Details of the Target

General Information of Target

Target ID LDTP18419
Target Name Nuclear body protein SP140-like protein (SP140L)
Gene Name SP140L
Gene ID 93349
Synonyms
Nuclear body protein SP140-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDAGSERSKAPSLPPRCPCGFWGSSKTMNLCSKCFADFQKKQPDDDSAPSTSNSQSDLF
SEETTSDNNNTSITTPTLSPSQQPLPTELNVTSPSKEECGPCTDTAHVSLITPTKRSCGT
DSQSENEASPVKRPRLLENTERSEETSRSKQKSRRRCFQCQTKLELVQQELGSCRCGYVF
CMLHRLPEQHDCTFDHMGRGREEAIMKMVKLDRKVGRSCQRIGEGCS
Target Bioclass
Transcription factor
Uniprot ID
Q9H930
Ensemble ID
ENST00000415673.7
HGNC ID
HGNC:25105
ChEMBL ID
CHEMBL4105997

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
BTD
 Probe Info  		C191(1.18)  LDD2118  [2]
HHS-475
 Probe Info  		Y107(0.50)  LDD0264  [3]
DBIA
 Probe Info  		C191(0.95)  LDD0078  [4]
N1
 Probe Info  		N.A.  LDD0245  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C476(0.00); C191(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C191(0.00); C399(0.00)  LDD0037  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C399(1.05); C457(1.00); C458(1.00)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C457(0.64); C458(0.64)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C191(1.05); C457(0.68); C458(0.68)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C191(1.03); C457(0.69); C458(0.69)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C191(1.18); C457(0.48); C458(0.48)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C191(1.53); C457(0.31); C458(0.31)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C191(1.21); C457(0.44); C458(0.44)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C191(1.07); C457(0.35); C458(0.35)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C191(1.53); C457(0.39); C458(0.39)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C191(1.58); C457(0.36); C458(0.47)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C191(0.79); C457(0.66); C458(0.52)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C191(0.86); C457(0.49); C458(0.41)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C457(0.89); C458(0.89)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C191(0.94); C457(0.67); C458(0.63)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C191(1.06); C457(0.67); C458(0.62)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C191(1.09); C457(0.58); C458(0.62)  LDD0546  [4]
 LDCM0237  AC12 HCT 116 C457(0.84); C458(0.84)  LDD0554  [4]
 LDCM0259  AC14 HCT 116 C457(0.76); C458(0.76)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C457(0.77); C458(0.77)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C457(0.44); C458(0.44)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C457(0.95); C458(0.95)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C457(0.67); C458(0.67)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C457(0.60); C458(0.60)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C457(0.43); C458(0.43)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C457(0.54); C458(0.54)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C457(0.73); C458(0.73)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C457(0.83); C458(0.83)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C457(0.79); C458(0.79)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C457(0.59); C458(0.59)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C457(0.56); C458(0.56)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C457(0.53); C458(0.53)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C457(0.98); C458(0.98)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C457(1.29); C458(1.29)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C457(0.74); C458(0.74)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C457(1.04); C458(1.04); C399(1.18); C191(1.44)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C457(0.61); C458(0.61); C399(1.41); C191(1.45)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C457(0.92); C458(0.92); C399(1.35); C191(3.01)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C457(0.76); C458(0.76); C399(1.22)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C399(1.39); C457(1.42); C458(1.42); C191(1.52)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C457(0.84); C458(0.84); C399(1.58); C191(2.21)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C457(0.89); C458(0.89); C399(1.23); C191(1.47)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C457(0.95); C458(0.95); C191(1.51); C399(3.09)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C457(0.90); C458(0.90); C399(1.30); C191(1.43)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C457(0.98); C458(0.98); C399(1.38)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C457(0.93); C458(0.93); C399(1.78)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C457(0.89); C458(0.89); C399(1.99)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C457(0.66); C458(0.66); C399(1.88)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C457(0.82); C458(0.82); C399(1.61)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C457(0.97); C458(0.97); C399(1.20)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C457(1.03); C458(1.03); C399(2.05)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C457(1.11); C458(1.11); C399(1.89)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C457(0.64); C458(0.64); C399(1.64)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C457(0.58); C458(0.58); C399(2.22)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C457(0.57); C458(0.57); C399(1.96)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C399(0.94); C191(1.26); C457(1.91); C458(1.91)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C399(0.92); C191(0.99); C457(1.32); C458(1.32)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C191(0.81); C399(0.93); C457(1.04); C458(1.04)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C191(0.85); C399(0.98); C457(1.12); C458(1.12)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C191(1.00); C457(1.08); C458(1.08); C399(1.29)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C457(0.73); C458(0.73); C399(1.18)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C457(0.93); C458(0.93); C399(1.32); C191(1.49)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C191(0.83); C457(0.95); C458(0.95); C399(1.18)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C457(1.09); C458(1.09); C399(1.25); C191(1.32)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C191(1.04); C399(1.22); C457(1.53); C458(1.53)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C457(0.94); C458(0.94); C399(1.26); C191(1.59)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C457(0.95); C458(0.95); C399(1.19); C191(1.73)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C457(0.86); C458(0.86)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C457(0.72); C458(0.72)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C457(1.18); C458(1.18)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C457(0.66); C458(0.66)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C457(0.55); C458(0.55); C399(1.03)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C457(0.60); C458(0.60)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C457(1.18); C458(1.18)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C457(0.89); C458(0.89)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C457(0.68); C458(0.68)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C457(0.54); C458(0.54)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C457(0.75); C458(0.75)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C457(0.82); C458(0.82)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C457(0.47); C458(0.47); C191(1.99)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C457(0.48); C458(0.48); C191(1.98)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C457(0.43); C458(0.43); C191(2.10)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C457(0.59); C458(0.59)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C457(0.66); C458(0.66); C191(1.63)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C457(1.05); C458(1.05); C191(1.75)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C457(0.48); C458(0.48); C191(1.84)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C457(0.64); C458(0.64); C191(1.79)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C457(0.52); C458(0.52); C191(1.36)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C457(0.51); C458(0.51); C191(1.33)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C457(0.52); C458(0.52); C191(1.22)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C457(0.44); C458(0.44); C191(1.54)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C457(0.77); C458(0.77)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C457(0.79); C458(0.79)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C457(0.70); C458(0.70)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C457(0.94); C458(0.94)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C457(1.11); C458(1.11)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C457(0.67); C458(0.67)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C457(0.89); C458(0.89)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C457(0.84); C458(0.84)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C457(0.84); C458(0.84)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C457(0.70); C458(0.70)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C457(0.71); C458(0.71)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C457(1.16); C458(1.16)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C457(0.92); C458(0.92)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C457(0.73); C458(0.73)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C457(0.75); C458(0.75)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C457(1.86); C458(1.86)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C457(1.05); C458(1.05)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C457(0.42); C458(0.42); C191(1.23); C399(2.13)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C457(0.38); C458(0.38); C191(0.95); C399(1.96)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C457(0.49); C458(0.49); C191(1.34); C399(1.78)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C457(0.64); C458(0.64); C191(0.96); C399(1.13)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C457(1.03); C458(1.03); C399(1.11); C191(1.12)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C457(0.57); C458(0.57); C191(1.43); C399(1.47)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C457(0.50); C458(0.50); C191(1.28); C399(1.71)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C457(1.06); C458(1.06); C191(1.43); C399(1.88)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C457(0.36); C458(0.36); C191(1.53); C399(1.98)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C457(0.38); C458(0.38); C191(1.27); C399(1.39)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C457(0.59); C458(0.59); C191(1.00); C399(1.46)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C457(0.76); C458(0.76); C399(1.29); C191(1.80)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C399(1.17); C457(1.18); C458(1.18); C191(1.78)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C457(0.46); C458(0.46); C191(1.45); C399(1.95)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C457(0.43); C458(0.43); C191(1.68); C399(1.79)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C457(0.37); C458(0.37); C191(1.69)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C457(0.57); C458(0.57); C191(1.16)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C457(0.86); C458(0.86)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C457(0.77); C458(0.77)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C457(0.47); C458(0.47)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C191(0.95)  LDD0078  [4]
 LDCM0367  CL1 PaTu 8988t C457(0.80); C458(0.80)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C457(0.53); C458(0.53)  LDD1247  [4]
 LDCM0369  CL100 HCT 116 C399(0.95); C457(1.12); C458(1.12)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C457(0.60); C458(0.60)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C457(1.05); C458(1.05)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C457(0.70); C458(0.70)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C457(0.75); C458(0.75)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C457(0.61); C458(0.61); C399(1.58); C191(1.85)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C457(0.57); C458(0.57); C399(1.65); C191(6.64)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C457(0.44); C458(0.44); C191(1.93); C399(2.53)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C457(0.45); C458(0.45); C399(2.08); C191(2.10)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C457(0.71); C458(0.71); C399(1.42); C191(1.92)  LDD0695  [4]
 LDCM0379  CL11 PaTu 8988t C457(1.33); C458(1.33)  LDD1258  [4]
 LDCM0380  CL110 HCT 116 C457(0.62); C458(0.62); C191(1.89); C399(2.41)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C457(0.66); C458(0.66); C399(1.50); C191(1.52)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C457(1.19); C458(1.19); C399(1.22)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C457(0.68); C458(0.68); C399(1.60)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C457(1.01); C458(1.01); C399(1.55)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C457(0.97); C458(0.97); C399(1.41)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C457(0.85); C458(0.85); C399(2.44)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C457(1.04); C458(1.04); C399(1.57); C191(2.66)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C399(0.95); C457(1.06); C458(1.06); C191(1.10)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C457(0.85); C458(0.85); C399(1.02); C191(1.16)  LDD0706  [4]
 LDCM0390  CL12 PaTu 8988t C457(0.95); C458(0.95)  LDD1269  [4]
 LDCM0391  CL120 HCT 116 C399(1.01); C457(1.42); C458(1.42); C191(1.64)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C457(1.18); C458(1.18)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C457(0.83); C458(0.83)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C457(0.59); C458(0.59)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C457(0.67); C458(0.67)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C457(0.88); C458(0.88); C191(1.19)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C457(0.71); C458(0.71); C191(1.29)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C457(0.64); C458(0.64); C191(1.17)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C457(0.48); C458(0.48); C191(1.56)  LDD0716  [4]
 LDCM0400  CL13 PaTu 8988t C457(0.67); C458(0.67)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C457(0.65); C458(0.65)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C457(0.57); C458(0.57)  LDD1281  [4]
 LDCM0403  CL16 HCT 116 C457(1.05); C458(1.05)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C457(0.99); C458(0.99); C191(2.18)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C457(1.13); C458(1.13); C191(1.62)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C457(0.88); C458(0.88); C191(1.72)  LDD0723  [4]
 LDCM0407  CL2 PaTu 8988t C457(0.89); C458(0.89)  LDD1286  [4]
 LDCM0408  CL20 HCT 116 C457(0.67); C458(0.67); C191(1.67)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C457(0.64); C458(0.64); C191(1.75)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C457(0.93); C458(0.93); C191(1.23)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C457(0.70); C458(0.70); C191(1.01)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C191(1.68); C457(0.68); C458(0.68)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C191(1.48); C457(0.62); C458(0.62)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C191(1.56); C457(0.52); C458(0.52)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C191(1.48); C457(0.75); C458(0.75)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C191(1.26); C457(0.84); C458(0.84)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C191(1.61); C457(0.85); C458(0.85)  LDD0734  [4]
 LDCM0418  CL3 PaTu 8988t C457(1.11); C458(1.11)  LDD1297  [4]
 LDCM0419  CL30 HCT 116 C191(1.81); C457(0.89); C458(0.89)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C191(1.08)  LDD0737  [4]
 LDCM0421  CL32 PaTu 8988t C399(1.21)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C399(1.29)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C399(1.34)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C399(1.60)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C399(2.47)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C399(1.81)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C399(1.44)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C457(1.23); C458(1.23)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C399(1.28)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C399(1.09)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C399(1.27)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C399(1.18)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C399(1.72)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C399(1.81)  LDD1314  [4]
 LDCM0436  CL46 HCT 116 C399(0.96)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C399(1.05)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C399(0.99)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C399(1.10)  LDD0756  [4]
 LDCM0440  CL5 PaTu 8988t C457(0.68); C458(0.68)  LDD1319  [4]
 LDCM0441  CL50 HCT 116 C399(1.17)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C399(1.11)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C399(0.91)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C399(0.80)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C399(0.69)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C399(0.95)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C399(0.78)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C399(1.15)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C399(0.84)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C399(1.02)  LDD0767  [4]
 LDCM0451  CL6 PaTu 8988t C457(0.62); C458(0.62)  LDD1330  [4]
 LDCM0452  CL60 HCT 116 C399(1.13)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C457(1.13); C458(1.13)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C457(1.16); C458(1.16)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C457(1.06); C458(1.06)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C457(0.95); C458(0.95)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C457(1.27); C458(1.27)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C457(0.74); C458(0.74)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C457(0.86); C458(0.86)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C457(0.82); C458(0.82)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C457(1.28); C458(1.28)  LDD0778  [4]
 LDCM0462  CL7 PaTu 8988t C457(0.71); C458(0.71)  LDD1341  [4]
 LDCM0463  CL70 HCT 116 C457(1.17); C458(1.17)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C457(0.92); C458(0.92)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C457(1.11); C458(1.11)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C457(0.88); C458(0.88)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C457(0.98); C458(0.98)  LDD0784  [4]
 LDCM0473  CL8 PaTu 8988t C457(0.79); C458(0.79)  LDD1352  [4]
 LDCM0484  CL9 PaTu 8988t C457(0.56); C458(0.56)  LDD1363  [4]
 LDCM0486  CL91 HCT 116 C399(0.78); C457(1.04); C458(1.04)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C399(0.88); C457(1.57); C458(1.57)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C399(0.89); C457(0.56); C458(0.56)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C399(1.28); C457(0.58); C458(0.58)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C399(1.03); C457(0.66); C458(0.66)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C399(1.05); C457(0.63); C458(0.63)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C399(1.07); C457(0.76); C458(0.76)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C399(1.07); C457(0.60); C458(0.60)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C399(1.11); C457(0.74); C458(0.74)  LDD0811  [4]
 LDCM0625  F8 Ramos C96(1.04)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C96(1.36)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C96(0.49)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C96(1.15)  LDD2191  [7]
 LDCM0576  Fragment14 Ramos C96(1.37)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C96(1.21)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C96(0.83)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C96(1.06)  LDD2196  [7]
 LDCM0586  Fragment28 Ramos C96(0.79)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C96(1.10)  LDD2199  [7]
 LDCM0590  Fragment32 Ramos C96(1.16)  LDD2201  [7]
 LDCM0468  Fragment33 HCT 116 C457(0.92); C458(0.92)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C96(0.69)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C96(1.03)  LDD2184  [7]
 LDCM0427  Fragment51 PaTu 8988t C399(1.25)  LDD1306  [4]
 LDCM0614  Fragment56 Ramos C96(0.96)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C96(1.44)  LDD2186  [7]
 LDCM0116  HHS-0101 DM93 Y107(0.50)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y107(0.68)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y107(0.47)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y107(0.70)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y107(0.48)  LDD0268  [3]
 LDCM0022  KB02 Ramos C96(1.84)  LDD2182  [7]
 LDCM0023  KB03 Ramos C96(1.55)  LDD2183  [7]
 LDCM0024  KB05 HMCB C756(1.98)  LDD3312  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C191(1.18)  LDD2118  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840