Details of the Target

General Information of Target

Target ID LDTP14932
Target Name Glucoside xylosyltransferase 1 (GXYLT1)
Gene Name GXYLT1
Gene ID 283464
Synonyms
GLT8D3; Glucoside xylosyltransferase 1; EC 2.4.2.42; Glycosyltransferase 8 domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRAALWTLGLGPLLLNLWAVPIGGPGALRLAYRHSTCDGVVLVRHHGAWGYVCNQEWTLA
EASVVCRQLGCGPAVGAPKYVPLPGEMAQPWLHNVSCRGNESSLWECSLGSWCQSPCPHA
WVVVALCSNGTFRELRLVKGRSPCAGLPEIRNVNGVDRLCVLHVEEAMVFCRELGCGPVL
QAPRRDVGVVRKYLACRGTEPTIRSCRLDNNFRSGCDLRLDAEVVCSGHTEARLVGGEHP
CAGRLEVTWGTVCDAALDLATAHVVCRELQCGAVVSTPEGARFGRGSGPVWTEAFRCAGN
ESLLFHCPRGRGSQCGHGHDAGLRCSEFRMVNGSSSCEGRVEFQVQGSWAPLCATHWDIA
DATVLCHQLNCGNAVAAPGGGHFGDGDAAIWPDAFHCEGTESYLWNCPVSTLGAPACAPG
NTASAVCSGLAHALRLREGQSRCDGRVEVSLDGVWGRVLDDAWDLRGAGVVCRQLGCRGA
QQAYDAPAPSRGSVQVALSRVRCLGTETRLTQCNVSATLQEPAGTSRDAGVVCSGEVGTA
SPMARRHGIPGALTLSLHREPQGAAGRGAGALHGGAWGTVCDDAWDLRDAHVVCRQLGCG
RALSALGAAHFGAGAGRIWLDELGCQGHESALWQCPSAGWGRHDWRHKEDAGVFCSESVA
LRLRGGTCCCAGWLDVFYNGTWGAMCSNALKDLSLSIICKQLGCGVWGVGLAGEQALPLC
GHRDRLGGQHRVPQAAQLHSVAMPFPPMAPALLRPSRAGLSEDRPQAAGEPLNCSSWLGC
PEEGALRVRGGEDRCSGRVELWHAGSWGTVCDDGWDLADAEVVCRQLGCGRAVAALGAAA
FGPGSGPVWLDEVGCRGSEASLWGCPAERWGRGDRAHEEDAGVRCWEPGPGPPLPAAPFR
TFWVVSVVLGSLLGLLLLGLMAFLILPRVTQAMQRGLGRSEVSPGEAIYDVIGEMPPAGL
YEEIMEAEAVLQDEEDGSVVKVDTEAAVSGEVSNLLEGQSIRAEGGHSRPVSQGYDEAAF
PLEEMTL
Target Bioclass
Enzyme
Family
Glycosyltransferase 8 family
Subcellular location
Membrane
Function Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
Uniprot ID
Q4G148
Ensemble ID
ENST00000280876.6
HGNC ID
HGNC:27482

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.C11Y .
DU145 SNV: p.A377S .
HCC1419 SNV: p.V226A .
HCT116 Deletion: p.L223YfsTer11 .
HUPT3 Substitution: p.C414H .
KMS27 Substitution: p.C414H .
MDAMB436 Substitution: p.E249R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y413(8.54)  LDD0260  [1]
m-APA
 Probe Info  		15.00  LDD0403  [2]
BTD
 Probe Info  		C414(2.99); C196(0.77)  LDD1700  [3]
DBIA
 Probe Info  		C123(1.07)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C123(0.00); C414(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C196(0.00); C123(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C196(0.00); C123(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C414(0.39)  LDD2095  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C414(1.09)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C414(1.32); C196(1.07)  LDD2152  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C414(0.45)  LDD2132  [3]
 LDCM0214  AC1 PaTu 8988t C123(1.40)  LDD1093  [4]
 LDCM0215  AC10 HEK-293T C414(0.97); C123(1.22); C196(1.47)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C414(0.92); C196(1.22)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C414(0.99); C196(1.39)  LDD1510  [9]
 LDCM0246  AC128 PaTu 8988t C123(1.14)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C123(0.85)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C123(1.08)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C123(0.93)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C123(0.79)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C123(0.79)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C123(1.10)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C123(0.93)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C123(0.90)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C123(0.79)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C123(0.81)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C123(0.92)  LDD1137  [4]
 LDCM0259  AC14 HEK-293T C196(1.38)  LDD1512  [9]
 LDCM0260  AC140 PaTu 8988t C123(0.76)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C123(0.94)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C123(0.88)  LDD1141  [4]
 LDCM0270  AC15 HEK-293T C414(0.98); C123(0.89); C196(1.35)  LDD1513  [9]
 LDCM0276  AC17 PaTu 8988t C123(0.79)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C123(1.16)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C123(0.90)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C123(1.66)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C123(0.87)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C123(0.83)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C123(0.81)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C123(1.08)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C123(1.13)  LDD1163  [4]
 LDCM0285  AC25 HEK-293T C414(1.07); C123(1.22); C196(1.42)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C414(0.94); C123(1.10); C196(1.23)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C414(1.06); C196(1.20)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C414(0.97); C196(1.22)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C388(0.99); C414(1.03); C196(1.02)  LDD1528  [9]
 LDCM0290  AC3 PaTu 8988t C123(1.17)  LDD1169  [4]
 LDCM0291  AC30 HEK-293T C196(1.32)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C414(0.98); C123(1.18); C196(1.33)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C388(0.93); C414(1.02); C196(1.01)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C414(1.09); C123(1.14); C196(1.36)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C414(0.97); C123(1.13); C196(1.44)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C414(1.02); C196(1.30)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C414(1.00); C196(1.39)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C388(1.01); C414(1.08); C196(1.11)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C196(1.36)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C414(1.05); C123(1.11); C196(1.34)  LDD1539  [9]
 LDCM0301  AC4 PaTu 8988t C123(1.23)  LDD1180  [4]
 LDCM0302  AC40 HEK-293T C388(0.97); C414(1.05); C196(1.05)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C414(0.94); C123(1.14); C196(1.47)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C414(1.01); C123(1.13); C196(1.51)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C414(1.05); C196(1.15)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C414(0.96); C196(1.32)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C388(1.00); C414(1.01); C196(1.13)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C196(1.27)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C414(1.08); C123(1.00); C196(1.33)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C388(1.06); C414(0.99); C196(1.04)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C414(1.03); C123(1.24); C196(1.42)  LDD1550  [9]
 LDCM0312  AC5 PaTu 8988t C123(1.31)  LDD1191  [4]
 LDCM0313  AC50 HEK-293T C414(0.95); C123(1.22); C196(1.40)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C414(0.97); C196(1.24)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C414(0.97); C196(1.37)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C388(1.08); C414(1.00); C196(1.13)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C196(1.28)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C414(0.96); C123(0.98); C196(1.22)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C388(1.10); C414(1.01); C196(1.10)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C414(0.95); C123(1.30); C196(1.41)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C414(0.93); C123(1.19); C196(1.31)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C414(0.93); C196(1.25)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C196(1.18)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C414(0.93); C196(1.33)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C388(0.97); C414(1.07); C196(1.09)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C196(1.24)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C414(0.96); C123(0.94); C196(1.47)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C388(1.03); C414(0.98); C196(1.08)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C414(1.02); C123(0.98); C196(1.32)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C388(1.07); C414(0.99); C196(1.13)  LDD1569  [9]
 LDCM0545  Acetamide MDA-MB-231 C414(0.47)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C414(0.79)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C388(0.95); C414(0.97); C196(1.05)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C414(1.02); C123(1.24); C196(1.37)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C388(1.02); C414(1.00); C196(1.07)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C123(1.07)  LDD0078  [4]
 LDCM0367  CL1 HEK-293T C388(1.14); C414(1.08); C123(1.13)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C196(1.55)  LDD1572  [9]
 LDCM0369  CL100 PaTu 8988t C123(0.98)  LDD1248  [4]
 LDCM0370  CL101 HEK-293T C388(1.04); C414(0.94); C123(1.24)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C414(1.00); C123(1.33); C196(1.46)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C414(0.94); C123(0.99); C196(1.38)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C414(0.99); C123(1.16); C196(1.50)  LDD1577  [9]
 LDCM0374  CL105 PaTu 8988t C123(0.87)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C123(0.86)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C123(0.79)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C123(0.85)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C123(0.98)  LDD1257  [4]
 LDCM0379  CL11 HEK-293T C414(1.11); C123(1.82); C196(0.93)  LDD1583  [9]
 LDCM0380  CL110 PaTu 8988t C123(0.99)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C123(1.07)  LDD1260  [4]
 LDCM0382  CL112 HEK-293T C414(1.03); C123(0.99); C196(1.48)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C388(1.07); C414(1.04); C123(1.28)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C414(1.07); C123(1.25); C196(1.49)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C414(1.01); C123(1.11); C196(1.37)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C414(1.00); C123(1.07); C196(1.54)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C388(1.07); C414(1.05); C123(1.31)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C414(0.99); C123(1.15); C196(1.29)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C414(0.98); C123(1.12); C196(1.35)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C388(1.01); C414(1.08); C196(0.86)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C414(1.00); C123(1.08); C196(1.44)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C388(0.97); C414(1.13); C123(1.29)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C414(1.00); C123(1.17); C196(1.30)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C414(0.96); C123(1.22); C196(1.42)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C414(1.05); C123(1.07); C196(1.45)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C388(0.97); C414(0.99); C123(1.43)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C414(0.85); C123(1.17); C196(1.34)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C414(0.92); C123(1.18); C196(1.46)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C414(0.93); C123(1.13); C196(1.41)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C388(1.14); C414(1.08); C123(1.14)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C414(1.06); C123(0.98); C196(1.47)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C414(1.13); C123(0.98); C196(1.49)  LDD1606  [9]
 LDCM0403  CL16 PaTu 8988t C123(1.16)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C123(1.10)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C123(1.14)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C123(1.24)  LDD1285  [4]
 LDCM0407  CL2 HEK-293T C414(0.96); C123(0.87); C196(1.30)  LDD1611  [9]
 LDCM0408  CL20 PaTu 8988t C123(1.19)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C123(1.37)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C123(1.35)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C123(1.18)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C123(1.12)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C123(1.11)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C123(1.12)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C123(1.22)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C123(1.39)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C123(1.37)  LDD1296  [4]
 LDCM0418  CL3 HEK-293T C414(1.10); C123(0.92); C196(1.13)  LDD1622  [9]
 LDCM0419  CL30 PaTu 8988t C123(1.28)  LDD1298  [4]
 LDCM0420  CL31 HEK-293T C414(1.11); C196(0.87)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C414(0.97); C196(0.85)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C388(1.05); C414(1.14); C196(1.03)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C196(0.80)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C414(1.13); C123(2.05); C196(0.74)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C388(1.11); C414(1.15); C196(0.81)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C388(0.96); C414(0.93); C123(1.26)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C414(1.11); C123(0.96); C196(1.27)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C414(1.03); C123(1.01); C196(1.36)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C414(1.03); C123(0.91); C196(1.08)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C414(1.07); C123(0.95); C196(1.17)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C414(1.07); C123(1.14); C196(0.89)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C414(0.92); C196(0.91)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C414(0.95); C196(0.90)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C388(0.97); C414(1.10); C196(0.92)  LDD1639  [9]
 LDCM0436  CL46 PaTu 8988t C123(0.89)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C123(1.02)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C123(0.95)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C123(0.97)  LDD1318  [4]
 LDCM0440  CL5 HEK-293T C414(1.14); C123(0.96); C196(1.01)  LDD1644  [9]
 LDCM0441  CL50 PaTu 8988t C123(1.05)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C123(0.90)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C123(1.06)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C123(0.93)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C123(0.87)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C123(1.03)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C123(0.92)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C123(1.04)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C123(1.02)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C123(0.91)  LDD1329  [4]
 LDCM0451  CL6 HEK-293T C414(1.09); C123(1.28); C196(1.45)  LDD1654  [9]
 LDCM0452  CL60 PaTu 8988t C123(0.97)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C123(1.01)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C123(0.84)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C123(0.79)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C123(0.90)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C123(1.02)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C123(1.06)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C123(1.22)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C123(1.29)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C123(1.25)  LDD1340  [4]
 LDCM0462  CL7 HEK-293T C414(1.20); C196(0.87)  LDD1665  [9]
 LDCM0463  CL70 PaTu 8988t C123(1.18)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C123(0.85)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C123(0.71)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C123(1.13)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C123(0.93)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C123(1.05)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C123(1.22)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C123(1.30)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C123(1.38)  LDD1351  [4]
 LDCM0473  CL8 HEK-293T C414(1.38); C196(1.42)  LDD1676  [9]
 LDCM0474  CL80 PaTu 8988t C123(1.26)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C123(1.43)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C123(1.65)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C123(1.59)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C123(1.19)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C123(1.43)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C123(1.31)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C123(1.31)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C123(1.51)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C123(1.23)  LDD1362  [4]
 LDCM0484  CL9 HEK-293T C388(0.99); C414(1.07); C196(0.91)  LDD1687  [9]
 LDCM0485  CL90 PaTu 8988t C123(1.76)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C123(0.99)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C123(1.12)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C123(1.29)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C123(1.27)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C123(1.37)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C123(1.09)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C123(1.23)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C123(1.16)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C123(1.20)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C414(0.83); C123(0.97); C196(1.23)  LDD1698  [9]
 LDCM0468  Fragment33 PaTu 8988t C123(0.92)  LDD1347  [4]
 LDCM0427  Fragment51 HEK-293T C414(1.01); C123(0.94); C196(1.17)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C414(0.99); C196(0.99)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C414(0.98); C196(1.01)  LDD1497  [9]
 LDCM0024  KB05 COLO792 C92(2.00); C414(3.30)  LDD3310  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C414(0.90)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C414(0.78)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C414(1.23)  LDD2093  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C414(0.89)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C414(0.56)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C414(1.83); C196(0.89)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C414(1.10)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C414(0.97); C196(0.70)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C414(0.98)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C414(1.52); C196(1.43)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C414(0.75)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C414(1.93); C196(2.43)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C414(1.07)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C414(0.96); C196(0.60)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C414(1.16); C196(0.94)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C414(1.21)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C414(0.65)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C414(0.50)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C414(1.59); C196(1.25)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C414(1.45); C196(0.77)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C414(1.08)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C414(2.99); C196(0.77)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C75(0.88)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C414(2.80); C196(1.98)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C414(1.00); C196(0.87)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C414(0.51)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C414(0.84)  LDD2150  [3]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840