Details of the Target

General Information of Target

Target ID LDTP15214
Target Name Vacuolar fusion protein MON1 homolog B (MON1B)
Gene Name MON1B
Gene ID 22879
Synonyms
HSRG1; KIAA0872; SAND2; Vacuolar fusion protein MON1 homolog B; HSV-1 stimulation-related gene 1 protein; HSV-I stimulating-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPWALAVTRWPPSAPVGQRRFSAGPGSTPGQLWGSPGLEGPLASPPARDERLPSQQPPS
RPPHLPVEERRASAPAGGSPRMLHPATQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFP
LPTGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPLIQACTMQQLPVPYQAYPHLISSDH
YILHPPPPAPPPQPTHMAPLGQFVSLQTQHPRMPLQRLDNDVDLRGDQPSLGSFTYSTSA
PGPALSPSVPLHYLPHDPLHQELSFGVPYSHMMPRRLSTQRYRLQQPLPPPPPPPPPPPY
YPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADI
EQLPSYRFNPDSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVDKWLKANRTCPIC
RADASEVPREAE
Target Bioclass
Other
Family
MON1/SAND family
Uniprot ID
Q7L1V2
Ensemble ID
ENST00000248248.8
HGNC ID
HGNC:25020

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.R249C DBIA    Probe Info 
HCT116 Insertion: p.E385GfsTer7 .
HCT15 SNV: p.R29I; p.R283Ter; p.L509M .
HT1080 Insertion: p.E320GfsTer119 DBIA    Probe Info 
MDAMB453 SNV: p.G282C DBIA    Probe Info 
MFE319 Insertion: p.E189GfsTer29 DBIA    Probe Info 
OVKATE Insertion: p.E320GfsTer119 DBIA    Probe Info 
RL952 SNV: p.S205G DBIA    Probe Info 
WM115 SNV: p.A321S .
WM2664 SNV: p.A321S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.28  LDD0403  [1]
BTD
 Probe Info  		C297(0.81)  LDD2097  [2]
DBIA
 Probe Info  		C297(1.10)  LDD0625  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C268(0.00); C349(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C349(0.00); C297(0.00); C250(0.00); C366(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C268(0.00); C349(0.00)  LDD0037  [4]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		C268(0.00); C297(0.00)  LDD0148  [7]
NAIA_5
 Probe Info  		C268(0.00); C349(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C366(1.07); C297(1.02); C268(1.05); C349(1.00)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C366(0.93); C297(0.99); C268(1.02); C349(0.92)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C366(0.87); C297(0.99); C268(0.91); C349(1.13)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C366(0.89); C297(1.07); C268(0.87); C349(0.86)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C366(0.94); C297(1.03); C268(1.15); C349(1.05)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C366(0.87); C297(1.07); C268(1.24); C349(1.01)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C366(1.06); C297(1.02); C268(1.01); C349(1.04)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C366(1.01); C297(0.96); C268(1.04); C349(1.04)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C366(0.81); C297(1.00); C268(0.94); C349(0.93)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C366(0.96); C297(0.96); C268(0.93); C349(1.03)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C366(1.01); C297(1.03); C268(1.14); C349(1.04)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C366(1.07); C297(0.95); C268(1.04); C349(0.93)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C366(1.09); C297(0.82); C268(1.16); C349(1.00)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C366(0.96); C297(1.02); C268(1.15); C349(0.99)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C366(0.89); C297(0.96); C268(0.93); C349(0.91)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C366(1.09); C297(1.01); C268(1.21); C349(1.03)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C366(0.96); C297(1.04); C268(0.98); C349(1.00)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C366(0.99); C297(1.02); C268(0.98); C349(0.98)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C366(0.96); C297(1.03); C268(1.23); C349(1.06)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C366(0.96); C297(1.07); C268(1.07); C349(0.97)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C366(0.88); C297(0.99); C268(1.15); C349(1.05)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C366(0.94); C297(0.92); C268(1.13); C349(1.03)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C366(0.98); C297(1.02); C268(1.09); C349(1.08)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C366(1.07); C297(0.98); C268(1.03); C349(0.93)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C366(1.07); C297(1.04); C268(1.08); C349(0.99)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C366(0.97); C297(0.93); C268(0.99); C349(1.01)  LDD1534  [9]
 LDCM0296  AC35 PaTu 8988t C349(1.15)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C349(0.99)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C349(1.18)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C349(1.14)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C349(1.15)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C366(0.94); C297(0.97); C268(1.31); C349(1.02)  LDD1540  [9]
 LDCM0302  AC40 PaTu 8988t C349(1.28)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C349(1.03)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C349(1.14)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C349(1.05)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C349(0.97)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C349(1.04)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C297(1.10)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C297(0.93)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C297(1.02)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C297(1.17)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C366(0.99); C297(0.93); C268(0.97); C349(0.93)  LDD1551  [9]
 LDCM0313  AC50 HCT 116 C297(1.23)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C297(1.26)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C297(1.06)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C297(0.95)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C297(1.00)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C297(0.97)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C297(0.92)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C366(1.10); C297(1.05); C268(1.15); C349(1.00)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C366(0.85); C297(1.00); C268(0.91); C349(1.02)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C366(0.95); C297(0.92); C268(0.95); C349(0.96)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C366(1.06); C297(0.93); C268(1.25); C349(0.98)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C366(0.82); C297(1.04); C268(1.05); C349(1.07)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C366(1.01); C297(1.00); C268(1.00); C349(0.95)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C366(1.08); C297(1.02); C268(1.02); C349(1.05)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C366(0.91); C297(1.03); C268(1.21); C349(1.04)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C366(0.97); C297(1.01); C268(0.83); C349(0.96)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C366(0.98); C297(0.97); C268(1.12); C349(1.11)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C366(1.07); C297(0.95); C268(1.23); C349(0.96)  LDD1569  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C297(1.53)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C366(0.99); C297(1.06); C268(1.11); C349(0.89)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C366(1.10); C297(1.12); C268(1.14); C349(0.98)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C366(0.95); C297(1.00); C268(1.04); C349(0.95)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 13.28  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C297(0.99)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C297(1.08)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C366(0.90); C297(0.98); C268(1.15); C349(0.91)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C366(0.98); C297(1.02); C268(0.96); C349(0.93)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C366(0.93); C297(1.20); C268(1.33); C349(0.87)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C366(0.92); C297(0.94); C268(1.09); C349(1.04)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C366(0.96); C297(1.05); C268(1.18); C349(0.95)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C366(1.17); C297(1.02); C268(0.99); C349(0.89)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C366(0.93); C297(1.11); C268(0.99); C349(0.92)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C366(0.94); C297(0.99); C268(1.18); C349(1.05)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C366(1.01); C297(0.99); C268(1.02); C349(0.97)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C366(1.01); C297(0.99); C268(1.73); C349(1.04)  LDD1582  [9]
 LDCM0379  CL11 HCT 116 C297(0.95)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C366(1.01); C297(1.17); C268(1.38); C349(0.82)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C366(0.89); C297(0.96); C268(1.20); C349(0.92)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C366(1.03); C297(1.30); C268(1.03); C349(0.89)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C366(0.91); C297(0.94); C268(0.91); C349(0.92)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C366(1.07); C297(1.35); C268(1.29); C349(0.88)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C366(0.89); C297(0.96); C268(1.09); C349(1.07)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C366(1.02); C297(0.99); C268(1.18); C349(0.94)  LDD1590  [9]
 LDCM0387  CL117 PaTu 8988t C349(0.93)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C349(1.02)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C349(1.02)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C297(0.91)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C349(1.02)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C297(0.84)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C297(1.32)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C297(1.50)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C297(1.32)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C366(0.91); C297(1.01); C268(0.95); C349(0.96)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C366(1.02); C297(1.00); C268(1.32); C349(0.90)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C366(1.06); C297(0.96); C268(1.02); C349(1.10)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C366(1.01); C297(1.01); C268(1.25); C349(0.95)  LDD1603  [9]
 LDCM0400  CL13 HCT 116 C297(1.00)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C297(0.89)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C297(0.96)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C366(0.95); C297(0.95); C268(1.01); C349(0.93)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C366(0.87); C297(1.06); C268(1.18); C349(0.99)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C366(0.88); C297(0.96); C268(1.00); C349(1.07)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C366(0.90); C297(1.12); C268(1.13); C349(0.97)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C297(0.99)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C366(0.81); C297(1.05); C268(1.33); C349(0.99)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C366(0.86); C297(1.43); C268(1.03); C349(0.92)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C366(0.83); C297(0.97); C268(1.27); C349(1.01)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C366(0.82); C297(1.06); C268(1.13); C349(0.87)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C366(1.00); C297(1.09); C268(1.02); C349(0.96)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C366(1.04); C297(1.04); C268(1.00); C349(1.04)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C366(0.97); C297(0.96); C268(1.03); C349(0.97)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C366(0.96); C297(0.92); C268(0.96); C349(0.99)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C366(0.87); C297(1.08); C268(1.26); C349(0.91)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C366(1.07); C297(1.04); C268(1.08); C349(0.99)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C297(0.89)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C366(0.96); C297(1.03); C268(1.08); C349(1.10)  LDD1623  [9]
 LDCM0420  CL31 PaTu 8988t C349(1.35)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C349(1.22)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C349(1.25)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C349(1.46)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C349(1.14)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C349(0.45)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C349(1.21)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C349(1.32)  LDD1307  [3]
 LDCM0429  CL4 HCT 116 C297(0.94)  LDD0746  [3]
 LDCM0430  CL40 PaTu 8988t C349(1.55)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C349(1.40)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C349(1.28)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C349(1.65)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C349(1.70)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C349(1.59)  LDD1314  [3]
 LDCM0436  CL46 HCT 116 C297(1.03)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C297(1.08)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C297(1.13)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C297(0.90)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C297(0.84)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C297(1.04)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C297(0.99)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C297(1.13)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C297(0.92)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C297(1.28)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C297(1.08)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C297(0.95)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C297(0.91)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C297(1.18)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C297(1.00)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C297(1.10)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C297(1.03)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C297(1.09)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C297(1.19)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C297(1.12)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C297(0.95)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C297(0.94)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C297(0.98)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C297(0.83)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C297(0.99)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C297(1.05)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C297(0.90)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C297(0.87)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C297(1.05)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C297(1.03)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C297(1.01)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C297(0.93)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C297(1.33)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C297(1.39)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C297(1.17)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C297(1.46)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C297(0.96)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C297(1.34)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C297(1.21)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C297(1.38)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C297(1.30)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C297(1.40)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C297(1.53)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C297(1.41)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C297(1.56)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C297(1.41)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C297(1.01)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C297(1.25)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C297(1.24)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C366(1.02); C297(0.99); C268(1.08); C349(1.11)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C366(0.90); C297(1.06); C268(1.10); C349(1.22)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C366(0.98); C297(1.17); C268(1.10); C349(1.01)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C366(0.92); C297(0.95); C268(1.32); C349(0.95)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C366(0.83); C297(1.52); C268(1.16); C349(0.79)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C366(1.01); C297(1.27); C268(1.16); C349(0.94)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C366(0.98); C297(1.04); C268(1.07); C349(0.99)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C366(1.04); C297(0.96); C268(1.21); C349(0.92)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C366(0.99); C297(0.98); C268(0.99); C349(0.99)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C366(0.89); C297(0.94); C268(0.90); C349(0.86)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C297(2.62)  LDD1702  [2]
 LDCM0625  F8 Ramos C349(2.02)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C349(0.78)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C349(1.03)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C349(0.63)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C349(0.70)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C349(1.35)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C349(0.40)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C349(0.57)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C349(0.67)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C349(1.02)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C349(0.71)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C349(1.47)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C349(0.96)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C349(0.84)  LDD2201  [10]
 LDCM0468  Fragment33 HCT 116 C297(1.13)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C349(1.65)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C349(0.75)  LDD2184  [10]
 LDCM0427  Fragment51 PaTu 8988t C349(1.42)  LDD1306  [3]
 LDCM0610  Fragment52 Ramos C349(0.76)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C349(0.97)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C349(1.10)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C349(1.25)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C297(0.98); C349(1.07)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C297(10.02)  LDD0315  [11]
 LDCM0024  KB05 HMCB C349(1.65)  LDD3312  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C297(0.81)  LDD2097  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C297(0.72)  LDD2140  [2]
 LDCM0131  RA190 MM1.R C87(1.34)  LDD0304  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 18 homolog (VPS18) VPS18 family Q9P253

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.