.91)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C115(0.59); C120(0.59); C286(1.05); C295(1.05)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C115(0.60); C120(0.60); C286(0.90); C295(0.90)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C115(0.55); C120(0.55); C286(0.84); C295(0.84)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C115(0.62); C120(0.62); C286(0.91); C295(0.91)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C115(0.61); C120(0.61); C286(0.60); C295(0.60)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C115(0.56); C120(0.56); C286(0.84); C295(0.84)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C115(0.62); C120(0.62); C286(0.82); C295(0.82)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C115(0.65); C120(0.65); C286(0.82); C295(0.82)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C115(0.64); C120(0.64); C286(0.82); C295(0.82)  LDD0546  [1]
 LDCM0246  AC128 HCT 116 C115(1.38); C120(1.38)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C115(1.05); C120(1.05)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C115(0.88); C120(0.88)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C115(1.13); C120(1.13)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C115(1.05); C120(1.05)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C115(0.97); C120(0.97)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C115(1.08); C120(1.08)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C115(1.17); C120(1.17)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C115(1.09); C120(1.09)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C115(1.06); C120(1.06)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C115(1.11); C120(1.11)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C115(1.11); C120(1.11)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C115(1.14); C120(1.14)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C115(1.21); C120(1.21)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C115(1.15); C120(1.15)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C115(1.08); C120(1.08); C224(1.07); C226(1.07)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C224(1.09); C226(1.09); C115(1.17); C120(1.17)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C224(1.31); C226(1.31); C115(1.44); C120(1.44)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C115(1.24); C120(1.24); C224(1.28); C226(1.28)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C224(1.04); C226(1.04); C115(1.17); C120(1.17)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C115(1.22); C120(1.22); C224(1.23); C226(1.23)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C115(0.99); C120(0.99); C224(1.03); C226(1.03)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C115(0.99); C120(0.99); C224(1.13); C226(1.13)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C115(0.90); C120(0.90); C224(1.11); C226(1.11)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C224(1.10); C226(1.10); C115(1.26); C120(1.26)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C115(1.19); C120(1.19); C224(1.19); C226(1.19)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C115(1.31); C120(1.31); C224(1.34); C226(1.34)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C115(1.23); C120(1.23); C224(1.17); C226(1.17)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C115(1.31); C120(1.31); C224(1.19); C226(1.19)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C115(1.35); C120(1.35); C224(1.37); C226(1.37)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C286(0.97); C295(0.97)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C286(1.66); C295(1.66)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C286(1.06); C295(1.06)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C286(1.17); C295(1.17)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C286(0.99); C295(0.99)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C286(0.90); C295(0.90)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C286(0.89); C295(0.89)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C286(0.95); C295(0.95)  LDD0601  [1]
 LDCM0320  AC57 HCT 116 C115(0.78); C120(0.78); C224(0.80); C226(0.80)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C224(0.81); C226(0.81); C115(0.89); C120(0.89)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C115(0.86); C120(0.86); C224(0.90); C226(0.90)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C115(0.68); C120(0.68); C224(0.70); C226(0.70)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C115(0.62); C120(0.62); C224(0.68); C226(0.68)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C224(0.85); C226(0.85); C115(0.97); C120(0.97)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C115(0.73); C120(0.73); C224(0.75); C226(0.75)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C224(0.89); C226(0.89); C115(0.89); C120(0.89)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C115(0.85); C120(0.85); C224(0.89); C226(0.89)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C224(0.80); C226(0.80); C115(0.81); C120(0.81)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C115(0.67); C120(0.67); C224(0.80); C226(0.80)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C286(0.93); C295(0.93); C224(1.04); C226(1.04)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C286(0.93); C295(0.93); C224(0.98); C226(0.98)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C286(0.83); C295(0.83); C224(0.96); C226(0.96)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C286(0.71); C295(0.71); C224(0.95); C226(0.95)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C286(0.89); C295(0.89); C224(1.12); C226(1.12)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C286(0.95); C295(0.95); C224(1.12); C226(1.12)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C286(0.92); C295(0.92); C224(0.97); C226(0.97)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C286(0.87); C295(0.87); C224(1.17); C226(1.17)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C286(0.82); C295(0.82); C224(1.08); C226(1.08)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C286(0.94); C295(0.94); C224(1.01); C226(1.01)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C224(0.84); C226(0.84); C286(1.03); C295(1.03)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C286(0.84); C295(0.84); C224(1.07); C226(1.07)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C286(0.88); C295(0.88); C224(1.07); C226(1.07)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C286(0.89); C295(0.89); C224(1.19); C226(1.19)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C286(0.90); C295(0.90); C224(1.09); C226(1.09)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C286(1.54); C295(1.54)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C286(1.25); C295(1.25)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C286(1.05); C295(1.05)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C286(1.05); C295(1.05)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C286(1.04); C295(1.04)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C286(0.99); C295(0.99)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C286(1.29); C295(1.29)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C286(0.86); C295(0.86)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C286(1.34); C295(1.34)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C286(1.61); C295(1.61)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C286(1.43); C295(1.43)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C286(1.27); C295(1.27)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C286(0.99); C295(0.99)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C286(1.17); C295(1.17)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C286(1.24); C295(1.24)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C115(0.56); C120(0.56); C286(0.73); C295(0.73)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C115(0.56); C120(0.56); C286(0.66); C295(0.66)  LDD0683  [1]
 LDCM0367  CL1 HCT 116 C286(0.87); C295(0.87)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C286(1.37); C295(1.37)  LDD0685  [1]
 LDCM0374  CL105 HCT 116 C286(1.25); C295(1.25)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C286(1.44); C295(1.44)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C286(1.15); C295(1.15)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C286(1.48); C295(1.48)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C286(1.48); C295(1.48)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C286(1.40); C295(1.40)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C286(1.68); C295(1.68)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C286(1.29); C295(1.29)  LDD0698  [1]
 LDCM0390  CL12 HCT 116 C286(1.11); C295(1.11)  LDD0707  [1]
 LDCM0396  CL125 HCT 116 C115(0.86); C120(0.86); C224(0.92); C226(0.92)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C115(0.72); C120(0.72); C224(0.82); C226(0.82)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C224(0.79); C226(0.79); C115(0.89); C120(0.89)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C115(0.87); C120(0.87); C224(1.03); C226(1.03)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C286(1.19); C295(1.19)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C286(1.01); C295(1.01)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C286(1.22); C295(1.22)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C224(0.88); C226(0.88)  LDD0720  [1]
 LDCM0407  CL2 HCT 116 C286(1.00); C295(1.00)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C286(1.08); C295(1.08)  LDD0735  [1]
 LDCM0421  CL32 HCT 116 C224(0.82); C226(0.82)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C224(0.95); C226(0.95)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C224(0.95); C226(0.95)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C224(0.92); C226(0.92)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C224(0.95); C226(0.95)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C224(1.12); C226(1.12)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C224(0.96); C226(0.96)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C286(1.05); C295(1.05)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C224(0.99); C226(0.99)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C224(0.92); C226(0.92)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C224(0.88); C226(0.88)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C224(0.96); C226(0.96)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C224(0.97); C226(0.97)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C224(1.07); C226(1.07)  LDD0752  [1]
 LDCM0440  CL5 HCT 116 C286(0.95); C295(0.95)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C286(1.21); C295(1.21)  LDD0768  [1]
 LDCM0453  CL61 HCT 116 C115(1.01); C120(1.01); C286(1.08); C295(1.08)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C115(0.97); C120(0.97); C286(1.12); C295(1.12)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C115(0.91); C120(0.91); C286(1.28); C295(1.28)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C115(0.89); C120(0.89); C286(1.43); C295(1.43)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C115(1.07); C120(1.07); C286(1.19); C295(1.19)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C115(0.96); C120(0.96); C286(1.69); C295(1.69)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C115(0.91); C120(0.91); C286(1.35); C295(1.35)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C115(0.74); C120(0.74); C286(1.27); C295(1.27)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C115(0.86); C120(0.86); C286(1.20); C295(1.20)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C286(1.25); C295(1.25)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C115(0.82); C120(0.82); C286(1.23); C295(1.23)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C115(0.99); C120(0.99); C286(1.54); C295(1.54)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C115(0.88); C120(0.88); C286(1.21); C295(1.21)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C115(0.83); C120(0.83); C286(1.30); C295(1.30)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C115(0.94); C120(0.94); C286(1.32); C295(1.32)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C115(0.99); C120(0.99)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C115(1.13); C120(1.13)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C115(0.86); C120(0.86)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C115(1.10); C120(1.10)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C286(1.50); C295(1.50)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C115(1.05); C120(1.05)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C115(1.20); C120(1.20)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C115(1.15); C120(1.15)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C115(1.00); C120(1.00)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C115(1.03); C120(1.03)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C115(1.04); C120(1.04)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C115(0.99); C120(0.99)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C115(1.08); C120(1.08)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C115(1.12); C120(1.12)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C115(0.97); C120(0.97)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C286(1.08); C295(1.08)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C115(1.00); C120(1.00)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C115(0.97); C120(0.97); C286(1.39); C295(1.39)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C224(1.02); C226(1.02)  LDD0744  [1]
 LDCM0022  KB02 Hep 3B2.1-7 C133(1.65)  LDD2353  [3]
 LDCM0023  KB03 Hep 3B2.1-7 C133(1.97)  LDD2770  [3]
 LDCM0024  KB05 SK-HEP1 C133(1.03)  LDD3424  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840