Details of the Target

General Information of Target

Target ID LDTP17491
Target Name TBC1 domain family member 9 (TBC1D9)
Gene Name TBC1D9
Gene ID 23158
Synonyms
KIAA0882; TBC1D9A; TBC1 domain family member 9; TBC1 domain family member 9A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLQTTWPQESVTFEDVAVYFTQNQWASLDPAQRALYGEVMLENYANVASLVAFPFPKPAL
ISHLERGEAPWGPDPWDTEILRGISQGGESWIKNEGLVIKQEASEETELHRMPVGGLLRN
VSQHFDFKRKALKQTFNLNPNLILRGGMKFYECKECGKIFRYNSKLIRHQMSHTGEKPFK
CKECGKAFKSSYDCIVHEKNHIGEGPYECKECGKGLSSNTALTQHQRIHTGEKPYECKEC
GKAFRRSAAYLQHQRLHTGEKLYKCKECWKAFGCRSLFIVHQRIHTGEKPYQCKECGKAF
TQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKLHPVEKKPVKVLGPSLVSPQC
SSPAIPPVLLQGSCSASAVAVPSLTFPHAVLIPTSGNFFMLLPTSGIPSSSAQIVRVFQG
LTPTVKPSPVILTPSSHSS
Target Bioclass
Other
Function May act as a GTPase-activating protein for Rab family protein(s).
Uniprot ID
Q6ZT07
Ensemble ID
ENST00000442267.3
HGNC ID
HGNC:21710

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y553(20.46)  LDD3495  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C166(1.10)  LDD0593  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C166(1.08)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C166(0.96)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C166(0.93)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C166(0.86)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C166(0.82)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C166(1.05)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C166(0.88)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C166(0.87)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C166(0.73)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C166(0.80)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C166(0.76)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C166(0.80)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C166(0.87)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C166(0.90)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C166(0.87)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C166(0.89)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C166(0.84)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C166(0.96)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C166(1.03)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C166(1.25)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C166(0.95)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C166(1.43)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C166(0.96)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C166(0.85)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C166(0.97)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C166(0.91)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C166(0.95)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C166(1.08)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C166(0.84)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C166(1.02)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C166(0.99)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C166(1.00)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C166(0.91)  LDD0857  [3]
 LDCM0270  AC15 HEK-293T C166(0.88)  LDD0868  [3]
 LDCM0276  AC17 HCT 116 C166(1.10)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C166(1.02)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C166(1.14)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C166(0.89)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C166(1.38)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C166(1.17)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C166(1.02)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C166(1.22)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C166(1.45)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C166(0.80)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C166(0.70)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C166(0.78)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C166(0.79)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C166(0.65)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C166(1.04)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C166(1.04)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C166(0.82)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C166(0.71)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C166(0.65)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C166(0.72)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C166(1.05)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C166(0.98)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C166(0.80)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C166(0.90)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C166(0.95)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C166(1.08)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C166(0.88)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C166(0.92)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C166(1.03)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C166(0.83)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C166(0.89)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C166(0.87)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C1180(1.04)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C313(1.09)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C1180(1.13)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C1180(1.08)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C166(0.88)  LDD0910  [3]
 LDCM0315  AC52 HEK-293T C1180(0.96)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C1180(0.96)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C1180(0.99)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C313(0.81)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C1180(1.11)  LDD1558  [6]
 LDCM0320  AC57 HCT 116 C166(1.04)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C166(0.81)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C166(0.74)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C166(1.09)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C166(0.74)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C166(0.91)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C166(0.90)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C166(0.85)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C166(0.77)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C166(0.69)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C166(0.80)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C166(0.75)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C166(1.11)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C166(1.12)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C166(1.13)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C166(0.92)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C166(1.06)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C166(0.87)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C166(0.91)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C166(0.96)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C166(0.98)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C166(1.04)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C166(1.07)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C166(1.00)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C166(0.93)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C166(1.07)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C166(0.89)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C166(0.90)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C166(0.92)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C166(0.84)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C166(0.89)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C166(0.70)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C166(1.10)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C166(0.95)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C166(1.10)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C166(1.16)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C166(1.28)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C166(0.83)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C166(0.84)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C166(0.75)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C166(0.88)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C166(1.20)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C166(1.26)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C166(1.08)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C166(0.90)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C166(0.88)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C166(0.89)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C166(0.87)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C166(0.86)  LDD0873  [3]
 LDCM0632  CL-Sc Hep-G2 C1235(1.85)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C1180(0.98); C883(0.85)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C1180(1.22)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C166(1.17)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C166(1.03)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C166(0.84)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C166(1.16)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C166(1.11)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C166(0.93)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C166(1.10)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C166(0.94)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C166(1.18)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C166(0.87)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C313(1.00)  LDD1583  [6]
 LDCM0380  CL110 HCT 116 C166(0.94)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C166(0.96)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C166(1.08)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C166(0.80)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C166(0.61)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C166(0.83)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C166(0.70)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C166(1.25)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C166(0.94)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C166(0.86)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C1180(1.50)  LDD1594  [6]
 LDCM0391  CL120 HCT 116 C166(0.80)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C1180(0.99); C883(1.04)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C166(0.63)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C80(0.87)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C883(1.15)  LDD1599  [6]
 LDCM0396  CL125 HCT 116 C166(0.78)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C166(0.68)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C166(0.62)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C166(0.90)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C1180(1.07); C883(1.01)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C166(1.19)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C80(0.74)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C883(1.22)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C1180(1.05)  LDD1608  [6]
 LDCM0407  CL2 HEK-293T C166(0.96)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C1180(1.18)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C1180(1.15)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C1180(1.20)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C313(1.10)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C1180(1.20)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C1180(1.08); C883(0.86)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C166(0.98)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C80(1.16)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C883(1.03)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C1180(1.01)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C80(0.91)  LDD1622  [6]
 LDCM0421  CL32 HEK-293T C1180(1.05)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C1180(1.06)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C1180(1.20)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C313(0.88)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C1180(1.18)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C1180(0.86); C883(1.41)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C80(0.82)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C883(1.14)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C883(1.29)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C1180(0.91)  LDD1635  [6]
 LDCM0434  CL44 HEK-293T C1180(1.14)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C1180(1.11)  LDD1639  [6]
 LDCM0436  CL46 HCT 116 C166(0.89)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C166(0.88)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C166(0.97)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C166(1.30)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C1180(1.09)  LDD1644  [6]
 LDCM0441  CL50 HCT 116 C166(1.03)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C166(0.91)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C166(0.90)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C166(1.09)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C166(0.97)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C166(1.13)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C166(1.32)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C166(1.07)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C166(1.17)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C166(1.00)  LDD0767  [3]
 LDCM0452  CL60 HCT 116 C166(0.88)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C1180(0.92); C883(0.94)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C166(1.03)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C80(1.05)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C883(1.23)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C1180(1.19)  LDD1660  [6]
 LDCM0460  CL68 HEK-293T C1180(1.19)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C1180(1.00)  LDD1664  [6]
 LDCM0463  CL70 HEK-293T C1180(1.18)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C313(1.03)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C1180(1.29)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C1180(0.89); C883(0.73)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C166(1.03)  LDD1670  [6]
 LDCM0469  CL76 HCT 116 C166(1.28)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C166(1.13)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C166(0.93)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C166(1.18)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C1180(0.94)  LDD1676  [6]
 LDCM0474  CL80 HCT 116 C166(0.98)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C166(1.16)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C166(1.29)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C166(1.05)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C166(1.16)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C166(0.96)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C166(0.92)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C166(1.23)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C166(1.34)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C166(1.03)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C1180(1.25)  LDD1687  [6]
 LDCM0485  CL90 HCT 116 C166(1.05)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C166(0.97)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C166(0.79)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C166(0.91)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C166(0.83)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C166(0.70)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C166(1.15)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C166(0.71)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C166(0.89)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C166(0.82)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C80(1.31)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C80(0.96)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C166(0.93)  LDD1631  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 AU565 C1033(1.73)  LDD2265  [7]
 LDCM0023  KB03 AU565 C1033(3.24)  LDD2682  [7]
 LDCM0024  KB05 ZR-75-1 C1033(1.67)  LDD3493  [7]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840