Details of the Target

General Information of Target

Target ID LDTP15007
Target Name Large ribosomal subunit protein uL2m (MRPL2)
Gene Name MRPL2
Gene ID 51069
Synonyms
Large ribosomal subunit protein uL2m; 39S ribosomal protein L2, mitochondrial; L2mt; MRP-L2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPTRDPFQQPTLDNDDSYLGELRASKKLPYKNPTHLAQQQEPWSRLNSTPTITSMRRDA
YYFDPEIPKDDLDFRLAALYNHHTGTFKNKSEILLNQKTTQDTYRTKIQFPGEFLTPPTP
PITFLANIRHWINPKKESIHSIQGSIVSPHTAATNGGYSRKKDGGFFST
Target Bioclass
Other
Family
Universal ribosomal protein uL2 family
Subcellular location
Mitochondrion
Uniprot ID
Q5T653
Ensemble ID
ENST00000388752.8
HGNC ID
HGNC:14056

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.36  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
BTD
 Probe Info  		C213(0.94)  LDD2099  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
DBIA
 Probe Info  		C213(0.59)  LDD0531  [5]
IA-alkyne
 Probe Info  		C213(0.00); C240(0.00)  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
TFBX
 Probe Info  		C134(0.00); C240(0.00); C213(0.00)  LDD0027  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
NAIA_5
 Probe Info  		C213(0.00); C240(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C213(0.59)  LDD2117  [3]
 LDCM0214  AC1 HCT 116 C213(0.59)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C213(1.03)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C213(1.19)  LDD0543  [5]
 LDCM0237  AC12 HCT 116 C213(1.33)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C213(0.93)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C213(1.18)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C213(0.57)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C213(1.33)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C213(0.79)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C213(0.55)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C213(0.39)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C213(0.53)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C213(0.79)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C213(0.87)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C213(1.54)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C213(0.52)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C213(0.36)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C213(0.75)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C213(0.93)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C213(1.28)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C213(1.42)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C213(0.98); C240(0.72)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C213(0.94); C240(0.92)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C213(0.89); C240(1.09)  LDD1517  [11]
 LDCM0279  AC2 HCT 116 C213(0.58)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C213(1.00); C240(1.12)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C213(1.00); C240(0.64)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C213(0.92); C240(1.13)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C213(1.01); C240(0.90)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C213(1.02); C240(1.09)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C213(0.94); C240(0.97)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C213(0.96); C240(0.84)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C213(1.00); C240(1.16)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C213(0.98); C240(1.11)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C213(0.98); C240(0.79)  LDD1528  [11]
 LDCM0290  AC3 HCT 116 C213(0.99)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C213(1.01); C240(1.27)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C213(1.09); C240(0.92)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C213(1.10); C240(0.97)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C213(0.92); C240(0.89)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C213(0.97); C240(1.08)  LDD1534  [11]
 LDCM0296  AC35 HCT 116 C213(1.16)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C213(1.12)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C213(1.18)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C213(1.10)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C213(1.00)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C213(0.98)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C213(0.81)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C213(1.22)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C213(1.06)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C213(1.54)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C213(0.89)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C213(0.92)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C213(0.95); C240(1.09)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C213(1.10); C240(1.05)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C213(1.07); C240(0.94)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C213(0.93); C240(0.86)  LDD1550  [11]
 LDCM0312  AC5 HCT 116 C213(0.74)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C213(1.02); C240(0.96)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C213(1.02); C240(1.01)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C213(1.00); C240(0.98)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C213(1.01); C240(0.71)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C213(1.02); C240(1.04)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C213(1.03); C240(1.00)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C213(1.01); C240(1.02)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C213(0.94); C240(0.94)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C213(0.94); C240(1.14)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C213(1.09); C240(1.18)  LDD1561  [11]
 LDCM0323  AC6 HCT 116 C213(0.91)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C213(0.96); C240(0.95)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C213(1.00); C240(1.07)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C213(0.95); C240(1.13)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C213(1.06); C240(1.08)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C213(1.05); C240(0.86)  LDD1567  [11]
 LDCM0332  AC68 HCT 116 C213(1.16)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C213(1.07)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C213(1.41)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C213(0.60)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C213(0.99)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C213(0.69)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C213(0.48)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C213(0.61)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C213(0.44)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C213(0.65)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C213(0.68)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C213(1.93)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C213(1.30)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C213(1.23)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C213(0.89)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C213(0.96)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C213(0.46)  LDD0665  [5]
 LDCM0248  AKOS034007472 HCT 116 C213(0.96)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C213(1.14)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C213(1.12)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C213(1.02)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C213(0.99); C240(1.11)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C213(1.19)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C213(1.15)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C213(0.90)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C213(1.24)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C213(1.17)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C213(0.98)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C213(0.97); C240(0.94)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C213(0.89)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C213(0.99); C240(0.87)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C213(0.94)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C213(1.07); C240(1.09)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C213(0.95); C240(0.82)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C213(0.97)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C213(0.92); C240(0.81)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C213(0.97)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C213(0.95); C240(0.86)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C213(0.89)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C213(0.95); C240(0.91)  LDD1590  [11]
 LDCM0387  CL117 HCT 116 C213(0.70)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C213(1.53)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C213(0.72)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C213(1.09); C240(0.93)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C213(1.50)  LDD0708  [5]
 LDCM0392  CL121 HEK-293T C213(0.89)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C213(0.96); C240(0.99)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C213(0.87)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C213(1.00); C240(1.11)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C213(0.98)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C213(0.95); C240(0.95)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C213(0.98)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C213(0.95); C240(1.05)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C213(0.99)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C213(0.93); C240(1.02)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C213(0.95)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C213(0.94); C240(0.93)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C213(0.90); C240(1.18)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C213(1.02); C240(1.12)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C213(1.05); C240(1.18)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C213(0.97); C240(1.12)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C213(1.12); C240(1.04)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C213(1.04); C240(0.65)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C213(0.98); C240(1.10)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C213(1.11); C240(1.04)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C213(1.09); C240(0.95)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C213(1.00)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C213(1.01); C240(1.07)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C213(0.94)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C213(1.05); C240(1.04)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C213(1.04); C240(1.01)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C213(0.99)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C213(1.01); C240(0.98)  LDD1623  [11]
 LDCM0420  CL31 HCT 116 C213(0.73)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C213(0.68)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C213(0.92)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C213(0.84)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C213(0.63)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C213(0.81)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C213(1.00)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C213(0.57)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C213(0.90); C240(1.18)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C213(1.04)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C213(0.77)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C213(0.79)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C213(0.54)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C213(0.85)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C213(0.73)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C213(1.00); C240(0.99)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C213(1.10); C240(1.01)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C213(1.22); C240(0.97)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C213(1.00)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C213(0.94); C240(0.99)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C213(1.05); C240(1.01)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C213(0.97); C240(1.00)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C213(0.93); C240(1.14)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C213(0.98); C240(0.95)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C213(1.16); C240(1.08)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C213(1.07); C240(1.11)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C213(1.00); C240(0.96)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C213(1.02); C240(1.04)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C213(1.26); C240(1.15)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C213(1.03); C240(1.03)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C213(1.21); C240(0.91)  LDD1655  [11]
 LDCM0453  CL61 HCT 116 C213(1.18)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C213(1.04)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C213(0.84)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C213(1.08)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C213(1.25)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C213(0.75)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C213(0.88)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C213(1.01)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C213(1.18)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C213(1.04); C240(1.03)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C213(1.28)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C213(1.15)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C213(2.02)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C213(0.75)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C213(0.98)  LDD0784  [5]
 LDCM0469  CL76 HEK-293T C213(0.95); C240(0.90)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C213(1.01); C240(0.90)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C213(0.96); C240(1.18)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C213(1.08); C240(1.09)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C213(0.97); C240(1.06)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C213(1.09); C240(0.91)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C213(1.10); C240(1.09)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C213(1.07); C240(1.33)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C213(1.15); C240(1.11)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C213(1.13); C240(0.89)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C213(0.99)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C213(0.98); C240(1.19)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C213(0.98)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C213(0.97); C240(0.96)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C213(1.03); C240(1.13)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C213(1.20); C240(0.88)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C213(0.93); C240(1.11)  LDD1688  [11]
 LDCM0486  CL91 HCT 116 C213(0.63)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C213(0.71)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C213(0.65)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C213(0.56)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C213(0.43)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C213(0.77)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C213(0.50)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C213(0.75)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C213(0.77)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C213(0.90)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C213(1.70)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C213(0.92)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C213(0.59)  LDD0744  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 HEK-293T C213(1.00)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C213(0.96)  LDD1497  [11]
 LDCM0024  KB05 HMCB C213(1.90)  LDD3312  [12]
 LDCM0109  NEM HeLa C213(0.00); C240(0.00)  LDD0224  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C213(0.94)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C213(0.82)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C213(0.49)  LDD2109  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C213(0.59)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C213(1.72)  LDD2129  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C213(0.78)  LDD2137  [3]

References

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2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840